MANABE Hiroyuki
Organization for Research Initiatives and Development
Associate Professor
Last Updated :2022/11/28

Researcher Profile and Settings

      Research funding number

      80511386

    Research Interests

    • flavor
    • 摂食
    • 光遺伝学
    • テトロード
    • 情動
    • 嗅皮質
    • 電気生理
    • 鋭波
    • 睡眠
    • 神経科学
    • 嗅覚

    Research Areas

    • Life sciences / Neuroscience - general

    Research Experience

    • さきがけ研究者, 2021/10 - Today
    • Doshisha University, 脳科学研究科, 2015/04 - Today
    • The University of Tokyo, 医学(系)研究科(研究院), 助教, 2011/04 - 2015/03

    Published Papers

    • Auditory cortex neurons show task-related and learning-dependent selectivity toward sensory input and reward during the learning process of an associative memory task.
      Shogo Takamiya; Kazuki Shiotani; Tomoya Ohnuki; Yuma Osako; Yuta Tanisumi; Shoko Yuki; Hiroyuki Manabe; Junya Hirokawa; Yoshio Sakurai
      eNeuro, 12 May 2022, Scientific journal
    • Hippocampal CA1 Neurons Represent Positive Feedback During the Learning Process of an Associative Memory Task
      Shogo Takamiya; Kazuki Shiotani; Tomoya Ohnuki; Yuma Osako; Yuta Tanisumi; Shoko Yuki; Hiroyuki Manabe; Junya Hirokawa; Yoshio Sakurai
      Frontiers in Systems Neuroscience, Frontiers Media SA, 15, 06 Sep. 2021, Scientific journal
    • Over-representation of fundamental decision variables in the prefrontal cortex underlies decision bias
      Tomoya Ohnuki; Yuma Osako; Hiroyuki Manabe; Yoshio Sakurai; Junya Hirokawa
      Neuroscience Research, Elsevier BV, 173 1 - 13, Jul. 2021, Scientific journal
    • Contribution of non-sensory neurons in visual cortical areas to visually guided decisions in the rat
      Yuma Osako; Tomoya Ohnuki; Yuta Tanisumi; Kazuki Shiotani; Hiroyuki Manabe; Yoshio Sakurai; Junya Hirokawa
      Current Biology, Elsevier BV, Apr. 2021, Scientific journal
    • Bi-directional encoding of context-based odors and behavioral states by the nucleus of the lateral olfactory tract
      Yuta Tanisumi; Kazuki Shiotani; Junya Hirokawa; Yoshio Sakurai; Hiroyuki Manabe
      iScience, Elsevier BV, 24(4) 102381 - 102381, Apr. 2021, Scientific journal
    • Dynamic coordination of the perirhinal cortical neurons supports coherent representations between task epochs
      Tomoya Ohnuki; Yuma Osako; Hiroyuki Manabe; Yoshio Sakurai; Junya Hirokawa
      Communications Biology, Springer Science and Business Media LLC, 3(1), Dec. 2020, Scientific journal
    • Encoding of odor information and reward anticipation in anterior cortical amygdaloid nucleus
      Kazuki Shiotani; Yuta Tanisumi; Junya Hirokawa; Yoshio Sakurai; Hiroyuki Manabe
      Cold Spring Harbor Laboratory, 20 Nov. 2020
    • Tuning of olfactory cortex ventral tenia tecta neurons to distinct task elements of goal-directed behavior
      Kazuki Shiotani; Yuta Tanisumi; Koshi Murata; Junya Hirokawa; Yoshio Sakurai; Hiroyuki Manabe
      eLife, eLife Sciences Publications, Ltd, 9, 04 Aug. 2020, Scientific journal
    • Dynamics of memory engrams
      Shogo Takamiya; Shoko Yuki; Junya Hirokawa; Hiroyuki Manabe; Yoshio Sakurai
      Neuroscience Research, Elsevier BV, 153 22 - 26, Apr. 2020, Scientific journal
    • GABAergic neurons in the olfactory cortex projecting to the lateral hypothalamus in mice
