TAHARA Yoshiro
Faculty of Science and Engineering Department of Chemical Engineering and Materials Science
Associate Professor
Last Updated :2022/12/05

Researcher Profile and Settings

Research Interests

  • Transdermal delivery
  • Cancer immunotherapy
  • Gel
  • Tissue engineering
  • Emulsion
  • Polysaccharides
  • Nanotechnology
  • Vaccine
  • Cancer
  • Biomaterials
  • Drug Delivery System

Research Areas

  • Nanotechnology/Materials / Biochemistry
  • Nanotechnology/Materials / Polymer chemistry
  • Life sciences / Biomaterials
  • Manufacturing technology (mechanical, electrical/electronic, chemical engineering) / Applied biofunctional and bioprocess engineering

Research Experience

  • Doshisha University, Faculty of science and engineering, Associate professor, 2019/04 - Today
  • Kyushu University, Japan, Department of Applied Chemistry, Research Assistant Professor, 2017/03 - 2019/03
  • JST-ERATO Akiyoshi Bio-Nanotransporter Project, Japan, Post-doctoral Researcher, 2012/04 - 2017/02
  • Kyoto University, Japan. (Advisor: Prof. Kazunari Akiyoshi), Department of Polymer Chemistry, Post-doctoral Researcher, 2012/04 - 2017/02
  • Japan Society for the Promotion of Science (JSPS) Research Fellow (DC1), 2009/04 - 2012/03

Education

  • Kyushu University, Japan. (Advisor: Prof. Masahiro Goto & Prof. Noriho Kamiya), Department of Applied Chemistry, Ph.D., Biochemical Engineering, 2007/04 - 2012/03
  • Kyushu University, Japan (Advisor: Prof. Masahiro Goto & Prof. Noriho Kamiya), Department of Applied Chemistry, B.S., Biochemical Engineering, 2003/04 - 2007/03

Degree

  • Ph.D., Kyushu University

Awards

  • Best Oral Presenter Award for Young Researchers, Japan Society of Drug Delivery System, Japan
    Jun. 2011
  • Best Poster Presenter Award for Young Researchers, Division of Biochemical Enginnering, The Society of Chemical Engineers, Japan
    Sep. 2010
  • Best Poster Presenter Award for Young Researchers, Japan Society of Drug Delivery System, Japan
    Jul. 2009
  • Best Poster Presenter Award for Young Researchers, Division of Biochemical Enginnering, The Society of Chemical Engineers, Japan
    Sep. 2007
  • Best Oral Presenter Award for Young Researchers, The Society of Chemical Engineers, Japan
    Jul. 2007

