MITA Yuichiro
Faculty of Life and Medical Sciences Department of Medical Life Systems
Assistant Professor
Last Updated :2021/10/23

Researcher Profile and Settings

Profile and Settings

  • Research funding number

    70609122

Research Areas

  • Life sciences/Food sciences

Academic & Professional Experience

  • University of Miyazaki, 2018/10 - 2019/03
  • University of Miyazaki, 2017/04 - 2018/09
  • Office for Research Initiatives and Development, Doshisha University, 2013/04 - 2017/03
  • Kyoto Prefectural University of Medicine, 2010/04 - 2013/03
  • Okayama University, 2009/09 - 2010/03

Education

  • Okayama University, Graduate School of Medicine , Dentistry and Pharmaceutical Sciences, 2005/04 - 2010/03
  • Kyoto Prefectural University, 2003/04 - 2005/03
  • Gunma University, 1999/04 - 2003/03

Academic Degrees

  • 博士(医学), 岡山大学

Published Papers

  • Impaired adaptation of energy intake induces severe obesity in aged mice on a high-fat diet.
    Okada T, Mita Y, Sakoda H, Nakazato M
    Physiological reports, 7(3)e13989 , Jan. 2019, English, Research paper (scientific journal)
  • Distribution of oxidized DJ-1 in Parkinson's disease-related sites in the brain and in the peripheral tissues: effects of aging and a neurotoxin.
    Mita Y, Kataoka Y, Saito Y, Kashi T, Hayashi K, Iwasaki A, Imanishi T, Miyasaka T, Noguchi N
    Scientific reports, 8(1)12056 , Aug. 2018
  • Genetic polymorphism at codon 546 of the human RAD17 contributes to the risk for esophageal squamous cell carcinoma.
    Yasuda Y, Sakai A, Ito S, Mita Y, Sonoyama T, Tanabe S, Shirakawa Y, Naomoto Y, Katayama H, Shimizu K
    International journal of molecular epidemiology and genetics, 7(1)58 - 66, 2016
  • Identification of a novel endogenous long non-coding RNA that inhibits selenoprotein P translation
    Y Mita, R Uchida, S Yasuhara, K Kishi, T Hoshi, Y Matsuo, T Yokooji, Y Shirakawa, T Toyama, Y Urano, T Inada, N Noguchi, Y Saito
    Nucleic Acids Research, 49(12)6893 - 6907, Jun. 2021, English, Research paper (scientific journal)
  • Liver-expressed antimicrobial peptide 2 antagonizes the effect of ghrelin in rodents.
    Md Nurul Islam, Yuichiro Mita, Keisuke Maruyama, Ryota Tanida, Weidong Zhang, Hideyuki Sakoda, Masamitsu Nakazato
    The Journal of endocrinology, 244(1)13 - 23, 01 Jan. 2020, English, Research paper (scientific journal)
  • Analysis of peripheral ghrelin signaling via the vagus nerve in ghrelin receptor–restored GHSR-null mice
    Tadashi Okada, T.M. Zaved Waise, Koji Toshinai, Yuichiro Mita, Hideyuki Sakoda, Masamitsu Nakazato
    Neuroscience Letters, Elsevier Ireland Ltd, 68150 - 55, 10 Aug. 2018, English, Research paper (scientific journal)
  • Selenoprotein P-neutralizing antibodies improve insulin secretion and glucose sensitivity in type 2 diabetes mouse models
    Yuichiro Mita, Kaho Nakayama, Shogo Inari, Yukina Nishito, Yuya Yoshioka, Naoko Sakai, Kanade Sotani, Takahiro Nagamura, Yuki Kuzuhara, Kumi Inagaki, Miki Iwasaki, Hirofumi Misu, Masaya Ikegawa, Toshinari Takamura, Noriko Noguchi, Yoshiro Saito
