| IWAISAKO Keiko |  |
| Faculty of Life and Medical Sciences Department of Medical Life Systems | |
| Professor |
Last Updated :2024/05/23
Researcher Profile and Settings
researchmap
Research funding number
70625300Research Areas
Research Experience
- Doshisha University, Faculty of Life and Medical Sciences, Professor, 2018 - Today
- Kyoto University, Program-Specific Senior Lecturer, 2013 - 2018
- Osaka City University Graduate School of Medicine, 医学研究科, Assistant Professor, 2012 - 2013
- Kyoto University Hospital, Department of Hepato-pancreato-billiary Surgery and Transplantation, Clinical Fellow, 2011 - 2012
- University of California San Diego, Department of Medicine, Postdoctoral Researcher, 2008 - 2011
- Osaka Red Cross Hospital, Department of Surgery, 2000 - 2004
- Kyoto University Hospital, Resident, 1999 - 2000
- Takeda Pharmaceutical Company Limited, フードビタミン研究所, 1990 - 1992
Education
- Graduate School of Medicine Kyoto University, 2004 - 2008
- Hamamatsu University School of Medicine, 1993 - 1999
- Kobe Pharmaceutical University, 1986 - 1990
Degree
Committee Memberships
- advisory committee, 2023/04 - Today, Central institute for experimental animals, Others
- 厚生労働省健康局 技術評価委員, 2023/03 - Today
- Program Officer of Department of Health and Clinical Data, Division of Data Sharing and Medical Art Practical Research Project for Allergic Diseases and Immunology (Research on Technology of Medical Transplantation), 2019 - Today, Japan Agency for Medical Research and Development (AMED)
Awards
- 浜松医科大学同窓会学術奨励賞
Jun. 2015 - Kyoto University Medical Student Support-Fund Young Investigator Award
May 2010
Published Papers
- Ferroptosis-related Gene Glutathione Peroxidase 4 Promotes Reprogramming of Glucose Metabolism via Akt-mTOR Axis in Intrahepatic Cholangiocarcinoma.
Yutaro Hori; Tomoaki Yoh; Hiroto Nishino; Keisuke Okura; Makoto Kurimoto; Yuichi Takamatsu; Motohiko Satoh; Takahiro Nishio; Yukinori Koyama; Takamichi Ishii; Keiko Iwaisako; Satoru Seo; Etsuro Hatano
Carcinogenesis, 20 Dec. 2023, Scientific journal - Periportal hepatocyte proliferation at midgestation governs maternal glucose homeostasis in mice
Satoshi Kozuki; Mio Kabata; Satoko Sakurai; Keiko Iwaisako; Tomomi Nishimura; Masakazu Toi; Takuya Yamamoto; Fumiko Toyoshima
Communications Biology, Springer Science and Business Media LLC, 6(1), 04 Dec. 2023, Scientific journal - Antagonist of sphingosine 1-phosphate receptor 3 reduces cold injury of rat donor hearts for transplantation
Eisho Kanemitsu; Xiangdong Zhao; Keiko Iwaisako; Asuka Inoue; Akihide Takeuchi; Shintaro Yagi; Hidetoshi Masumoto; Hiroaki Ohara; Motoyasu Hosokawa; Tomonari Awaya; Junken Aoki; Etsuro Hatano; Shinji Uemoto; Masatoshi Hagiwara
Translational Research, Elsevier BV, Nov. 2022, Scientific journal - Clinically Relevant Model of Oxaliplatin-Induced Sinusoidal Obstruction Syndrome.
Rei Toda; Satoru Seo; Yusuke Uemoto; Koshiro Morino; Hiroto Nishino; Naohiko Nakamura; Masayuki Okuno; Kohta Iguchi; Motohiko Sato; Kojiro Nakamura; Kojiro Taura; Shunsaku Nakagawa; Takayuki Nakagawa; Tatsuaki Tsuruyama; Toshiaki Manabe; Hiroaki Kawaguchi; Keiko Iwaisako; Masaya Ikegawa; Shinji Uemoto; Etsuro Hatano
Hepatology research : the official journal of the Japan Society of Hepatology, 53(2) 145 - 159, 23 Sep. 2022, Scientific journal - Suppression of intrahepatic cholangiocarcinoma cell growth by
SKI via upregulation of the CDK inhibitor p21
Etsushi Kawamura; Tsutomu Matsubara; Atsuko Daikoku; Sanae Deguchi; Masahiko Kinoshita; Hideto Yuasa; Hayato Urushima; Naoshi Odagiri; Hiroyuki Motoyama; Kohei Kotani; Ritsuzo Kozuka; Atsushi Hagihara; Hideki Fujii; Sawako Uchida‐Kobayashi; Shogo Tanaka; Shigekazu Takemura; Keiko Iwaisako; Masaru Enomoto; YH Taguchi; Akihiro Tamori; Shoji Kubo; Kazuo Ikeda; Norifumi Kawada
FEBS Open Bio, Wiley, 17 Sep. 2022, Scientific journal - Bile Duct Regeneration with an Artificial Bile Duct Made of Gelatin Hydrogel Nonwoven Fabrics.
Yusuke Uemoto; Kojiro Taura; Daichi Nakamura; Li Xuefeng; Nguyen Hai Nam; Yusuke Kimura; Kenji Yoshino; Hiroaki Fuji; Tomoaki Yoh; Takahiro Nishio; Gen Yamamoto; Yukinori Koyama; Satoru Seo; Tatsuaki Tsuruyama; Keiko Iwaisako; Shinji Uemoto; Yasuhiko Tabata; Etsuro Hatano
Tissue engineering. Part A, 28(17-18) 737 - 748, 21 Jun. 2022, Scientific journal - Characterization and role of collagen gene expressing hepatic cells following partial hepatectomy in mice.
Yusuke Kimura; Yukinori Koyama; Kojiro Taura; Aoi Kudoh; Kanae Echizen; Daichi Nakamura; Xuefeng Li; Nguyen Hai Nam; Yusuke Uemoto; Takahiro Nishio; Gen Yamamoto; Satoru Seo; Keiko Iwaisako; Akira Watanabe; Etsuro Hatano
Hepatology (Baltimore, Md.), 23 May 2022, Scientific journal - Increased Expressions of Programmed Death Ligand 1 and Galectin 9 in Transplant Recipients Who Achieved Tolerance After Immunosuppression Withdrawal.
Nguyen Hai Nam; Kojiro Taura; Yukinori Koyama; Takahiro Nishio; Gen Yamamoto; Yusuke Uemoto; Yusuke Kimura; Li Xuefeng; Daichi Nakamura; Kenji Yoshino; Eri Ogawa; Tatsuya Okamoto; Atsushi Yoshizawa; Satoru Seo; Keiko Iwaisako; Tomoaki Yoh; Koichiro Hata; Toshihiko Masui; Hideaki Okajima; Hironori Haga; Shinji Uemoto; Etsuro Hatano
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 28(4) 647 - 658, Apr. 2022, Scientific journal - In situ vaccination using unique TLR9 ligand K3-SPG induces long-lasting systemic immune response and synergizes with systemic and local immunotherapy.
Hirokazu Okada; Ken Takahashi; Hiroaki Yaku; Kouji Kobiyama; Keiko Iwaisako; Xiangdong Zhao; Masahiro Shiokawa; Norimitsu Uza; Yuzo Kodama; Ken J Ishii; Hiroshi Seno
Scientific reports, 12(1) 2132 - 2132, 08 Feb. 2022, Scientific journal - Alteration of the immune environment in bone marrow from children with recurrent B cell precursor acute lymphoblastic leukemia.
Takashi Mikami; Itaru Kato; James Badger Wing; Hiroo Ueno; Keiji Tasaka; Kuniaki Tanaka; Hirohito Kubota; Satoshi Saida; Katsutsugu Umeda; Hidefumi Hiramatsu; Tomoya Isobe; Mitsuteru Hiwatari; Ai Okada; Kenichi Chiba; Yuichi Shiraishi; Hiroko Tanaka; Satoru Miyano; Yuki Arakawa; Koichi Oshima; Katsuyoshi Koh; Souichi Adachi; Keiko Iwaisako; Seishi Ogawa; Shimon Sakaguchi; Junko Takita
Cancer science, 113(1) 41 - 52, Jan. 2022, Scientific journal - Immunotherapy-based targeting of MSLN+ activated portal fibroblasts is a strategy for treatment of cholestatic liver fibrosis.
Takahiro Nishio; Yukinori Koyama; Xiao Liu; Sara B Rosenthal; Gen Yamamoto; Hiroaki Fuji; Jacopo Baglieri; Na Li; Laura N Brenner; Keiko Iwaisako; Kojiro Taura; James S Hagood; Nicholas F LaRusso; Tapan K Bera; Ira Pastan; David A Brenner; Tatiana Kisseleva
Proceedings of the National Academy of Sciences of the United States of America, 118(29), 20 Jul. 2021, Scientific journal - Sinusoidal Obstruction Syndrome Promotes Liver Metastatic Seeding of Colorectal Cancer Cells in a Rat Model.
Hiroto Nishino; Masayuki Okuno; Satoru Seo; Rei Toda; Kenji Yoshino; Yosuke Kasai; Motohiko Satoh; Keiko Iwaisako; Kojiro Taura; Etsuro Hatano
Anticancer research, 41(4) 1803 - 1810, Apr. 2021, Scientific journal - Novel mouse model for cholestasis-induced liver fibrosis resolution by cholecystojejunostomy.
Kenji Yoshino; Kojiro Taura; Keiko Iwaisako; Yuki Masano; Yusuke Uemoto; Yusuke Kimura; Nguyen Hai Nam; Hiroto Nishino; Yoshinobu Ikeno; Yukihiro Okuda; Takahiro Nishio; Gen Yamamoto; Satoru Seo; Shinji Uemoto
Journal of gastroenterology and hepatology, 36(9) 2493 - 2500, 15 Jan. 2021, Scientific journal - Gene expression profiles of liver cancer cell lines reveal two hepatocyte-like and fibroblast-like clusters.
