| MISONO Hiroaki | |
| Graduate School of Brain Science | |
| Professor |
Last Updated :2025/05/04
Researcher Profile and Settings
researchmap
Research Interests
Research Areas
- Life sciences / Cell biology / Protein trafficking and localization
- Life sciences / Neuroscience - general
Research History
- Molecular mechanisms of neurotransmitter release
- Processing of Alzheimer amyloid beta proteins
- Ion channel trafficking in neurons
Research Experience
- Doshisha University, Graduate School of Brain Science, Professor, 2011 - Today
- University of Maryland, Department of Neural and Pain Sciences, Assistant Professir (tenure-track), 2006 - 2011
- University of California, Davis, Department of Pharmacology, School of Medicine, Assistant Research Scientist, 2003 - 2006
- State University of New York at Stony Brook, Department of Biochemistry, Postdoctoral fellow, 2001/09 - 2003/07
- University of Tokyo, Department of Neuropathology, Faculty of Medicine, Postdoctoral researcher, 1998/04 - 2001/08
Education
- Sophia University, Faculty of Science and Technology, Biological Sciences, 1993/04 - 1998/03
- Sophia University, Faculty of Art, Department of Psychology, 1989/04 - 1993/03
Degree
Committee Memberships
Published Papers
- Active Transport by Cytoplasmic Dynein Maintains the Localization of MAP2 in Developing Neurons.
Yoji Yonemura; Yuri Sakai; Rinaho Nakata; Ayaka Hagita-Tatsumoto; Tomohiro Miyasaka; Hiroaki Misonou
bioRxiv : the preprint server for biology, 30 Apr. 2023 - Identification of Tau Protein as a Novel Marker for Maturation and Pathological Changes of Oligodendrocytes
Tomohiro Torii; Yuki Miyamoto; Rinaho Nakata; Yuto Higashi; Yohei Shinmyo; Hiroshi Kawasaki; Tomohiro Miyasaka; Hiroaki Misonou
Glia, in press(4) 1002 - 1017, Dec. 2022, Scientific journal - The organization of microtubules and Tau in oligodendrocytes: Tau pathology in damaged oligodendrocytes
Tomohiro Torii; Tomohiro Miyasaka; Hiroaki Misonou
Frontiers in Cell and Developmental Biology, Frontiers Media SA, 10 950682 - 950682, 05 Oct. 2022, Scientific journal - Inhibition of microtubule assembly competent tubulin synthesis leads to accumulation of phosphorylated tau in neuronal cell bodies.
Fujiwara H; Watanabe S; Iwata M; Ueda S; Nobuhara M; Wada-Kakuda S; Misonou H; Miyasaka T
Biochemical and biophysical research communications, 521(3) 779 - 785, Nov. 2019, Scientific journal - Ectopic Expression Induces Abnormal Somatodendritic Distribution of Tau in the Mouse Brain.
Atsuko Kubo; Shouyou Ueda; Ayaka Yamane; Satoko Wada-Kakuda; Mai Narita; Makoto Matsuyama; Akane Nomori; Akihiko Takashima; Taisuke Kato; Osamu Onodera; Motohito Goto; Mamoru Ito; Takami Tomiyama; Hiroshi Mori; Shigeo Murayama; Yasuo Ihara; Hiroaki Misonou; Tomohiro Miyasaka
The Journal of neuroscience : the official journal of the Society for Neuroscience, 39(34) 6781 - 6797, 21 Aug. 2019 - Regulatory mechanisms for the axonal localization of tau protein in neurons.
Iwata M; Watanabe S; Yamane A; Miyasaka T; Misonou H
Molecular Biology of the Cell, 30(19) mbcE19030183 - 2457, Jul. 2019, Scientific journal - Distribution of endogenous normal tau in the mouse brain
Atsuko Kubo; Hiroaki Misonou; Makoto Matsuyama; Akane Nomori; Satoko Wada‐Kakuda; Akihiko Takashima; Mitsuhiro Kawata; Shigeo Murayama; Yasuo Ihara; Tomohiro Miyasaka
Journal of Comparative Neurology, Wiley, 527(5) 985 - 998, Apr. 2019, Scientific journal - Perineuronal Nets in the Deep Cerebellar Nuclei Regulate GABAergic Transmission and Delay Eyeblink Conditioning.