      Koshi Murata; Tomoki Kinoshita; Yugo Fukazawa; Kenta Kobayashi; Kazuto Kobayashi; Kazunari Miyamichi; Hiroyuki Okuno; Haruhiko Bito; Yoshio Sakurai; Masahiro Yamaguchi; Kensaku Mori; Hiroyuki Manabe
      Scientific Reports, Springer Science and Business Media LLC, 9(1) 7132 - 7132, Dec. 2019, Scientific journal
    • Opposing Roles of Dopamine Receptor D1- and D2-Expressing Neurons in the Anteromedial Olfactory Tubercle in Acquisition of Place Preference in Mice
      Koshi Murata; Tomoki Kinoshita; Yugo Fukazawa; Kenta Kobayashi; Akihiro Yamanaka; Takatoshi Hikida; Hiroyuki Manabe; Masahiro Yamaguchi
      Frontiers in Behavioral Neuroscience, Frontiers Media SA, 13, 15 Mar. 2019, Scientific journal
    • Sharp wave-associated activity patterns of cortical neurons in the mouse piriform cortex.
      Katori K; Manabe H; Nakashima A; Eer D; Sasaki T; Ikegaya Y; Takeuchi H
      The European journal of neuroscience, 48(10) 3246 - 3254, Aug. 2018, Scientific journal
    • Multiple Approaches to the Investigation of Cell Assembly in Memory Research-Present and Future.
      Sakurai Y; Osako Y; Tanisumi Y; Ishihara E; Hirokawa J; Manabe H
      Frontiers in systems neuroscience, Frontiers Media SA, 12 21 , 2018, Scientific journal
    • CDKL5 controls postsynaptic localization of GluN2B-containing NMDA receptors in the hippocampus and regulates seizure susceptibility.
      Kosuke Okuda; Shizuka Kobayashi; Masahiro Fukaya; Aya Watanabe; Takuto Murakami; Mai Hagiwara; Tempei Sato; Hiroe Ueno; Narumi Ogonuki; Sayaka Komano-Inoue; Hiroyuki Manabe; Masahiro Yamaguchi; Atsuo Ogura; Hiroshi Asahara; Hiroyuki Sakagami; Masashi Mizuguchi; Toshiya Manabe; Teruyuki Tanaka
      Neurobiology of disease, 106 158 - 170, Oct. 2017, Scientific journal
    • Temporal coordination of olfactory cortex sharp-wave activity with up- and downstates in the orbitofrontal cortex during slow-wave sleep
      Naomi Onisawa; Hiroyuki Manabe; Kensaku Mori
      JOURNAL OF NEUROPHYSIOLOGY, AMER PHYSIOLOGICAL SOC, 117(1) 123 - 135, Jan. 2017, Scientific journal
    • Possible functional role of olfactory subsystems in monitoring inhalation and exhalation
      Kensaku Mori; Hiroyuki Manabe; Kimiya Narikiyo
      FRONTIERS IN NEUROANATOMY, FRONTIERS RESEARCH FOUNDATION, 8 107 , Sep. 2014
    • Top-down inputs from the olfactory cortex in the postprandial period promote elimination of granule cells in the olfactory bulb
      Sayaka Komano-Inoue; Hiroyuki Manabe; Mizuho Ota; Ikue Kusumoto-Yoshida; Takeshi K. Yokoyama; Kensaku Mori; Masahiro Yamaguchi
      EUROPEAN JOURNAL OF NEUROSCIENCE, WILEY-BLACKWELL, 40(5) 2724 - 2733, Sep. 2014
    • Unique characteristics of the olfactory system
      Kensaku Mori; Hiroyuki Manabe
      The Olfactory System: From Odor Molecules to Motivational Behaviors, Springer Japan, 1 - 18, 01 Feb. 2014, In book
    • Parallel tufted cell and mitral cell pathways from the olfactory bulb to the olfactory cortex
      Shin Nagayama; Kei M. Igarashi; Hiroyuki Manabe; Kensaku Mori
      The Olfactory System: From Odor Molecules to Motivational Behaviors, Springer Japan, 133 - 160, 01 Feb. 2014, In book
    • Sharp wave-associated synchronized inputs from the piriform cortex activate olfactory tubercle neurons during slow-wave sleep
      Kimiya Narikiyo; Hiroyuki Manabe; Kensaku Mori
      JOURNAL OF NEUROPHYSIOLOGY, AMER PHYSIOLOGICAL SOC, 111(1) 72 - 81, Jan. 2014, Scientific journal