Published Papers

  • PEER REVIEWED PUBLICTIONS
    Apr. 2023
  • Three-Dimensional Culture of Cartilage Tissue on Nanogel-Cross-Linked Porous Freeze-Dried Gel Scaffold for Regenerative Cartilage Therapy: A Vibrational Spectroscopy Evaluation.
    Tetsuya Adachi; Nao Miyamoto; Hayata Imamura; Toshiro Yamamoto; Elia Marin; Wenliang Zhu; Miyuki Kobara; Yoshihiro Sowa; Yoshiro Tahara; Narisato Kanamura; Kazunari Akiyoshi; Osam Mazda; Ichiro Nishimura; Giuseppe Pezzotti
    International journal of molecular sciences, 23(15) 8099 , 01 Aug. 2022, Scientific journal
  • Glycine-Mediated Paclitaxel Dispersion in a Phospholipid Complex
    Yoshiro Tahara; Ueyama Kenichi; Matsumoto Michiaki
    Journal of Chemical Engineering of Japan, The Society of Chemical Engineers, Japan, 55(6) 225 - 229, 20 Jun. 2022
  • Removal of Perfluorooctanoic Acid from Water Using a Hydrophobic Ionic Liquid Selected Using the Conductor-like Screening Model for Realistic Solvents
    Mariusz Grabda; Maciej Zawadzki; Sylwia Oleszek; Michiaki Matsumoto; Marek Królikowski; Yoshiro Tahara
    Environmental Science & Technology, American Chemical Society (ACS), 56(10) 6445 - 6454, 17 May 2022, Scientific journal
  • Extraction of 1,3-Propanediol with Aqueous Two-Phase Systems Formed by Protic Ionic Liquids and Inorganic Salts
    Michiaki MATSUMOTO; Fumiya SHINJI; Yoshiro TAHARA
    Solvent Extraction Research and Development, Japan, Japan Association of Solvent Extraction, 29(2) 67 - 71, 25 Apr. 2022, Scientific journal
  • A solid-in-oil-in-water emulsion: An adjuvant-based immune-carrier enhances vaccine effect
    Yoshiro Tahara; Riko Mizuno; Tomoki Nishimura; Sada-atsu Mukai; Rie Wakabayashi; Noriho Kamiya; Kazunari Akiyoshi; Masahiro Goto
    Biomaterials, Elsevier BV, 282 121385 - 121385, Mar. 2022, Scientific journal
  • Adsorption of metallic ions on amidoxime-chitosan/ cellulose hydrogels
    Takaaki Tatsumi; Yoshiro Tahara; Michiaki Matsumoto
    Separations, 8(11), Nov. 2021, Scientific journal
  • Extraction of proteins with aqueous two-phase systems formed by protic ionic liquids and inorganic salts
    Michiaki Matsumoto; Fumiya Shinji; Yoshiro Tahara
    Solvent Extraction Research and Development, 28(2) 141 - 148, 06 Jun. 2021, Scientific journal
  • Effects of imprinting and water activity on transesterification and thermostability with lipases in ionic liquid
    M. Matsumoto; K. Nakao; Y. Tahara
    Chemical and Biochemical Engineering Quarterly, (1) 57 - 63, 10 Feb. 2021, Scientific journal
  • Permeation of Phenylalanine through Polymer Inclusion Membrane Containing Bi-functional Ionic Liquid
    Michiaki Matsumoto; Kei Inoue; Yoshiro Tahara
    Solvent Extraction Research and Development, 27(2) 143 - 147, 11 Dec. 2020, Scientific journal
  • Solid-in-oil nanodispersions as a novel delivery system to improve the oral bioavailability of bisphosphate, risedronate sodium
    Yanting Hou; Hongyu Piao; Yoshiro Tahara; Shouhong Qin; Jingying Wang; Qingliang Kong; Meijuan Zou; Gang Cheng; Masahiro Goto
    European Journal of Pharmaceutical Sciences, Elsevier BV, 155(1) 105521 - 105521, 01 Dec. 2020, Scientific journal
  • Biocompatible Ionic Liquid Enhances Transdermal Antigen Peptide Delivery and Preventive Vaccination Effect', Molecular Pharmaceutics
    Yoshiro Tahara; Kaho Morita; Rie Wakabayashi; Noriho Kamiya; Masahiro Goto
    Molecular Pharmaceutics, 17(10) 3845 - 3856, 05 Oct. 2020
  • In Vivo Regeneration of Large Bone Defects by Cross-Linked Porous Hydrogel: A Pilot Study in Mice Combining Micro Tomography, Histological Analyses, Raman Spectroscopy and Synchrotron Infrared Imaging
    Tetsuya Adachi; Francesco Boschetto; Nao Miyamoto; Toshiro Yamamoto; Elia Marin; Wenliang Zhu; Narisato Kanamura; Yoshiro Tahara; Kazunari Akiyoshi; Osam Mazda; Ichiro Nishimura; Giuseppe Pezzotti
    Materials, MDPI AG, 13(19) 4275 - 4275, 01 Oct. 2020, Scientific journal
  • Lactic Acid Permeation through Deep Eutectic Solvents-Based Polymer Inclusion Membranes
    Michiaki Matsumoto; Sae Takemori; Yoshiro Tahara
    Membranes, MDPI AG, 10(9) 244 - 244, 19 Sep. 2020, Scientific journal
  • Choline and amino acid based biocompatible ionic liquid mediated transdermal delivery of the sparingly soluble drug acyclovir
    Md. Rafiqul Islam; Md. Raihan Chowdhury; Rie Wakabayashi; Yoshiro Tahara; Noriho Kamiya; Muhammad Moniruzzaman; Masahiro Goto
    International Journal of Pharmaceutics, Elsevier BV, 582 119335 - 119335, 30 May 2020, Scientific journal
  • Extraction of Rare Earth Metal Ions with an Undiluted Hydrophobic Pseudoprotic Ionic Liquid