Keita Fukuyama; Masataka Asagiri; Masahiro Sugimoto; Hiraki Tsushima; Satoru Seo; Kojiro Taura; Shinji Uemoto; Keiko Iwaisako
PloS one, 16(2) e0245939 , 2021, Scientific journal - Utility of Mac-2-binding protein glycosylation isomer (M2BPGi) to evaluate graft status after liver transplantation.
Yusuke Kimura; Kojiro Taura; Nguyen Hai Nam; Yusuke Uemoto; Kenji Yoshino; Yoshinobu Ikeno; Yukihiro Okuda; Takahiro Nishio; Gen Yamamoto; Kazutaka Tanabe; Yukinori Koyama; Takayuki Anazawa; Ken Fukumitsu; Takashi Ito; Shintaro Yagi; Naoko Kamo; Satoru Seo; Keiko Iwaisako; Koichiro Hata; Takumi Imai; Shinji Uemoto
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 27(3) 403 - 415, 11 Aug. 2020, Scientific journal - Extent of liver resection is associated with incomplete liver restoration and splenomegaly a long period after liver resection.
Nguyen Hai Nam; Kojiro Taura; Yusuke Kimura; Yusuke Uemoto; Kenji Yoshino; Ken Fukumitsu; Takamichi Ishii; Satoru Seo; Keiko Iwaisako; Shinji Uemoto
Surgery, 168(1) 40 - 48, Jul. 2020, Scientific journal - Cytotoxic T Lymphocytes Regenerated from iPS Cells Have Therapeutic Efficacy in a Patient-Derived Xenograft Solid Tumor Model.
Soki Kashima; Takuya Maeda; Kyoko Masuda; Seiji Nagano; Takamitsu Inoue; Masashi Takeda; Yuka Kono; Takashi Kobayashi; Shigeyoshi Saito; Takahiro Higuchi; Hiroshi Ichise; Yuka Kobayashi; Keiko Iwaisako; Koji Terada; Yasutoshi Agata; Kazuyuki Numakura; Mitsuru Saito; Shintaro Narita; Masaki Yasukawa; Osamu Ogawa; Tomonori Habuchi; Hiroshi Kawamoto
iScience, 23(4) 100998 - 100998, 24 Apr. 2020, Scientific journal - Tyrosine kinase inhibitor imatinib augments tumor immunity by depleting effector regulatory T cells.
Atsushi Tanaka; Hiroyoshi Nishikawa; Shinsuke Noguchi; Daisuke Sugiyama; Hiromasa Morikawa; Yoshiko Takeuchi; Danbee Ha; Naoya Shigeta; Toshio Kitawaki; Yuka Maeda; Takuro Saito; Yoshinori Shinohara; Yoshihiro Kameoka; Keiko Iwaisako; Fumihiko Monma; Kohshi Ohishi; Julia Karbach; Elke Jäger; Kenichi Sawada; Naoyuki Katayama; Naoto Takahashi; Shimon Sakaguchi
The Journal of experimental medicine, 217(2), 03 Feb. 2020, Scientific journal - Traditional Chinese Medicine Fuzheng Huayu Prevents Development of Liver Fibrosis in Mice.
Chunyan Jiang; Keiko Iwaisako; Min Cong; Karin Diggle; Tarek Hassanein; David A Brenner; Tatiana Kisseleva
Archives of clinical and biomedical research, 4(5) 561 - 580, 2020, Scientific journal - High-resolution imaging mass spectrometry combined with transcriptomic analysis identified a link between fatty acid composition of phosphatidylinositols and the immune checkpoint pathway at the primary tumour site of breast cancer
Masahiro Kawashima; Mariko Tokiwa; Tomomi Nishimura; Yukiko Kawata; Masahiro Sugimoto; Tatsuki R. Kataoka; Takaki Sakurai; Keiko Iwaisako; Eiji Suzuki; Masatoshi Hagiwara; Adrian L. Harris; Masakazu Toi
British Journal of Cancer, Springer Science and Business Media LLC, 122(2) 245 - 257, Jan. 2020, Scientific journal - Copper-deficiency anemia in older patients with swallowing disorders: A case report
Kazutaka Tanabe; Keiko Iwaisako
Current Research in Nutrition and Food Science, 7(3) 638 - 647, Dec. 2019, Scientific journal - Long-term impact and clinical significance of living donor liver transplantation with respect to donor liver restoration and spleen size: a prospective study.
Yoshino K; Taura K; Ikeno Y; Kimura Y; Hai Nam N; Uemoto Y; Okuda Y; Nishio T; Yamamoto G; Iwaisako K; Seo S; Kaido T; Uemoto S
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 20(3) 808 - 816, Sep. 2019, Scientific journal - Activated hepatic stellate cells and portal fibroblasts contribute to cholestatic liver fibrosis in MDR2 knockout mice.
Takahiro Nishio; Ronglin Hu; Yukinori Koyama; Shuang Liang; Sara B Rosenthal; Gen Yamamoto; Daniel Karin; Jacopo Baglieri; Hsiao-Yen Ma; Jun Xu; Xiao Liu; Debanjan Dhar; Keiko Iwaisako; Kojiro Taura; David A Brenner; Tatiana Kisseleva
Journal of hepatology, 71(3) 573 - 585, Sep. 2019, Scientific journal - ESTABLISHMENT OF FOLFOX-INDUCED SINUSOIDAL OBSTRUCTION SYNDROME MODEL IN MICROMINIPIG
Toda Rei; Seo Satoru; Uemoto Yusuke; Nishino Hiroto; Nakamura Naohiko; Sato Motohiko; Iguchi Kohta; Iwaisako Keiko; Taura Kojiro; Tsuruyama Tatsuaki; Kawaguchi Hiroaki; Ikegawa Masaya; Hatano Etsuro; Uemoto Shinji
GASTROENTEROLOGY, W B SAUNDERS CO-ELSEVIER INC, 156(6) S1207 - S1208, May 2019 - Serum Nardilysin, a Surrogate Marker for Epithelial-Mesenchymal Transition, Predicts Prognosis of Intrahepatic Cholangiocarcinoma after Surgical Resection.
Tomoaki Yoh; Etsuro Hatano; Yosuke Kasai; Hiroaki Fuji; Kiyoto Nishi; Kan Toriguchi; Hideaki Sueoka; Mikiko Ohno; Satoru Seo; Keiko Iwaisako; Kojiro Taura; Rina Yamaguchi; Masato Kurokawa; Jiro Fujimoto; Takeshi Kimura; Shinji Uemoto; Eiichiro Nishi
Clinical cancer research : an official journal of the American Association for Cancer Research, 25(2) 619 - 628, 15 Jan. 2019, Scientific journal - Necrostatin-7 suppresses RANK-NFATc1 signaling and attenuates macrophage to osteoclast differentiation.
Hiroaki Fuji; Saori Ohmae; Naruto Noma; Masatoshi Takeiri; Hideto Yasutomi; Kazuya Izumi; Moe Ito; Masayasu Toyomoto; Soichiro Iwaki; Kenji Takemoto; Satoru Seo; Kojiro Taura; Shigeaki Hida; Mineyoshi Aoyama; Yasushi Ishihama; Masatoshi Hagiwara; Norihiko Takeda; Etsuro Hatano; Keiko Iwaisako; Shinji Uemoto; Masataka Asagiri
Biochemical and biophysical research communications, 503(2) 544 - 549, 05 Sep. 2018, Scientific journal - CAAT/enhancer binding protein-homologous protein deficiency attenuates liver ischemia/reperfusion injury in mice.
Seidai Wada; Etsuro Hatano; Tomoaki Yoh; Naohiko Nakamura; Yukihiro Okuda; Masayuki Okuno; Yosuke Kasai; Keiko Iwaisako; Satoru Seo; Kojiro Taura; Shinji Uemoto
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 24(5) 645 - 654, May 2018, Scientific journal - Preoperative metabolic tumor volume of intrahepatic cholangiocarcinoma measured by 18F-FDG-PET is associated with the KRAS mutation status and prognosis.
Yoshinobu Ikeno; Satoru Seo; Keiko Iwaisako; Tomoaki Yoh; Yuji Nakamoto; Hiroaki Fuji; Kojiro Taura; Hideaki Okajima; Toshimi Kaido; Shimon Sakaguchi; Shinji Uemoto
Journal of translational medicine, 16(1) 95 - 95, 11 Apr. 2018, Scientific journal - Pancreatic Stellate Cells Have Distinct Characteristics From Hepatic Stellate Cells and Are Not the Unique Origin of Collagen-Producing Cells in the Pancreas
Gen Yamamoto; Kojiro Taura; Keiko Iwaisako; Masataka Asagiri; Shinji Ito; Yukinori Koyama; Kazutaka Tanabe; Kohta Iguchi; Motohiko Satoh; Takahiro Nishio; Yukihiro Okuda; Yoshinobu Ikeno; Kenji Yoshino; Satoru Seo; Etsuro Hatano; Shinji Uemoto
PANCREAS, LIPPINCOTT WILLIAMS & WILKINS, 46(9) 1141 - 1151, Oct. 2017, Scientific journal - Downregulation of neuropilin-1 on macrophages modulates antibody-mediated tumoricidal activity
Kosuke Kawaguchi; Eiji Suzuki; Mariko Nishie; Isao Kii; Tatsuki R. Kataoka; Masahiro Hirata; Masashi Inoue; Fengling Pu; Keiko Iwaisako; Moe Tsuda; Ayane Yamaguchi; Hironori Haga; Masatoshi Hagiwara; Masakazu Toi
CANCER IMMUNOLOGY IMMUNOTHERAPY, SPRINGER, 66(9) 1131 - 1142, Sep. 2017, Scientific journal - Gallbladder-derived surfactant protein D regulates gut commensal bacteria for maintaining intestinal homeostasis
Hana Sarashina-Kida; Hideo Negishi; Junko Nishio; Wataru Suda; Yuki Nakajima; Mika Yasui-Kato; Keiko Iwaisako; Sujin Kang; Nobuyasu Endo; Hideyuki Yanai; Masataka Asagiri; Hiroshi Kida; Masahira Hattori; Atsushi Kumanogoh; Tadatsugu Taniguchi
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, 114(38) 10178 - 10183, Sep. 2017, Scientific journal - Hepatic vagus nerve regulates Kupffer cell activation via alpha 7 nicotinic acetylcholine receptor in nonalcoholic steatohepatitis
Takahiro Nishio; Kojiro Taura; Keiko Iwaisako; Yukinori Koyama; Kazutaka Tanabe; Gen Yamamoto; Yukihiro Okuda; Yoshinobu Ikeno; Kenji Yoshino; Yosuke Kasai; Masayuki Okuno; Satoru Seo; Takaki Sakurai; Masataka Asagiri; Etsuro Hatano; Shinji Uemoto
JOURNAL OF GASTROENTEROLOGY, SPRINGER JAPAN KK, 52(8) 965 - 976, Aug. 2017, Scientific journal - Nardilysin promotes hepatocellular carcinoma through activation of signal transducer and activator of transcription 3
Yosuke Kasai; Kan Toriguchi; Etsuro Hatano; Kiyoto Nishi; Mikiko Ohno; Tomoaki Yoh; Keita Fukuyama; Takahiro Nishio; Masayuki Okuno; Keiko Iwaisako; Satoru Seo; Kojiro Taura; Masato Kurokawa; Makoto Kunichika; Shinji Uemoto; Eiichiro Nishi
CANCER SCIENCE, WILEY, 108(5) 910 - 917, May 2017, Scientific journal - Nardilysin promotes hepatocellular carcinoma through activation of signal transducer and activator of transcription 3.