    • Sniff rhythm-paced fast and slow gamma-oscillations in the olfactory bulb: relation to tufted and mitral cells and behavioral states
      Hiroyuki Manabe; Kensaku Mori
      JOURNAL OF NEUROPHYSIOLOGY, AMER PHYSIOLOGICAL SOC, 110(7) 1593 - 1599, Oct. 2013, Scientific journal
    • Reorganization of neuronal circuits of the central olfactory system during postprandial sleep
      Masahiro Yamaguchi; Hiroyuki Manabe; Koshi Murata; Kensaku Mori
      FRONTIERS IN NEURAL CIRCUITS, FRONTIERS RESEARCH FOUNDATION, 7 132 , Aug. 2013
    • Olfactory consciousness and gamma oscillation couplings across the olfactory bulb, olfactory cortex, and orbitofrontal cortex.
      Kensaku Mori; Hiroyuki Manabe; Kimiya Narikiyo; Naomi Onisawa
      Frontiers in psychology, 4 743 - 743, 2013, Scientific journal
    • 睡眠のグローバル制御とローカル制御 嗅覚系で食後徐波睡眠時に起こる鋭波とその機能
      眞部 寛之; 楠本 郁恵[吉田]; 駒野 清香; 太田 瑞穂; 森 憲作
      日本睡眠学会定期学術集会プログラム・抄録集, (一社)日本睡眠学会, 37回 159 - 159, Jun. 2012
    • Elimination of Adult-Born Neurons in the Olfactory Bulb Is Promoted during the Postprandial Period
      Takeshi K. Yokoyama; Daisuke Mochimaru; Koshi Murata; Hiroyuki Manabe; Ko Kobayakawa; Reiko Kobayakawa; Hitoshi Sakano; Kensaku Mori; Masahiro Yamaguchi
      NEURON, CELL PRESS, 71(5) 883 - 897, Sep. 2011, Scientific journal
    • Olfactory Cortex Generates Synchronized Top-Down Inputs to the Olfactory Bulb during Slow-Wave Sleep
      Hiroyuki Manabe; Ikue Kusumoto-Yoshida; Mizuho Ota; Kensaku Mori
      JOURNAL OF NEUROSCIENCE, SOC NEUROSCIENCE, 31(22) 8123 - 8133, Jun. 2011, Scientific journal
    • 徐波睡眠時に起こる、嗅皮質、嗅球での鋭波発生メカニズムの解析(Neuronal circuits responsible for the generation of olfactory cortex and olfactory bulb sharp waves during slow-wave sleep)
      眞部 寛之; 楠本 郁恵[吉田]; 太田 瑞穂; 森 憲作
      神経化学, 日本神経化学会, 49(2-3) 507 - 507, Aug. 2010
    • 嗅皮質の鋭波は眼窩前頭皮質や扁桃体と連動しながら徐波睡眠時に起こる(Olfactory cortex sharp waves occur during slow wave sleep in a coordinated manner with orbitofrontal cortex and amygdala)
      太田 瑞穂; 真部 寛之; 楠本 郁恵[吉田]; 森 憲作
      神経化学, 日本神経化学会, 49(2-3) 731 - 731, Aug. 2010
    • 嗅皮質は、徐波睡眠時に鋭波を発生する(Olfactory cortex generates sharp waves during slow-wave sleep)
      楠本 郁恵[吉田]; 眞部 寛之; 太田 瑞穂; 森 憲作
      神経化学, 日本神経化学会, 49(2-3) 731 - 731, Aug. 2010
    • Unique alternative translation from two open reading frames on Acpin1 mRNA yields an acrosomal protein and a salivary-gland-specific protein
      Tomohiro Ueda; Hiroyuki Manabe; Keizo Tokuhiro; Mika Hirose; Yasuhiro Matsuoka; Yasushi Miyagawa; Akira Tsujimura; Kyoko Fujita; Morimasa Wada; Akihiko Okuyama; Yoshitake Nishimune; Hiromitsu Tanaka
      INTERNATIONAL JOURNAL OF UROLOGY, WILEY-BLACKWELL PUBLISHING, INC, 16(7) 639 - 646, Jul. 2009, Scientific journal
    • PP-538 半数体精子細胞に発現するδ20遺伝子の単離と解析(第95回日本泌尿器科学会総会)
      植田 知博; 松岡 庸洋; 真部 寛之; 辻村 晃; 西宗 義武; 田中 宏光; 奥山 明彦
      日本泌尿器科学会雑誌, 一般社団法人 日本泌尿器科学会, 98(2) 531 - 531, 2007
    • MP-616 マウス半数体精子細胞に発現するTISP79の単離と解析(一般演題ポスター,第94回日本泌尿器科学会総会)
      植田 知博; 田中 宏光; 真部 寛之; 松岡 庸洋; 辻村 晃; 西宗 義武; 奥山 明彦
      日本泌尿器科学会雑誌, 一般社団法人 日本泌尿器科学会, 97(2) 520 - 520, 2006
    • Cloning and characterization of a mouse spergen-1 localized in sperm mitochondria
      Y Matsuoka; N Iguchi; K Kitamura; H Nishimura; H Manabe; Y Miyagawa; M Koga; K Matsumiya; A Okuyama; H Tanaka; Y Nishimune
      INTERNATIONAL JOURNAL OF ANDROLOGY, BLACKWELL PUBLISHING LTD, 27(3) 152 - 160, Jun. 2004, Scientific journal