Hirono M; Watanabe S; Karube F; Fujiyama F; Kawahara S; Nagao S; Yanagawa Y; Misonou H
The Journal of neuroscience : the official journal of the Society for Neuroscience, 38(27) 6130 - 6144, Jul. 2018 - Precise localizations of voltage-gated sodium and potassium channels in neurons
Hiroaki Misonou
Developmental Neurobiology, John Wiley and Sons Inc., 78(3) 271 - 282, 01 Mar. 2018 - Trafficking of Kv2.1 Channels to the Axon Initial Segment by a Novel Nonconventional Secretory Pathway
Camilla Stampe Jensen; Shoji Watanabe; Jeroen Ingrid Stas; Jessica Klaphaak; Ayaka Yamane; Nicole Schmitt; Soren-Peter Olesen; James S. Trimmer; Hanne Borger Rasmussen; Hiroaki Misonou
JOURNAL OF NEUROSCIENCE, SOC NEUROSCIENCE, 37(48) 11523 - 11536, Nov. 2017, Scientific journal - Perineuronal nets in the deep cerebellar nuclei regulate GABAergic transmission and delay eyeblink conditioning
Hirono M; Watanabe S; Karube F; Fujiyama F; Kawahara S; Nagao S; Yanagawa Y; Misonou H
J Neurosci, 291 51 , 2017 - Distinct Cell- and Layer-Specific Expression Patterns and Independent Regulation of Kv2 Channel Subtypes in Cortical Pyramidal Neurons
Hannah I. Bishop; Dongxu Guan; Elke Bocksteins; Laxmi Kumar Parajuli; Karl D. Murray; Melanie M. Cobb; Hiroaki Misonou; Karen Zito; Robert C. Foehring; James S. Trimmer
JOURNAL OF NEUROSCIENCE, SOC NEUROSCIENCE, 35(44) 14922 - 14942, Nov. 2015, Scientific journal - BK Channels Localize to the Paranodal Junction and Regulate Action Potentials in Myelinated Axons of Cerebellar Purkinje Cells
Moritoshi Hirono; Yasuhiro Ogawa; Kaori Misono; Daniel R. Zollinger; James S. Trimmer; Matthew N. Rasband; Hiroaki Misonou
JOURNAL OF NEUROSCIENCE, SOC NEUROSCIENCE, 35(18) 7082 - 7094, May 2015, Scientific journal - Androgen receptor and chemokine receptors 4 and 7 form a signaling axis to regulate CXCL12-dependent cellular motility
Jordy J. Hsiao; Brandon H. Ng; Melinda M. Smits; Jiahui Wang; Rohini J. Jasavala; Harryl D. Martinez; Jinhee Lee; Jhullian J. Alston; Hiroaki Misonou; James S. Trimmer; Michael E. Wright
BMC CANCER, BIOMED CENTRAL LTD, 15 204 , Mar. 2015, Scientific journal - Live-cell Imaging of Post-Golgi Transport Vesicles in Cultured Hippocampal Neurons
Camilla Stampe Jensen; Hiroaki Misonou
CELLULAR AND MOLECULAR NEUROBIOLOGY, SPRINGER/PLENUM PUBLISHERS, 35(1) 123 - 135, Jan. 2015, Scientific journal - 正常脳におけるタウの神経細胞内局在
久保 厚子; 御園生 裕明; 松田 響子; 松山 誠; 河田 光博; 初田 裕幸; 村山 繁雄; 井原 康夫; 宮坂 知宏
Dementia Japan, (一社)日本認知症学会, 28(4) 472 - 472, Oct. 2014 - tau-Tgマウス脳における内在性および外来性タウの神経細胞内局在
久保 厚子; 御園生 裕明; 松山 誠; 高島 明彦; 井原 康夫; 宮坂 知宏
Dementia Japan, (一社)日本認知症学会, 28(4) 472 - 472, Oct. 2014 - Specific Sorting and Post-Golgi Trafficking of Dendritic Potassium Channels in Living Neurons
Camilla Stampe Jensen; Shoji Watanabe; Hanne Borger Rasmussen; Nicole Schmitt; Soren-Peter Olesen; Nicholas A. Frost; Thomas A. Blanpied; Hiroaki Misonou
JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 289(15) 10566 - 10581, Apr. 2014, Scientific journal - Kv2.2: A Novel Molecular Target to Study the Role of Basal Forebrain GABAergic Neurons in the Sleep-Wake Cycle
Tracey O. Hermanstyne; Kalpana Subedi; Wei Wei Le; Gloria E. Hoffman; Andrea L. Meredith; Jessica A. Mong; Hiroaki Misonou