    Michiaki Matsumoto; Takuya Yamaguchi; Yoshiro Tahara
    Metals, MDPI AG, 10(4) 502 - 502, 11 Apr. 2020, Scientific journal
  • A Solid-in-Oil Nanodispersion System for Transcutaneous Immunotherapy of Cow's Milk Allergies.
    Momoko Kitaoka; Wei Xiao; Qingliang Kong; Yoshiro Tahara; Noriho Kamiya; Masahiro Goto
    Pharmaceutics, 12(3) 205 , Mar. 2020, Scientific journal
  • Solid-in-Oil Nanodispersions for Transcutaneous Immunotherapy of Japanese Cedar Pollinosis.
    Qingliang Kong; Momoko Kitaoka; Rie Wakabayashi; Yoshiro Tahara; Noriho Kamiya; Masahiro Goto
    Pharmaceutics, 12(3) 240 , Mar. 2020, Scientific journal
  • Transcutaneous Cancer Vaccine Using a Reverse Micellar Antigen Carrier
    Shuto Kozaka, Yoshiro Tahara, Rie Wakabayashi, Tahakhiro, Nakata, Taro Ueda, Noriho Kamiya, Masahiro Goto
    Molecular Pharmaceutics, 17(2) 645 - 655, 03 Feb. 2020
  • Ionic liquids with N-methyl-2-pyrrolidonium cation as an enhancer for topical drug delivery: Synthesis, characterization, and skin-penetration evaluation
    Rahman Md. Moshikur, Md. Raihan Chowdhury, Rie Wakabayashi, Yoshiro Tahara, Noriho Kamiya, Muhammad Moniruzzaman, Masahiro Goto
    Journal of Molecular Liquids, 1 112166 , 01 Feb. 2020, Scientific journal
  • Solid-in-oil nanodispersions for intranasal vaccination: Enhancement of mucosal and systemic immune responses
    Qingliang Kong, Momoko Kitaoka, Yoshiro Tahara, Rie Wakabayashi, Noriho Kamiya, Masahiro Goto
    International Journal of Pharmaceutics, 572(15) 118777 , 15 Dec. 2019
  • Transcutaneous delivery of immunomodulating pollen extract-galactomannan conjugate by solid-in-oil nanodispersions for pollinosis immunotherapy
    Qingliang Kong, Kouki Higasijima, Rie Wakabayashi, Yoshiro Tahara, Momoko Kitaoka, Hiroki Obayashi, Yanting Hou, Noriho Kamiya, Masahiro Goto
    Pharmaceutics, 11(11) 563 , Nov. 2019
  • Synthesis and characterization of choline–fatty-acid-based ionic liquids: A new biocompatible surfactant
    Md Korban Ali; Rahman Md Moshikur; Rie Wakabayashi; Yoshiro Tahara; Muhammad Moniruzzaman; Noriho Kamiya; Masahiro Goto
    Journal of Colloid and Interface Science, 551(1) 72 - 80, 01 Sep. 2019
  • Development of a novel ionic liquid-curcumin complex to enhance its solubility, stability, and activity
    Md. Raihan Chowdhury; Rahman Md Moshikur; Rie Wakabayashi; Yoshiro Tahara; Noriho Kamiya; Muhammad Moniruzzaman; Masahiro Goto
    Chemical Communications, 55 7737 - 7740, 11 Jul. 2019
  • In vivo biocompatibility, pharmacokinetics, antitumor efficacy, and hypersensitivity evaluation of ionic liquid-mediated paclitaxel formulations
    Md. Raihan Chowdhury; Rahman Md Moshikur; Rie Wakabayashi; Yoshiro Tahara; Noriho Kamiya; Muhammad Moniruzzaman; Masahiro Goto
    International Journal of Pharmaceutics, 565 219 - 226, 30 Jun. 2019
  • Osteogenic response of mesenchymal progenitor cells to natural polysaccharide nanogel and atelocollagen scaffolds: A spectroscopic study
    Satoshi Horiguchi; Tetsuya Adachi; Alfredo Rondinella; Francesco Boschetto; Elia Marin; Wenliang Zhu; Yoshiro Tahara; Toshiro Yamamoto; Narisato Kanamura; Kazunari Akiyoshi; Giuseppe Pezzotti; Osam Mazda
    Materials Science and Engineering C, 99 1325 - 1340, Jun. 2019, Scientific journal
  • Transcutaneous Codelivery of Tumor Antigen and Resiquimod in Solid-in-Oil Nanodispersions Promotes Antitumor Immunity
    Rie Wakabayashi; Hidetoshi Kono; Shuto Kozaka; Yoshiro Tahara; Noriho Kamiya; Masahiro Goto
    ACS Biomaterials Science & Engineering, 5(5) 2297 - 2306, 13 May 2019
  • Ionic liquids with methotrexate moieties as a potential anticancer prodrug: Synthesis, characterization and solubility evaluation
    Rahman Md. Moshikur; Md. Raihan Chowdhury; Rie Wakabayashi; Yoshiro Tahara; Muhammad Moniruzzaman; Masahiro Goto
    Journal of Molecular Liquids, 278(15) 226 - 233, 15 Mar. 2019
  • Antigen Delivery Targeting Tumor-Associated Macrophages Overcomes Tumor Immune Resistance
    Daisuke Muraoka; Naohiro Seo; Tae Hayashi; Yoshiro Tahara; Keisuke Fujii; Isao Tawara; Yoshihiro Miyahara; Kana Okamori; Hideo Yagita; Seiya Imoto; Rui Yamaguchi; Mitsuhiro Komura; Satoru Miyano; Masahiro Goto; Shin-ichi Sawada; Akira Asai; Hiroaki Ikeda; Kazunari Akiyoshi; Naozumi Harada; Hiroshi Shiku
    Journal of Clinical Investigation, 129(3) 1278 - 1294, 01 Mar. 2019
  • Structural effects and lymphocyte activation properties of self-assembled polysaccharide nanogels for effective antigen delivery
    Risako Miura; Yoshiro Tahara; Shin-ichi Sawada; Yoshihiro Sasaki; Kazunari Akiyoshi
    Scientific Reports, NATURE PUBLISHING GROUP, 8 16464 - 16472, Nov. 2018, Scientific journal
