| OHTA Tetsuo |  |
| Faculty of Life and Medical Sciences Department of Biomedical Information | |
| Professor |
Last Updated :2025/04/25
Researcher Profile and Settings
researchmap
Research Areas
- Nanotechnology/Materials / Organic functional materials
- Nanotechnology/Materials / Synthetic organic chemistry
Research History
Research Experience
- Doshisha University, Faculty of Life and Medical Sciences, 2008 - Today
- - 同志社大学工学部教授, 2001 - 2008
- Doshisha University, 1995 - 2001
- Associate Professor, Doshisha University, 1995 - 2001
- - Professor, Doshisha University, 2001 -
- Kyoto University, Faculty of Engineering, 1989 - 1995
- Research associate, Kyoto University, 1989 - 1995
- 岡崎国立共同研究機構分子科学研究所文部教官助手, 1989 - 1989
- Research associate, Institute for Molecular Science, 1989 - 1989
- 岡崎国立共同研究機構分子科学研究所文部技官, 1984 - 1989
- Research assistant, Institute for Molecular Science, 1984 - 1989
Education
- Kyoto University, Graduate School, Division of Engineering, - 1984
- Kyoto University, 工学研究科, 石油化学専攻, - 1982
- Kyoto University, Graduate School, Division of Engineering, - 1982
- Kyoto University, Faculty of Engineering, 石油化学科, - 1980
- Kyoto University, Faculty of Engineering, - 1980
Degree
Association Memberships
Committee Memberships
Published Papers
- Primary Amine Discrimination Using a 19F NMR Reporter Bearing two Different Fluorine‐Containing Moieties
Naoto Hamaguchi; Rina Nishizawa; Mayu Ikeda; Miki Yokoyama; Hiyono Suzuki; Kouichi Matsumoto; Tetsuo Ohta; Yohei Oe
ChemistrySelect, Wiley, 9(2), 10 Jan. 2024, Scientific journal - Synthesis of Cationic Sandwich-type Ruthenium Complexes with η6-Arene Ligands Bearing Long Alkyl Chains and Their Behavior in Water
Yushi Nakamura; Misato Wakabayashi; Koichiro Sadakane; Tetsuo Ohta; Yohei Oe
Chemistry Letters, The Chemical Society of Japan, 51(9) 936 - 939, 05 Sep. 2022, Scientific journal - Ruthenium-catalyzed hydroxyethylation of cyclic amines with ethylene glycol
Yushi Nakamura; Shuhei Tomioka; Yohei Oe; Tetsuo Ohta
Heterocycles, 98 1074 - 1088, 2019, Scientific journal - Alkylation of the Methyl Group of 2-Methylquinolines and Similar Methyl-N-Heteroaromatics with a Ru/In Dual Catalyst
Yushi Nakamura; Akihiro Azuma; Soichiro Kato; Yohei Oe; Tetsuo Ohta
Chem. Lett., 48 1192 - 1195, 2019, Scientific journal - A simple quantitative chiral analysis of amino acid esters by fluorine-19 nuclear magnetic resonance using the modified James-Bull method
Naoto Hamaguchi; Yuta Okuno; Yohei Oe; Tetsuo Ohta
Chirality, 31 34 - 40, 2019, Scientific journal - Selective N-Monoalkylation of 6-Aminouracils with Alcohols: An Environmentally Benign Protocol for the Synthesis of 6-Alkylaminouracils
Anggi Eka Putra; Yohei Oe; Tetsuo Ohta
European Journal of Organic Chemistry, Wiley-VCH Verlag, 2018(3) 392 - 397, 23 Jan. 2018, Scientific journal - A formal anti-Markovnikov hydroalkoxylation of allylic alcohols with a ruthenium catalyst
Yushi Nakamura; Tetsuo Ohta; Yohei Oe
Chemistry Letters, Chemical Society of Japan, 47(3) 288 - 291, 2018, Scientific journal - Preparation of Isocyanoaryllithiums via Halogen-Lithium Exchange Reaction and Their Reaction with Various Electrophiles
Yohei Oe; Takashi Miyamoto; Yoshihiko Ito; Tetsuo Ohta
CHEMISTRY LETTERS, CHEMICAL SOC JAPAN, 46(12) 1763 - 1765, Dec. 2017, Scientific journal - Ruthenium-catalyzed selective synthesis of monoalkylated barbituric acids through "borrowing hydrogen" methodology
Anggi Eka Putra; Yohei Oe; Tetsuo Ohta
TETRAHEDRON LETTERS, PERGAMON-ELSEVIER SCIENCE LTD, 58(12) 1098 - 1101, Mar. 2017, Scientific journal - Development of efficient catalytic systems based on the "borrowing hydrogen" methodology for regioselective alkylation of heterocyclic compounds and synthesis of amino alcohols
Yushi Nakamura; Anggi Eka Putra; Yohei Oe; Tetsuo Ohta
Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry, Society of Synthetic Organic Chemistry, 74(12) 1182 - 1193, 2016, Scientific journal - Pd/C-Catalyzed Alkylation of Heterocyclic Nucleophiles with Alcohols through the "Borrowing Hydrogen" Process
Anggi Eka Putra; Yohei Oe; Tetsuo Ohta
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, WILEY-V C H VERLAG GMBH, (35) 7799 - 7805, Dec. 2015, Scientific journal - Synthesis of RuCl2(xantphos) L (L = PPh3, P(OPh)(3), DMSO) complexes, and their catalytic activity for the addition of carboxylic acids onto olefins
Shoko Higashi; Hiroto Takenaka; Yoshihiko Ito; Yohei Oe; Tetsuo Ohta
JOURNAL OF ORGANOMETALLIC CHEMISTRY, ELSEVIER SCIENCE SA, 791 46 - 50, Aug. 2015, Scientific journal - Ultrasound radiation from a three-layer thermoacoustic transformation device
Takuya Nishioka; Yu Teshima; Takashi Mano; Ken Sakai; Takaaki Asada; Mami Matsukawa; Tetsuo Ohta; Shizuko Hiryu
ULTRASONICS, ELSEVIER SCIENCE BV, 57 84 - 89, Mar. 2015, Scientific journal - Palladium-catalyzed arylation of aldehydes with bromo-substituted 1,3-diaryl-imidazoline carbene ligand
Tetsuya Yamamoto; Takuma Furusawa; Azamat Zhumagazin; Tetsu Yamakawa; Yohei Oe; Tetsuo Ohta
TETRAHEDRON, PERGAMON-ELSEVIER SCIENCE LTD, 71(1) 19 - 26, Jan. 2015, Scientific journal - Experimental evaluation of binaural recording system using a miniature dummy head
Shunsuke Uchibori; Yuki Sarumaru; Kaoru Ashihara; Tetsuo Ohta; Shizuko Hiryu
Acoustical Science and Technology, Acoustical Society of Japan, 36(1) 42 - 45, 2015, Scientific journal - A formal anti-Markovnikov hydroamination of allylic alcohols via tandem oxidation/1,4-conjugate addition/1,2-reduction using a Ru catalyst
Yushi Nakamura; Tetsuo Ohta; Yohei Oe
CHEMICAL COMMUNICATIONS, ROYAL SOC CHEMISTRY, 51(35) 7459 - 7462, 2015, Scientific journal - Obstacle-Avoidance Navigation by an Autonomous Vehicle Inspired by a Bat Biosonar Strategy
Yasufumi Yamada; Kentaro Ito; Arie Oka; Shinichi Tateiwa; Tetsuo Ohta; Ryo Kobayashi; Shizuko Hiryu; Yoshiaki Watanabe
Biomimetic and Biohybrid Systems, Springer International Publishing, Vol. 9222 135 - 144, 2015, International conference proceedings - Palladium-catalyzed hydroxymethylation of aryl- and heteroarylboronic acids using aqueous formaldehyde
Tetsuya Yamamoto; Azamat Zhumagazin; Takuma Furusawa; Ryoji Tanaka; Tetsu Yamakawa; Yohei Oe; Tetsuo Ohta
IUBMB Life, Blackwell Publishing Ltd, 356(17) 3525 - 3529, 24 Nov. 2014, Scientific journal - Palladium-Catalyzed Hydroxymethylation of Aryl- and Heteroarylboronic Acids using Aqueous Formaldehyde
Tetsuya Yamamoto; Azamat Zhumagazin; Takuma Furusawa; Ryoji Tanaka; Tetsu Yamakawa; Yohei Oe; Tetsuo Ohta
ADVANCED SYNTHESIS & CATALYSIS, WILEY-V C H VERLAG GMBH, 356(17) 3525 - 3529, Nov. 2014, Scientific journal - Prey pursuit strategy of Japanese horseshoe bats during an in-flight target-selection task
