Researcher Profile and Settings

URL

http://izawalab.wixsite.com/izawalab

researchmap

https://researchmap.jp/tig-2005-ers

Research Interests

• スポーツ生理・生化学
• Physiology and Biochemistry of Sport

Research Areas

• Life sciences / Nutrition and health science
• Life sciences / Sports science

Research Experience

• Doshisha University, Graduate School of Health and Sports Science, 教授, 2010/04 - Today
• Doshisha University, Faculty of Health and Sports Science, 教授, 2008/04 - Today
• 国立大学法人筑波大学, 生命領域学際研究センター, 客員教授, 2010/11 - 2016/03
• Tokyo Metropolitan University, 2005 - 2008
• 東京都立大学大学院理学研究科博士課程教授, 2000 - 2008
• 東京都立大学大学院理学研究科博士課程助教授, 1997 - 2000
• The University of Electro-Communications, Faculty of Electro-Communications, 1992 - 1997
• Tokyo University of Pharmacy and Life Sciences, School of Pharmacy, 1992 - 1992
• Tokyo University of Pharmacy and Life Sciences, School of Pharmacy, 1981 - 1992

Education

• University of Tsukuba, Master's Program in Health and Sport Sciences, 健康教育学専攻, - 1981
• University of Tsukuba, Graduate School, Division of Physical Education, - 1981
• University of Tsukuba, School of Health and Physical Education, - 1979
• University of Tsukuba, School of Health and Physical Education, - 1979

Association Memberships

• American Physiological Society, Aug. 2020, 9999
• 日本臨床栄養協会
• JAPAN SOCIETY FOR THE STUDY OF OBESITY
• 日本運動生理学会
• 日本生理学会
• 日本生化学会
• 日本比較生理生化学会
• 日本宇宙航空環境学会
• 日本体力医学会
• Japanese society of exercise and sport
• Japanese society of physiology
• Japanese society of biochemistry

Committee Memberships

• 健康医科学研究助成選考委員会 委員長, 2023/04 - Today, 明治安田厚生事業団, Others
• 健康医科学研究助成選考委員会 委員, 2010/04 - Today, 明治安田厚生事業団, Others
• 評議員, 1994/04 - Today, 日本運動生理学会, Society, 日本運動生理学会
• 評議員, 1986 - Today, 日本生理学会, Society, 日本生理学会
• 評議員, 1986 - Today, 日本体力医学会, Society, 日本体力医学会
• 学術委員会学会選考委員会 委員, 2017/11 - 2023/10, 日本体力医学会, Society
• 編集委員会 委員, 2012/05 - 2016/09, 日本運動生理学会, Society
• 編集委員会 委員, 2012/05 - 2016/09, 日本体力医学会, Society
• 学術委員会称号委員会 委員, 2003/05 - 2006/03, 日本体力医学会, Society
• 理事, 2001/04 - 2006/03, 日本運動生理学会, Society
• 編集委員会 委員, 2001/04 - 2003/03, 日本運動生理学会, Society
• 学術委員会プロジェクト研究委員会 委員, 2000/07 - 2003/03, 日本体力医学会, Society

Awards

• 大塚スポーツ医･科学賞 特別賞
  Sep. 2018, 日本体力医学会・大塚製薬, 脂肪由来間葉系幹細胞の神経様細胞への分化能に及ぼす高脂肪食摂取および運動トレーニングの影響
• 若手奨励賞
  Mar. 2016, 京都滋賀体育学会, 脂肪由来間葉系幹細胞の神経様細胞への分化能に及ぼす高脂肪食摂取および運動トレーニングの影響
• 第１回杏林医学会研究奨励賞（優秀論文賞）
  Nov. 2012, 杏林医学会, Higher levels of ATGL are associated with exercise-induced enhancement of lipolysis in rat epididymal adipocytes. PLoS One, 7, e40876 (2012).
• 平成22年度日本衛生学会奨励賞
  Sep. 2012, 日本衛生学会, Preventive and improvement effects of exercise training and supplement intake in white adipose tissues on obesity and lifestyle-related diseases, Environ. Health Prev. Med., 17, 348-356 (2012).
• 第20回日本運動生理学会大会奨励賞
  Jul. 2012, 第20回日本運動生理学会大会, 水泳運動は骨格筋前駆細胞から褐色脂肪細胞への分化を促進する
• 第21回体力・栄養・免疫学会大会倉掛賞(優秀発表賞)
  Aug. 2011, 体力・栄養・免疫学会, 脂肪細胞の脂肪分解反応に及ぼす新規カテキン型ポリフェノール複合体Oligonolの効果
• 第80回日本衛生学会学術総会学術総会会長賞
  May 2010, 日本衛生学会, 運動トレーニングによる脂肪細胞の脂肪分解反応とAdipose Triglyceride Lipase (ATGL) の役割
• 第13回日本運動生理学会若手優秀発表賞
  Jul. 2005, 第13回日本運動生理学会, 腫瘍壊死因子α（TNF-α）が誘導する脂肪合成関連遺伝子の発現に及ぼす運動トレーニングの影響
• 第13回日本運動生理学会大会若手優秀発表賞
  Jul. 2005, 第13回日本運動生理学会大会, β-アドレナリン受容体を介する情報伝達系の運動による変化：Gタンパク共役型受容体キナーゼ(GRK)とユビキチン-プロテアソームの役割