  • Nanogel tectonic porous 3D scaffold for direct reprogramming fibroblasts into osteoblasts and bone regeneration
    Yoshiki Sato; Kenta Yamamoto; Satoshi Horiguchi; Yoshiro Tahara; Kei Nakai; Shin-ichiro Kotani; Fumishige Oseko; Giuseppe Pezzotti; Toshiro Yamamoto; Tsunao Kishida; Narisato Kanamura; Kazunari Akiyoshi; Osam Mazda
    Scientific Reports, NATURE PUBLISHING GROUP, 8 15824 - 15833, Oct. 2018, Scientific journal
  • Characterization and cytotoxicity evaluation of biocompatible amino acid esters used to convert salicylic acid into ionic liquids
    Rahman Md. Moshikur; Md. Raihan Chowdhury; Rie Wakabayashi; Yoshiro Tahara; Muhammad Moniruzzaman; Masahiro Goto
    International Journal of Pharmaceutics, Elsevier B.V., 546(1-2) 31 - 38, 30 Jul. 2018, Scientific journal
  • Ionic-Liquid-Based Paclitaxel Preparation: A New Potential Formulation for Cancer Treatment
    Md. Raihan Chowdhury, Rahman; Md. Moshikur; Rie Wakabayashi; Yoshiro Tahara; Noriho Kamiya; Muhammad Moniruzzaman; Masahiro Goto
    Molecular Pharmaceutics, 15(6) 2484 - 2488, 06 Jun. 2018
  • Mechanistic investigation of transcutaneous protein delivery using solid-in-oil nanodispersion: A case study with phycocyanin.
    Safrina Dyah Hardiningtyas; Rie Wakabayashi; Momoko Kitaoka; Yoshiro Tahara; Kosuke Minamihata; Masahiro Goto; Noriho Kamiya
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 127(0) 44 - 50, Jun. 2018, Scientific journal
  • Solid-in-Oil Peptide Nanocarriers for Transcutaneous Cancer Vaccine Delivery against Melanoma
    Rie Wakabayashi; Masato Sakuragi; Shuto Kozaka; Yoshiro Tahara; Noriho Kamiya; Masahiro Goto
    Molecular Pharmaceutics, 15(3) 955 - 961, 05 May 2018
  • Genipin-stabilized caseinatehitosan nanoparticles for enhanced stability and anti-cancer activity of curcumin
    Muhamad Alif Razi; Rie Wakabayashi; Yoshiro Tahara; Masahiro Goto; Noriho Kamiya
    Colloids and Surfaces B: Biointerfaces, Elsevier B.V., 164(1) 308 - 315, 01 Apr. 2018, Scientific journal
  • Activated CD8+ T Cell Extracellular Vesicles Prevent Tumour Progression by Targeting of Lesional Mesenchymal Cells
    Naohiro Seo; Yoshitaka Shirakura; Yoshiro Tahara; Fumiyasu Momose; Naozumi Harada; Hiroaki Ikeda; Kazunari Akiyoshi; Hiroshi Shiku
    Nature Communications, NATURE PUBLISHING GROUP, 9(0) 435 , Jan. 2018, Scientific journal
  • Glycan profiling analysis using evanescent-field fluorescence-assisted lectin array: Importance of sugar recognition for cellular uptake of exosomes from mesenchymal stem cells
    Asako Shimoda; Yoshiro Tahara; Shin-ichi Sawada; Yoshihiro Sasaki; Kazunari Akiyoshi
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, 491(3) 701 - 707, Sep. 2017, Scientific journal
  • Self-Assembled Nanogels of Cholesterol-Bearing Hydroxypropyl Cellulose: A Thermoresponsive Building Block for Nanogel Tectonic Materials
    Yoshiro Tahara; Mizuki Sakiyama; Shigeo Takeda; Tomoki Nishimura; Sada-atsu Mukai; Shin-ichi Sawada; Yoshihiro Sasaki; Kazunari Akiyoshi
    LANGMUIR, AMER CHEMICAL SOC, 32(47) 12283 - 12289, Nov. 2016, Scientific journal
  • Current advances in self-assembled nanogel delivery systems for immunotherapy
    Yoshiro Tahara; Kazunari Akiyoshi
    ADVANCED DRUG DELIVERY REVIEWS, ELSEVIER SCIENCE BV, 95(1) 65 - 76, Dec. 2015
  • Nanocarrier-Integrated Microspheres: Nanogel Tectonic Engineering for Advanced Drug-Delivery Systems
    Yoshiro Tahara; Sada-atsu Mukai; Shin-ichi Sawada; Yoshihiro Sasaki; Kazunari Akiyoshi
    ADVANCED MATERIALS, WILEY-V C H VERLAG GMBH, 27(34) 5080 - 5088, Sep. 2015, Scientific journal
  • Effective CpG DNA delivery using amphiphilic cycloamylose nanogels
    Y. Tahara; J. Yasuoka; S. Sawada; Y. Sasaki; K. Akiyoshi
    BIOMATERIALS SCIENCE, ROYAL SOC CHEMISTRY, 3(2) 256 - 264, 01 Feb. 2015, Scientific journal
  • Nanogel-Based Immunologically Stealth Vaccine Targets Macrophages in the Medulla of Lymph Node and Induces Potent Antitumor Immunity
    Daisuke Muraoka; Naozumi Harada; Tae Hayashi; Yoshiro Tahara; Fumiyasu Momose; Shin-ichi Sawada; Sada-atsu Mukai; Kazunari Akiyoshi; Hiroshi Shiku
    ACS NANO, AMER CHEMICAL SOC, 8(9) 9209 - 9218, Sep. 2014, Scientific journal
  • Sucrose laurate-enhanced transcutaneous immunization with a solid-in-oil nanodispersion
    Momoko Kitaoka; Kana Imamura; Yuya Hirakawa; Yoshiro Tahara; Noriho Kamiya; Masahiro Goto
    MEDCHEMCOMM, ROYAL SOC CHEMISTRY, 5(1) 20 - 24, 01 Jan. 2014, Scientific journal
  • Needle-free immunization using a solid-in-oil nanodispersion enhanced by a skin-permeable oligoarginine peptide
