| MAO QIYUE |  |
| Organization for Research Initiatives and Development | |
| Assistant Professor |
Last Updated :2025/06/13
Researcher Profile and Settings
researchmap
Research funding number
10906762Research Experience
- Doshisha University, 特任助教, 2024/08 - Today
- Georgia State University, Postdoctoral fellow, 2023/04 - 2024/07
- Doshisha University, Faculty of Science and Engineering, 助手（有期）, 2021/04 - 2023/03
Education
- Doshisha University, Graduate School of Science and Engineering, 応用化学専攻, 2018/04 - 2021/03
- Doshisha University, Graduate School of Science and Engineering, 応用化学専攻, 2016/04 - 2018/03
- Doshisha University, Faculty of Science and Engineering, Department of Molecular Chemistry and Biochemistry, 2012/04 - 2016/03
Association Memberships
Published Papers
- Detoxification of hydrogen sulfide by synthetic heme model compounds
Atsuki Nakagami; Qiyue Mao; Masaki Horitani; Masahito Kodera; Hiroaki Kitagishi
Scientific Reports, 10 Dec. 2024, Scientific journal - Metal-Free CO Prodrugs Activated by Molecular Oxygen Protect against Doxorubicin-Induced Cardiomyopathy in Mice
Xiaoxiao Yang; Wen Lu; Rodrigo W. Alves de Souza; Qiyue Mao; Dipak Baram; Ravi Tripathi; Gangli Wang; Leo E. Otterbein; Binghe Wang
Journal of Medicinal Chemistry, 14 Nov. 2024, Scientific journal - Green-Light-Triggered and Self-Calibrated Cascade Release of Nitric Oxide and Carbon Monoxide for Synergistic Glaucoma Therapy
Xiaohua Chen; Jiamin Liu; Ming Chen; Jie Zhou; Yuyang Zhang; Xinru Hu; Weixi Geng; Qiyue Mao; Hiroaki Kitagishi; Jinquan Chen; Xuhong Qian; Youjun Yang; Yuan Lei; Xiao Luo
Journal of the American Chemical Society, 06 Nov. 2024, Scientific journal - The strategy of using heme proteins and synthetic porphyrins as injectable antidotes for fire gas poisoning
Qiyue Mao; Atsuki Nakagami; Masahito Kodera; Hiroaki Kitagishi
Chemistry Letters, 05 Nov. 2024, Scientific journal - Characterization of the CO release properties of a common CO donor, CORM-401, in the context of its application in studying CO biology
Nicola Bauer; Qiyue Mao; Xiaoxiao Yang; Binghe Wang
Medicinal Chemistry Research, Aug. 2024, Scientific journal - Carbon Monoxide as a Potential Therapeutic Agent: A Molecular Analysis of Its Safety Profiles
Shubham Bansal; Dongning Liu; Qiyue Mao; Nicola Bauer; Binghe Wang
Journal of Medicinal Chemistry, 27 Jun. 2024, Scientific journal - Front Cover: Cyclodextrin‐Based Catenanes Platformed with meso‐Arylporphyrin (Eur. J. Org. Chem. 22/2024)
Kaoru Asai; Qiyue Mao; Atsuki Nakagami; Hiroaki Kitagishi
European Journal of Organic Chemistry, 10 Jun. 2024, Scientific journal - Cyclodextrin‐Based Catenanes Platformed with meso‐Arylporphyrin
Kaoru Asai; Qiyue Mao; Atsuki Nakagami; Hiroaki Kitagishi
European Journal of Organic Chemistry, 10 Jun. 2024, Scientific journal - Abstract 4132: Low-dose carbon monoxide therapies suppress cancer metastasis
Tiantian Zhang; Cheryl Zhang; Xiang Chen; Xiaoxiao Yang; Qiyue Mao; George Zhang; Zhengming Chen; Adrian Tan; Jenny Zhaoying Xiang; Erika Hissong; Yao-Tseng Chen; Binghe Wang; Nancy Du
Cancer Research, 22 Mar. 2024, Scientific journal - On the Question of CO’s Ability to Induce HO-1 Expression in Cell Culture: A Comparative Study Using Different CO Sources
Xiaoxiao Yang; Qiyue Mao; Binghe Wang
ACS Chemical Biology, 15 Mar. 2024, Scientific journal - Clickable bisreactive small gold nanoclusters for preparing multifunctionalized nanomaterials: application to photouncaging of an anticancer molecule
Kenji Watanabe; Qiyue Mao; Zhouen Zhang; Machi Hata; Masahito Kodera; Hiroaki Kitagishi; Takashi Niwa; Takamitsu Hosoya
Chemical Science, Dec. 2023, Scientific journal - Inclusion Complex Formation with Tetra‐PEGylated Tetraphenylporphyrin and Face‐to‐Face Cyclodextrin Dimer through Unprecedented Molecular Threading
Qiyue Mao; Hiroaki Kitagishi
Chemistry – A European Journal, 07 Jun. 2023, Scientific journal - Development of carbon monoxide-releasing molecules conjugated to polysaccharides (glyco-CORMs) for delivering CO during obesity