Published Papers

• Exercise training-driven exosomal miRNA-323-5p activity suppresses adipogenic conversion of 3T3-L1 cells via the DUSP3/ERK pathway.
  Seita Osawa; Hisashi Kato; Daigo Kemmoku; Sachiko Yamaguchi; Lureien Jiang; Yoshifumi Tsuchiya; Hisashi Takakura; Tetsuya Izawa
  Biochemical and biophysical research communications, 734 150447 - 150447, 26 Jul. 2024, Scientific journal
  

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• High-intensity interval training enhances mRNA expression of IGF1Ea in rat Achilles tendon
  Yoshifumi Tsuchiya; Hisashi Takakura; Seita Osawa; Tetsuya Izawa
  Molecular Biology Reports, Springer Science and Business Media LLC, 51(1), 29 Feb. 2024, Scientific journal
  

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• Impact of high-intensity interval training on tendon related gene expression in rat Achilles tendon
  Yoshifumi Tsuchiya; Hisashi Takakura; Seita Osawa; Tetsuya Izawa
  Biochemical and Biophysical Research Communications, Elsevier BV, Mar. 2023, Scientific journal
  

  DOI URL
• Depression of Bone Density at the Weight-Bearing Joints in Wistar Hannover Rats by a Simulated Mechanical Stress Associated With Partial Gravity Environment
  Shenke Zhang; Daishin Ueno; Takashi Ohira; Hisashi Kato; Tetsuya Izawa; Sakuya Yamanouchi; Yukari Yoshida; Akihisa Takahashi; Yoshinobu Ohira
  Frontiers in Cell and Developmental Biology, Frontiers Media SA, 9, 26 Jul. 2021, Scientific journal
  

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• Metabolomic Profiles in Adipocytes Differentiated from Adipose-Derived Stem Cells Following Exercise Training or High-Fat Diet
  Seita Osawa; Hisashi Kato; Yuki Maeda; Hisashi Takakura; Junetsu Ogasawara; Tetsuya Izawa
  International Journal of Molecular Sciences, MDPI AG, 22(2) 966 - 966, 19 Jan. 2021, Scientific journal
  

  DOI URL
• Homeobox A5 and C10 genes modulate adaptation of brown adipose tissue during exercise training in juvenile rats
  Hisashi Kato; Takuto Ario; Toshiaki Kishida; Manami Tadano; Seita Osawa; Yuki Maeda; Hisashi Takakura; Tetsuya Izawa
  Experimental Physiology, Wiley, 106(2) 463 - 474, 05 Jan. 2021, Scientific journal
  

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• Effect of hypoxia exposure after endurance training on muscle oxidative metabolism(和訳中)
  Takakura Hisashi; Takahashi Kazuya; Sudo Mizuki; Ando Soichi; Kato Hisashi; Oosawa Seita; Izawa Tetsuya
  The Journal of Physical Fitness and Sports Medicine, (一社)日本体力医学会, 9(6) 324 - 324, Nov. 2020
• Exercise Training-Enhanced Lipolytic Potency to Catecholamine Depends on the Time of the Day
  Hisashi Kato; Junetsu Ogasawara; Hisashi Takakura; Ken Shirato; Takuya Sakurai; Takako Kizaki; Tetsuya Izawa
  International Journal of Molecular Sciences, MDPI AG, 21(18) 6920 - 6920, 21 Sep. 2020, Scientific journal
  