SLEEP, AMER ACAD SLEEP MEDICINE, 36(12) 1839 - 1848, Dec. 2013, Scientific journal - Neuronal trafficking of voltage-gated potassium channels
Camilla S. Jensen; Hanne B. Rasmussen; Hiroaki Misonou
MOLECULAR AND CELLULAR NEUROSCIENCE, ACADEMIC PRESS INC ELSEVIER SCIENCE, 48(4) 288 - 297, Dec. 2011 - Immunolocalization of the Voltage-Gated Potassium Channel Kv2.2 in GABAergic Neurons in the Basal Forebrain of Rats and Mice
Tracey O. Hermanstyne; Yoshitaka Kihira; Kaori Misono; Ashley Deitchler; Yuchio Yanagawa; Hiroaki Misonou
JOURNAL OF COMPARATIVE NEUROLOGY, WILEY-LISS, 518(21) 4298 - 4310, Nov. 2010, Scientific journal - Formation of Heteromeric Kv2 Channels in Mammalian Brain Neurons
Yoshitaka Kihira; Tracey O. Hermanstyne; Hiroaki Misonou
JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 285(20) 15048 - 15055, May 2010, Scientific journal - Homeostatic Regulation of Neuronal Excitability by K+ Channels in Normal and Diseased Brains
Hiroaki Misonou
NEUROSCIENTIST, SAGE PUBLICATIONS INC, 16(1) 51 - 64, Feb. 2010 - Regulation of intrinsic excitability in hippocampal neurons by activity-dependent modulation of the K(V)2.1 potassium channel
Durga P. Mohapatra; Hiroaki Misonou; Sheng-Jun Pan; Joshua E. Held; D. James Surmeier; James S. Trimmer
CHANNELS, LANDES BIOSCIENCE, 3(1) 46 - 56, Jan. 2009, Scientific journal - Dynamic regulation of the Kv2.1 voltage-gated potassium channel during brain ischemia through neuroglial interaction
Hiroaki Misonou; Scott M. Thompson; Xiang Cai
JOURNAL OF NEUROSCIENCE, SOC NEUROSCIENCE, 28(34) 8529 - 8538, Aug. 2008, Scientific journal - Dendritic A-type potassium channel subunit expression in CA1 hippocampal interneurons
M. Menegola; H. Misonou; H. Vacher; J. S. Trimmer
NEUROSCIENCE, PERGAMON-ELSEVIER SCIENCE LTD, 154(3) 953 - 964, Jun. 2008, Scientific journal - Regulation of Kv1 channel trafficking by the mamba snake neurotoxin dendrotoxin K
Helene Vacher; Durga P. Mohapatra; Hiroaki Misonou; Jaimes S. Trimmer
FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, 21(3) 906 - 914, Mar. 2007, Scientific journal - Requirement of subunit co-assembly and ankyrin-G for M-channel localization at the axon initial segment
Hanne B. Rasmussen; Christian Frokjaer-Jensen; Camilla S. Jensen; Henrik S. Jensen; Nanna K. Jorgensen; Hiroaki Misonou; James S. Trimmer; Soren-Peter Olesen; Nicole Schmitt
JOURNAL OF CELL SCIENCE, COMPANY OF BIOLOGISTS LTD, 120(6) 953 - 963, Mar. 2007, Scientific journal - Bidirectional activity-dependent regulation of neuronal ion channel phosphorylation
Hiroaki Misonou; Milena Menegola; Durga P. Mohapatra; Lauren K. Guy; Kang-Sik Park; James S. Trimmer
JOURNAL OF NEUROSCIENCE, SOC NEUROSCIENCE, 26(52) 13505 - 13514, Dec. 2006, Scientific journal - Cellular excitability and the regulation of functional neuronal identity: From gene expression to neuromodulation
David J. Schulz; Richard A. Baines; Chris M. Hempel; Lingjun Li; Birgit Liss; Hiroaki Misonou
JOURNAL OF NEUROSCIENCE, SOC NEUROSCIENCE, 26(41) 10362 - 10367, Oct. 2006, Scientific journal - Graded regulation of the Kv2.1 potassium channel by variable phosphorylation