Yosuke Kasai; Kan Toriguchi; Etsuro Hatano; Kiyoto Nishi; Mikiko Ohno; Tomoaki Yoh; Keita Fukuyama; Takahiro Nishio; Masayuki Okuno; Keiko Iwaisako; Satoru Seo; Kojiro Taura; Masato Kurokawa; Makoto Kunichika; Shinji Uemoto; Eiichiro Nishi
Cancer science, 108(5) 910 - 917, May 2017, Scientific journal - Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis
Yukinori Koyama; Ping Wang; Shuang Liang; Keiko Iwaisako; Xiao Liu; Jun Xu; Mingjun Zhang; Mengxi Sun; Min Cong; Daniel Karin; Kojiro Taura; Chris Benner; Sven Heinz; Tapan Bera; David A. Brenner; Tatiana Kisseleva
JOURNAL OF CLINICAL INVESTIGATION, AMER SOC CLINICAL INVESTIGATION INC, 127(4) 1254 - 1270, Apr. 2017, Scientific journal - Actin-binding protein coronin 1A controls osteoclastic bone resorption by regulating lysosomal secretion of cathepsin K
Saori Ohmae; Naruto Noma; Masayasu Toyomoto; Masahiro Shinohara; Masatoshi Takeiri; Hiroaki Fuji; Kenji Takemoto; Keiko Iwaisako; Tomoko Fujita; Norihiko Takeda; Makoto Kawatani; Mineyoshi Aoyama; Masatoshi Hagiwara; Yasushi Ishihama; Masataka Asagiri
SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, 7 1 - 12, Mar. 2017, Scientific journal - Pattern of RECK CpG methylation as a potential marker for predicting breast cancer prognosis and drug-sensitivity
Gongping Shi; Yoko Yoshida; Kanako Yuki; Tomomi Nishimura; Yukiko Kawata; Masahiro Kawashima; Keiko Iwaisako; Kiyotsugu Yoshikawa; Junichi Kurebayashi; Masakazu Toi; Makoto Noda
ONCOTARGET, IMPACT JOURNALS LLC, 7(50) 82158 - 82169, Dec. 2016, Scientific journal - Diagnostic performance of F-18-fluorodeoxyglucose PET/CT and bone scintigraphy in breast cancer patients with suspected bone metastasis
Naoki Niikura; Jun Hashimoto; Toshiki Kazama; Jun Koizumi; Rin Ogiya; Mayako Terao; Risa Oshitanai; Toru Morioka; Banri Tsuda; Takuho Okamura; Yuki Saito; Keiko Iwaisako; Takayuki Iwamoto; Naoki Hayashi; Yutaka Imai; Yutaka Tokuda
BREAST CANCER, SPRINGER JAPAN KK, 23(4) 662 - 667, Jul. 2016, Scientific journal - Hepatic Stellate Cells Relay Inflammation Signaling From Sinusoids to Parenchyma in Mouse Models of Immune-Mediated Hepatitis
Tomoko Fujita; Kitipong Soontrapa; Yoshiya Ito; Keiko Iwaisako; Catharina Sagita Moniaga; Masataka Asagiri; Masataka Majima; Shuh Narumiya
HEPATOLOGY, WILEY, 63(4) 1325 - 1339, Apr. 2016, Scientific journal - Controversies over the Epithelial-to-Mesenchymal Transition in Liver Fibrosis
Kojiro Taura; Keiko Iwaisako; Etsuro Hatano; Shinji Uemoto
JOURNAL OF CLINICAL MEDICINE, MDPI AG, 5(1), Jan. 2016 - Comprehensive analysis of transcriptome and metabolome analysis in Intrahepatic Cholangiocarcinoma and Hepatocellular Carcinoma
Yoshiki Murakami; Shoji Kubo; Akihiro Tamori; Saori Itami; Etsushi Kawamura; Keiko Iwaisako; Kazuo Ikeda; Norifumi Kawada; Takahiro Ochiya; Y-H Taguchi
SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, 5 16294 , Nov. 2015, Scientific journal - Migration of splenic lymphocytes promotes liver fibrosis through modification of T helper cytokine balance in mice
Kazutaka Tanabe; Kojiro Taura; Yukinori Koyama; Gen Yamamoto; Takahiro Nishio; Yukihiro Okuda; Kojiro Nakamura; Kan Toriguchi; Kenji Takemoto; Kenya Yamanaka; Keiko Iwaisako; Satoru Seo; Masataka Asagiri; Etsuro Hatano; Shinji Uemoto
JOURNAL OF GASTROENTEROLOGY, SPRINGER JAPAN KK, 50(10) 1054 - 1068, Oct. 2015, Scientific journal - Intestinal Ischemic Preconditioning Ameliorates Hepatic Ischemia/Reperfusion Injury in Rats: Role of Heme Oxygenase 1 in the Second Window of Protection
Shoichi Kageyama; Koichiro Hata; Hirokazu Tanaka; Hirofumi Hirao; Toyonari Kubota; Yusuke Okamura; Keiko Iwaisako; Yasutsugu Takada; Shinji Uemoto
LIVER TRANSPLANTATION, WILEY-BLACKWELL, 21(1) 112 - 122, Jan. 2015, Scientific journal - Inhibition of MMP-2-Mediated Mast Cell Invasion by NF-kappa B Inhibitor DHMEQ in Mast Cells
Naruto Noma; Masataka Asagiri; Masatoshi Takeiri; Saori Ohmae; Kenji Takemoto; Keiko Iwaisako; Nagahiro Minato; Mari Maeda-Yamamoto; Siro Simizu; Kazuo Umezawa
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, KARGER, 166(2) 84 - 90, 2015, Scientific journal - Evaluation of Liver Fibrosis Using Texture Analysis on Combined-Contrast-Enhanced Magnetic Resonance Images at 3.0T
Takeshi Yokoo; Tanya Wolfson; Keiko Iwaisako; Michael R. Peterson; Haresh Mani; Zachary Goodman; Christopher Changchien; Michael S. Middleton; Anthony C. Gamst; Sameer M. Mazhar; Yuko Kono; Samuel B. Ho; Claude B. Sirlin
BIOMED RESEARCH INTERNATIONAL, HINDAWI LTD, 2015 387653 , 2015, Scientific journal - Whey-hydrolyzed peptide-enriched immunomodulating diet prevents progression of liver cirrhosis in rats
Kanta Jobara; Toshimi Kaido; Tomohide Hori; Keiko Iwaisako; Kosuke Endo; Yoichiro Uchida; Shinji Uemoto
NUTRITION, ELSEVIER SCIENCE INC, 30(10) 1195 - 1207, Oct. 2014, Scientific journal - Origin of myofibroblasts in the fibrotic liver in mice
Keiko Iwaisako; Chunyan Jiang; Mingjun Zhang; Min Cong; Thomas Joseph Moore-Morris; Tae Jun Park; Xiao Liu; Jun Xu; Ping Wang; Yong-Han Paik; Fanli Meng; Masataka Asagiri; Lynne A. Murray; Alan F. Hofmann; Takashi Iida; Christopher K. Glass; David A. Brenner; Tatiana Kisseleva
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, 111(32) E3297 - E3305, Aug. 2014, Scientific journal - Effects of oral intake of hydrogen water on liver fibrogenesis in mice
Yukinori Koyama; Kojiro Taura; Etsuro Hatano; Kazutaka Tanabe; Gen Yamamoto; Kojiro Nakamura; Kenya Yamanaka; Koji Kitamura; Masato Narita; Hiromitsu Nagata; Atsuko Yanagida; Taku Iida; Keiko Iwaisako; Hikohito Fujinawa; Shinji Uemoto
HEPATOLOGY RESEARCH, WILEY-BLACKWELL, 44(6) 663 - 677, Jun. 2014, Scientific journal - Cilostazol attenuates hepatic stellate cell activation and protects mice against carbon tetrachloride-induced liver fibrosis
Shunichi Saito; Koichiro Hata; Keiko Iwaisako; Atsuko Yanagida; Masatoshi Takeiri; Hirokazu Tanaka; Shoichi Kageyama; Hirofumi Hirao; Kazuo Ikeda; Masataka Asagiri; Shinji Uemoto
HEPATOLOGY RESEARCH, WILEY-BLACKWELL, 44(4) 460 - 473, Apr. 2014, Scientific journal - Necrostatin-1 protects against reactive oxygen species (ROS)-induced hepatotoxicity in acetaminophen-induced acute liver failure
Kenji Takemoto; Etsuro Hatano; Keiko Iwaisako; Masatoshi Takeiri; Naruto Noma; Saori Ohmae; Kan Toriguchi; Kazutaka Tanabe; Hirokazu Tanaka; Satoru Seo; Kojiro Taura; Keigo Machida; Norihiko Takeda; Shigehira Saji; Shinji Uemoto; Masataka Asagiri
FEBS OPEN BIO, ELSEVIER SCIENCE LONDON, 4 777 - 787, 2014, Scientific journal - Strategies to Detect Hepatic Myofibroblasts in Liver Cirrhosis of Different Etiologies.