Yuki Kinoshita; Daiki Ogata; Yoshiaki Watanabe; Hiroshi Riquimaroux; Tetsuo Ohta; Shizuko Hiryu
JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY, SPRINGER, 200(9) 799 - 809, Sep. 2014, Scientific journal - Adaptive changes in echolocation sounds by Pipistrellus abramus in response to artificial jamming sounds
Eri Takahashi; Kiri Hyomoto; Hiroshi Riquimaroux; Yoshiaki Watanabe; Tetsuo Ohta; Shizuko Hiryu
JOURNAL OF EXPERIMENTAL BIOLOGY, COMPANY OF BIOLOGISTS LTD, 217(16) 2885 - 2891, Aug. 2014, Scientific journal - An Efficient Synthesis of 2,3-Diaminoacid Derivatives Using Phosphine Catalyst
Yohei Oe; Hiroaki Kishimoto; Nahoko Sugioka; Daisuke Harada; Yukio Sato; Tetsuo Ohta; Isao Furukawa
Int. J. Org. Chem., 4 189 - 194, 2014, Scientific journal - 1P2-5 Investigation of Radiated ultrasound from electroacoustic transformation device -Thermophone-(Poster Session)
Nishioka Takuya; Teshima Yu; Mano Takashi; Sakai Ken; Asada Takaaki; Matsukawa Mami; Ota Tetsuo; Hiryu Shizuko
Proceedings of Symposium on Ultrasonic Electronics, Institute for Ultrasonic Elecronics, 34 45 - 46, 20 Nov. 2013 - Transition-Metal-Catalyzed Regioselective Alkylation of Indoles with Alcohols
Anggi Eka Putra; Kei Takigawa; Hatsuki Tanaka; Yoshihiko Ito; Yohei Oe; Tetsuo Ohta
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, WILEY-V C H VERLAG GMBH, 2013(28) 6344 - 6354, Oct. 2013, Scientific journal - Ruthenium-Catalyzed Enantioselective Synthesis of beta-Amino Alcohols from 1,2-Diols by "Borrowing Hydrogen"
Anggi Eka Putra; Yohei Oe; Tetsuo Ohta
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, WILEY-V C H VERLAG GMBH, 2013(27) 6146 - 6151, Sep. 2013, Scientific journal - Human echolocation system using a miniature dummy head
Shunsuke Uchibori; Masataka Kinoshita; Kaoru Ashihara; Tetsuo Ohta; Shizuko Hiryu
Proceedings of Meetings on Acoustics, 19, 2013, International conference proceedings - Prey pursuit strategy of Japanese horseshoe bats, rhinolophus ferrumequinum nippon, during target selection task
Yuki Kinoshita; Daiki Ogata; Ikkyu Aihara; Yoshiaki Watanabe; Hiroshi Riquimaroux; Tetsuo Ohta; Shizuko Hiryu
Proceedings of Meetings on Acoustics, 19, 2013, International conference proceedings - Investigation of acoustic gaze strategy by Pipistrellus abramus and Rhinolophus ferrumequinum nippon during obstacle avoidance flight
Yasufumi Yamada; Arie Oka; Shizuko Hiryu; Tetsuo Ohta; Hiroshi Riquimaroux; Yoshiaki Watanabe
Proceedings of Meetings on Acoustics, Vol. 19 1 - 9, 2013, International conference proceedings - Three-Component Coupling Catalyzed by Phosphine: Preparation of a-Amino g-Oxo Acid Derivatives,
太田 哲男
Int. J. Org. Chem., 2 111–116 , 2012 - Addition reaction of 2-phenylbenzoic acid onto unactivated olefins catalyzed by Ru(II)-xantphos catalysis
Yohei Oe; Tetsuo Ohta; Yoshihiko Ito
TETRAHEDRON LETTERS, PERGAMON-ELSEVIER SCIENCE LTD, 51(21) 2806 - 2809, May 2010, Scientific journal - One-Pot Reductive N-Alkylation with Carbonyl Compounds To Give Tertiary Amines via Borane Reduction of Imines
Masashi Tokizane; Kaori Sato; Yuki Sakami; Yoichiro Imori; Chika Matsuo; Tetsuo Ohta; Yoshihiko Ito
SYNTHESIS-STUTTGART, GEORG THIEME VERLAG KG, (1) 36 - 42, Jan. 2010, Scientific journal - Asymmetric 1,4-addition of organoboronic acids to alpha,beta-unsaturated ketones and 1,2-addition to aldehydes catalyzed by a palladium complex with a ferrocene-based phosphine ligand
Yoshinori Suzuma; Shoko Hayashi; Tetsuya Yamamoto; Yohei Oe; Tetsuo Ohta; Yoshihiko Ito
TETRAHEDRON-ASYMMETRY, PERGAMON-ELSEVIER SCIENCE LTD, 20(23) 2751 - 2758, Dec. 2009, Scientific journal - Addition reaction of arylboronic acids to aldehydes and alpha,beta-unsaturated carbonyl compounds catalyzed by conventional palladium complexes in the presence of chloroform
Tetsuya Yamamoto; Michiko Iizuka; Hiroto Takenaka; Tetsuo Ohta; Yoshihiko Ito
JOURNAL OF ORGANOMETALLIC CHEMISTRY, ELSEVIER SCIENCE SA, 694(9-10) 1325 - 1332, Apr. 2009, Scientific journal - Asymmetric reduction of racemic 2-isoxazolines
Masashi Tokizane; Kaori Sato; Tetsuo Ohta; Yoshihiko Ito
TETRAHEDRON-ASYMMETRY, PERGAMON-ELSEVIER SCIENCE LTD, 19(21) 2519 - 2528, Nov. 2008, Scientific journal - Copper-Catalyzed Addition Reaction of Carbon Nucleophiles to Olefins
Niigawa Kei; Ohnishi Noriko; Miyamoto Takashi; Ohta Tetsuo; Ito Yoshihiko
The science and engineering review of Doshisha University, Doshisha University, 48(4) 1 - 7, Jan. 2008 - Asymmetric 1,4-addition reaction of arylboronic acid to eneone catalyzed by palladium with ferrocene-based phosphine ligand
Yoshinori Suzuma; Tetsuya Yamamoto; Tetsuo Ohta; Yoshihiko Ito
CHEMISTRY LETTERS, CHEMICAL SOC JAPAN, 36(3) 470 - 471, Mar. 2007, Scientific journal - Reduction of alpha,beta-unsaturated ketones with diphenylsilanes bearing several substituents on their phenyl moiety catalyzed by rhodium-phosphine complexes
Daisuke Imao; Miyuki Hayama; Kohta Ishikawa; Tetsuo Ohta; Yoshihiko Ito
CHEMISTRY LETTERS, CHEMICAL SOC JAPAN, 36(3) 366 - 367, Mar. 2007, Scientific journal - Easy access to esters with a benzylic quaternary carbon center from diallyl malonates by palladium-catalyzed decarboxylative allylation
Daisuke Imao; Akihiro Itoi; Asako Yamazaki; Masamichi Shirakura; Ryota Ohtoshi; Kenta Ogata; Yohki Ohmori; Tetsuo Ohta; Yoshihiko Ito
JOURNAL OF ORGANIC CHEMISTRY, AMER CHEMICAL SOC, 72(5) 1652 - 1658, Mar. 2007, Scientific journal - Intramolecular cyclization of phenol derivatives with C=C double bond in a side chain
Yoshihiko Ito; Risa Kato; Kentaro Hamashima; Yohei Kataoka; Yohei Oe; Tetsuo Ohta; Isao Furukawa
JOURNAL OF ORGANOMETALLIC CHEMISTRY, ELSEVIER SCIENCE SA, 692(1-3) 691 - 697, Jan. 2007, Scientific journal - Ruthenium-catalyzed intramolecular cyclization of hetero-functionalized allylbenzenes
Tetsuo Ohta; Yohei Kataoka; Akio Miyoshi; Yohei Oe; Isao Furukawa; Yoshihiko Ito
JOURNAL OF ORGANOMETALLIC CHEMISTRY, ELSEVIER SCIENCE SA, 692(1-3) 671 - 677, Jan. 2007, Scientific journal - Palladium catalyzed conjugate 1,4-addition of organoboronic acids to alpha,beta-unsaturated ketones
T Yamamoto; M Iizuka; T Ohta; Y Ito
CHEMISTRY LETTERS, CHEMICAL SOC JAPAN, 35(2) 198 - 199, Feb. 2006, Scientific journal - Reduction of carboxylic acid derivatives using diphenylsilane in the presence of a Rh-PPh3 complex
T Ohta; M Kamiya; M Nobutomo; K Kusui; Furukawa, I
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, CHEMICAL SOC JAPAN, 78(10) 1856 - 1861, Oct. 2005, Scientific journal - Palladium-catalyzed addition of arylboronic acids to aldehydes
T Yamamoto; T Ohta; Y Ito
ORGANIC LETTERS, AMER CHEMICAL SOC, 7(19) 4153 - 4155, Sep. 2005, Scientific journal - Optically active palladium-catalyzed asymmetric amination of aryl halide
J Tagashira; D Imao; T Yamamoto; T Ohta; Furukawa, I; Y Ito