Kang-Sik Park; Durga P. Mohapatra; Hiroaki Misonou; James S. Trimmer
SCIENCE, AMER ASSOC ADVANCEMENT SCIENCE, 313(5789) 976 - 979, Aug. 2006, Scientific journal - Immunolocalization of the Ca2+-activated K+ channel Slo1 in axons and nerve terminals of mammalian brain and cultured neurons
H Misonou; M Menegola; L Buchwalder; EW Park; A Meredith; KJ Rhodes; RW Aldrich; JS Trimmer
JOURNAL OF COMPARATIVE NEUROLOGY, WILEY-LISS, 496(3) 289 - 302, May 2006, Scientific journal - Calcium-and metabolic state-dependent modulation of the voltage-dependent Kv2.1 channel regulates neuronal excitability in response to ischemia
H Misonou; DP Mohapatra; M Menegola; JS Trimmer
JOURNAL OF NEUROSCIENCE, SOC NEUROSCIENCE, 25(48) 11184 - 11193, Nov. 2005, Scientific journal - Kv2.1: A voltage-gated K+ channel critical to dynamic control of neuronal excitability
H Misonou; DP Mohapatra; JS Trimmer
NEUROTOXICOLOGY, ELSEVIER SCIENCE BV, 26(5) 743 - 752, Oct. 2005, Scientific journal - A primary culture system for biochemical analyses of neuronal proteins
H Misonou; JS Trimmer
JOURNAL OF NEUROSCIENCE METHODS, ELSEVIER SCIENCE BV, 144(2) 165 - 173, Jun. 2005, Scientific journal - Regulation of ion channel localization and phosphorylation by neuronal activity
H Misonou; DP Mohapatra; EW Park; Leung, V; DK Zhen; K Misonou; AE Anderson; JS Trimmer
NATURE NEUROSCIENCE, NATURE PUBLISHING GROUP, 7(7) 711 - 718, Jul. 2004, Scientific journal - Determinants of voltage-gated potassium channel surface expression and localization in mammalian neurons
H Misonou; JS Trimmer
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY, TAYLOR & FRANCIS INC, 39(3) 125 - 145, May 2004 - gamma-secretase activity is present in rafts but is not cholesterol-dependent
S Wada; M Morishima-Kawashima; Y Qi; H Misono; Y Shimada; Y Ohno-Iwashita; Y Ihara
BIOCHEMISTRY, AMER CHEMICAL SOC, 42(47) 13977 - 13986, Dec. 2003, Scientific journal - A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels
R Shibata; H Misonou; CR Campomanes; AE Anderson; LA Schrader; LC Doliveira; KI Carroll; JD Sweatt; KJ Rhodes; JS Trimmer
JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 278(38) 36445 - 36454, Sep. 2003, Scientific journal - Potential link between amyloid beta-protein 42 and C-terminal fragment gamma 49-99 of beta-amyloid precursor protein
T Sato; N Dohmae; Y Qi; N Kakuda; H Misonoum; R Mitsumori; H Maruyama; EH Koo; C Haass; K Takio; M Morishima-Kawashima; S Ishiura; Y Ihara
JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 278(27) 24294 - 24301, Jul. 2003, Scientific journal - Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch
YJ Gu; H Misonou; T Sato; N Dohmae; K Takio; Y Ihara
JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 276(38) 35235 - 35238, Sep. 2001, Scientific journal - Oxidative stress induces intracellular accumulation of amyloid beta-protein (A beta) in human neuroblastoma cells
H Misonou; M Morishima-Kawashima; Y Ihara
BIOCHEMISTRY, AMER CHEMICAL SOC, 39(23) 6951 - 6959, Jun. 2000, Scientific journal - Oxidative stress induces intracellular accumulation of Alzheimer amyloid beta-protein in human neuroblastoma cells.