Shruti Mohan; Louis-Antoine Barel; Djamal Eddine Benrahla; Bernard Do; Qiyue Mao; Hiroaki Kitagishi; Michael Rivard; Roberto Motterlini; Roberta Foresti
Pharmacological Research, 191 106770 - 106770, May 2023, Scientific journal - A synthetic porphyrin as an effective dual antidote against carbon monoxide and cyanide poisoning
Qiyue Mao; XUANSU ZHAO; Akiko Kiriyama; Shigeru Negi; Yasutaka Fukuda; Hideki Yoshioka; Akira Kawaguchi; Roberto Motterlini; roberta foresti; Hiroaki Kitagishi
Proceedings of the National Academy of Sciences, 120(9 2209924120) 1 - 10, 28 Feb. 2023, Scientific journal - Spontaneous reduction of iron(
iii )porphyrin to iron(ii )porphyrin–CO complex in mouse circulation
Masataka Noguchi; Qiyue Mao; Atsuki Nakagami; Hiroaki Kitagishi
Chemical Communications, 2023, Scientific journal - Supramolecular Dual Polypeptides Induced Tubulin Aggregation for Synergistic Cancer Theranostics
Mian Tang; Yao-Hua Liu; Hua Liu; Qiyue Mao; Qilin Yu; Hiroaki Kitagishi; Ying-Ming Zhang; Lehui Xiao; Yu Liu
Journal of Medicinal Chemistry, 13 Oct. 2022, Scientific journal - Capture of carbon monoxide using a heme protein model: from biomimetic chemistry of heme proteins to physiological and therapeutic applications
Hiroaki Kitagishi; Qiyue Mao
Polymer Journal, Apr. 2022, Scientific journal - FRET‐Based In‐Cell Detection of Highly Selective Supramolecular Complexes of meso‐Tetraarylporphyrin with Peptide/BODIPY‐Modified Per‐O‐Methyl‐β‐Cyclodextrins
Atsuki Nakagami; Qiyue Mao; Géraldine Gouhier; Hidetoshi Arima; Hiroaki Kitagishi
ChemBioChem, Wiley, 16 Nov. 2021, Scientific journal - Functional Myoglobin Model Composed of a Strapped Porphyrin/Cyclodextrin Supramolecular Complex with an Overhanging COOH That Increases O2/CO Binding Selectivity in Aqueous Solution
Qiyue Mao; Pradip K. Das; Le Gac Stéphane; Bernard Boitrel; Vincent Dorcet; Koji Oohora; Takashi Hayashi; Hiroaki Kitagishi
Inorganic Chemistry, 60(16) 12392 - 12404, 16 Aug. 2021, Scientific journal - Sensitive quantification of carbon monoxide in vivo reveals a protective role of circulating hemoglobin in CO intoxication
Qiyue Mao; Akira T. Kawaguchi; Shun Mizobata; Roberto Motterlini; roberta foresti; Hiroaki Kitagishi
Communications Biology, 4(1), 29 Mar. 2021, Scientific journal - Supramolecular Complexation in Biological Media: NMR Study on Inclusion of an Anionic Tetraarylporphyrin into a Per‐O‐Methylated β‐Cyclodextrin Cavity in Serum, Blood, and Urine
Hiroaki Kitagishi; Mai Saito; Qiyue Mao; Akiko Kiriyama; Shigeru Negi; Koji Kano
Chemistry – An Asian Journal, 14(19) 3320 - 3328, Oct. 2019, Scientific journal - Optimized synthesis of a per-O-methylated β-cyclodextrin dimer linked at the secondary face by a pyridine ligand
Qiyue Mao; Hiroaki Kitagishi
Journal of Inclusion Phenomena and Macrocyclic Chemistry, 93(1-2) 67 - 76, 15 Feb. 2019, Scientific journal - HemoCD as a Totally Synthetic Artificial Oxygen Carrier: Improvements in the Synthesis and O2 /CO Discrimination
Hiroaki Kitagishi; Qiyue Mao; Naoya Kitamura; Takahiro Kita
Artificial Organs, 41(4) 372 - 380, Apr. 2017, Scientific journal
Research Projects
- An artificial hemoglobin model as an antidote for fire gas poisoning
毛 斉悦
本研究では、火災現場で実装できる火災ガスに対する解毒剤の開発を目指している。火災で発する毒ガス成分の中で、主に一酸化炭素やシアン化水素が致命な毒性を示す。我々が開発したシクロデキストリン /ポルフィリン超分子錯体であるhemoCD-Pは、生体内において、COスカベンジャーとして機能する。hemoCD-Iは生体内でシアン化物イオンと強く結合する。本研究はこの二つの化合物の毒物に対する特異的な認識能を利用し、CO/HCNを同時に解毒することができる薬剤hemoCD-Twinsを開発した。hemoCD-Twinsを健常マウスに投与し、生体内における薬物動態などの基本物性も調べたところ、ラットに血圧および心拍に影響がなく、さらに、速やかに尿中に排出されることがわかった。次に、動物実験を用いて、解毒剤であるhemoCD-Twinsの有効性を実証した。CO/HCN同時中毒マウスモデルを作成し、CO/HCNの混合ガスをマウスに吸入させた後、コントロール群の0%の生存率に対して、hemoCD-Twinsを投与したマウスの生存率が８割に著しく上昇した。さらに、hemoCD-Twinsを投与した後に生存したマウスにおいては、速やかに行動回復したことも観測できた。また、国立建築研究所の趙博士との共同研究も進んでおり、実際の火災で発する煙をマウスに吸入させ、hemoCD-Twins投与群はコントロール群より生存率が向上したことを証明した。火災中毒の解毒剤として特許の出願を行った。, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2021/08 -2023/03, Grant-in-Aid for Research Activity Start-up, Doshisha University