    Momoko Kitaoka; Kana Imamura; Yuya Hirakawa; Yoshiro Tahara; Noriho Kamiya; Masahiro Goto
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, ELSEVIER SCIENCE BV, 458(2) 334 - 339, Dec. 2013, Scientific journal
  • Cationic amphiphilic polysaccharide nanoballs: protein stabilization and intracellular delivery by nano-encapsulation
    Haruko Takahashi; Yoshiro Tahara; Shin-ichi Sawada; Kazunari Akiyoshi
    BIOMATERIALS SCIENCE, ROYAL SOC CHEMISTRY, 1(8) 842 - 849, 01 Aug. 2013, Scientific journal
  • Nanogel bottom-up gel biomaterials for protein delivery: Photopolymerization of an acryloyl-modified polysaccharide nanogel macromonomer
    Yoshiro Tahara; Satoshi Kosuge; Shin-Ichi Sawada; Yoshihiro Sasaki; Kazunari Akiyoshi
    Reactive and Functional Polymers, 73(7) 958 - 964, Jul. 2013, Scientific journal
  • Preparation of Multiple Emulsions to Depress the Rlease of Drugs and Enhanced Permeation Effect in Transdermal Delivery
    Yuko Abe; Yoshiro Tahara; Rie Wakabayashi; Noriho Kamiya; Masahiro Goto
    Membrane, THE MEMBRANE SOCIETY OF JAPAN, 38(2) 92 - 96, Mar. 2013
  • S/O-nanodispersion electrospun fiber mesh effective for sustained release of healthy plasmid DNA with the structural and functional integrity
    Tatsuya Okuda; Yoshiro Tahara; Noriho Kamiya; Masahiro Goto; Satoru Kidoaki
    JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, TAYLOR & FRANCIS LTD, 24(10) 1277 - 1290, Jan. 2013, Scientific journal
  • Transdermal delivery of insulin using a solid-in-oil nanodispersion enhanced by arginine-rich peptides
    Yoshiro Tahara; Shota Honda; Noriho Kamiya; Masahiro Goto
    MEDCHEMCOMM, ROYAL SOC CHEMISTRY, 3(12) 1496 - 1499, 22 Nov. 2012, Scientific journal
  • Solid-in-oil dispersion: A novel core technology for drug delivery systems
    Yoshiro Tahara; Noriho Kamiya; Masahiro Goto
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, ELSEVIER SCIENCE BV, 438(1-2) 249 - 257, 15 Nov. 2012
  • A novel double-coating carrier produced by solid-in-oil and solid-in-water nanodispersion technology for delivery of genes and proteins into cells
    Yoshiro Tahara; Takeshi Kaneko; Riki Toita; Chiharu Yoshiyama; Takuya Kitaoka; Takuro Niidome; Yoshiki Katayama; Noriho Kamiya; Masahiro Goto
    JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE BV, 161(3) 713 - 721, Aug. 2012, Scientific journal
  • Oil Gel Sheets Utilizing Solid–in–Oil Technique
    Asami Funatsu; Yoshiro Tahara; Sakurako Yamanaka; Masahiro Goto
    Membrane, THE MEMBRANE SOCIETY OF JAPAN, 36(2) 57 - 62, Mar. 2011
  • A Solid-in-Oil Dispersion of Gold Nanorods Can Enhance Transdermal Protein Delivery and Skin Vaccination
    Dakrong Pissuwan; Keisuke Nose; Ryohsuke Kurihara; Kenji Kaneko; Yoshiro Tahara; Noriho Kamiya; Masahiro Goto; Yoshiki Katayama; Takuro Niidome
    SMALL, WILEY-V C H VERLAG GMBH, 7(2) 215 - 220, Jan. 2011, Scientific journal
  • Transcutaneous immunization by a solid-in-oil nanodispersion
    Yoshiro Tahara; Kenichi Namatsu; Noriho Kamiya; Masayori Hagimori; Seitaro Kamiya; Masayuki Arakawa; Masahiro Goto
    CHEMICAL COMMUNICATIONS, ROYAL SOC CHEMISTRY, 46(48) 9200 - 9202, 28 Dec. 2010, Scientific journal
  • Ionic liquid-in-oil microemulsion as a potential carrier of sparingly soluble drug: Characterization and cytotoxicity evaluation
    Muhammad Moniruzzaman; Miki Tamura; Yoshiro Tahara; Noriho Kamiya; Masahiro Goto
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, ELSEVIER SCIENCE BV, 400(1-2) 243 - 250, 15 Nov. 2010, Scientific journal
  • Ionic liquid-assisted transdermal delivery of sparingly soluble drugs
    Muhammad Moniruzzaman; Yoshiro Tahara; Miki Tamura; Noriho Kamiya; Masahiro Goto
    CHEMICAL COMMUNICATIONS, ROYAL SOC CHEMISTRY, 46(9) 1452 - 1454, 07 Mar. 2010, Scientific journal
  • A transdermal delivery system of an ascorbic acid derivative utilizing solid-in-oil technique
    Aiko Okuma; Hongyu Piao; Yoshiro Tahara; Noriho Kamiya; Masahiro Goto
    Membrane, THE MEMBRANE SOCIETY OF JAPAN, 34(4) 227 - 232, Jul. 2009
  • A solid-in-oil nanodispersion for transcutaneous protein delivery
    Yoshiro Tahara; Shota Honda; Noriho Kamiya; Hongyu Piao; Akihiko Hirata; Eiji Hayakawa; Takeru Fujii; Masahiro Goto
    JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE BV, 131(1) 14 - 18, Oct. 2008, Scientific journal
  • Design and in vivo evaluation of solid-in-oil suspension for oral delivery of human growth hormone
    Hiromu Yoshiura; Yoshiro Tahara; Masakazu Hashida; Noriho Kamiya; Akihiko Hirata; Takeru Fujii; Masahiro Goto
    BIOCHEMICAL ENGINEERING JOURNAL, ELSEVIER SCIENCE SA, 41(2) 106 - 110, Sep. 2008, Scientific journal