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• Effects of physical activity and melatonin on brain-derived neurotrophic factor and cytokine expression in the cerebellum of high-fat diet-fed rats.
  Ai Sugiyama; Hisashi Kato; Hisashi Takakura; Seita Osawa; Yuki Maeda; Tetsuya Izawa
  Neuropsychopharmacology reports, 18 Jul. 2020, Scientific journal
  

  DOI URL
• Exercise ameliorates high-fat diet-induced impairment of differentiation of adipose-derived stem cells into neuron-like cells in rats
  Hisashi Kato; Hidemasa Minamizato; Hideki Ohno; Yoshinobu Ohira; Tetsuya Izawa
  Journal of Cellular Physiology, Wiley, 234(2) 1452 - 1460, Feb. 2019, Scientific journal
  

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• Effect of a 9-week exercise training regimen on expression of developmental genes related to growth-dependent fat expansion in juvenile rats
  Hisashi Kato; Takuya Shibahara; Nazibur Rahman; Hisashi Takakura; Yoshinobu Ohira; Tetsuya Izawa
  Physiological Reports, 6(19) e13880 , Sep. 2018, Scientific journal
  

  DOI URLScopus URLScopus Citedby URL
• Differential response of adipose tissue gene and protein expressions to 4- and 8-week administration of β-guanidinopropionic acid in mice
  Hisashi Kato; Shinya Masuda; Tomotaka Ohira; Luna Ohira; Hisashi Takakura; Yoshinobu Ohira; Tetsuya Izawa
  Physiological Reports, 6(5) e13616 , Mar. 2018, Scientific journal
  

  DOI URLScopus URLScopus Citedby URL
• Detrimental responses of the properties in rat soleus muscle to passive continuous stretch
  Hisashi Kato; Daishin Ueno; Takashi Ohira; Fuminori Kawano; Katsumasa Goto; Hideki Ohno; Tetsuya Izawa; Yoshinobu Ohira
  Japanese Journal of Aerospace and Environmental Medicine, 54(3) 37 - 44, 2017, Scientific journal
• Exercise Training Attenuates the Dysregulated Expression of Adipokines and Oxidative Stress in White Adipose Tissue
  Takuya Sakurai; Junetsu Ogasawara; Ken Shirato; Tetsuya Izawa; Shuji Oh-ishi; Yoshinaga Ishibashi; Zsolt Radak; Hideki Ohno; Takako Kizaki
  Oxidative Medicine and Cellular Longevity, HINDAWI LTD, 2017 9410954 , 2017, Scientific journal
  

  DOI URL
• Endurance exercise training induces fat depot-specific differences in basal autophagic activity
  Goki Tanaka; Hisashi Kato; Tetsuya Izawa
  Biochemical and Biophysical Research Communications, ACADEMIC PRESS INC ELSEVIER SCIENCE, 466(3) 512 - 517, Oct. 2015, Scientific journal
  

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• Melatonin promotes adipogenesis and mitochondrial biogenesis in 3T3-L1 preadipocytes
  Hisashi Kato; Goki Tanaka; Shinya Masuda; Junetsu Ogasawara; Takuya Sakurai; Takako Kizaki; Hideki Ohno; Tetsuya Izawa
  Journal of Pineal Research, WILEY, 59(2) 267 - 275, Sep. 2015, Scientific journal
  

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• Habitual exercise training acts as a physiological stimulator for constant activation of lipolytic enzymes in rat primary white adipocytes
  Junetsu Ogasawara; Tetsuya Izawa; Takuya Sakurai; Ken Shirato; Yoshinaga Ishibashi; Yoshinobu Ohira; Hitoshi Ishida; Hideki Ohno; Takako Kizaki
  Biochemical and Biophysical Research Communications, ACADEMIC PRESS INC ELSEVIER SCIENCE, 464(1) 348 - 353, Aug. 2015, Scientific journal
  