TETRAHEDRON-ASYMMETRY, PERGAMON-ELSEVIER SCIENCE LTD, 16(13) 2307 - 2314, Jul. 2005, Scientific journal - Effective reductive amination of carbonyl compounds with hydrogen catalyzed by iridium complex in organic solvent and in ionic liquid
D Imao; S Fujihara; T Yamamoto; T Ohta; Y Ito
TETRAHEDRON, PERGAMON-ELSEVIER SCIENCE LTD, 61(29) 6988 - 6992, Jul. 2005, Scientific journal - Ruthenium-catalyzed addition reaction of alcohols across olefins
Y Oe; T Ohta; Y Ito
SYNLETT, GEORG THIEME VERLAG KG, (1) 179 - 181, Jan. 2005, Scientific journal - Ruthenium catalyzed addition reaction of carboxylic acid across olefins without beta-hydride elimination
Y Oe; T Ohta; Y Ito
CHEMICAL COMMUNICATIONS, ROYAL SOC CHEMISTRY, (14) 1620 - 1621, 2004, Scientific journal - Asymmetric allylic substitution catalyzed by palladium-Yliphos complex
T Ohta; H Sasayama; O Nakajima; N Kurahashi; T Fujii; Furukawa, I
TETRAHEDRON-ASYMMETRY, PERGAMON-ELSEVIER SCIENCE LTD, 14(5) 537 - 542, Mar. 2003, Scientific journal - Reductive cleavage of the C-O bond of acetals and orthoesters: reduction by silane in the presence of a Rh-PPh3 complex
T Ohta; T Michibata; K Yamada; R Omori; Furukawa, I
CHEMICAL COMMUNICATIONS, ROYAL SOC CHEMISTRY, (10) 1192 - 1193, 2003, Scientific journal - Kinetic resolution of isoxazolidines by a Pd-BINAP complex
T Ohta; H Kamizono; A Kawamoto; K Hori; Furukawa, I
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, WILEY-V C H VERLAG GMBH, (22) 3855 - 3863, Nov. 2002, Scientific journal - alpha-Amino acid: an effective ligand for asymmetric catalysis of transfer hydrogenation of ketones
T Ohta; S Nakahara; Y Shigemura; K Hattori; Furukawa, I
APPLIED ORGANOMETALLIC CHEMISTRY, JOHN WILEY & SONS LTD, 15(8) 699 - 709, Aug. 2001, Scientific journal - Asymmetric allylic amination catalyzed by Pd-BINAP complexes
H Kodama; T Taiji; T Ohta; Furukawa, I
SYNLETT, GEORG THIEME VERLAG KG, (3) 385 - 387, Mar. 2001, Scientific journal - Preparation of 1,6-naphthyridine-2,5(1H,6H)-diones
T Ohta; H Fujisawa; M Kawazome; Y Nakai; Furukawa, I
JOURNAL OF HETEROCYCLIC CHEMISTRY, HETERO CORPORATION, 38(1) 159 - 164, Jan. 2001, Scientific journal - Enantioselective addition of diethylzinc to aldehydes catalyzed by 3,3 '-bis(2-oxazolyl)-1,1 '-bi-2-naphthol (BINOL-Box) ligands derived from 1,1 '-bi-2-naphthol
H Kodama; J Ito; A Nagaki; T Ohta; Furukawa, I
APPLIED ORGANOMETALLIC CHEMISTRY, WILEY-BLACKWELL, 14(11) 709 - 714, Nov. 2000, Scientific journal - Palladium-catalyzed asymmetric allylic substitution using novel phosphino-ester (PHEST) ligands with 1,1 '-binaphthyl skeleton
H Kodama; T Taiji; T Ohta; Furukawa, I
TETRAHEDRON-ASYMMETRY, PERGAMON-ELSEVIER SCIENCE LTD, 11(19) 4009 - 4015, Oct. 2000, Scientific journal - Synthesis of 3-ethoxyisoxazole derivatives and 3-ethoxy-1H-pyrazole derivatives from beta-oxo thionoesters
T Ohta; H Fujisawa; Y Nakai; Furukawa, I
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, CHEMICAL SOC JAPAN, 73(8) 1861 - 1864, Aug. 2000, Scientific journal - Lanthanide-catalyzed asymmetric 1,3-dipolar cycloaddition of nitrones to alkenes using 3,3 '-bis(2-oxazolyl)-1,1 '-bi-2-naphthol (BINOL-Box) ligands
H Kodama; J Ito; K Hori; T Ohta; Furukawa, I
JOURNAL OF ORGANOMETALLIC CHEMISTRY, ELSEVIER SCIENCE SA, 603(1) 6 - 12, May 2000, Scientific journal - Enantioselective Conjugate Addition of Diethylzinc to Chalcone Catalyzed by Chiral Binaphthol Monoester-copper (BIMES-Cu) Complexes
太田 哲男
Appl. Organomet. Chem., 14 709 - 714, 2000 - Rhodium-catalyzed reduction of esters to alcohols using diphenylsilane
T Ohta; M Kamiya; K Kusui; T Michibata; M Nobutomo; Furukawa, I
TETRAHEDRON LETTERS, PERGAMON-ELSEVIER SCIENCE LTD, 40(38) 6963 - 6966, Sep. 1999, Scientific journal - Asymmetric hydroformylation of olefins in highly crosslinked polymer matrixes
K Nozaki; F Shibahara; Y Itoi; E Shirakawa; T Ohta; H Takaya; T Hiyama
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, CHEMICAL SOC JAPAN, 72(8) 1911 - 1918, Aug. 1999, Scientific journal - Palladium(II)-catalyzed asymmetric 1,3-dipolar cycloaddition of nitrones to 3-alkenoyl-1,3-oxazolidin-2 ones
K Hori; H Kodama; T Ohta; Furukawa, I
JOURNAL OF ORGANIC CHEMISTRY, AMER CHEMICAL SOC, 64(14) 5017 - 5023, Jul. 1999, Scientific journal - Mild synthesis of alpha-oxoketene O,N-acetals from beta-oxothioxo esters and amines
Furukawa, I; H Fujisawa; T Abe; T Ohta
SYNTHETIC COMMUNICATIONS, MARCEL DEKKER INC, 29(4) 599 - 606, 1999, Scientific journal - Organophosphorous chemistry: Selective transformation of benzoin to benzil, desyl bromide, or benzyl phenyl ketone
Furukawa, I; M Sasaki; T Inoue; T Ohta
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, GORDON BREACH PUBLISHING, TAYLOR & FRANCIS GROUP, 143 85 - 99, Dec. 1998, Scientific journal - Syntheses of 5-(alkylaminocarbonyl)-4,6-dimethyl-2-pyridones from N-alkyl-3-oxobutanamides
Furukawa, I; H Fujisawa; M Kawazome; Y Nakai; T Ohta
SYNTHESIS-STUTTGART, GEORG THIEME VERLAG, (12) 1715 - 1717, Dec. 1998, Scientific journal - Practical synthesis of androgen: The efficient transformation of 17-oxo group to 17 alpha-hydroxy group
T Ohta; HY Zhang; Y Torihara; T Hida; Furukawa, I
STEROIDS, ELSEVIER SCIENCE INC, 63(12) 630 - 632, Dec. 1998, Scientific journal - Transition metal-catalyzed cyclization of 2-allylphenol to 2,3-dihydro-2-methylbenzofuran without beta-elimination
K Hori; H Kitagawa; A Miyoshi; T Ohta; Furukawa, I
CHEMISTRY LETTERS, CHEMICAL SOC JAPAN, (11) 1083 - 1084, Nov. 1998, Scientific journal - Palladium(II)-catalyzed 1,3-dipolar cycloaddition of nitrones with enol ethers
K Hori; J Ito; T Ohta; Furukawa, I
TETRAHEDRON, PERGAMON-ELSEVIER SCIENCE LTD, 54(42) 12737 - 12744, Oct. 1998, Scientific journal - alpha-amino acidate-Ru(II) catalysts for asymmetric transfer hydrogenation: First utilization of alpha-amino acids as an efficient ligand
T Ohta; S Nakahara; Y Shigemura; K Hattori; Furukawa, I
CHEMISTRY LETTERS, CHEMICAL SOC JAPAN, (6) 491 - 492, Jun. 1998, Scientific journal - Asymmetric hydroformylation of olefins in a highly cross-linked polymer matrix
K Nozaki; Y Itoi; F Shibahara; E Shirakawa; T Ohta; H Takaya; T Hiyama
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMER CHEMICAL SOC, 120(16) 4051 - 4052, Apr. 1998, Scientific journal - Novel synthesis of N-alkyl-3,4-disubstituted pyrrolidine-2,5-diones: Condensation of alpha-oxoketene O,N-acetals and maleic anhydride
Furukawa, I; T Abe; H Fujisawa; T Ohta
TETRAHEDRON, PERGAMON-ELSEVIER SCIENCE LTD, 53(52) 17643 - 17652, Dec. 1997, Scientific journal - Improved synthetic route to dexamethasone acetate from tigogenin
T Ohta; HY Zhang; Y Torihara; Furukawa, I