    MISC

    • Visually-evoked choice behavior driven by distinct population computations with non-sensory neurons in visual cortical areas
      Yuma Osako; Tomoya Ohnuki; Yuta Tanisumi; Kazuki Shiotani; Hiroyuki Manabe; Yoshio Sakurai; Junya Hirokawa
      Cold Spring Harbor Laboratory, 15 Jun. 2020
    • Dynamic coding of choice targets in the perirhinal cortex
      Tomoya Ohnuki; Yuma Osako; Hiroyuki Manabe; Yoshio Sakurai; Junya Hirokawa
      bioRxiv, 514612, Jan. 2019
    • Analysis of the neuronal circuits of odor-induced eating behavior in mice
      眞部寛之; 村田航志
      浦上財団研究報告書, 25 79‐83 , 27 Mar. 2018
    • The olfactory cortex internally generates exhalation-phased active state without olfactory sensory input
      Kimiya Narikiyo; Hiroyuki Manabe; Yoshihiro Yoshihara; Kensaku Mori
      CHEMICAL SENSES, OXFORD UNIV PRESS, 41(9) E148 - E148, Nov. 2016, Summary international conference
    • Temporally-coordinated communication between olfactory cortex and orbitofrontal cortex during slow-wave sleep in rats
      Hiroyuki Manabe; Naomi Onisawa; Kensaku Mori
      CHEMICAL SENSES, OXFORD UNIV PRESS, 41(9) E151 - E152, Nov. 2016, Summary international conference
    • How can the brain encode unlimited amount of memory? - temporary cell assemblies in hippocampus
      Sakurai, Yoshio; Manabe, Hiroyuki; Hirokawa, Junya
      INTERNATIONAL JOURNAL OF PSYCHOLOGY, ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD, 51 874 - 874, Jul. 2016, Summary international conference
    • 嗅皮質鋭波中のニューロン再活性化の解析
      眞部 寛之
      上原記念生命科学財団研究報告集, 上原記念生命科学財団, 27 1 - 5, Dec. 2013
    • Synchronized top-down inputs from the olfactory cortex participate in the cell death of adult-born neurons in the olfactory bulb
      Sayaka Komano; Hiroyuki Manabe; Mizuho Ota; Ikue Kusumoto-Yoshida; Takeshi Yokoyama; Kensaku Mori; Masahiro Yamaguchi
      NEUROSCIENCE RESEARCH, ELSEVIER IRELAND LTD, 71 E237 - E237, 2011, Summary international conference
    • Olfactory cortex generates sharp waves during slow-wave sleep
      Ikue Kusumoto-Yoshida; Hiroyuki Manabe; Mizuho Ota; Kensaku Mori
      NEUROSCIENCE RESEARCH, ELSEVIER IRELAND LTD, 68 E390 - E390, 2010, Summary international conference
    • Neuronal circuits responsible for the generation of olfactory cortex and olfactory bulb sharp waves during slow-wave sleep
      Hiroyuki Manabe; Ikue Kusumoto-Yoshida; Mizuho Ota; Kensaku Mori
      NEUROSCIENCE RESEARCH, ELSEVIER IRELAND LTD, 68 E98 - E98, 2010, Summary international conference
    • Olfactory cortex sharp waves occur during slow wave sleep in a coordinated manner with orbitofrontal cortex and amygdala
      Mizuho Ota; Hiroyuki Manabe; Ikue Kusumoto-Yoshida; Kensaku Mori
      NEUROSCIENCE RESEARCH, ELSEVIER IRELAND LTD, 68 E390 - E390, 2010, Summary international conference
    • Neocortex-independent slow wave activity in the olfactory cortex: A study with urethane anesthetized rats
      Hideki Kashiwadani; Hiroyuki Manabe; Kensaku Mori
      NEUROSCIENCE RESEARCH, ELSEVIER IRELAND LTD, 61 S105 - S105, 2008, Summary international conference
    • Neocortex-independent slow-wave activity in the olfactory cortex: A study with freely behaving rats
      Hiroyuki Manabe; Hideki Kashiwadani; Kensaku Mori
      NEUROSCIENCE RESEARCH, ELSEVIER IRELAND LTD, 61 S178 - S178, 2008, Summary international conference
    • Behavioral state-dependent simultaneously change between the respiratory pattern and information processing mode in hippocampus
      Hiroyuki Manabe; Kensaku Mori
      NEUROSCIENCE RESEARCH, ELSEVIER IRELAND LTD, 58 S167 - S167, 2007, Summary international conference