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• Macrophage deficiency in osteopetrotic (op/op) mice inhibits activation of satellite cells and prevents hypertrophy in single soleus fibers
  T. Ohira; X. D. Wang; T. Ito; F. Kawano; K. Goto; T. Izawa; H. Ohno; T. Kizaki; Y. Ohira
  American Journal of Physiology-Cell Physiology, AMER PHYSIOLOGICAL SOC, 308(10) C848 - C855, May 2015, Scientific journal
  

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• Endurance training facilitates myoglobin desaturation during muscle contraction in rat skeletal muscle
  Hisashi Takakura; Yasuro Furuichi; Tatsuya Yamada; Thomas Jue; Minoru Ojino; Takeshi Hashimoto; Satoshi Iwase; Tatsuya Hojo; Tetsuya Izawa; Kazumi Masuda
  Scientific Reports, NATURE PUBLISHING GROUP, 5 9403 , Mar. 2015, Scientific journal
  

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• Effect of Circadian Rhythm on Clinical and Pathophysiological Conditions and Inflammation
  Takako Kizaki; Shogo Sato; Ken Shirato; Takuya Sakurai; Junetsu Ogasawara; Tetsuya Izawa; Yoshinobu Ohira; Kenji Suzuki; Hideki Ohno
  Critical Reviews in Immunology, BEGELL HOUSE INC, 35(4) 261 - 275, 2015, Scientific journal
  

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• The molecular mechanism underlying continuous exercise training-induced adaptive changes of lipolysis in white adipose cells
  Junetsu Ogasawara; Tetsuya Izawa; Tomonobu Sakurai; Takuya Sakurai; Ken Shirato; Yoshinaga Ishibashi; Hitoshi Ishida; Hideki Ohno; Takako Kizaki
  Journal of Obesity, Hindawi Limited, 2015 47340 , 2015, Scientific journal
  

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• Age-induced muscle atrophy and increase in fatigue resistance.
  Masuda S; Takakura H; Kato H; Izawa T
  Journal of Physical Firness and Sports Medicine, The Japanese Society of Physical Fitness and Sports Medicine, 3(4) 435 - 439, Oct. 2014, Scientific journal
  

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• ETAS, an Enzyme-treated Asparagus Extract, Attenuates Amyloid beta-Induced Cellular Disorder in PC12 Cells
  Junetsu Ogasawara; Tomohiro Ito; Koji Wakame; Kentaro Kitadate; Takuya Sakurai; Shogo Sato; Yoshinaga Ishibashi; Tetsuya Izawa; Kazuto Takahashi; Hitoshi Ishida; Ichiro Takabatake; Takako Kizaki; Hideki Ohno
  Natural Product Communications, NATURAL PRODUCTS INC, 9(4) 561 - 564, Apr. 2014, Scientific journal
• A Circadian Clock Gene, Rev-erb alpha, Modulates the Inflammatory Function of Macrophages through the Negative Regulation of Ccl2 Expression
  Shogo Sato; Takuya Sakurai; Junetsu Ogasawara; Motoko Takahashi; Tetsuya Izawa; Kazuhiko Imaizumi; Naoyuki Taniguchi; Hideki Ohno; Takako Kizaki
  Journal of Immunology, AMER ASSOC IMMUNOLOGISTS, 192(1) 407 - 417, Jan. 2014, Scientific journal
  

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• Direct and indirect suppression of interleukin-6 gene expression in murine macrophages by nuclear orphan receptor REV-ERB α
  Shogo Sato; Takuya Sakurai; Junetsu Ogasawara; Ken Shirato; Yoshinaga Ishibashi; Shuji Oh-Ishi; Kazuhiko Imaizumi; Shukoh Haga; Yoshiaki Hitomi; Tetsuya Izawa; Yoshinobu Ohira; Hideki Ohno; Takako Kizaki
  Scientific World Journal, Hindawi Publishing Corporation, 2014, 2014, Scientific journal
  

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• Role of nitric oxide in muscle regeneration following eccentric muscle contractions in rat skeletal muscle
  Tomonobu Sakurai; Osamu Kashimura; Yutaka Kano; Hideki Ohno; Li Li Ji; Tetsuya Izawa; Thomas M. Best
  Journal of Physiological Sciences, 63(4) 263 - 270, Jul. 2013, Scientific journal
  

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• 高所環境は肥満を改善する（総説）
  大野秀樹; 木崎節子; 櫻井拓也; 井澤鉄也
  登山医学, (一社)日本登山医学会, 33(1) 161 - 171, 2013, Scientific journal
  