MISC

  • BOOK CHAPTERS etc
    Apr. 2023
  • 若手研究者からのメッセージ
    田原義朗
    日本化学会バイオテクノロジー部会NEWS LETTER, 26(1) 14 - 19, Aug. 2022
  • Solid-in-Oil Nanodispersion Technique for Transdermal Drug Delivery System of Biopharmaceutical Molecules
    TAHARA Yoshiro; GOTO Masahiro
    Oleoscience, Japan Oil Chemists' Society, 22(3) 121 - 126, 04 Mar. 2022
  • イオン液体を利用した経皮吸収製剤の開発動向
    田原義朗; 後藤雅宏
    2022
  • Current Advances of Transdermal Drug Delivery Systems Using Ionic Liquids
    Yoshiro Tahara; Masahiro Goto
    MEMBRANE, The Membrane Society of Japan, 46(5) 300 - 305, 05 Oct. 2021
  • Ionic Liquids for Transdermal Vaccination
    Yoshiro Tahara
    Application of Ionic Liquids in Drug Delivery, 10 187 - 193, 28 Aug. 2021
  • Solid-in-oil-in-water(S/O/W)型多層エマルションとDDS への応用
    田原義朗; 後藤雅宏
    オレオサイエンス, 19(5) 15 - 20, Sep. 2019
  • イオン液体という第3の液体を用いた創薬研究
    田原義朗; 後藤雅宏
    日本化学会バイオテクノロジー部会ニュースレター, 23(1) 3 - 12, Aug. 2019
  • 油状ナノ基剤を用いたDDS 技術と非侵襲性経皮ワクチンへの応用
    田原義朗; 後藤雅宏
    化学工学, 83(7) 408 - 411, Jul. 2019
  • イオン液体を用いた創薬研究
    田原義朗
    化学工学, 83(6) 365 , Jun. 2019
  • S/O技術によるペプチドの経皮吸収
    Yoshiro Tahara; Masahiro Goto
    COSMETIC STAGE, 13(2) 48 - 52, Dec. 2018
  • Solid-in-Oil(S/O)化技術と経皮ワクチンへの応用
    Yoshiro Tahara; Masahiro Goto
    PHARM TECH JAPAN, 34(14) 199 - 202, Nov. 2018
  • イオン液体を用いたDDSと経皮デリバリーへの応用の現状
    Yoshiro Tahara; Masahiro Goto
    Drug Delivery System, 33(4) 303 - 310, Sep. 2018
  • S/O 技術による皮膚浸透促進と化粧品開発
    Yoshiro Tahara; Masahiro Goto
    月刊ファインケミカル, 47(3) pp.38 - 44, Mar. 2018
  • 微粒子等を用いたドラッグデリバリーシステム
    田原義朗; 秋吉一成
    動物用ワクチンとバイオ医薬品, pp.248 - 251, Jul. 2017
  • 経皮吸収製剤における最新のDDS技術
    田原義朗; 後藤雅宏
    DDS先端技術の先端バイオ医薬品への応用開発, 8(1) pp.404 - 409, Jun. 2017
  • Transdermal protein delivery and immunization by a solid-in-oil nanodispersion technique
    Yoshiro Tahara; Masahiro Goto
    Drug Delivery System, Japan Society of Drug Delivery System, 32(3) 176 - 183, 2017, Book review
  • 自己組織化ナノゲルによるDDS開発
    田原義朗; 秋吉一成
    月刊ファインケミカル, シーエムシー出版, 45(11) pp.25 - 32, Nov. 2016
  • 物理架橋ナノゲルの調製とDDS応用
    田原義朗; 秋吉一成
    DDSキャリア作製プロトコル集, pp.124 - 130, Aug. 2015
  • Pullulan
    Yoshiro Tahara; Kazunari Akiyoshi
    Encyclopedia of polymeric nanomaterials, 2121 - 2129, Jun. 2015
  • ナノゲル基盤材料によるタンパク質医薬の徐放技術とその応用
    田原義朗; 秋吉一成
    遺伝子医学MOOK別冊 – ここまで広がるドラッグ徐放技術の最前線 –, pp.124 - 130, Mar. 2013
  • S/O®技術を用いたタンパク性医薬品の経皮吸収改善と経皮免疫への応用
    後藤雅宏; 田原義朗
    遺伝子医学MOOK別冊 – ペプチド・タンパク性医薬品の新規DDS製剤の開発と応用 –, pp.141 - 147, Jun. 2011
  • タンパク質の経皮デリバリーは本当に可能か?
    後藤雅宏; 田原義朗
    化学, 化学同人, 66(5) pp.54 - 57, May 2011
  • Development and clarification of a novel transcutaneous protein delivery system and its mechanism by a solid-in-oil nanodispersion
    Yoshiro Tahara; Shota Honda; Noriho Kamiya; Masahiro Goto
    JOURNAL OF BIOSCIENCE AND BIOENGINEERING, SOC BIOSCIENCE BIOENGINEERING JAPAN, 108 S39 - S40, Nov. 2009, Summary international conference
  • S/O化技術の魅力と新しい経皮薬物送達システム実現の可能性
    田原義朗; 神谷典穂; 後藤雅宏
    PHARM TECH JAPAN, 25 pp.1409 - 1414, Jun. 2009
  • タンパク質の経皮デリバリーの実現
    田原義朗; 神谷典穂; 後藤雅宏
    バイオサイエンスとインダストリー, 67 pp.68 - 70, Apr. 2009

Industrial Property Rights

  • Patent right
    多孔質三次元細胞培養用足場材料及びその製造方法
    佐藤 良樹, 山本 健太, 堀口 智史, 田原 義朗, 山本 俊郎, 岸田 綱郎, 秋吉 一成, 松田 修
    JP2019033678, WO2020-045488, 京都府公立大学法人
  • Patent right
    表面麻酔剤
    原田 耕志, タランヌム フェルドゥス, 後藤 雅宏, 田原 義朗
    特願2018-162980, 特開2020-033321, 国立大学法人山口大学, 国立大学法人九州大学
  • Patent right
    免疫組成物
    後藤 雅宏, 田原 義朗, 水野 梨瑚
    特願2018-099129, 特開2019-202957, 国立大学法人九州大学
  • Patent right
    多孔質三次元細胞培養足場材料及びその製造方法
    佐藤良樹, 山本健太, 堀口智史, 田原義朗, 山本俊郎, 岸田綱郎, 秋吉一成, 松田修
    特願2018-158931
  • Patent right
    Crosslinked hydrophobized-polysaccharide nanogel particles and manufacturing method therefor
    Kazunari Akiyoshi, Yoshiro Tahara, Sadaatsu Mukai, Shinichi Sawada
    JP2014059082, WO2014-157606, 国立大学法人京都大学
  • Patent right
    Water-soluble drug carrier and process for production thereof
    Masahiro Goto, Noriho Kamiya, Yoshiro Tahara
    JP2010004021, WO2011-004552, 特許第5618307号, 国立大学法人九州大学