Keiko Iwaisako; Kojiro Taura; Yukinori Koyama; Kenji Takemoto; Masataka Asagiri
Current pathobiology reports, 2(4) 209 - 215, 2014 - Sorafenib attenuates monocrotaline-induced sinusoidal obstruction syndrome in rats through suppression of JNK and MMP-9
Kojiro Nakamura; Etsuro Hatano; Masato Narita; Aya Miyagawa-Hayashino; Yukinori Koyama; Hiromitsu Nagata; Keiko Iwaisako; Kojiro Taura; Shinji Uemoto
JOURNAL OF HEPATOLOGY, ELSEVIER SCIENCE BV, 57(5) 1037 - 1043, Nov. 2012, Scientific journal - A case of cytokeratin 20-positive large-cell neuroendocrine carcinoma of the breast
Kae Okoshi; Tatsuyoshi Saiga; Shigeo Hisamori; Keiko Iwaisako; Hisato Kobayashi; Hiroki Ogawa
BREAST CANCER, SPRINGER JAPAN KK, 19(4) 360 - 364, Oct. 2012, Scientific journal - Interleukin-17 Signaling in Inflammatory, Kupffer Cells, and Hepatic Stellate Cells Exacerbates Liver Fibrosis in Mice
Fanli Meng; Kai Wang; Tomonori Aoyama; Sergei I. Grivennikov; Yonghan Paik; David Scholten; Min Cong; Keiko Iwaisako; Xiao Liu; Mingjun Zhang; Christoph H. Oesterreicher; Felix Stickel; Klaus Ley; David A. Brenner; Tatiana Kisseleva
GASTROENTEROLOGY, W B SAUNDERS CO-ELSEVIER INC, 143(3) 765 - +, Sep. 2012, Scientific journal - Identification of Small Molecule Activators of Cryptochrome
Tsuyoshi Hirota; Jae Wook Lee; Peter C. St John; Mariko Sawa; Keiko Iwaisako; Takako Noguchi; Pagkapol Y. Pongsawakul; Tim Sonntag; David K. Welsh; David A. Brenner; Francis J. Doyle; Peter G. Schultz; Steve A. Kay
SCIENCE, AMER ASSOC ADVANCEMENT SCIENCE, 337(6098) 1094 - 1097, Aug. 2012, Scientific journal - Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis
Tatiana Kisseleva; Min Cong; YongHan Paik; David Scholten; Chunyan Jiang; Chris Benner; Keiko Iwaisako; Thomas Moore-Morris; Brian Scott; Hidekazu Tsukamoto; Sylvia M. Evans; Wolfgang Dillmann; Christopher K. Glass; David A. Brenner
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, 109(24) 9448 - 9453, Jun. 2012, Scientific journal - Protection from liver fibrosis by a peroxisome proliferator-activated receptor delta agonist
Keiko Iwaisako; Michael Haimerl; Yong-Han Paik; Kojiro Taura; Yuzo Kodama; Claude Sirlin; Elizabeth Yu; Ruth T. Yu; Michael Downes; Ronald M. Evans; David A. Brenner; Bernd Schnabl
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, 109(21) E1369 - E1376, May 2012, Scientific journal - What's new in liver fibrosis? The origin of myofibroblasts in liver fibrosis
Keiko Iwaisako; David A. Brenner; Tatiana Kisseleva
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, WILEY-BLACKWELL, 27 65 - 68, Mar. 2012, Scientific journal - Origin of myofibroblasts in liver fibrosis.
Brenner DA; Kisseleva T; Scholten D; Paik YH; Iwaisako K; Inokuchi S; Schnabl B; Seki E; De Minicis S; Oesterreicher C; Taura K
Fibrogenesis & tissue repair, 5(Suppl 1) S17 , 2012 - Cell signals influencing hepatic fibrosis.
Cong M; Iwaisako K; Jiang C; Kisseleva T
International journal of hepatology, 2012 158547 , 2012 - Downregulation of the Wnt antagonist Dkk2 links the loss of Sept4 and myofibroblastic transformation of hepatic stellate cells
Atsuko Yanagid; Keiko Iwaisako; Etsuro Hatano; Kojiro Taura; Fumiaki Sato; Masato Narita; Hiromitsu Nagata; Hiroyuki Asechi; Shinji Uemoto; Makoto Kinoshita
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, ELSEVIER SCIENCE BV, 1812(11) 1403 - 1411, Nov. 2011, Scientific journal - Downregulation of the Wnt antagonist Dkk2 links the loss of Sept4 and myofibroblastic transformation of hepatic stellate cells.
Yanagida A; Iwaisako K; Hatano E; Taura K; Sato F; Narita M; Nagata H; Asechi H; Uemoto S; Kinoshita M
Biochimica et biophysica acta, 1812(11) 1403 - 1411, Nov. 2011 - Non-alcoholic steatohepatitis-induced fibrosis: Toll-like receptors, reactive oxygen species and Jun N-terminal kinase
David A. Brenner; Ekihiro Seki; Kojiro Taura; Tatiana Kisseleva; Samuele Deminicis; Keiko Iwaisako; Sayaka Inokuchi; Bernd Schnabl; Christopher H. Oesterreicher; Yong H. Paik; Kouichi Miura; Yuzo Kodama
HEPATOLOGY RESEARCH, WILEY-BLACKWELL, 41(7) 683 - 686, Jul. 2011 - The Nicotinamide Adenine Dinucleotide Phosphate Oxidase (NOX) Homologues NOX1 and NOX2/gp91(phox) Mediate Hepatic Fibrosis in Mice
Yong-Han Paik; Keiko Iwaisako; Ekihiro Seki; Sayaka Inokuchi; Bernd Schnabl; Christoph H. Oesterreicher; Tatiana Kisseleva; David A. Brenner
HEPATOLOGY, WILEY-BLACKWELL, 53(5) 1730 - 1741, May 2011, Scientific journal - Genetic Labeling Does Not Detect Epithelial-to-Mesenchymal Transition of Cholangiocytes in Liver Fibrosis in Mice
David Scholten; Christoph H. Oesterreicher; Anjali Scholten; Keiko Iwaisako; Guoqiang Gu; David A. Brenner; Tatiana Kisseleva
GASTROENTEROLOGY, W B SAUNDERS CO-ELSEVIER INC, 139(3) 987 - 998, Sep. 2010, Scientific journal - Resistance to cisplatin-induced apoptosis via PI3K-dependent survivin expression in a rat hepatoma cell line
Hiroyuki Asechi; Etsuro Hatano; Takashi Nitta; Masaharu Tada; Keiko Iwaisako; Nobuyuki Tamaki; Hiromitsu Nagata; Masato Narita; Atsuko Yanagida; Iwao Ikai; Shinji Uemoto
INTERNATIONAL JOURNAL OF ONCOLOGY, SPANDIDOS PUBL LTD, 37(1) 89 - 96, Jul. 2010, Scientific journal - Hepatocytes Do Not Undergo Epithelial-Mesenchymal Transition in Liver Fibrosis in Mice
Kojiro Taura; Kouichi Miura; Keiko Iwaisako; Christoph H. Osterreicher; Yuzo Kodama; Melitta Penz-Osterreicher; David A. Brenner
HEPATOLOGY, JOHN WILEY & SONS INC, 51(3) 1027 - 1036, Mar. 2010, Scientific journal - c-Jun N-terminal Kinase-1 From Hematopoietic Cells Mediates Progression From Hepatic Steatosis to Steatohepatitis and Fibrosis in Mice
Yuzo Kodama; Tatiana Kisseleva; Keiko Iwaisako; Kouichi Miura; Kojiro Taura; Samuele De Minicis; Christoph H. Osterreicher; Bernd Schnabl; Ekihiro Seki; David A. Brenner