    NATURE COMMUNICATIONS, NATURE PUBLISHING GROUP, 8(1)1658 , Nov. 2017, English, Research paper (scientific journal)
  • Deficiency of the hepatokine selenoprotein P increases responsiveness to exercise in mice through upregulation of reactive oxygen species and AMP-activated protein kinase in muscle
    Hirofumi Misu, Hiroaki Takayama, Yoshiro Saito, Yuichiro Mita, Akihiro Kikuchi, Kiyo-aki Ishii, Keita Chikamoto, Takehiro Kanamori, Natsumi Tajima, Fei Lan, Yumie Takeshita, Masao Honda, Mutsumi Tanaka, Seiji Kato, Naoto Matsuyama, Yuya Yoshioka, Kaito Iwayama, Kumpei Tokuyama, Nobuhiko Akazawa, Seiji Maeda, Kazuhiro Takekoshi, Seiichi Matsugo, Noriko Noguchi, Shuichi Kaneko, Toshinari Takamura
    NATURE MEDICINE, NATURE PUBLISHING GROUP, 23(4)508 - +, Apr. 2017, English, Research paper (scientific journal)
  • (D)-Glutamate is metabolized in the heart mitochondria
    Makoto Ariyoshi, Masumi Katane, Kenji Hamase, Yurika Miyoshi, Maiko Nakane, Atsushi Hoshino, Yoshifumi Okawa, Yuichiro Mita, Satoshi Kaimoto, Motoki Uchihashi, Kuniyoshi Fukai, Kazunori Ono, Syuhei Tateishi, Daichi Hato, Ryoetsu Yamanaka, Sakiko Honda, Yohei Fushimura, Eri Iwai-Kanai, Naotada Ishihara, Masashi Mita, Hiroshi Homma, Satoaki Matoba
    SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, 743911 , Mar. 2017, English, Research paper (scientific journal)
  • Oxidation and interaction of DJ-1 with 20S proteasome in the erythrocytes of early stage Parkinson's disease patients
    Yoshiro Saito, Yoko Akazawa-Ogawa, Akihiro Matsumura, Kazumasa Saigoh, Sayoko Itoh, Kenta Sutou, Mayuka Kobayashi, Yuichiro Mita, Mototada Shichiri, Shin Hisahara, Yasuo Hara, Harutoshi Fujimura, Hiroyuki Takamatsu, Yoshihisa Hagihara, Yasukazu Yoshida, Takao Hamakubo, Susumu Kusunoki, Shun Shimohama, Noriko Noguchi
    SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, 630793 , Jul. 2016, English, Research paper (scientific journal)
  • Enhancement of lipid peroxidation and its amelioration by vitamin E in a subject with mutations in the SBP2 gene
    Yoshiro Saito, Mototada Shichiri, Takashi Hamajima, Noriko Ishida, Yuichiro Mita, Shohei Nakao, Yoshihisa Hagihara, Yasukazu Yoshida, Kazuhiko Takahashi, Etsuo Niki, Noriko Noguchi
    JOURNAL OF LIPID RESEARCH, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 56(11)2172 - 2182, Nov. 2015, English, Research paper (scientific journal)
  • An alpha-adrenergic agonist protects hearts by inducing Akt1-mediated autophagy
    Mikihiko Nakaoka, Eri Iwai-Kanai, Maki Katamura, Yoshifumi Okawa, Yuichiro Mita, Satoaki Matoba
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, 456(1)250 - 256, Jan. 2015, English, Research paper (scientific journal)
  • Immunostaining of Oxidized DJ-1 in Human and Mouse Brains