Research Projects

  • Development of theranostics system for oral candidiasis
    金村 成智; 槇村 浩一; 足立 哲也; 田原 義朗; 山本 俊郎; PEZZOTTI G.
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), 2022/04 -2026/03, Coinvestigator, Grant-in-Aid for Scientific Research (C), Kyoto Prefectural University of Medicine
  • Creation of Non-Invasive Transdermal Vaccine Using Solid-in-Oil Nano-dispersion Technique
    後藤 雅宏; 田原 義朗; 神谷 典穂; 若林 里衣
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A), 2021/04 -2024/03, Coinvestigator, Grant-in-Aid for Scientific Research (A), Kyushu University
  • 経口投与のための油状微粒子の開発
    田原 義朗
    日本学術振興会, 科学研究費助成事業 基盤研究(C), 2021/04 -2024/03, Principal investigator, 基盤研究(C), 同志社大学
  • Advanced Pharmaceutical Application of Ionic Liquids
    後藤 雅宏; 田原 義朗; 原田 耕志; 若林 里衣
    イオン液体の創薬応用が、最近注目されるようになったが、世界的にも臨床レベルでイオン液体が利用された例は少なく、研究領域として大きく発展するまでには至っていない。そこで本開拓研究では、この問題点を医工連携研究により克服し、これまでの製剤技術の体系や方向性を大きく変革するようなイオン液体研究にチャレンジする。特に、イオン液体を用いた創薬研究においてポイントとなる、薬物利用が可能な安全性と安定性が確認されたイオン液体製剤を開発する。 本研究では、ヒトに安全なイオン液体を創成し(戦略1)その有効性の検証を行うとともに(戦略3)、薬物動体解析による機能評価(戦略2)を繰り返すという、医工連携研究を展開する。本研究では、結果のみを重視しがちな医療従事者に対し、化学工学的機能解析の重要性を共有し、イオン液体の経皮製剤開発をモデルとして、新たな創薬開発の仕組みを構築する。大規模な臨床試験(Phase I~III)を行う前に、戦略1~3のプロセスが有機的に連携することで、より有効性の高い製剤開発の手法を構築し、イオン液体を利用した創薬研究における新分野を開拓する。これまでに、具体的に麻酔薬、がんワクチン、そして最近ではアビガンにイオン液体が有効であることを明らかにしている。 生体適合性のイオン液体としては、素材にコリン、アミノ酸、脂肪酸及びリン脂質を用いて構成したイオン液体が毒性も小さく有効であることを確認した。また、コリンとオレイン酸から構成される生体適合性イオン液体を用いることで、がん抗原ペプチドの経皮ワクチン製剤の構築が可能となった。また、このイオン液体は低毒性であり皮膚刺激性の低い製剤であることを明らかにした。イオン液体によってがん抗原ペプチドの皮膚深部への浸透が達成され、皮膚樹状細胞へのがん抗原ペプチドの効率的送達を可能にすることで、高い抗腫瘍効果が得られた。, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Pioneering), 2020/04 -2022/03, Coinvestigator, Grant-in-Aid for Challenging Research (Pioneering), Kyushu University
  • Creation of Transdermal Drug Delivery Systems Using Solid-in-oil Nano-dispersion Technique
    後藤 雅宏; 田原 義朗; 神谷 典穂; 若林 里衣; 南畑 孝介
    昨年までの研究で、抗原ペプチドの性質によってS/O製剤の調製条件や免疫の活性に違いがみられることが示唆された。よって本年度は、S/Oシステムにおける免疫産生メカニズムの解明と抗原ペプチドの最適化を行った。さらに、より実現性の高いターゲットに絞り込むことで、新しい形での油状製剤を用いた経皮ワクチンまたは経皮ドラッグデリバリーシステムを構築することを目指した。 1.S/O製剤における免疫活性化メカニズムの解明と抗原ペプチドの最適化:抗原ペプチドを用いたがん免疫療法の検討により、親水基アミノ酸を付与することで改善されることが分かった。このような戦略は花粉症ペプチドなどにも応用可能であると考え、今まで不安定なペプチドに対して機能性ペプチドの導入を試みた。また抗原の免疫原性向上の観点から、抗原提示細胞との相互作用が高いペプチド配列、糖鎖などを修飾した抗原の開発も行った。特に抗原の糖鎖修飾によって免疫細胞への送達量が向上し、S/O製剤に特徴的なリンパ節内での抗原取り込みが明らかとなった。 2.臨床実績のある花粉症抗原の利用:すでに、スギ花粉粗抗原を経口投与する事でヒトにおける花粉症の減感作療法の臨床試験が実施されている。そこで本年度は、既に臨床投与実績のある抗原をS/O製剤化する事で、スギ花粉粗抗原を経皮投与しても花粉症治療効果が得られるかを検証した。その結果、すでに市販されている花粉症治療薬に、同等あるいはそれ以上の減感作効果がマウス実験で確認された。 3.ワクチン機能増強のためのアジュバント開発:これまでの基礎検討ではアジュバントとして、マウスでの活性化が高いCpGやR848を中心に検討してきたが、本年度は臨床応用を目指して、ヒトの経皮投与アジュバントとしてすでに認可されているイミキモドを使用し、S/Oワクチンに対して大きなアジュバント効果が得られることを確認した。, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (S), 2016/05 -2021/03, Grant-in-Aid for Scientific Research (S), Kyushu University
  • A solid-in-oil-in-water emulsion adjuvant for efficient vaccine delivery
    Tahara Yoshiro
    Vaccine is one of the most important strategy to prevent infectious diseases. In this study, a solid-in-oil-in-water (S/O/W) emulsion adjuvant was prepared. In the traditional emulsion adjuvant, antigens were added in the outer water phase and were separately delivered to antigen presenting cells. On the other hand, in the S/O/W emulsion adjuvant, antigens were encapsulated in the inner oil phase by solid-in-oil nanodispersion technology. From the vaccine study, the S/O/W emulsion produced the antigen-specific antibody and prevented tumor growth by antigen-specific immune responses compared to the traditional emulsion. This performance was resulted from the property of the S/O/W emulsion that deliver antigens to the antigen presenting cells together with adjuvant. These results suggested that the S/O/W emulsion is the promising vaccine delivery carrier., Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (A), 2017/04 -2021/03, Principal investigator, Competitive research funding, Grant-in-Aid for Young Scientists (A)
  • Creation of Transdermal Drug Delivery Systems Using Solid-in-oil Nano-dispersion Technique
    Goto Masahiro; KUBOTA Fukiko; KITAOKA Momoko; TAHARA Yoshiro