Biochemistry, 39, 2000 - Protein kinase C controls the priming step of regulated exocytosis in adrenal chromaffin cells
H Misonou; M Ohara-Imaizumi; T Murakami; M Kawasaki; K Ikeda; T Wakai; K Kumakura
CELLULAR AND MOLECULAR NEUROBIOLOGY, PLENUM PUBL CORP, 18(4) 379 - 390, Aug. 1998, Scientific journal - Regulation of the priming of exocytosis and the dissociation of SNAP-25 and VAMP-2 in adrenal chromaffin cells
H Misonou; M OharaImaizumi; K Kumakura
NEUROSCIENCE LETTERS, ELSEVIER SCI IRELAND LTD, 232(3) 182 - 184, Sep. 1997, Scientific journal - Distinct roles of C2A and C2B domains of synaptotagmin in the regulation of exocytosis in adrenal chromaffin cells
M OharaImaizumi; M Fukuda; M Niinobe; H Misonou; K Ikeda; T Murakami; M Kawasaki; K Mikoshiba; K Kumakura
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, 94(1) 287 - 291, Jan. 1997, Scientific journal - Dissociation of SNAP-25 and VAMP-2 by MgATP in permeabilized adrenal chromaffin cells
H Misonou; T Nishiki; M Sekiguchi; M Takahashi; Y Kamata; S Kozaki; M OharaImaizumi; K Kumakura
BRAIN RESEARCH, ELSEVIER SCIENCE BV, 737(1-2) 351 - 355, Oct. 1996, Scientific journal - ESSENTIAL ROLE OF MYOSIN LIGHT-CHAIN KINASE IN THE MECHANISM FOR MGATP-DEPENDENT PRIMING OF EXOCYTOSIS IN ADRENAL CHROMAFFIN CELLS
K KUMAKURA; K SASAKI; T SAKURAI; M OHARAIMAIZUMI; H MISONOU; S NAKAMURA; Y MATSUDA; Y NONOMURA
JOURNAL OF NEUROSCIENCE, OXFORD UNIV PRESS INC, 14(12) 7695 - 7703, Dec. 1994, Scientific journal
MISC
- チューブリン変性を起点としたタウ異常性の獲得の可能性
藤原ひとみ; 渡辺祥司; 岩田実里; 上田翔洋; 延原美香; 和田聡子; 御園生裕明; 宮坂知宏
Dementia Japan, 32(3), 2018 - タウ蛋白質の神経細胞における軸索局在化機構と細胞内動態
岩田実里; 渡辺祥司; 宮坂知宏; 御園生裕明
Dementia Japan, 32(3), 2018 - 神経細胞におけるタウ蛋白質の分子動態
岩田実里; 渡辺祥司; 宮坂知宏; 御園生裕明
日本生化学会大会(Web), 91st, 2018 - 神経細胞におけるタウ蛋白質の動態と軸索局在機構の解明
岩田実里; 渡辺祥司; 宮坂知宏; 朴洪宣; 御園生裕明
日本生化学会大会(Web), 90th, 2017 - 神経細胞におけるアルツハイマー病原因蛋白質タウの軸索局在の分子機序
岩田実里; 渡辺祥司; 宮坂知宏; 朴洪宣; 御園生裕明
日本生化学会大会(Web), 89th, 2016 - 神経細胞におけるタウ蛋白質の軸索局在化機構の解明
岩田実里; 渡辺祥司; 宮坂知宏; 朴洪宣; 御園生裕明
Dementia Japan, 30(4), 2016 - Dynamic regulation of neuronal potassium channel Kv2.1
H Misonou
JOURNAL OF NEUROCHEMISTRY, BLACKWELL PUBLISHING, 96 83 - 83, Mar. 2006, Summary international conference - クロマフィン細胞の開口放出素過程とSNAP-25/VAMP-2複合体
御園生 裕明; 西木 禎一; 関口 真理子; 高橋 正身; 鎌田 洋一; 小崎 俊司; 今泉 美佳; 熊倉 鴻之助
神経化学, 35(3) 514 - 515, 05 Sep. 1996 - 開口放出機構におけるアクチン・ネットワークの役割
今泉 美佳; 御園生 裕明; 池田 顕; 熊倉 鴻之助
神経化学, 日本神経化学会, 34(2) 296 - 297, 15 Jun. 1995 - Regulation of the priming of exocytosis and the dissociation of SNAP-25 and VAMP-2 in adrenal chromaffin cells.