    Yoshiro Saito, Tomohiro Miyasaka, Hiroyuki Hatsuta, Kazuko Takahashi-Niki, Kojiro Hayashi, Yuichiro Mita, Osamu Kusano-Arai, Hiroko Iwanari, Hiroyoshi Ariga, Takao Hamakubo, Yasukazu Yoshida, Etsuo Niki, Shigeo Murayama, Yasuo Ihara, Noriko Noguchi
    JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, LIPPINCOTT WILLIAMS & WILKINS, 73(7)714 - 728, Jul. 2014, English, Research paper (scientific journal)
  • Cytosolic p53 inhibits Parkin-mediated mitophagy and promotes mitochondrial dysfunction in the mouse heart
    Atsushi Hoshino, Yuichiro Mita, Yoshifumi Okawa, Makoto Ariyoshi, Eri Iwai-Kanai, Tomomi Ueyama, Koji Ikeda, Takehiro Ogata, Satoaki Matoba
    NATURE COMMUNICATIONS, NATURE PUBLISHING GROUP, 42308 , Aug. 2013, English, Research paper (scientific journal)
  • p53-TIGAR axis attenuates mitophagy to exacerbate cardiac damage after ischemia
    Atsushi Hoshino, Satoaki Matoba, Eri Iwai-Kanai, Hideo Nakamura, Masaki Kimata, Mikihiko Nakaoka, Maki Katamura, Yoshifumi Okawa, Makoto Ariyoshi, Yuichiro Mita, Koji Ikeda, Tomomi Ueyama, Mitsuhiko Okigaki, Hiroaki Matsubara
    JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 52(1)175 - 184, Jan. 2012, English, Research paper (scientific journal)
  • p53 Promotes Cardiac Dysfunction in Diabetic Mellitus Caused by Excessive Mitochondrial Respiration-Mediated Reactive Oxygen Species Generation and Lipid Accumulation
    Hideo Nakamura, Satoaki Matoba, Eri Iwai-Kanai, Masaki Kimata, Atsushi Hoshino, Mikihiko Nakaoka, Maki Katamura, Yoshifumi Okawa, Makoto Ariyoshi, Yuichiro Mita, Koji Ikeda, Mitsuhiko Okigaki, Souichi Adachi, Hideo Tanaka, Tetsuro Takamatsu, Hiroaki Matsubara
    CIRCULATION-HEART FAILURE, LIPPINCOTT WILLIAMS & WILKINS, 5(1)106 - U254, Jan. 2012, English, Research paper (scientific journal)
  • TP53 codon 72 polymorphism is associated with pancreatic cancer risk in males, smokers and drinkers
    Takayuki Sonoyama, Akiko Sakai, Yuichiro Mita, Yukiko Yasuda, Hirofumi Kawamoto, Takahito Yagi, Masao Yoshioka, Tetsushige Mimura, Kei Nakachi, Mamoru Ouchida, Kazuhide Yamamoto, Kenji Shimizu
    MOLECULAR MEDICINE REPORTS, SPANDIDOS PUBL LTD, 4(3)489 - 495, May 2011, English, Research paper (scientific journal)
  • p53 and TIGAR regulate cardiac myocyte energy homeostasis under hypoxic stress
    Masaki Kimata, Satoaki Matoba, Eri Iwai-Kanai, Hideo Nakamura, Atsushi Hoshino, Mikihiko Nakaoka, Maki Katamura, Yoshifumi Okawa, Yuichiro Mita, Mitsuhiko Okigaki, Koji Ikeda, Tetsuya Tatsumi, Hiroaki Matsubara
    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, AMER PHYSIOLOGICAL SOC, 299(6)H1908 - H1916, Dec. 2010, English, Research paper (scientific journal)
  • Missense polymorphisms of PTPRJ and PTPN13 genes affect susceptibility to a variety of human cancers
    Yuichiro Mita, Yukiko Yasuda, Akiko Sakai, Hiromasa Yamamoto, Shinichi Toyooka, Mehmet Gunduz, Shunsuke Tanabe, Yoshio Naomoto, Mamoru Ouchida, Kenji Shimizu
    JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, SPRINGER, 136(2)249 - 259, Feb. 2010, English, Research paper (scientific journal)