GASTROENTEROLOGY, W B SAUNDERS CO-ELSEVIER INC, 137(4) 1467 - 1477, Oct. 2009, Scientific journal - P-glycoprotein expression affects F-18-fluorodeoxyglucose accumulation in hepatocellular carcinoma in vivo and in vitro
Satoru Seo; Etsuro Hatano; Tatsuya Higashi; Akio Nakajima; Yuji Nakamoto; Masaharu Tada; Nobuyuki Tamaki; Keiko Iwaisako; Koji Kitamura; Iwao Ikai; Shinji Uemoto
INTERNATIONAL JOURNAL OF ONCOLOGY, SPANDIDOS PUBL LTD, 34(5) 1303 - 1312, May 2009, Scientific journal - Hepatic Stellate Cells Secrete Angiopoietin 1 That Induces Angiogenesis in Liver Fibrosis
Kojiro Taura; Saimuele De Minicis; Ekihiro Seki; Etsuro Hatano; Keiko Iwaisako; Christoph H. Osterreicher; Yuzo Kodama; Kouichi Miura; Iwao Ikai; Shinji Uemoto; David A. Brenner
GASTROENTEROLOGY, W B SAUNDERS CO-ELSEVIER INC, 135(5) 1729 - 1738, Nov. 2008, Scientific journal - Loss of Sept4 exacerbates liver fibrosis through the dysregulation of hepatic stellate cells
Keiko Iwaisako; Etsuro Hatano; Kojiro Taura; Akio Nakajima; Masaharu Tada; Satoru Seo; Nobuyuki Tamaki; Fumiaki Sato; Iwao Ikai; Shinji Uemoto; Makoto Kinoshita
JOURNAL OF HEPATOLOGY, ELSEVIER SCIENCE BV, 49(5) 768 - 778, Nov. 2008, Scientific journal - Fluorine-18 fluorodeoxyglucose positron emission tomography predicts lymph node metastasis, P-glycoprotein expression, and recurrence after resection in mass-forming intrahepatic cholangiocarcinoma
Satoru Seo; Etsuro Hatano; Tatsuya Higashi; Akio Nakajima; Yuji Nakamoto; Masaharu Tada; Nobuyuki Tamaki; Keiko Iwaisako; Akira Mori; Ryuichiro Doi; Iwao Kai; Shinji Uemoto
SURGERY, MOSBY-ELSEVIER, 143(6) 769 - 777, Jun. 2008, Scientific journal - CHOP deficiency attenuates cholestasis-induced liver fibrosis by reduction of hepatocyte injury
Nobuyuki Tamaki; Etsuro Hatano; Kojiro Taura; Masaharu Tada; Yuzo Kodama; Takashi Nitta; Keiko Iwaisako; Satoru Seo; Akio Nakajima; Iwao Ikai; Shinji Uemoto
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, AMER PHYSIOLOGICAL SOC, 294(2) G498 - G505, Feb. 2008, Scientific journal - Two cases of ischemic colitis accompanied with elevated serum CEA
Keiko Iwaisako; Naoko Kamo; Satoru Seo; Minoru Ukikusa
Japanese Journal of Gastroenterological Surgery, Japanese Society of Gastroenterological Surgery, 41(5) 575 - 580, 2008, Scientific journal - Fluorine-18 fluorodeoxyglucose positron emission tomography predicts tumor differentiation, P-glycoprotein expression, and outcome after resection in hepatocellular carcinoma
Satoru Seo; Etsuro Hatano; Tatsuya Higashi; Tadashi Hara; Masaharu Tada; Nobuyuki Tamaki; Keiko Iwaisako; Iwai Ikai; Shinji Uemoto
CLINICAL CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, 13(2) 427 - 433, Jan. 2007, Scientific journal - Clinical significance of pyrimidine nucleoside phosphorylase (PyNPase) in breast cancer
S. Seo; A. Miki; K. Iwaisako; N. Kamo; T. Inomoto; T. Kitai; M. Ukikusa
Gan to kagaku ryoho. Cancer & chemotherapy, 33(11) 1579 - 1582, 2006 - Herpes simplex pancreatitis
M Shintaku; Y Umehara; K Iwaisako; M Tahara; Y Adachi
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE, COLLEGE AMER PATHOLOGISTS, 127(2) 231 - 234, Feb. 2003, Scientific journal - Preoperative assessment of hepatic function: Utility of a new convenient two-compartment model analysis using galactosyl human serum albumin scintigraphy
K Kinoshita; M Ukikusa; K Iwaisako; A Arimoto; N Fujisawa; T Ozaki; H Tanaka; S Seo; M Naitoh; A Nomura; T Inomoto; T Kitai; K Ino; H Higashiyama; T Hanafusa; Y Nakajima
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, BLACKWELL PUBLISHING ASIA, 18(1) 99 - 104, Jan. 2003, Scientific journal - Ga-67 uptake in ischemic enteritis in a patient with Churg-Strauss syndrome
H Ohta; M Shintaku; K Iwaisako; A Arimoto; Y Nakashima; M Ukikusa
CLINICAL NUCLEAR MEDICINE, LIPPINCOTT WILLIAMS & WILKINS, 26(7) 653 - 653, Jul. 2001, Scientific journal - FLUORIDE LEVELS IN TAP AND UNDERGROUND WATER SAMPLES FROM KINKI AREA IN JAPAN
A ADACHI; N AKAMATSU; K IWAISAKO; M SENKOKU; T KOBAYASHI
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, SPRINGER VERLAG, 46(5) 677 - 680, May 1991, Scientific journal
MISC
- 大腸癌肝転移症例に対する術前化学療法の肝機能への影響と短期手術成績の関連について
戸田 怜; 瀬尾 智; 中村 大地; 栗本 信; 高松 雄一; 堀 佑太郎; 木村 有佑; 上本 裕介; 楊 知明; 西尾 太宏; 山本 玄; 佐藤 元彦; 祝迫 恵子; 秦 浩一郎; 増井 俊彦; 田浦 康二朗; 波多野 悦朗
日本外科学会定期学術集会抄録集, 122回 DP - 2, Apr. 2022 - 外科医が行う臓器保存の研究とその副次的効果
金光 瑛彰; 趙 向東; 祝迫 恵子; 八木 真太郎; 萩原 正敏
日本外科学会定期学術集会抄録集, (一社)日本外科学会, 121回 SF - 7, Apr. 2021 - 最新型マスサイトメトリーを用いた小児白血病の骨髄免疫環境解析
三上 貴司; 加藤 格; Wing James B.; 田中 邦昭; 才田 聡; 梅田 雄嗣; 平松 英文; 足立 壮一; 祝迫 惠子; 坂口 志文; 滝田 順子
日本癌学会総会記事, (一社)日本癌学会, 79回 OJ14 - 4, Oct. 2020 - 若年胆管癌組織を使った癌抑制遺伝子の探索
川村 悦史; 松原 勤; 樋口 萌; 出口 早苗; 高田 さゆり; 大黒 敦子; 伊藤 得路; 木下 正彦; 松原 三佐子; 小田桐 直志; 田中 肖吾; 竹村 茂一; 村上 善基; 榎本 大; 田守 昭博; 久保 正二; 祝迫 惠子; 池田 一雄; 河田 則文
肝臓, 60(Suppl.3) A926 - A926, Nov. 2019 - SOSの病態解明に向けたFOLFOX誘導性マイクロミニブタSOSモデルの確立
戸田怜; 瀬尾智; 上本裕介; 西野裕人; 中村直彦; 奥野将之; 佐藤元彦; 井口公太; 祝迫恵子; 田浦康二朗; 川口博明; 鶴山竜昭; 池川雅哉; 波多野悦朗; 上本伸二
日本外科学会定期学術集会(Web), (一社)日本外科学会, 119th ROMBUNNO.SF‐060‐8 (WEB ONLY) - 8, 2019 - 新規バイオマーカーの臨床応用、予後予測因子・治療効果予測因子 脂質代謝物は乳癌の新しいバイオマーカーとなるか? 高解像度質量顕微鏡の解析から見えてきた事
川島 雅央; 常盤 麻里子; 西村 友美; 川田 有希子; 片岡 竜樹; 桜井 孝規; 祝迫 惠子; 鈴木 栄治; 戸井 雅和
日本乳癌学会総会プログラム抄録集, (一社)日本乳癌学会, 26回 303 - 303, May 2018 - 慢性肝傷害・肝線維化における制御性T細胞の肝保護効果
池野 嘉信; 廣田 圭司; 田浦 康二朗; 祝迫 惠子; 上本 裕介; 吉野 健史; 山本 玄; 瀬尾 智; 海道 利実; 上本 伸二
肝臓, (一社)日本肝臓学会, 59(Suppl.1) A391 - A391, Apr. 2018 - 肝内胆管癌に対する癌免疫療法の臨床応用にむけた取り組み
藤 浩明; 祝迫 惠子; 朝霧 成挙; 瀬尾 智; 田浦 康二朗; 海道 利実; 岡島 英明; 坂口 教子; 坂口 志文; 上本 伸二
日本外科学会定期学術集会抄録集, (一社)日本外科学会, 118回 2473 - 2473, Apr. 2018 - 肝内胆管癌における術前imagingによるgenetic and molecular profilingの試み
池野嘉信; 瀬尾智; 楊知明; 祝迫惠子; 中本裕士; 福光剣; 石井隆道; 田浦康二朗; 海道利実; 上本伸二