    Presentations

    • 睡眠のグローバル制御とローカル制御 嗅覚系で食後徐波睡眠時に起こる鋭波とその機能
      眞部 寛之; 楠本 郁恵; 田; 駒野 清香; 太田 瑞穂; 森 憲作
      日本睡眠学会定期学術集会プログラム・抄録集, Jun. 2012
    • 嗅皮質は、徐波睡眠時に鋭波を発生する(Olfactory cortex generates sharp waves during slow-wave sleep)
      楠本 郁恵; 吉田; 眞部 寛之; 太田 瑞穂; 森 憲作
      神経化学, Aug. 2010
    • 徐波睡眠時に起こる、嗅皮質、嗅球での鋭波発生メカニズムの解析(Neuronal circuits responsible for the generation of olfactory cortex and olfactory bulb sharp waves during slow-wave sleep)
      眞部 寛之; 楠本 郁恵; 田; 太田 瑞穂; 森 憲作
      神経化学, Aug. 2010
    • PP-538 半数体精子細胞に発現するδ20遺伝子の単離と解析(第95回日本泌尿器科学会総会)
      植田 知博; 松岡 庸洋; 真部 寛之; 辻村 晃; 西宗 義武; 田中 宏光; 奥山 明彦
      日本泌尿器科学会雑誌, 2007
    • Behavioral state-dependent simultaneously change between the respiratory pattern and information processing mode in hippocampus
      Manabe Hiroyuki; Mori Kensaku
      NEUROSCIENCE RESEARCH, 2007
    • MP-616 マウス半数体精子細胞に発現するTISP79の単離と解析(一般演題ポスター,第94回日本泌尿器科学会総会)
      植田 知博; 田中 宏光; 真部 寛之; 松岡 庸洋; 辻村 晃; 西宗 義武; 奥山 明彦
      日本泌尿器科学会雑誌, 2006