ORGANIC PROCESS RESEARCH & DEVELOPMENT, AMER CHEMICAL SOC, 1(6) 420 - 424, Nov. 1997, Scientific journal - Asymmetric hydroformylation of heterocyclic olefins catalyzed by chiral phosphine-phosphite-Rh(I) complexes
T Horiuchi; T Ohta; E Shirakawa; K Nozaki; H Takaya
JOURNAL OF ORGANIC CHEMISTRY, AMER CHEMICAL SOC, 62(13) 4285 - 4292, Jun. 1997, Scientific journal - Asymmetric hydroformylation of conjugated dienes catalyzed by chiral phosphine-phosphite-Rh(I) complex
T Horiuchi; T Ohta; E Shirakawa; K Nozaki; H Takaya
TETRAHEDRON, PERGAMON-ELSEVIER SCIENCE LTD, 53(23) 7795 - 7804, Jun. 1997, Scientific journal - Organolanthanide-catalyzed imine hydrogenation. Scope, selectivity, mechanistic observations, and unusual byproducts
Y Obora; T Ohta; CL Stern; TJ Marks
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMER CHEMICAL SOC, 119(16) 3745 - 3755, Apr. 1997, Scientific journal - Synthesis of (R)-2-diphenylphosphino-2'-diphenylphosphinomethyl,-1,1'-binaphthyl and its use for asymmetric hydrogenation of alpha-alkylstyrenes
K Inagaki; T Ohta; K Nozaki; H Takaya
JOURNAL OF ORGANOMETALLIC CHEMISTRY, ELSEVIER SCIENCE SA LAUSANNE, 531(1-2) 159 - 163, Mar. 1997, Scientific journal - An anionic dinuclear BINAP-ruthenium(II) complex: Crystal structure of NH2Et2 {RuCl((R)-p-MeO-BI-NAP)}(2)(mu-Cl)(3) and its use in asymmetric hydrogenation (vol 15, pg 1522, 1996)
Ohta T; Tonomura Y; Nozaki K; Takaya H; Mashima K
Organometallics, 16(15) 3568 , 1997 - Highly efficient enantioselective synthesis of optically active carboxylic acids by Ru(OCOCH3)(2)[(S)-H-8-BINAP]
T Uemura; XY Zhang; K Matsumura; N Sayo; H Kumobayashi; T Ohta; K Nozaki; H Takaya
JOURNAL OF ORGANIC CHEMISTRY, AMER CHEMICAL SOC, 61(16) 5510 - 5516, Aug. 1996, Scientific journal - Palladium-catalyzed asymmetric 1,3-dipolar cycloaddition of nitrones to olefins
K Hori; H Kodama; T Ohta; Furukawa, I
TETRAHEDRON LETTERS, PERGAMON-ELSEVIER SCIENCE LTD, 37(33) 5947 - 5950, Aug. 1996, Scientific journal - An anionic dinuclear BINAP-ruthenium(II) complex: Crystal structure of [NH(2)Et(2)][{RuCl((R)-p-MeO-BINAP)}(2)(mu-Cl)(3)] and its use in asymmetric hydrogenation
T Ohta; Y Tonomura; K Nozaki; H Takaya; K Mashima
ORGANOMETALLICS, AMER CHEMICAL SOC, 15(6) 1521 - 1523, Mar. 1996, Scientific journal - Asymmetric Hydroformylation of Conjugated Dienes Catalyzed by BINAPHOS-Rh(I) Complexes
太田 哲男
J. Chem. Soc. , Chem. Commun., (3) 155 , 1996 - BINAP-RU(II) AND BINAP-RH(I)-CATALYZED ASYMMETRIC HYDROGENATION OF OLEFINS WITHOUT HETEROATOM-FUNCTIONALITIES
T OHTA; H IKEGAMI; T MIYAKE; H TAKAYA
JOURNAL OF ORGANOMETALLIC CHEMISTRY, ELSEVIER SCIENCE SA LAUSANNE, 502(1-2) 169 - 176, Oct. 1995, Scientific journal - A SIMPLE AND CONVENIENT SYNTHESIS OF ALKYL AZIDES UNDER MILD CONDITIONS
M ITO; K KOYAKUMARU; T OHTA; H TAKAYA
SYNTHESIS-STUTTGART, GEORG THIEME VERLAG, (4) 376 - 378, Apr. 1995 - ASYMMETRIC HYDROGENATION OF OLEFINS WITH APROTIC OXYGEN FUNCTIONALITIES CATALYZED BY BINAP RU(II) COMPLEXES
T OHTA; T MIYAKE; N SEIDO; H KUMOBAYASHI; H TAKAYA
JOURNAL OF ORGANIC CHEMISTRY, AMER CHEMICAL SOC, 60(2) 357 - 363, Jan. 1995, Scientific journal - ASYMMETRIC HYDROGENATION OF ALLYLIC ALCOHOLS USING BINAP-RUTHENIUM COMPLEXES - (S)-(-)-CITRONELLOL - (6-OCTEN-1-OL, 3,7-DIMETHYL, (S)-)
H TAKAYA; T OHTA; S INOUE
ORGANIC SYNTHESES, VOL 72, JOHN WILEY & SONS INC, 72 74 - 85, 1995 - SYNTHESIS OF OPTICALLY-ACTIVE BENZYL-ALPHA-D ALCOHOLS BY ASYMMETRIC HYDROGENATION OF BENZALDEHYDE-ALPHA-D AND ITS DERIVATIVES CATALYZED BY BINAP-RU(II) COMPLEXES
T OHTA; T TSUTSUMI; H TAKAYA
JOURNAL OF ORGANOMETALLIC CHEMISTRY, ELSEVIER SCIENCE SA LAUSANNE, 484(1-2) 191 - 193, Dec. 1994, Scientific journal - ASYMMETRIC-SYNTHESIS OF SILANES WITH A STEREOGENIC CENTER AT SILICON VIA HYDROSILYLATION OF SYMMETRICAL KETONES WITH PROCHIRAL DIARYL SILANES CATALYZED BY BINAP RH-I COMPLEXES
T OHTA; M ITO; A TSUNETO; H TAKAYA
JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, ROYAL SOC CHEMISTRY, (21) 2525 - 2526, Nov. 1994, Scientific journal - SYNTHESIS OF (R)-7,7'-BIS(DIPHENYLPHOSPHINO)-2,2'-DIMETHOXY-1,1'-BINAPTHYL AND (S)-7,7'-BIS(DIPHENYLPHOSPHINO)-2,2'-DIMETHOXY-1,1'-BINAPHTHYL, A NEW AXIALLY DISSYMMETRIC BIS(TRIARYLPHOSPHINE)
T HORIUCHI; T OHTA; M STEPHAN; H TAKAYA
TETRAHEDRON-ASYMMETRY, PERGAMON-ELSEVIER SCIENCE LTD, 5(3) 325 - 328, Mar. 1994, Scientific journal - Synthesis of Primary 1-Deuterio Alcohols by Asymmetric Hydrogenation of Aldehydes Catalyzed by BINAP-Ru(II) Complexes
太田 哲男
J. Organomet. Chem., 484 191 - 193, 1994 - GENERAL ASYMMETRIC-SYNTHESIS OF ISOQUINOLINE ALKALOIDS - ENANTIOSELECTIVE HYDROGENATION OF ENAMIDES CATALYZED BY BINAP-RUTHENIUM(II) COMPLEXES
M KITAMURA; Y HSIAO; M OHTA; M TSUKAMOTO; T OHTA; H TAKAYA; R NOYORI
JOURNAL OF ORGANIC CHEMISTRY, AMER CHEMICAL SOC, 59(2) 297 - 310, Jan. 1994 - A CONVENIENT SYNTHESIS OF OPTICALLY PURE DIMETHYL 1,1'-BINAPHTHALENE-2,2'-DICARBOXYLATE FROM 1,1'-BINAPHTHALENE-2,2'-DIOL
T OHTA; M ITO; K INAGAKI; H TAKAYA
TETRAHEDRON LETTERS, PERGAMON-ELSEVIER SCIENCE LTD, 34(10) 1615 - 1616, Mar. 1993, Scientific journal - A HIGHLY EFFECTIVE ONE-POT BICYCLOANNULATION METHODOLOGY FOR THE SYNTHESIS OF BERBAN AND YOHIMBAN SYSTEMS BASED ON ORGANOTIN-MEDIATED 3-COMPONENT COUPLING (N-ACYLATIVE PENTADIENYLATION OF C=N BONDS)
R YAMAGUCHI; T HAMASAKI; T SASAKI; T OHTA; K UTIMOTO; S KOZIMA; H TAKAYA
JOURNAL OF ORGANIC CHEMISTRY, AMER CHEMICAL SOC, 58(5) 1136 - 1143, Feb. 1993, Scientific journal - AN EFFICIENT SYNTHESIS OF OPTICALLY-ACTIVE 4-METHYLOXETAN-2-ONE - ASYMMETRIC HYDROGENATION OF DIKETENE CATALYZED BY BINAP RUTHENIUM(II) COMPLEXES [BINAP = 2,2'-BIS(DIPHENYLPHOSPHINO)-1,1'-BINAPHTHYL]
T OHTA; T MIYAKE; H TAKAYA
JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, ROYAL SOC CHEMISTRY, (23) 1725 - 1726, Dec. 1992, Scientific journal - ASYMMETRIC HYDROGENATION OF UNSATURATED CARBONYL-COMPOUNDS CATALYZED BY BINAP RU(II) COMPLEXES - ENANTIOSELECTIVE SYNTHESIS OF GAMMA-BUTYROLACTONES AND CYCLOPENTANONES
T OHTA; T MIYAKE; N SEIDO; H KUMOBAYASHI; S AKUTAGAWA; H TAKAYA
TETRAHEDRON LETTERS, PERGAMON-ELSEVIER SCIENCE LTD, 33(5) 635 - 638, Jan. 1992, Scientific journal - NEW 2,2'-BIS(DIPHENYLPHOSPHINO)-1,1'-BINAPHTHYL-RU(II) COMPLEXES FOR ASYMMETRIC CATALYTIC-HYDROGENATION
H TAKAYA; T OHTA; K MASHIMA
HOMOGENEOUS TRANSITION METAL CATALYZED REACTIONS, AMER CHEMICAL SOC, 230(230) 123 - 142, 1992, International conference proceedings - PHOTOCATALYTIC ASYMMETRIC REDUCTION OF 3-METHYL-2-OXOBUTANOIC ACID WITH CHIRAL RH(I) COMPLEXES AND POWDERY SEMICONDUCTORS
H WANG; T SAKATA; M AZUMA; T OHTA; H TAKAYA
CHEMISTRY LETTERS, CHEMICAL SOC JAPAN, (8) 1331 - 1334, Aug. 1990, Scientific journal - NEW CHIRAL RUTHENIUM COMPLEXES FOR ASYMMETRIC CATALYTIC HYDROGENATIONS
H TAKAYA; T OHTA; K MASHIMA; R NOYORI