日本外科学会定期学術集会(Web), (一社)日本外科学会, 118回 2015 - 2015, Apr. 2018 - 肝内胆管癌における新規バイオマーカーによる予後予測 新たな治療戦略の確立を目指して
池野 嘉信; 瀬尾 智; 楊 知明; 祝迫 惠子; 田浦 康二朗; 安近 健太郎; 岡島 英明; 海道 利実; 上本 伸二
日本消化器外科学会総会, (一社)日本消化器外科学会, 72回 PN6 - 7, Jul. 2017 - 肝右葉グラフトドナーにおける術後合併症のリスクファクターの検討
吉野 健史; 田浦 康二朗; 池野 嘉信; 奥田 雄紀浩; 西尾 太宏; 山本 玄; 祝迫 恵子; 瀬尾 智; 岡島 英明; 海道 利実; 上本 伸二
日本外科学会定期学術集会抄録集, (一社)日本外科学会, 117回 SF - 19, Apr. 2017 - 肝迷走神経はα7ニコチン性アセチルコリン受容体を介して非アルコール性脂肪性肝炎の進展を抑制する
西尾 太宏; 田浦 康二朗; 祝迫 惠子; 吉野 健史; 池野 嘉信; 奥田 雄紀浩; 山本 玄; 瀬尾 智; 波多野 悦朗; 上本 伸二
日本外科学会定期学術集会抄録集, (一社)日本外科学会, 117回 SF - 67, Apr. 2017 - 寛容と免疫調節 マウス肝移植における肝動脈再建 免疫寛容パターンに及ぼす影響(Tolerance and immune regulation Reconstruction of the hepatic artery in mouse liver transplantation: impact on patterns of immunologic tolerance)
Zhao Xiangdong; Iwaisako Keiko; Noma Naruto; Ohmae Saori; Fuji Hiroaki; Asagiri Masataka; Ikeno Yoshinobu; Masano Yuki; Kawamoto Hiroshi; Uemoto Shinji
日本免疫学会総会・学術集会記録, (NPO)日本免疫学会, 45(Proceedings) 110 - 110, Nov. 2016 - Hepatic Vagus Nerve Regulates Inflammatory Response of Kupffer Cell via alpha 7 Nicotinic Acetylcholine Receptor in Nonalcoholic Steatohepatitis
Takahiro Nishio; Kojiro Taura; Kazutaka Tanabe; Gen Yamamoto; Yukihiro Okuda; Yoshinobu Ikeno; Kenji Yoshino; Keiko Iwaisako; Satoru Seo; Shinji Uemoto
HEPATOLOGY, WILEY, 64 754A - 754A, Oct. 2016, Summary international conference - CHOP deficiency attenuates liver ischemia reperfusion injury in mice
Seidai Wada; Etsuro Hatano; Keiko Iwaisako; Tomoaki Yoh; Naohiko Namakura; Masayuki Okuno; Yosuke Kasai; Satoru Seo; Kojiro Taura; Shinji Uemoto
HEPATOLOGY, WILEY, 64 270A - 270A, Oct. 2016, Summary international conference - Neuropilin-1 expressing macrophages promote neuropilin-1 expression on lymphocytes by direct interaction and exert antitumor activity in HER2 positive breast cancer
Kosuke Kawaguchi; Eiji SUzuki; Masashi Inoue; Isao Kii; Tatsuki R. Karaoke; Masahiro Hiram; Keiko Iwaisako; Pu Fengling; Mariko Niche; Ayane Yamaguchi; Hironori Haga; Masatoshi Hagiwara; Masakazu Toi
CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, 76, Jul. 2016, Summary international conference - 肝内胆管癌における新たなバイオマーカーの展望
池野嘉信; 波多野悦朗; 瀬尾智; 祝迫惠子; 田浦康二朗; 安近健太郎; 岡島英明; 海道利実; 上本伸二
日本外科学会定期学術集会(Web), 116th OP‐068‐1 (WEB ONLY) , 2016 - Intervention of RIPK-dependent necrosis in the pathogenesis of drug-induced fulminant liver failure
Kenji Takemoto; Etsuro Hatano; Keiko Iwaisako; Masatoshi Takeiri; Naruto Noma; Saori Ohmae; Kan Toriguchi; Kazutaka Tanabe; Keigo Machida; Kojiro Taura; Shinji Uemoto; Masa Asagiri
HEPATOLOGY, WILEY-BLACKWELL, 62 1143A - 1144A, Oct. 2015, Summary international conference - Origin of myofibroblast in liver fibrosis
祝迫 惠子; 朝霧 成挙; 上本 伸二
細胞, ニューサイエンス社, 47(4) 172 - 175, Apr. 2015 - PS-083-6 ホエイペプチド含有免疫調整dietによるラット肝硬変発症抑制効果ならび機序に関する検討(PS-083 肝 基礎-3,ポスターセッション,第114回日本外科学会定期学術集会)
城原 幹太; 海道 利実; 堀 智英; 祝迫 惠子; 遠藤 耕介; 内田 洋一朗; 川島 昭浩; 佐々木 一; 上本 伸二
日本外科学会雑誌, 一般社団法人日本外科学会, 115(2) 741 - 741, 05 Mar. 2014 - Influence of oxygen-binding cytoglobin expressed in hepatic stellate cells on acetaminophen-induced acute hepatocyte damage: In vivo and in vitro studies
Yuga Teranishi; Tsutomu Matsubara; Keiko Iwaisako; Kazuki Nakatani; Thuy T. Le; Frank J. Gonzalez; Kazuo Ikeda; Norifumi Kawada
HEPATOLOGY, WILEY-BLACKWELL, 58 380A - 380A, Oct. 2013, Summary international conference - PS-085-1 ホエイペプチド含有免疫調整剤によるラット肝硬変抑制効果(PS ポスターセッション,第113回日本外科学会定期学術集会)
城原 幹太; 海道 利実; 遠藤 耕介; 内田 洋一朗; 祝迫 恵子; 川島 昭浩; 佐々木 一; 上本 伸二
日本外科学会雑誌, 一般社団法人日本外科学会, 114(2) 638 - 638, 05 Mar. 2013 - The origin of myofibroblasts in experimental liver disease
Mingjun Zhang; Xiao Liu; Chunyan Jiang; Keiko Iwaisako; Min Cong; David Brenner; Tatiana Kisseleva
HEPATOLOGY, WILEY-BLACKWELL, 56 760A - 761A, Oct. 2012, Summary international conference - 肝巨大血管腫にDiffuse Hepatic Hemangiomatosisを伴った症例をどう扱うか? 切除か、移植か、経過観察か?
秦 浩一郎; 後藤 徹; 岡村 祐輔; 祝迫 惠子; 八木 真太郎; 海道 利実; 上本 伸二
日本消化器外科学会総会, (一社)日本消化器外科学会, 67回(Supplement1) 1 - 1, Jul. 2012 - 生体肝移植後、カルシニューリン阻害剤が原因で発症し治療に難渋した血栓性微小血管障害症(TMA)の1例
岡村 裕輔; 田中 宏和; 八木 真太郎; 後藤 徹; 木田 睦士; 祝迫 恵子; 秦 浩一郎; 上本 伸二
日本消化器外科学会総会, (一社)日本消化器外科学会, 67回(Supplement1) 3 - 3, Jul. 2012 - 外科領域における凝固障害症例の治療戦略を探る 肝移植後血栓性微小血管障害(TMA)の病態解明と新規治療法の開発に向けて
秦 浩一郎; 田中 宏和; 平尾 浩史; 影山 詔一; 斉藤 俊一; 岡村 裕輔; 冨山 浩司; 内田 洋一郎; 祝迫 恵子; 八木 真太郎; 吉澤 敦; 藤本 康弘; 小川 晃平; 小倉 靖弘; 海道 利実; 上本 伸二
日本外科学会雑誌, (一社)日本外科学会, 113(臨増2) 148 - 148, Mar. 2012 - IL-6/STAT3-INDUCED MTOR AND AUTOPHAGY SIGNALING IN OBESITY-PROMOTED LIVER CANCER
Eek Joong Park; Debanjan Dhar; JunHee Lee; HongSook Kim; Ning Li; Syed Raza Ali; Andrei V. Budanov; Yong Han Paik; Keiko Iwaisako; Michael Karin; David Brenner; Ekihiro Seki
HEPATOLOGY, WILEY-BLACKWELL, 54 388A - 388A, Oct. 2011, Summary international conference - Hepatic Stellate Cells Revert to an Inactive Phenotype During Regression of Fibrosis
Tatiana Kisseleva; Yonghan Paik; David Scholten; Fanli Meng; Keiko Iwaisako; Chunyan Jiang; David A. Brenner
GASTROENTEROLOGY, W B SAUNDERS CO-ELSEVIER INC, 140(5) S916 - S917, May 2011, Summary international conference - The Origin of Myofibroblasts Contributing to Liver Fibrosis in Mice
Keiko Iwaisako; Chunyan Jiang; David Scholten; Yonghan Paik; Fanli Meng; David A. Brenner; Tatiana Kisseleva
GASTROENTEROLOGY, W B SAUNDERS CO-ELSEVIER INC, 140(5) S917 - S917, May 2011, Summary international conference - ADIPONECTIN DEFICIENCY ATTENUATES LIVER FIBROSIS IN MICE
M. Penz-Oesterreicher; C. Oesterreicher; K. Iwaisako; D. A. Brenner
JOURNAL OF HEPATOLOGY, ELSEVIER SCIENCE BV, 54 S417 - S417, Mar. 2011, Summary international conference - 経口抗血小板薬Cilostazolの肝線維化抑制効果に関する基礎的検討
斉藤 俊一; 祝迫 恵子; 秦 浩一郎; 影山 詔一; 田中 宏和; 柳田 敦子; 上本 伸二
日本消化器外科学会総会, (一社)日本消化器外科学会, 65回 522 - 522, Jul. 2010 - An oral antiplatelet agent, Cilostazol, attenuates CCl4-induced hepatic fibrogenesis in mice