Misonou, H; Ohara-Imaizumi, M; Kumakura, K
Neurosci. Lett., 232(3) 182 - 184, 1994
Books etc
- Handbook of Ion Channels
Misonou H; Trimmer JS
CRC Press, 2016, Contributor, Phosphorylation of voltage-gated ion channels - New Strategies in Stroke Intervention
Misonou H; Trimmer JS
Sptinger, 2010, Contributor, The Diverse Roles of K + Channels in Brain Ischemia - Protein Trafficking in Neurons
Vacher H; Misonou H; Trimmer JS
Academic Press, 2007, Contributor, Determinants of Voltage-Gated Potassium Channel Distribution in Neurons
Research Projects
- Noval regulatory mechanisms of axonal action potentials
Misono Hiroaki; Hirono Moritoshi; Watanabe Shoji
This research project aimed to elucidate the novel regulatory mechanisms of axonal action potentials by calcium signaling and calcium-dependent ion channels. Particularly, we aimed to develop new methods to identify and quantify axonal ion channels using various microscopy techniques including electron microscopy and super-resolution microscopy, to study how ion channels localize to the axon, and to develop reliable markers of the axons. We have obtained results indicating molecular mechanisms of ion channel localization and new properties of an axonal marker, tau protein, which is a causative factor of Alzheimer's disease., Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2016/04 -2019/03, Grant-in-Aid for Scientific Research (C), Doshisha University - Action potential regulation at the node of Ranvier and perineuronal nets' regulation of GABAergic transmission in the deep cerebellar nuclei
Hirono Moritoshi; MISONOU Hiroaki; WATANABE Shoji; YANAGAWA Yuchio; HIRAI Hirokazu
Regulation of axonal action potentials (APs) by K+ channels is important in the CNS. Application of BK channel blockers and T-type Ca2+ channel blockers to axons of cerebellar Purkinje cells (PCs) increased the failure rate of antidromic APs, suggesting that paranodal BK channels support high-fidelity firing at the node of Ranvier. Perineuronal nets (PNNs) are the extracellular matrix of neurons and are found around large neurons in the deep cerebellar nuclei (DCN). Enzymatic PNN depletion of DCN neurons reduced the paired-pulse ratio of inhibitory postsynaptic currents (IPSCs) and increased the miniature IPSC frequency without changing the amplitude, suggesting that PNN depletion enhances GABA release from presynaptic terminals. Mice having received the enzyme in the interpositus nuclei exhibited a higher conditioned response rate in delay eyeblink conditioning than control mice, suggesting that PNNs suppress GABAergic transmission and impede motor learning in the adult cerebellum., Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2015/04 -2018/03, Grant-in-Aid for Scientific Research (C), Doshisha University - Role of Axonal BK channel in Cerebellar Purkinje Cells
Misono Hiroaki; Hirono Moritoshi; Watanabe Shoji
Purkinje cells are the sole output of the cerebellar cortex. Therefore, to understand information processing in the cerebellar circuit for motor coordination and learning, it is necessary to understand the mechanisms regulating action potential conduction in their myelinated axons. In particular, voltage-gated potassium (Kv) channels are of importance. In this study, we found novel expression of the calcium and voltage-activated BK channel in Purkinje cell axons. Our results suggest that axonal BK channels uniquely support high-fidelity firing of action potentials in myelinated Purkinje cell axons, thereby underpinning the output of the cerebellar cortex to the deep cerebellar nuclei. They also indicate that there are dynamic changes in calcium near the nodes of Ranvier. Taken together, our research opened a new possibility that neuronal signals can be dynamically regulated in the axon., Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2014/04 -2016/03, Grant-in-Aid for Challenging Exploratory Research, Doshisha University - Molecular mechanisms for ion channel regulation in neurophysiology
Competitive research funding