PURE AND APPLIED CHEMISTRY, BLACKWELL SCIENCE LTD, 62(6) 1135 - 1138, Jun. 1990, Scientific journal - STEREOCHEMISTRY AND MECHANISM OF THE ASYMMETRIC HYDROGENATION OF UNSATURATED CARBOXYLIC-ACIDS CATALYZED BY BINAP RUTHENIUM(II) DICARBOXYLATE COMPLEXES
T OHTA; H TAKAYA; R NOYORI
TETRAHEDRON LETTERS, PERGAMON-ELSEVIER SCIENCE LTD, 31(49) 7189 - 7192, 1990, Scientific journal - NEW CHIRAL RH(I) AND RU(II) COMPLEXES - HIGHLY EFFICIENT CATALYSTS FOR HOMOGENEOUS ASYMMETRIC HYDROGENATION
H TAKAYA; T OHTA; K MASHIMA; M KITAMURA; R NOYORI
FUTURE OPPORTUNITIES IN CATALYTIC AND SEPARATION TECHNOLOGY, ELSEVIER SCIENCE PUBL B V, 54 322 - 339, 1990, International conference proceedings - SYNTHESIS OF NEW CATIONIC BINAP-RUTHENIUM(II) COMPLEXES AND THEIR USE IN ASYMMETRIC HYDROGENATION [BINAP = 2,2'-BIS(DIPHENYLPHOSPHINO)-1,1'-BINAPHTHYL]
K MASHIMA; KH KUSANO; T OHTA; R NOYORI; H TAKAYA
JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, ROYAL SOC CHEMISTRY, (17) 1208 - 1210, Sep. 1989, Scientific journal - BINAP-RUTHENIUM(II) DICARBOXYLATE COMPLEXES - NEW, HIGHLY EFFICIENT CATALYSTS FOR ASYMMETRIC HYDROGENATIONS
T OHTA; H TAKAYA; R NOYORI
INORGANIC CHEMISTRY, AMER CHEMICAL SOC, 27(3) 566 - 569, Feb. 1988, Scientific journal - HOMOGENEOUS ASYMMETRIC HYDROGENATION OF FUNCTIONALIZED KETONES
M KITAMURA; T OHKUMA; S INOUE; N SAYO; H KUMOBAYASHI; S AKUTAGAWA; T OHTA; H TAKAYA; R NOYORI
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMER CHEMICAL SOC, 110(2) 629 - 631, Jan. 1988 - ASYMMETRIC HYDROGENATION OF UNSATURATED CARBOXYLIC-ACIDS CATALYZED BY BINAP-RUTHENIUM(II) COMPLEXES
T OHTA; H TAKAYA; M KITAMURA; K NAGAI; R NOYORI
JOURNAL OF ORGANIC CHEMISTRY, AMER CHEMICAL SOC, 52(14) 3174 - 3176, Jul. 1987 - ENANTIOSELECTIVE HYDROGENATION OF ALLYLIC AND HOMOALLYLIC ALCOHOLS
H TAKAYA; T OHTA; N SAYO; H KUMOBAYASHI; S AKUTAGAWA; S INOUE; KASAHARA, I; R NOYORI
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMER CHEMICAL SOC, 109(5) 1596 - 1597, Mar. 1987 - ASYMMETRIC-SYNTHESIS OF ISOQUINOLINE ALKALOIDS BY HOMOGENEOUS CATALYSIS
R NOYORI; M OHTA; Y HSIAO; M KITAMURA; T OHTA; H TAKAYA
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMER CHEMICAL SOC, 108(22) 7117 - 7119, Oct. 1986 - RUTHENIUM-CATALYZED N-ALKYLATION AND N-BENZYLATION OF AMINOARENES WITH ALCOHOLS
Y WATANABE; Y TSUJI; H IGE; Y OHSUGI; T OHTA
JOURNAL OF ORGANIC CHEMISTRY, AMER CHEMICAL SOC, 49(18) 3359 - 3363, 1984, Scientific journal - RUTHENIUM-CATALYZED OXIDATION OF ALCOHOLS AND CATECHOLS USING TERT-BUTYL HYDROPEROXIDE
Y TSUJI; T OHTA; T IDO; H MINBU; Y WATANABE
JOURNAL OF ORGANOMETALLIC CHEMISTRY, ELSEVIER SCIENCE SA LAUSANNE, 270(3) 333 - 341, 1984, Scientific journal - RUTHENIUM CATALYZED REDUCTION OF NITROARENES AND AZAAROMATIC COMPOUNDS USING FORMIC-ACID
Y WATANABE; T OHTA; Y TSUJI; T HIYOSHI; Y TSUJI
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, CHEMICAL SOC JAPAN, 57(9) 2440 - 2444, 1984, Scientific journal - THE RUTHENIUM CATALYZED N-ALKYLATION OF AMIDES WITH ALCOHOLS
Y WATANABE; T OHTA; Y TSUJI
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, CHEMICAL SOC JAPAN, 56(9) 2647 - 2651, 1983, Scientific journal - RUTHENIUM-CATALYZED REDUCTION OF CARBONYL-COMPOUNDS USING FORMIC-ACID
Y WATANABE; T OHTA; Y TSUJI
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, CHEMICAL SOC JAPAN, 55(8) 2441 - 2444, 1982, Scientific journal - THE RUTHENIUM COMPLEX-CATALYZED REDUCTION OF KETONES BY FORMIC-ACID
Y WATANABE; T OTA; Y TSUJI
CHEMISTRY LETTERS, CHEMICAL SOC JAPAN, (12) 1585 - 1586, 1980, Scientific journal
MISC
- Synthesis of ruthenium complexes having η6-arene ligand with a long, alkyl chain and their behavior in water
Misato wakabayashi; Yuushi Nakamura; Tetsuo Ohta; Yohei Oe
The International Chemical Congress of Pacific Basin Societies 2021, Dec. 2021, Others - 長鎖アルキル鎖を有するピアノ椅子型ルテニウム錯体の合成と水中での挙動
若林美賢; 中村祐士; 太田哲男; 大江洋平
第41回有機合成若手セミナー, Aug. 2021, Others - Asymmetric hydrogenation of unsaturated carboxylic acids catalyzed by Ru(OCOCH[3])[2](BINAP) : 2. mechanistic consideration
Ohta Tetsuo; Oe Yohei; Takaya Hidemasa
ハリス理化学研究所報告, Alternative:Harris Science Research Institute of Doshisha University, 57(57) 68–75 - 75, 2016 - Asymmetric hydrogenation of unsaturated carboxylic acids catalyzed by Ru(OCOCH[3])[2](BINAP) : 1. reaction profile
Ohta Tetsuo; Oe Yohei; Takaya Hidemasa
ハリス理化学研究所報告, Alternative:Harris Science Research Institute of Doshisha University, 57(57) 57–67 - 67, 2016 - 非対称NHC‐Pd触媒を用いるアリールボロン酸のカルボニル化合物への求核付加反応
山本哲也; 古澤拓馬; 大江洋平; 山川哲; 太田哲男
日本化学会講演予稿集, 93rd(4) 1539 , 08 Mar. 2013 - Studies on Transition Metal-Catalyzed Addition Reaction of Oxygen-, Nitrogen-, and Carbon-Nucleophiles onto Olefins
Yohei Oe; Shoko Higashi; Tetsuo Ohta
JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, SOC SYNTHETIC ORGANIC CHEM JPN, 69(2) 118 - 128, Feb. 2011, Book review - Studies on transition metal-catalyzed addition reaction of oxygen-, Nitrogen-, and carbon-nucleophiles onto olefins
Yohei Oe; Shoko Higashi; Tetsuo Ohta
Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry, 69(2) 118 - 128, 2011, Book review - Asymmetric addition of diethylzinc to aldehydes catalyzed by metal complexes with chitosan and D-(+)-Glucosamine derivatives as a ligand
Ohta Tetsuo; Maeda Noriteru; Kujime Ryo; Oe Yohei; Yamashita Takayuki; Furukawa Isao
The science and engineering review of Doshisha University, Doshisha University, 52(2) 113–126 - 126, 2011 - Palladium-Catalyzed Addition of Organoboron Compounds to Carbonyl Compounds
YAMAMOTO TETSUYA; OE YOHEI; OHTA TETSUO; YAMAKAWA TETSU
Symp Organomet Chem Jpn, 57th 158 , 01 Sep. 2010 - Palladium-Catalyzed 1,2-Addition of Alkylborane Reagents to Aldehydes
Yamamoto Tetsuya; Okabe Taro; Iizuka Michiko; Ito Yoshihiko; Oe Yohei; Ohta Tetsuo
The science and engineering review of Doshisha University, Doshisha University, 50(4) 1 - 5, Jan. 2010 - Palladium-Catalyzed 1,2-Addition of Alkylborane Reagents to Aldehydes
太田 哲男
Sci. Eng.Rev. Doshisha Univ., 50(3) 159 - 163, 2009 - Addition Reaction of Heteroatom Nucleophiles onto Styrene Catalyzed by Ru(II) Complex
Oe Yohei; Ohta Tetsuo; Ito Yoshihiko
The science and engineering review of Doshisha University, Doshisha University, 50(2) 94 - 99, 2009 - Palladium-Catalyzed 1,2-Addition of Alkylborane Reagents to Aldehydes
Sci. Eng.Rev. Doshisha Univ., 50(3) 159 - 163, 2009 - 銅触媒を用いた炭素求核剤のオレフィンヘの付加反応
太田 哲男
同志社大学理工学研究報告, 48(4) 221 - 227, 2008 - Reduction of alpha,beta-unsaturated ketones with diphenylsilanes bearing several substituents on their phenyl moiety catalyzed by rhodium-phosphine complexes
Daisuke Imao; Miyuki Hayama; Kohta Ishikawa; Tetsuo Ohta; Yoshihiko Ito
CHEMISTRY LETTERS, CHEMICAL SOC JAPAN, 36(3) 366 - 367, Mar. 2007 - Palladium-Catalyzed Conjugated Addition of Arylboronic Acid.