    Transdermal drug delivery is receiving a growing concern to alternate conventional drug administration techniques such as oral administration or needle-stick based administration methods. In this project, we proposed a patch system based on a solid-in-oil nanodispersion technique as a simple and efficient delivery method of drugs, especially protein and peptide vaccines, through the skin. The skin is an attractive route for vaccination, because there are many immune cells. We developed the solid-in-oil nanodisperison technique to deliver pharmaceutical bioactives efficiently through the skin. Solid-in-oil nanodispersions are nanosized drug carriers designed to overcome the skin barrier. Drug administration using a patch is user-friendly, and can improve patient compliance. Protein and peptide antigen drugs were efficiently delivered across the intact skin using the solid-in-oil nanodispersions. The technique is potent transcutaneous immunization method without needles., Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (S), 2012/05 -2017/03, Grant-in-Aid for Scientific Research (S), Kyushu University
  • Developmet of nanogel-cross-linked microspheres by bottom-up aproach and application for drug delivery system
    Tahara Yoshiro
    Bottom-up approach expanding attractive characters of nanometer-sized drug carriers into multifunctional drug delivery system is important for the next generation of biomaterials. Self-assembled nanogels have been known as one of the most beneficial nanometer-sized drug carriers. In this study, nanogel-cross-linked (NanoClik) microsphere was prepared through cross-linking of nanogels and demonstrated the application for drug delivery systems, in which micrometer-sized materials are needed. The most interesting characters of the NanoClik microspheres is that "drug-loaded nanogels" were released from the NanoClik microspheres following the hydrolysis of their cross-linker moieties. These system could be used to achieve the sustained delivery of drugs through the effective association of nanogels. These findings therefore suggest that NanoClik microspheres have high potential in terms of their application to the field of the nanocarrier-based material science., Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), 2014/04 -2016/03, Principal investigator, Competitive research funding, Grant-in-Aid for Young Scientists (B), Kyoto University
  • Raspberry-like nanogel-based material prepared by emulsion
    TAHARA Yoshiro
    Nanogel consisting of self-assembled polysaccharides is one of the most attractive carriers for drug delivery systems. In the present study, "raspberry-like nanogel-based material" was prepared by bottom-up approach using nanogels as building units. The effective control and design of the cross-linking and nano-domains in macro-scale hydrogels are important focuses of research. Raspberry-like nanogel-based material was prepared through cross-linking of nanogels in water-in-oil emulsion. The basic characters of raspberry-like nanogel-based materials were evaluated by confocal laser scanning microscopy and laser diffraction particle size analysis. The size of raspberry-like nanogel-based material was controlled in micrometer range. These findings suggested that raspberry-like nanogel-based material enables to be used as carrier for a novel drug delivery system., Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Research Activity Start-up, 2012/08 -2014/03, Principal investigator, Competitive research funding, Grant-in-Aid for Research Activity Start-up, Kyoto University
  • 生体分子の油状ナノ分散化技術を応用した高効率経皮免疫システムの創製
    田原 義朗
    過去の研究で申請者は独自の油状ナノ分散化技術を利用して、抗原を油状基剤中に分散させ、経皮浸透性が向上することを確認した。そこで当該年度では、本系を経皮免疫という実際のアプリケーションへ展開するための研究を行った。経皮免疫法とは抗原を皮膚から投与し、体内の抗原特異的な免疫力を増強・記憶させ、以後その病気にかかりにくくする塗り薬型のワクチン療法である。具体的には卵白アルブミンや卵白リゾチームをモデル抗原タンパク質として、これらを経皮吸収促進効果をもつ油状基剤へナノ分散したものを、マウスの耳介部、モルモットの背部、ウサギの耳介部などへ塗布(経皮デリバリー)し、血清中の抗体価の評価を行った。その結果、本手法によって全例について、血清中の抗体価が上昇し、免疫感受性の高いモルモットでは注射と同等の効果を得ることを確認した。また前年度までに申請者は、本技術を応用した新規細胞デリバリー用キャリアの開発を行ってきた。このキャリアは薬物(遺伝子やタンパク質)の周りを界面活性剤で2重に被覆した新しいダブルコーティングキャリアである。本キャリアは、内封する物質とキャリアの構成成分との間に特別な相互作用を必要とせず、遺伝子でもタンパク質でも封入可能であるという特徴をもつ。遺伝子を封入したキャリアについては、細胞毒性を示すこと無く遺伝子発現が可能であることを確認し、異なる等電点をもったカチオン性のタンパク質や、アニオン性のタンパク質であってもキャリアに封入可能かつ、細胞デリバリーが可能であるということを確認した。現在までにも遺伝子やタンパク質などからなる薬物を細胞デリバリー可能なキャリアは存在するが、その中でも本キャリアは、内封する薬物の種類が限定されないという優れた性質をもっていることから、経皮デリバリーのみに留まらず、大変多くの種類のドラッグデリバリーシステムへの応用が期待できる。, 日本学術振興会, 科学研究費助成事業 特別研究員奨励費, 2009/04 -2011, Principal investigator, Competitive research funding, 特別研究員奨励費, 九州大学