S. Saito; K. Hata; K. Iwaisako; S. Kageyama; H. Tanaka; A. Yanagida; K. Takafuji; S. Uemoto
BRITISH JOURNAL OF SURGERY, WILEY-BLACKWELL, 97 S26 - S26, Jun. 2010, Summary international conference - DECREASED HEPATIC FIBROSIS AFTER BILE DUCT LIGATION IN NOX1-DEFICIENT OR NOX2/GP91(PHOX)-DEFICIENT MICE
Yonghan Paik; Keiko Iwaisako; Sayaka Inokuchi; Ekihiro Seki; Melitta Penz-Oesterreicher; Bernd Schnabl; Christoph Oesterreicher; David A. Brenner
HEPATOLOGY, WILEY-BLACKWELL, 50(4) 383A - 384A, Oct. 2009, Summary international conference - A SPECIFIC PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR (PPAR)-delta AGONIST ATTENUATES LIVER FIBROGENESIS
Keiko Iwaisako; Kojiro Taura; Yonghan Paik; David A. Brenner; Bernd Schnabl
HEPATOLOGY, JOHN WILEY & SONS INC, 50(4) 405A - 406A, Oct. 2009, Summary international conference - HP-070-4 乳癌術後腋窩貯留液はヒト脂肪組織由来幹細胞の増殖を促進する(乳がん(基礎研究),ハイブリッドポスター,第109回日本外科学会定期学術集会)
辻 和香子; 稲本 俊; 祝迫 惠子; 上野 貴之; 戸井 雅和
日本外科学会雑誌, 一般社団法人日本外科学会, 110(2) 513 - 513, 25 Feb. 2009 - HEME OXYGENASE-1 INDUCED BY PHOSPHODIESTERASE III INHIBITOR PROTECTS RAT LIVER FROM SINUSOIDAL OBSTRUCTION SYNDROME
Mosato Narita; Etsuro Hatano; Keiko Iwaisako; Atsuko Yonagida; Hiromitsu Nagata; Hiroyuki Asechi; Kojiro Toura; Iwao Ikai; Shinji Uemoto
HEPATOLOGY, JOHN WILEY & SONS INC, 48(4) 466A - 466A, Oct. 2008, Summary international conference - 職域などで行われる乳癌検診の実態把握と精度管理
OKOSHI YOSHIE; YOSHIBAYASHI HIROFUMI; HISAMORI SHIGEO; IWAISAKO KEIKO; MIZUNO YASUHIRO; SAKAGUCHI KOICHI; TOI MASAKAZU
日本乳癌学会学術総会プログラム・抄録集, (一社)日本乳癌学会, 16th 346 - 346, 01 Sep. 2008 - A case of common hepatic arterial embolism occurred subsequent to superior mesenteric arterial embolism
加茂 直子; 鍛 利幸; 祝迫 惠子
Surgery, 南江堂, 70(7) 802 - 805, Jul. 2008 - O-2-167 新規抗癌剤による肝障害sinusoidal obstruction syndrome発症のメカニズムとその予防(肝 研究1,一般演題(口演),第63回日本消化器外科学会総会)
成田 匡大; 波多野 悦朗; 玉置 信行; 祝迫 恵子; 瀬尾 智; 長田 博光; 柳田 敦子; 阿世知 弘行; 猪飼 伊和夫; 上本 伸二
日本消化器外科学会雑誌, 一般社団法人日本消化器外科学会, 41(7) 1229 - 1229, 01 Jul. 2008 - A Case Of Systemic Lupus Erythematosus Complicated with Perforations of the Colon
IWAISAKO Keiko; OKAMOTO Taisuke; UKIKUSA Minoru
日本腹部救急医学会雑誌 = Journal of abdominal emergency medicine, 28(3) 507 - 510, 31 Mar. 2008 - Phosphodiesterase III inhibitor overcomes rat sinusoidal obstruction syndrome through heme oxygenase-1 induction
M. Narita; E. Hatano; N. Tamaki; K. Iwaisako; S. Seo; H. Nagata; A. Yanagida; H. Asechi; I. Ikai; S. Uemoto
JOURNAL OF HEPATOLOGY, ELSEVIER SCIENCE BV, 48 S357 - S358, 2008, Summary international conference - A CASE OF MESENTERIC CASTLEMAN'S DISEASE
IWAISAKO Keiko; ARIMOTO Akira; KAMO Naoko; SEO Satoru; UKIKUSA Minoru
日本臨床外科学会雑誌 = The journal of the Japan Surgical Association, 68(12) 3100 - 3105, 25 Dec. 2007 - P-2-648 傍大動脈リンパ節転移を伴う胆道癌長期生存例の検討(胆 胆管癌1,一般演題(ポスター),第62回日本消化器外科学会定期学術総会)
玉置 信行; 波多野 悦朗; 祝迫 惠子; 瀬尾 智; 多田 正晴; 中島 研郎; 安近 健太郎; 猪飼 伊和夫; 上本 伸二
日本消化器外科学会雑誌, 一般社団法人日本消化器外科学会, 40(7) 1419 - 1419, 01 Jul. 2007 - P-3-104 後腹膜腫瘍に対し左腎静脈合併切除後,左腎機能が高度に低下した1例(腹膜・後腹膜 腫瘍3,一般演題(ポスター),第62回日本消化器外科学会定期学術総会)
祝迫 惠子; 波多野 悦朗; 瀬尾 智; 玉置 信行; 多田 正晴; 中島 研郎; 安近 健太郎; 猪飼 伊和夫; 上本 伸二
日本消化器外科学会雑誌, 一般社団法人日本消化器外科学会, 40(7) 1447 - 1447, 01 Jul. 2007 - 浸潤性乳管癌と神経内分泌的形質発現を伴った乳癌の異時性両側乳癌の一例
OKOSHI KAE; OGAWA HIROKI; HISAMORI SHIGEO; IWAISAKO KEIKO; UEMURA RYO; OE HIDEAKI; BABA NOBUO; SAKANASHI SHIRO
日本乳癌学会学術総会プログラム・抄録集, (一社)日本乳癌学会, 15th 512 - 512, 01 Jun. 2007 - DP-005-2 99mTc-GSAシンチを用いた機能的肝容量測定の肝切除術前検査における有用性-CTボリュームメトリーとの乖離(第107回日本外科学会定期学術集会)
祝迫 恵子; 阿世知 弘之; 長田 博光; 成田 匡大; 柳田 敦子; 玉置 信行; 瀬尾 智; 多田 正晴; 波多野 悦朗; 猪飼伊 和夫; 上本 伸二
日本外科学会雑誌, 一般社団法人日本外科学会, 108(2) 341 - 341, 10 Mar. 2007 - 0685 門脈腫瘍栓を伴う肝内胆管癌4例の検討(肝内胆管癌,一般演題,第61回日本消化器外科学会定期学術総会)
玉置 信行; 波多野 悦朗; 瀬尾 智; 祝迫 惠子; 多田 正晴; 安近 健太郎; 宇山 直樹; 藤井 英明; 猪飼 伊和夫
日本消化器外科学会雑誌, 一般社団法人日本消化器外科学会, 39(7) 1122 - 1122, 01 Jul. 2006 - Involvement of endoplasmic reticulum stress-induced apoptosis in cholestatic liver injury
Masaharu Tada; Etsuro Hatano; Satoru Seo; Nobuyuki Tamaki; Keiko Iwaisako; Takashi Nitta; Iwao Ikai; Yasuyuki Shimahara
GASTROENTEROLOGY, W B SAUNDERS CO-ELSEVIER INC, 130(4) A818 - A818, Apr. 2006, Summary international conference - 閉塞性黄疸に伴う肝障害における小胞体ストレス誘導性アポトーシスの意義
多田 正晴; 波多野 悦朗; 祝迫 恵子; 玉置 信行; 瀬尾 智; 猪飼 伊和夫; 嶌原 康行
日本外科学会雑誌, 一般社団法人日本外科学会, 107(2) 373 - 373, 05 Mar. 2006 - 臨床報告 幽門輪温存膵頭十二指腸切除後の難治性膵液瘻が経皮ドレナージの合併症で内瘻化され治癒した1例
瀬尾 智; 大久保 遊平; 祝迫 惠子
臨床外科, 医学書院, 60(12) 1453 - 1456, Nov. 2005 - Soluble form of Fas ligand rather than AFPmRNA in the peripheral blood predicts postoperative recurrence in patients with hepatocellular carcinoma.
N Koizumi; E Hatano; K Taura; T Nitta; M Tada; S Seo; K Iwaisako; N Tamaki; H Fujii; Ikai, I; Y Shimahara
GASTROENTEROLOGY, W B SAUNDERS CO, 128(4) A759 - A759, Apr. 2005, Summary international conference - P-glycoprotein expression and FDG-PET predict tumor differencistion, and postoperative recurrence in hepatocellular carcinoma
S Seo; E Hatano; K Taura; N Koizumi; M Tada; N Tamaki; K Iwaisako; Ikai, I; Y Shimahara
GASTROENTEROLOGY, W B SAUNDERS CO, 128(4) A765 - A765, Apr. 2005, Summary international conference - 症例 左側腹部痛にて発見された高齢者上腰ヘルニアの1例
尾崎 岳; 田中 宏典; 祝迫 惠子
外科, 南江堂, 66(9) 1101 - 1103, Sep. 2004 - PS-072-5 ASOに対する術中腸骨動脈ステントを利用した低侵襲下肢血行再建術の検討
東山 洋; 鍛 利幸; 祝迫 惠子; 瀬尾 智; 三木 明; 兼松 清果; 横井 暁子; 山中 健也; 大久保 遊平; 奥田 雄紀浩; 端 裕之; 井ノ本 琢也; 亥埜 恵一; 有本 明; 中島 康夫; 浮草 実
日本外科学会雑誌, 一般社団法人日本外科学会, 105 451 - 451, 15 Mar. 2004 - ASOに対する術中ステントとクロスオーバーバイパスを組み合わせた低侵襲手術の検討
東山 洋; 鍛 利幸; 祝迫 惠子; 兼松 清果; 三木 明; 加茂 直子; 瀬尾 智; 岡本 大輔; 古家 敬三; 井ノ本 琢也; 亥埜 恵一; 有本 明; 中島 康夫; 浮草 実
日本外科学会雑誌, 一般社団法人日本外科学会, 104 671 - 671, 30 Apr. 2003 - A new convenient 2-compartment model analysis using galactosyl human serum albumin scintigraphy for preoperative assessment of hepatic function.