IIZUKA MICHIKO; YAMAMOTO TETSUYA; OTA TETSUO; ITO YOSHIHIKO
日本化学会講演予稿集, 86th(2) 951 , 13 Mar. 2006 - Asymmetric etherification of aryl halide by chiral palladium catalyst
Yamamoto Tetsuya; Tagashira Jyunya; Imao Daisuke; Ohta Tetsuo; Furukawa Isao; Ito Yoshihiko
The science and engineering review of Doshisha University, Doshisha University, 47(1) 1 - 9, 2006 - Asymmetric Etherification of Aryl Halide by Chiral Palladium Catalyst
Yamamoto Tetsuya; Tagashira Jyunya; Imao Daisuke; Ohta Tetsuo; Furukawa Isao; Ito Yoshihiko
Sci. Eng. Rev. Doshisha Univ., Doshisha University, 47(1) 1 - 9, 2006 - Specific Effect of Chloroform on Palladium Catalyzed Addition of Arylboronic Acids to Aldehydes and .ALPHA.,.BETA.-Unsaturated Ketones
YAMAMOTO TETSUYA; IIZUKA MICHIKO; SATO KAORI; OHTA TETSUO; ITO YOSHIHIKO
Symp Organomet Chem Jpn, 52nd 292 - 293, 2005 - Synthesis and properties of metal-containing polymers: Part 2.
T. Ohta; M. Honda; T. Hishida; Y. Shimada; I. Furukawa
“Hybrid Nanostructured Materials and Their Applications,” ed by T. Ohachi, A. S. Somintac, and M. Wada, Words: Tokyo, 119–136 , 2005 - Synthesis and properties of metal-containing polymers: Part 2.
T. Ohta; M. Honda; T. Hishida; Y. Shimada; I. Furukawa
“Hybrid Nanostructured Materials and Their Applications,” ed by T. Ohachi, A. S. Somintac, and M. Wada, Words: Tokyo, 119–136 , 2005 - 多座配位複素芳香環の配位高分子:ピラジン-2,3-ジカルボン酸ならびにピリダジンの配位高分子合成とその構造解析 (第41回同志社大学理工学研究所研究発表会,2003年度同志社大学ハイテク・リサーチ,学術フロンティア合同シンポジウム講演予稿集)
太田 哲男
同志社大学理工学研究報告, 同志社大学理工学研究所, 44(4) 86 - 91, Jan. 2004 - Synthesis and Properties of Metal-Containing Polymers
太田 哲男
Nanostructured Materials and Their Applications, 133 - 143, 2004 - Synthesis and Properties of Metal-Containing Polymers
133 - 143, 2004 - Palladium-catalyzed Asymmetric Etherification of Aryl Halide.
YAMAMOTO TETSUYA; TAGASHIRA JUN'YA; OTA TETSUO
日本化学会講演予稿集, 83rd(2) 996 , 03 Mar. 2003 - Preparation of heterocyclic compounds from α-Oxoketene O,N-acetals
Tetsuo Ohta; Yohei Oe; Isao Furukawa
Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry, Society of Synthetic Organic Chemistry, 60(10) 932 - 941, 2002 - Synthesis of (2Z,4E)-3-Methy1-2,4-pentadienoic Acids from Ethyl 3,3-Dimethylacrylate and Carbonyl Compounds
Ohta Tetsuo; Niiyama Takeshi; Furukwa Isao
The science and engineering review of Doshisha University, Doshisha University, 43(3) 158 - 164, 2002 - Enantioselective Sythesis of (+)-cis-Methy Dihydrojasmonate
Inoue Hiroki; Ashida Masayo; Ohta Tetsuo
The science and engineering review of Doshisha University, Doshisha University, 43(2) 115 - 123, 2002 - Enantioselective Synthesis of (+)-cis-Methyl Dihydrojasmonate
Sci. Eng. Rev. Doshisha Univ., 43 115 - 123, 2002 - A New Synthetic Route to Dexamethasone from Tigogenin ; Application of Remote Functionalozation
Hida Takemasa; Zhang Huyue; Ikeda Takuya
The science and engineering review of Doshisha University, Doshisha University, 42(2) 71 - 76, 2001 - A New Synthetic Route to Dexamethasone from Tigogenin; Application of Remote Functionalization
Hida Takemasa; Zhang Huyue; Ikeda Takuya
Sci. Eng. Rev. Doshisha Univ., Doshisha University, 42(2) 71 - 76, 2001 - Enantioselective Addition of Diethylzinc to Aromatic Aldehydes Catalyzed by New BINOL‐derived Ligands.
児玉英彦; 永木愛一郎; 羽曽部卓; 国定直記; 山下隆之; 太田哲男; 古川功
日本化学会講演予稿集, 78th(2) 1038 , 15 Mar. 2000 - ルテニウム触媒を用いるβ-水素脱離を伴わない新規分子内環化反応 (同志社大学理工学研究所第37回研究発表会講演予稿集)
太田 哲男; 北川 英樹; 三好 章夫
同志社大学理工学研究報告, 同志社大学理工学研究所, 40(4) 95 - 98, Jan. 2000 - 新規光学活性1,1'-ビ-2-ナフト-ルモノエステル（BIMES）配位子の合成とその不斉反応への応用
太田 哲男
同志社大学理工学研究報告, 41(2) 26 - 32, 2000 - Ytterbium-Catalyzed 1,3-Depolar Cycloaddition of N-Benzylideneaniline N-oxide to 3-Crotonoyl-1, 3-oxazolidin-2-one
HORI Kazushige; ITO Junji; OGURA.Yukiko; OKAMOTO Takashi; OHTA Tetsuo; FURUKAWA Isao
The science and engineering review of Doshisha University, Doshisha University, 39(4) 8 - 14, Jan. 1999 - バナジウム触媒によるアルコ-ルのアルデヒドやケトンへの酸化反応における添加物の効果
太田 哲男
同志社大学理工学研究報告, 40(4) 177 - 181, 1999 - Preperation of Novel Chiral Phosphorus Ylides and Their Palladium, Rhodium and Ruthenium Complexes
OHTA Tetsuo; FUJII Takeshi; KURAHASHI Nobukazu; SASAYAMA Hiroyuki; FURUKAWA Isao
The science and engineering review of Doshisha University, Doshisha University, 39(3) 15 - 23, Oct. 1998 - イッテルビウム触媒によるN-ベンジリデンアニリン N-オキシドと3-クロトノイル-1,3-オキサゾリジン-2-オンの1,3-双極子付加環化反応
太田 哲男
同志社大学理工学研究報告, 39(4) 182 - 188, 1998 - 新規光学活性ホスフィンイリド配位子とそのパラジウム，ロジウム，ルテニウム錯体の合成
太田 哲男
同志社大学理工学研究報告, 39(4) 133 - 141, 1998 - Hydrogenation of imines catalyzed by organolanthanide complexes.
Y Obora; T Ohta; CL Stern; TJ Marks
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, AMER CHEMICAL SOC, 211 129 - INOR, Mar. 1996, Summary international conference - RECENT ADVANCES IN ASYMMETRIC HYDROGENATION BY MEANS OF TRANSITION-METAL COMPLEXES
H TAKAYA; T OHTA
JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, SOC SYNTHETIC ORGANIC CHEM JPN, 51(11) 1013 - 1023, Nov. 1993, Book review - Recent Advances in Asymmetric Hydrogenation by Means of Transition Metal Complexes
Hidemasa Takaya; Tetsuo Ohta
Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry, 51(11) 1013 - 1023, 1993 - NEW ASPECTS IN ASYMMETRIC HYDROGENATION OF OLEFINS AND KETONES CATALYZED BY BINAP-METAL COMPLEXES
H TAKAYA; T OHTA; K MASHIMA; H KUMOBAYASHI; S AKUTAGAWA
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, AMER CHEMICAL SOC, 203 611 - INOR, Apr. 1992, Summary international conference - NEW 2,2'-BIS(DIPHENYLPHOSPHINO)-1,1'-BINAPHTHYL-RU(II) COMPLEXES FOR ASYMMETRIC CATALYTIC-HYDROGENATION
H TAKAYA; T OHTA; K MASHIMA
ADVANCES IN CHEMISTRY SERIES <D>, AMER CHEMICAL SOC, (230) 123 - 142, 1992, Book review - Asymmetric Hydrogenation and Hydrogen Transfer Reactions Catalyzed by Chiral Transition-Metal Complexes
TAKAYA Hidemasa; OHTA Tetsuo; MASHIMA Kazushi
Journal of Japan Oil Chemists' Society, Japan Oil Chemists' Society, 39(10) 866 - 874, 1990 - Binap-Ru(OCOCH3)2: Highly efficient catalyst for asymmetric hydrogenation
Tetsuo Ohta; Hidemasa Takaya
Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry, 48(11) 1018 - 1019, 1990 - Erratum: Enantioselective hydrogenation of allylic and homoallylic alcohols (Journal of the American Chemical Society (1987) 109, (1596-1597))
Hidemasa Takaya; Tetsuo Ohta; Noboru Sayo; Hidenori Kumobayashi; Susumu Akutagawa; Shin Ichi Inoue; Isamu Kasahara; Ryoji Noyori
Journal of the American Chemical Society, 109 4129 , 01 Dec. 1987
Books etc
- Synthesis and properties of metal-containing polymers: Part 2.