Misc

  • インスリン抵抗性の病態から治療への展開 ヘパトカインセレノプロテインPを標的とするインスリン抵抗性治療薬の開発を目指して
    御簾 博文, 三田 雄一郎, 斎藤 芳郎, 篁 俊成
    糖尿病, (一社)日本糖尿病学会, 61(Suppl.1)S - 29, Apr. 2018, Japanese
  • セレノプロテインPの阻害抗体による糖尿病治療効果の解析 インスリン抵抗性および分泌能を改善する抗体医薬の開発
    三田 雄一郎, 中山 華穂, 稲荷 尚吾, 西藤 有希奈, 吉岡 佑弥, 曽谷 奏, 高部 稚子, 御簾 博文, 篁 俊成, 高橋 和彦, 野口 範子, 斎藤 芳郎
    糖尿病, (一社)日本糖尿病学会, 59(Suppl.1)S - 444, Apr. 2016, Japanese
  • 膵臓β細胞モデルMIN6は過剰なSelenoprotein Pにより障害を受ける
    稲荷 尚吾, 高部 稚子, 三田 雄一郎, 御簾 博文, 篁 俊成, 野口 範子, 斎藤 芳郎
    日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, (公社)日本生化学会, 88回・38回[4T特L - 10(3P1201)], Dec. 2015, Japanese
  • セレンタンパク質研究の最前線 血漿セレノプロテインPによるセレン代謝制御と2型糖尿病
    斎藤 芳郎, 吉岡 佑弥, 三田 雄一郎, 御簾 博文, 田中 睦, 篁 俊成, 野口 範子
    Biomedical Research on Trace Elements, 日本微量元素学会, 25(2)50 - 50, Jun. 2014, Japanese
  • Decrease of Insulin Secretion is Induced by Excess Selenoprotein P-Improving Effects of Neutralizing Antibody
    Yoshiro Saito, Yuichiro Mita, Kaho Nakayama, Shogo Inari, Takahiro Nagamura, Noriko Noguchi
    FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, 112156 - 156, Nov. 2017, English, Research paper, summary (international conference)
  • Tigar (tp53-induced Glycolysis And Apoptosis Regulator) Decreases Glycogenic Energy Metabolism and Deteriorates Left Ventricular Function in Pressure Overload-induced Heart Failure Model
    Yoshifumi Okawa, Eri Iwai-Kanai, Yuichiro Mita, Atsushi Hoshino, Maki Katamura, Makoto Ariyoshi, Satoshi Kaimoto, Kuniyoshi Fukai, Motoki Uchihashi, Satoaki Matoba
    CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, 128(22), Nov. 2013, English, Research paper, summary (international conference)
  • Inhibition of Protease Oxidation Preserves Protein Turnover of Mitochondrial Electron Transport Complex and Improves Respiration Capacity in Pressure Overload Heart
    Atsushi Hoshino, Satoaki Matoba, Yuichiro Mita, Eri Iwai-Kanai, Hiroaki Matsubara
    CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, 126(21), Nov. 2012, English, Research paper, summary (international conference)
  • Inhibition of Cytosolic p53 Preserves Mitochondrial Integrity and Prevents Cardiac Aging
    Atsushi Hoshino, Satoaki Matoba, Maki Katamura, Yoshifumi Okawa, Makoto Ariyoshi, Satoshi Kaimoto, Yuichiro Mita, Hiroaki Matsubara
    CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, 126(21), Nov. 2012, English, Research paper, summary (international conference)
  • Curcumin Prevents Doxorubicin-Induced Cardiotoxicity Through Phosphorylated Bcl-2-Regulated Autophagy
    Maki Katamura, Satoaki Matoba, Eri Iwi-Kanai, Atsushi Hoshino, Yoshifumi Okawa, Yuichiro Mita, Makoto Ariyoshi, Satoshi Kaimoto, Hiroaki Matsubara
    CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, 126(21), Nov. 2012, English, Research paper, summary (international conference)
  • p53-Tigar Axis Attenuates Mitophagy Tt Exacerbate Cardiac Damage After Ischemia
    Atsushi Hoshino, Satoaki Matoba, Eri Iwai-Kanai, Maki Katamura, Yoshifumi Okawa, Makoto Ariyoshi, Yuichiro Mita, Hiroaki Matsubara
    CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, 124(21), Nov. 2011, English, Research paper, summary (international conference)
  • p53 Promotes Cardiac Dysfunction in Diabetes Mellitus by Excessive Mitochondrial Respiration and Fat/cd36 Upregulation
    Hideo Nakamura, Satoaki Matoba, Eri Iwai-Kanai, Masaki Kimata, Atsushi Hoshino, Mikihiko Nakaoka, Maki Katamura, Yoshihumi Okawa, Yuichiro Mita, Makoto Ariyoshi, Koji Ikeda, Mitsuhiko Okigaki, Hiroaki Matsubara
    CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, 124(21), Nov. 2011, English, Research paper, summary (international conference)
  • p53 Promotes Cardiac Aging Through The Inhibition Of Parkin Mediated Mitochondrial Quality Control
    Atsushi Hoshino, Satoaki Matoba, Eri Iwai-Kanai, Maki Katamura, Yoshifumi Okawa, Makoto Ariyoshi, Yuichiro Mita, Hiroaki Matsubara
    CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, 124(21), Nov. 2011, English, Research paper, summary (international conference)
  • p53-mediated Acceleration of Mitochondrial Oxygen Consumption Promotes Lipotoxicity via SCO2 in Diabetic Mice
    Hideo Nakamura, Satoaki Matoba, Eri Iwai-Kanai, Masaki Kimata, Atsushi Hoshino, Mikihiko Nakaoka, Maki Katamura, Yoshifumi Okawa, Yuichiro Mita, Tetsuya Tatsumi, Hiroaki Matsubara
    CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, 122(21), Nov. 2010, English, Research paper, summary (international conference)

Research Grants & Projects

  • Regulatory mechanism of selenoprotein P expression and its deterioration mechanism of glucose metabolism
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A), 2020/04 -2024/03, Grant-in-Aid for Scientific Research (A)
  • Analysis of the effect of a novel modification of Parkinson's disease-related protein DJ-1 on the onset and progression of Parkinson's disease
    Takeda Science foundation, 2020 -2023