K Kinoshita; M Ukikusa; K Iwaisako; A Arimoto
HEPATOLOGY, W B SAUNDERS CO, 36(4) 173A - 173A, Oct. 2002, Summary international conference - A CASE OF SPONTANEOUS RUPTURE OF A GAS-CONTAINING PYOGENIC LIVER ABSCESS
OKAMOTO Taisuke; TANAKA Hironori; OZAKI Takashi; IWAISAKO Keiko; MIKI Akira; KAMO Naoko; FURUKE Keizo; HIGASHIYAMA Hiroshi; ARIMOTO Akira; NAKASHIMA Yasuo; UKIKUSA Minoru
日本臨床外科学会雑誌 = The journal of the Japan Surgical Association, 63(5) 1264 - 1268, 25 May 2002 - PP218045 Churg-Strauss症候群(アレルギー性肉芽腫性血管炎)の一剖検例
祝迫 惠子; 尾崎 岳; 田中 宏典; 瀬尾 智; 井ノ本 琢也; 鍛 利幸; 亥埜 恵一; 東山 洋; 有本 明; 中島 康夫; 浮草 実
日本消化器外科学会雑誌, 一般社団法人日本消化器外科学会, 34(7) 1143 - 1143, 01 Jul. 2001 - PP204079 99mTc-GSA肝シンチによる新たな肝切除術前肝予備能の検討
木下 浩一; 祝迫 恵子; 有本 明; 藤澤 憲良; 尾崎 岳; 田中 宏典; 瀬尾 智; 内藤 雅人; 野村 明成; 井ノ本 琢也; 鍛利 利幸; 亥埜 恵一; 東山 洋; 浮草 実
日本消化器外科学会雑誌, 一般社団法人日本消化器外科学会, 34(7) 1066 - 1066, 01 Jul. 2001 - PP91 乳癌診断に対するpower doppler USの有効性と, 血流動態とPyNPase活性値との関連性の検討
瀬尾 智; 藤沢 憲良; 祝迫 恵子; 尾崎 岳; 田中 宏典; 内藤 雅人; 野村 明成; 木下 浩一; 井ノ本 琢也; 鍛 利幸; 亥埜 恵一; 東山 洋; 有本 明; 花房 徹兒; 中島 康夫; 浮草 実
日本外科学会雑誌, 一般社団法人日本外科学会, 102 246 - 246, 10 Mar. 2001 - REMOVAL EFFICIENCY OF PHENOLS FROM CHEMICAL WASTE-WATER BY A TREATMENT-PLANT USING ACTIVATED CARBON ADSORPTION AND COAGULATION PRECIPITATION PROCESSES
A ADACHI; N AKAMATSU; K IWAISAKO; M SENKOKU; T KOBAYASHI
JAPANESE JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH, PHARMACEUTICAL SOC JAPAN, 38(3) 300 - 303, 1992, Introduction scientific journal
Research Projects
- Development of artificial bile duct for physiological bile duct reconstruction
田浦 康二朗; 鶴山 竜昭; 上本 伸二; 田畑 泰彦; 祝迫 惠子; 瀬尾 智; 福光 剣
ゼラチンは体内で酵素分解され、最終分解物はアミノ酸となる生体分解性の素材である。ゼラチンを利用した様々な製品が実臨床で使用されている。我々は日本毛織株式会社と協力して人工胆管の作製に着手し、不織布構造のゼラチンハイドロゲル(以下、ゼラチン不織布)を足場として採用し、これによる人工胆管を作製した。 生体材料の適正として、足場に細胞が浸潤し、組織構造を形成することが重要である。足場によって誘導されたさまざま細胞が、足場内でタンパク質や成長因子を分泌し、それらによってできた細胞外マトリックスに胆管上皮細胞や血管内皮細胞など特徴的な細胞が生着すると考えている。 我々は細胞外マトリックスの主成分として組織再生に重要なコラーゲンを分泌する線維芽細胞を用いて足場としての適正の評価を行った。ゼラチン不織布内に線維芽細胞が入り込み、足場内で増殖し、さらにコラーゲンタンパクが分泌されることを確認した。 小動物を用いた人工胆管の移植実験では、移植部位の経時的な評価を行い、ゼラチン不織布が、足場として、細胞浸潤、組織構造の構築を促した。ゼラチン不織布はやがて完全に分解され、胆管構造が再生されることを確認した。 これらの知見から大動物への移植実験のための人工胆管の試作を開始した。克服する課題は多く、大動物の胆管に吻合するための強度を得るためにはゼラチン不織布のみでは不十分であったので、強度を補完する目的で、ポリグリコール酸を組み込んだゼラチン不織布チューブを作製し、強度の向上を確認した。, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2020/04 -2023/03, Grant-in-Aid for Scientific Research (C), Kyoto University - 肝胆膵領域のがん間質の線維化についての解析 新たなバイオマーカーや治療標的の探索
祝迫 惠子; 趙 向東; 瀬尾 智
肝胆膵領域のがん組織の多くは「がん間質の線維化」という共通した病理組織学的所見があることから、がん間質に存在する免疫細胞や筋線維芽細胞について、組織学的、細胞の形態、遺伝子発現解析を行い、その役割や相互作用を明らかにすることを目的とし、今年度は、肝内胆管がんの免疫組織学的解析を行い、予後との関連について解析した。これまでに、肝内担癌がんについて、がん組織へのCD8陽性T細胞、CD4陽性T細胞、CD20陽性B細胞の浸潤やFOXP3陽性T制御性T細胞の浸潤が予後に関連することを確認していたが、今年度はCD68陽性マクロファージ、CD66b陽性好中球などミエロイド系細胞の解析を行い予後との関連について解析した。リンパ球系とは異なる組織領域に分布するため、定量化について検討が必要と考えている。CD68陽性マクロファージ、CD66b陽性好中球は、T細胞やB細胞に比べて、症例によっては非常に浸潤が多く、組織から抽出したRNAを用いたqRT-PCRによる遺伝子発現解析と病理組織学的解析との相関についても検討を行う。 肝内胆管がんのがん間質に豊富に存在する細胞外基質について、コラーゲンのタイプ別に識別し、定量的解析を行い、非がん部に比較してがん部にはコラーゲンタイプ3が多く存在することが、遺伝子発現レベルの解析でも確認することができた。 がん組織の各種因子について、予後との関連を明らかにすることで、新たな治療標的を見出せる可能性があると考えている。, 日本学術振興会, 科学研究費助成事業, 2020/04 -2023/03, 基盤研究(C), 同志社大学 - Development of selective immunosuppressive therapy preserving natural immunity for treating chronic rejection after lung transplantation
Yoshikawa Toyofumi
The greatest cause to prevent long-term survival after lung transplantation is chronic allograft dysfunction (CLAD), which is mainly due to chronic rejection. The etiology of CLAD remains unknown and there is no proper therapy for progressive CLAD. Since lungs communicate with the outer world, immunity in lungs is developed, while lungs are susceptible to infection. Thus, in lung transplantation, it is crucial to develop a selective immune suppression which does not decrease immunity against infection. Herein, we focused on a MEK inhibitor (trametinib), which has a new mechanism for immunosuppression, as an immunosuppressant which does not decrease immunity against infection. We performed several studies to prove that a MEK inhibitor alleviated chronic rejection in a rat lung transplantation model., Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2018/04 -2021/03, Grant-in-Aid for Scientific Research (B) - 制御性T細胞による免疫抑制療法 ーマウス肝移植モデルを用いた検討ー
趙 向東; 祝迫 惠子
臓器移植後の理想的な免疫抑制療法は、移植臓器に対する免疫反応のみを抑制する方法であるが、現在、そのような免疫抑制療法は確立されていない。一方、肝移植などで免疫抑制剤の服用が不要となる症例が報告されており、臓器移植において、免疫寛容は成立しうると考えられている。ただし、免疫寛容のメカニズムについてはほとんど解明されておらず、臨床的にも免疫抑制剤の減量・離脱についてのエビデンスはない。本研究は、マウスを用いて臓器移植における拒絶反応の詳細な解析を行い、さらに免疫寛容を成立させてそのメカニズムを明らかにし、新たな免疫抑制療法の確立を目的として本研究は行われた。各種の臓器移植がすでにヒトに実施されているにもかかわらず、マウスの臓器移植モデルを用いるのは、免疫学的に詳細な解析を行い、新しい治療法についての科学的なエビデンスを構築するためであり、これまでの臓器移植に関する動物実験が、短期の生存率のみを比較しているという弱点を克服するため、マウスの肝動脈吻合を行う同所性同種異系マウスの肝移植法を確立し長期観察を可能にした。移植後16週までの経時的な肝組織の解析を行い、マウスの同種異系肝移植では、部分的寛容が誘導されうることを見出した。本研究において確立したマウス肝移植の手法を寛容誘導法開発のプロジェクトに融合させることによって活用し、今後もさらに発展継続させていく予定である。寛容誘導の方法として、免疫抑制系の細胞療法の検討を行っている。, 日本学術振興会, 科学研究費助成事業, 2018/04 -2020/03, 基盤研究(C), 京都大学 - A novel approach in the treatment of intrahepatic cholangiocarcinoma or pancreatic cancer: Focusing on the stromal myofibroblast
Iwaisako Keiko
Analysis of clinical specimens of cholangiocarcinoma showed that the higher the fibrosis of the cancerous tissue, the better the prognosis. On the other hand, in the non-tumor of the liver, the higher the fibrosis, the worse the prognosis. There was a correlation between fibroblast infiltration and fibrosis, and the more regulatory T cells infiltrating tumor, the worse the prognosis. For fibrosis, the subtype of collagen, which is a component, was analyzed. The proportion of type III in tumor was higher than that of non-tumor areas, and a correlation was observed between type III non-tumor areas and the infiltration of regulatory T cells into tumor. It was suggested that it may influence prognosis and contribute to the prognosis., Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2017/04 -2020/03, Grant-in-Aid for Scientific Research (C) - Genetic risk verification of juvenile-onset cholangiocarcinoma
Kawamura Etsushi; IKEDA kazuo; TAMORI akihiro; MATSUBARA tsutomu; TAKEMURA shigekazu; IWAISAKO keiko; TANAKA shogo; KINOSHITA masahiko; ITO tokuji; DAIKOKU atsuko; ODAGIRI naoshi; TAKADA sayuri; HIGUCHI moe
Using postoperative cholangiocarcinoma specimens from printing workers, we extracted five genes involved in carcinogenesis by microarray analysis. We focused on the tumor suppressor gene SKI, and found that SKI is involved in the regulation of protein expressions related to cell cycle and MAPK pathway (p21, p27, and phosphorylated ERK1/2) in the proliferation of human cholangiocarcinoma cells. This is the first time that the relationship between SKI and cholangiocarcinoma cell proliferation has been demonstrated. We are continuing our research to develop these results as a basis for the development of diagnostic markers and nucleic acid drugs for cholangiocarcinoma., Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2015/04 -2019/03, Grant-in-Aid for Scientific Research (C), Osaka City University - The study of stromal cells constituting fibrous stroma for the treatment of liver cancer
IWAISAKO Keiko
In liver cancer, it is thought that various fibrosis presents and supports the progress of cancer. In this study, we aimed to find a new treatment strategy for liver cancer by analyzing cells constituting fibrous cancer stroma. To analysis of clinical samples, we have discriminated "tumor" and "non-tumor" macroscopically and investigated in bulk. However, the microscopically observation revealed that "tumor" tissue markedly increased fibrosis and infiltration of fibroblasts and immune cells. Therefore, using by laser capture microdissection, we isolated cancer stroma and investigated gene expression. It was found that fibrotic genes and marker genes of immune cells were highly expressed in the stroma of cholangiocellular carcinoma. Stroma cells of cholangiocellular carcinoma can be considered as therapeutic targets., Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2014/04 -2017/03, Grant-in-Aid for Scientific Research (C), Kyoto University