2005 - Synthesis and properties of metal-containing polymers: Part 2.
Words, Tokyo, "Hybrid Nanostructured Materials and Their Applications", 2005 - "役にたつ化学シリーズ 有機化学"
朝倉書店, 2004 - Asymmetric Hydrogenation
"Catalytic Asymmetric Synthesis", VHC Publishers, New York, 1993 - Asymmetric Hydrogenation
"Catalytic Asymmetric Synthesis", VHC Publishers, New York, 1993 - New 2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl-Ru(II) Complexes for Asymmetric Catalytic Hydrogenation
"Homogeneous Transition Metal Catalyzed Reactions", Eds. , Advances in Chemistry Series No. 230, American Chemical Society, Washington DC, 1992 - New 2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl-Ru(II) Complexes for Asymmetric Catalytic Hydrogenation
"Homogeneous Transition Metal Catalyzed Reactions", Eds. , Advances in Chemistry Series No. 230, American Chemical Society, Washington DC, 1992 - Metal-Promoted Cycloaddition of Small-ring Compounds
"Comprehensive Organic Synthesis", Pergamon Press, Oxford, Vol. 5, 1991 - Metal-Promoted Cycloaddition of Small-ring Compounds
"Comprehensive Organic Synthesis", Pergamon Press, Oxford, Vol. 5, 1991 - New Chiral Rh(I) and Ru(II) Complexes : Highly Efficient Catalysts for Homogeneous Asymmetric Hydrogenation
"Future Opportunities in Catalytic and Separation Technology", Eds, Elsevier Amsterdam, 1990 - New Chiral Rh(I) and Ru(II) Complexes : Highly Efficient Catalysts for Homogeneous Asymmetric Hydrogenation
"Future Opportunities in Catalytic and Separation Technology", Eds, Elsevier Amsterdam, 1990
Research Projects
- α,β‐不飽和カルボニル化合物への窒素求核剤の形式的1,3-付加反応
太田 哲男
日本学術振興会, 科学研究費助成事業, 2022/04 -2025/03, 基盤研究(C), 同志社大学 - Synthesis and utilization of ruthenium complexes with polystyrene-supported arene ligand
Tetsuo Ohta
In this study, the author investigated the synthesis of [(arene) RuCl2]2 having polymer-bound arene ligand, the complexation of small molecular ligand with it and its application to the catalytic reactions. When the reaction of polymer P-1 with [(ethyl 4-methylbenzencarboxylate)RuCl2]2 was performed in a mixed solvent of cyclohexane and chlorobenzene to afford dark green powder. 1H NMR analysis of the resulting powder implied the possibility of the formation of proposed ruthenium complex P-l-Ru. Treatment of P-l-Ru with a small molecular phosphine ligand Dppe (diphenylphosphinoethane) afforded yellowish powder. Both P-l-Ru and P-l-Ru(dppe) showed the recyclable catalytic activity on the transfer hydrogenation of acetophenone to 1-phenylethanol., Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2019/04 -2022/03, Grant-in-Aid for Scientific Research (C), Doshisha University - 金属触媒を用いるβ-水素脱離を制御したオレフィンへの求核付加反応の開発
太田 哲男
[RuCl_2(p-cymene)]_2をAgOTfで処理して得られる錯体にホスフィン配位子を組み合わせると,クロロホルム中で本反応に対する触媒活性を示すことが明らかとなった。スルホンアミド類とスチレンの反応においては二座ホスフィン配位子の利用が効果的であり,80%を超える収率で目的物を与えた。 ルテニウム前駆体に1,2-ビスジフェニルホスフィノベンゼン(DPPBen)を作用させた後,AgOTfで処理して得られた錯体の^1H NMRからp-シメンがルテニウム上に芳香環として配位していること,^<19>F NMRからルテニウムに配位したOTfと配位していないOTf^-が存在すること,^<31>P NMRからジホスフィン配位子がキレート配位していることが明らかとなった。また,単結晶X線構造解析にも成功し,NMRの解析結果が正しいこと,並びに,ルテニウムに配位したOTfは単座型であることが示された。単離・構造決定したルテニウム-DPPBen錯体を用いてスチレンに対する各種ヘテロ求核剤の付加反応を検討したところ,アルコールやカルボン酸さらにはスルホンアミドがスチレンに効率よく付加することを見出した。 Xantphos-ルテニウムカチオン性錯体は良好な触媒活性を示し,これまで反応の進行がほとんど見られなかったオレフィン類に対しても付加反応が進行することが示された。2-フェニル安息香酸のオレフィンに対する付加反応では,オレフィンとして1-ヘキセンや1-オクテンのような直鎖アルケン,(Z)-二置換であるシクロヘキセンでも80%を超える収率で反応が進行した。さらには,これまで反応しなかった脂肪族カルボン酸でも付加が観察され,マンデル酸が芦アリルアニソールに付加し,64%収率でマンデル酸3-(4-メトキシフェニル)-2-プロピルを与えた。, 日本学術振興会, 科学研究費助成事業, 2004 -2005, 特定領域研究, 同志社大学 - Synthesis of α-Amino Acids via Phosphine-Catalyzed Three-Component Coupling Reactions
OHTA Tetsuo
Protonation of the highly reactive zwitterionic intermediate produced in the reaction of triphenylphosphine with dimethyl acetylenedicarboxylate from the protic substrate having carbonyl moieties leads smoothly to vinylphosphonium salt, which underwent an intramolecular Wittig reaction to afford heterocyclic compound in one-pot. This reaction was successfully applied to the intermolecular three-component coupling reaction of acetylenecarboxylates, protic nucleophiles, and aldehydes catalyzed by phosphine. It was found that three-component coupling reaction of phthalimide, ethyl propiolate, and aldehydes in the presence of a catalytic amount of triphenylphosphine proceeded to afford the corresponding γ-oxo-α-amino acid derivatives in moderate to good yields. An efficient synthesis of α,β-diamino acid derivatives via vinylphosphonium salts generated from ethyl propiolate and triphenylphosphine was also developed. That is the reaction of ethyl propiolate with phthalimide in the presence of a catalytic amount of tirphenylphosphine gave ethyl 2,3-diphthalimidoylpropanoate in almost quantitative yield in polar solvent. Both amino acid derivatives could be obtained in optically active using chiral phosphine catalyst., Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2002 -2003, Grant-in-Aid for Scientific Research (C), Doshisha University - ホスホリン錯体の合成とその触媒作用の研究
太田 哲男
1.4,4',5,5'-テトラメチル-2,2'-ジホスホリン型配位子 Matheyらの報告に従い、上記ジホスホリン化合物の合成を行った。本化合物は、論文によると総収率10%程度で得られることが示されているが、我々の検討では、純粋なものは数パーセントしか得られないことがわかった。得られた化合物を用いてパラジウムとの錯体合成を行ったところ、二価のパラジウム化合物とは錯体を形成しなかった。このことは、本化合物が電子供与性が弱く、高原子価の金属錯体の安定化にはあまり効果がないことを示しており、我々の予測通りであった。0価のパラジウム錯体とは錯形成したと思われるスペクトルが得られたが、その充分なキャラクタリゼーションには至らなかった 2.フェナンスレンの1、10位がリンで置換されたジホスホリン型配位子の合成 一般に、1,10-フェナントロリンは、その強制的な平面構造のため、2,2'-ビピリジンよりも強い配位力をもつ。そこで、上記の2,2'-ジホスホリンよりもフェナンスレンの1、10位がリンで置換されたジホスホリン化合物がより配位子として有効であると考え、合成を試みた。合成経路として、2、3位を置換基で保護し、l、4位にリンと結合させるための官能基を持つアルキル基を導入したベンゼンを出発物質に用いる合成経路を検討した。側鎖の適当な位置にオレフィンを導入することでリン原子が導入できると考えられたので、2-メチル-3-プロペニルの導入を試みた。クロスカップリングの条件を検討することで、目的のジオレフィン化合物の合成に成功した。ついで、Friedel-Craft条件でのリン原子の導入に成功した。現在、熱もしくは光による環化反応の検討を行っている。この反応系では、大量合成が可能なことから、今後、反応条件の検討を行い、目的化合物を得て、錯体合成、触媒反応を検討していく予定である。, 日本学術振興会, 科学研究費助成事業, 1997 -1997, 萌芽的研究, 同志社大学 - 配位力を制御した新規キラル錯体の合成とその触媒作用の研究
太田 哲男
1.モノホスフィンモノイリド型配位子並びに金属錯体の合成と触媒反応への応用 ビスホスフィン配位子TolBINAPをブロモ酢酸エステル、ブロモアセトニトリルと反応させることによりモノホスホニウム塩が選択的に得られ、それをメチルリチウムで処理すると、対応する光学活性モノホスフィンモノイリド(YLIPHOS)が得られた。次にYLIPHOSを配位子としたRu、Rh、Pdの錯体合成を行った。本YLIPHOSはRh、Pdと8員環キレート錯体を形成する。このとき、イリド炭素が中心金属に配位した金属-イリド炭素結合が形成されており、その配位力は、置換基や中心金属によって影響を受ける。また、この金属-イリド炭素結合は、配位と解離の平衡状態にあると考えることができる。ところが、Ru金属を用いた場合、YLIPHOSは単座の配位子として金属に配位していると思われる。得られた錯体の触媒活性を検討したところ、Pdの錯体がGrignard試薬とブロモベンゼンやアリルフェニルエーテルとのクロスカップリング反応の触媒として有効であり、光学収率6.5%並びに17%で生成物が得られた。この結果は、立体選択性は若干低いものの、本錯体が不斉触媒として機能することを示している。 2.アミノ酸を配位子に持つ新規不斉触媒の開発 アミノ酸は天然由来の安価なキラル化合物であるが、これまで後周期遷移金属錯体を用いる不斉触媒反応の配位子として有用な反応は見出されていない。本研究で、プロリンをルテニウムに配位させることにより、アセトフェノンがイソプロピルアルコールからの不斉水素移動反応に活性な触媒を生成することがわかった。室温24時間の反応で90%を越える収率と、79%の不斉収率で本反応が進行する。, 日本学術振興会, 科学研究費助成事業, 1996 -1996, 基盤研究(C), 同志社大学 - Development of Novel Catalyst System for Highly Enantioselective Hydroformylations and Its Application for the Syntheses of Biologically Active Compounds.
NOZAKI Kyoko; HAGIWARA Isao; TOMITA Tetsuro; SAYO Noboru; KUMOBAYASHI Hidenori; OHTA Tetsuo
(1) Asymmetric hydroformylation of sulfur-containing olefins, such as vinyl-and allyl-sulfide, sulfoxide, sulfones has been performed in high enantioselectivities by using a rhodium complex of chiral phosphine-phosphite, (R,S) -BINAPHOS.The resulting oxo-aldehydes have potential use as synthetic intermediates for various biologically active compounds. (2) Asymmetric hydroformylation of conjugated dienes have also been examined. There are four carbons in the dienes which are capable to be attached to the formyl group. For various diences, the present system chooses one of the four possibilities, in high enantioselectivities. (3) Highly enantioselective copolymerization of propene and carbon monoxide has been performed by using Pd (II) - (R,S) -BINAPHOS.The catalyst system produces poly (alt-propene-CD) of the highest molecular weight as well as in the highest enantioselectivity ever reported. The reaction mechanism was also investigated by NMR studies., Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 1994 -1995, Grant-in-Aid for Developmental Scientific Research (B), KYOTO UNIVERSITY - Development of Direct Synthesis of Optically Active Compounds
TAKAYA Hidemasa; SAYO Noboru; KUMOBAYASHI Hidenori; TAMAO Kyoko; OHTA Tetsuo
Several BINAP derivatives have been prepared and their donor-acceptor propeties have been elucidated. New cationic complexes [RuX(binap)(arene)]Y were synthesized in high yields and their catalytic abilities as well as their behaviors in solution have been investigated. Optimization of the reaction conditions of asymmetric hydrogenation of methyl 2-benzamidomethy1-3-oxobutanoate by use of these complexes as catalysts afforded the corresponding alcohol in 98% de and 99% ee. Asymmetric hydrogenation of alpha-alkylidenecyclopentanones, alkylidenelactones, alkenyl ethers, and alpha-keto esters has also been performed in high enantioselectivities. Hydrogenation of various 1,2-benzocycloalkanones and 3-thiacycloalkanones catalyzed by newly developed BINAP-ir(I)-aminophosphine systems afforded the corresponding secondary alcohols in up to 96% ee., Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 1991 -1992, Grant-in-Aid for Developmental Scientific Research (B), KYOTO UNIVERSITY - 新規キラルシクロペンタジエニル配位子をもつ金属錯体の合成とその不斉反応触媒機能
太田 哲男
日本学術振興会, 科学研究費助成事業, 1991 -1991, 奨励研究(A), 京都大学 - 新規反応活性メタラサイクル化合物の合成、構造、反応性に関する研究
高谷 秀正; 太田 哲男
環状有機化合物の環を構成する炭素の一部が金属で置き替った化合物はメタラサイクル化合物と呼ばれ、近年、遷移金属錯体を触媒とするメタセシス反応、カルベノイド反応、オリゴメリゼ-ション、重合反応など多くの重要な反応の中間体としてその化学が注目されている。本課題では主としてチタノセン残基を環内に含むチタナシクロペンタン及び1ーオキサー5ーチタナシクロペンタンの誘導体の合成、構造、反応性などについて研究を進めた。具体的には、本研究者らが既に錯体Cp^*_2Ti(C_2H_4)〔1〕(Cp^*はペンタメチルシクロペンタジエニル基)と高歪みチレフィンのメチレンシクロプロパン〔2〕とから初めて単離可能なほど安定なチタナシクロペンタン体〔3〕の合成に成功しているので、これらの成果をベ-スにしてさらに本分野の展開を計った。 (1)〔1〕と2ーフェニルメチレンシクロプロパン〔4〕の反応により得られるチタナシクロペンタン〔5〕の構造をX線構造解析により明らかにした。 (2)錯体〔1〕とフェニルアレン〔6〕ならびに2,2ージフェニルメチレンシクロプロパン〔7〕の反応を検討した。これらの歪化合物は、メチレンシクロプロパンの場合とは異なり、チタナシクロペンタンは得られず、〔6〕の場合は配位子交換により新規チタノセンーアレン錯体が得られ、〔7〕は1,1ージフェニルブタジエンに定量的に異性化した。 (3)錯体〔3、5〕の反応性を検討するために熱分解,加水分解、水素化分解を行った。熱分解反応では、βー炭素炭素結合開裂反応による生成物とともに、前周期メタラサイクル化合物では初めて還元的脱離による生成物が見られた。それらの化合物の生成経路を重水素標識実験により明らかにした。 (4)〔1〕と金属カルボニル化合物(Mn、Re、Cr、Mo、W)〔8〕の反応による親規オキサチタナシクロペンタンカルベンー金属錯体〔9〕の合成に成功した。錯体〔9〕の熱分解反応ならびに、アルキン類、イソニトリルとの反応を検討した結果、本錯体の構造上の特徴がその反応性に良く反映されていることがわかった。 (5)錯体〔5〕と一酸化炭素の反応を検討し、シクロペンタノン誘導体の生成を確認した。その反応機構を推定するためにオキサチタナシクロペンタン錯体〔10〕とCOの反応を行ったところ、チタン炭素結合にCOが挿入した6員環チタン錯体が得られ、X線構造解析によって本錯体がη^1ーアシル構造をもつことを初めて明らかにした。 (6)キラルなシクロペンタジエン化合物である1,5ージフェニルトリプタセペンの合成経路を確立し、チタン錯体の合成を行った。今後、この錯体の触媒活性などについてさらに検討を加える。, 日本学術振興会, 科学研究費助成事業, 1991 -1991, 一般研究(C), 京都大学 - Development of New Chiral Transition-Metal Catalysts for Highly Efficient Asymmetric Synthesis
TAKAYA Hidemasa; MASHIMA Kazushi
We had already developed atroisomeric bis (triarylphosphine) ligand, 2, 2^'-bis (diphenylphosphino)-1, 1^'-binaphthyl (abbreviated to BINAP) and showed that its metal complexes had high efficiency as catalysts for asymmetric hydrogenation of -acylaminoacrylic acids and asymmetric isomerization of allylamines into enamines by 1, 3-hydrogen migration. We also reported synthesis of Ru (OCOR) _2 (binap), the first mononuclear BINAP-Ru (II) complexes, and demonstrated that they are highly efficient catalysts for the asymmetric hydrogenations of emanides, alpha, beta- and beta, gamma-unsaturated carboxylic acids, allylic and homoallylic alcohols. In order to expand the synthetic utility of BINAP ligand, we have continued our investigation on the development of new highly efficient asymmetric reactions catalyzed by various BINAP-Ru (II) complexes which have been summarized below. (1) New cationic BINAP-Ru (II) complexes [RuX (binap) (arene)]y (X=Cl, Br, and I ; Y = Cl, Br, I, BF_<4'> and BPh_4 ; arene = benzene and p-cymene) have been synthesized in high yields and the molecular structures have been determined by spectroscopic and X-ray analyses. We have shown that these complexes are highly efficient catalysts for enantioselective hydrogenation of various unsaturated substrates. Especially important is the high efficiency of these complexes as catalysts for asymmetric hydrogenation of functionalized ketones. (2) A number of substituted BINAP derivatives have been synthesized. Various factors controlling the catalytic activity and selectivity of the asymmetric hydrogenation of ketones have been elucidated by use of these complexes. (3) Highly diastereoselective hydrogenation of methyl 2-benzamidomethyl-3-oxobutanoate via dynamic kinetic resolution has been accomplished by using [RuI ((R-3, 5-di-tert-Bu-binap) (p-cymene)] I as catalyst, giving methyl (2S, 3R-2-benzamidomethyl-3-hydroxybutanoate (98% 99%), a versatile intermediate intermediate for the synthesis of beta-lactam antibiotics. (4) Mechanism of asymmetric hydrogenation of alpha,beta-unsaturated carboxylic acids catalyzed by Ru (OCOCH_3) _2 (bianp) has been elucidated based mainly on deuterium-labeled experiments. (5) New monocationic trinuclear complexes [Ru_3X_5 (binap) _3] Y have been prepared and their roles in catalytic reactions have been discussed. (6) Several new bis (triaryphophine) ligands have been synthesized and their use for asymmetric catalysis have been investigated., Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 1989 -1990, Grant-in-Aid for General Scientific Research (B), Kyoto University - ヘテロ原子の特性を生かした有機合成
Competitive research funding - 有機金属化合物の合成と利用
Competitive research funding - 不斉触媒反応に関する研究
Competitive research funding - Organic Synthesis by Use of Special Feature of Hetero Atom
Competitive research funding - Synthesis and Application of Organometallic Compounds
Competitive research funding - Study on Asymmetric Catalysis
Competitive research funding