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• The Effects of Exercise Training on Obesity-Induced Dysregulated Expression of Adipokines in White Adipose Tissue
  Takuya Sakurai; Junetsu Ogasawara; Takako Kizaki; Shogo Sato; Yoshinaga Ishibashi; Motoko Takahashi; Osamu Kobayashi; Shuji Oh-ishi; Junichi Nagasawa; Kazuto Takahashi; Hitoshi Ishida; Tetsuya Izawa; Hideki Ohno
  International Journal of Endocrinology, HINDAWI PUBLISHING CORPORATION, Article ID 801743 28 , 2013, Scientific journal
  

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• Oligomerised lychee fruit-derived polyphenol attenuates cognitive impairment in senescence-accelerated mice and endoplasmic reticulum stress in neuronal cells.
  Sakurai T; Kitadate K; Nishioka H; Fujii H; Ogasawara J; Kizaki T; Sato S; Fujiwara T; Akagawa K; Izawa T; Ohno H
  British Journal of Nutrition, 110(9) 1549 - 1558, 2013, Scientific journal
  

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• Preventive and improvement effects of exercise training and supplement intake in white adipose tissues on obesity and lifestyle-related diseases
  Takuya Sakurai; Junetsu Ogasawara; Takako Kizaki; Yoshinaga Ishibashi; Yoshikazu Sumitani; Kazuto Takahashi; Hitoshi Ishida; Hiromi Miyazaki; Daizoh Saitoh; Shukoh Haga; Tetsuya Izawa; Hideki Ohno
  Environmental Health and Preventive Medicine, 17(5) 348 - 356, Sep. 2012, Scientific journal
  

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• Oligonol-induced Degradation of Perilipin 1 is Regulated through Lysosomal Degradation Machinery
  Junetsu Ogasawara; Kentaro Kitadate; Hiroshi Nishioka; Hajime Fujii; Takuya Sakurai; Takako Kizaki; Tetsuya Izawa; Hitoshi Ishida; Hideki Ohno
  Natural Product Communications, NATURAL PRODUCTS INC, 7(9) 1193 - 1196, Sep. 2012, Scientific journal
• Higher Levels of ATGL Are Associated with Exercise-Induced Enhancement of Lipolysis in Rat Epididymal Adipocytes
  Junetsu Ogasawara; Takuya Sakurai; Takako Kizaki; Yoshinaga Ishibashi; Tetsuya Izawa; Yoshikazu Sumitani; Hitoshi Ishida; Zsolt Radak; Shukoh Haga; Hideki Ohno
  PLOS ONE, PUBLIC LIBRARY SCIENCE, 7(7) e40876 , Jul. 2012, Scientific journal
  

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• 運動は肥満・糖尿病によるアルツハイマー病発症リスクを軽減するか
  櫻井拓也; 小笠原準悦; 木崎節子; 石橋義永; 藤原智徳; 赤川公朗; 井澤鉄也; 芳賀脩光; 大野秀樹
  第27回健康医科学研究助成論文集, 87 - 96, 2012
• The effects of exercise on macrophage function.
  Kizaki T; Sato S; Sakurai T; Ogasawara J; Imaizumi K; Izawa T; Nagasawa J; Saitoh D; Haga S; Ohno H
  Journal of Physical Fitness and Sports Medicine, The Japanese Society of Physical Fitness and Sports Medicine, 1(1) 113 - 123, 2012, Scientific journal
  

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• Effect of physical exercise on lipolysis in white adipocytes.
  Ogasawara J; Sakurai T; Kizaki T; Takahashi K; Ishida H; Izawa T; Toshinai K; Nakano N; Ohno H
  Journal of Physical Fitness and Sports Medicine, The Japanese Society of Physical Fitness and Sports Medicine, 1(2) 351 - 356, 2012, Scientific journal
  

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• Exercise training and the promotion of neurogenesis and neurite outgrowth in the hippocampus.
  Sakurai T; Ogasawara J; Kizaki T; Ichibashi Y; Fujiwara T; Akagawa K; Izawa T; Radak Z; Ohno H
  Journal of Physical Fitness and Sports Medicine, The Japanese Society of Physical Fitness and Sports Medicine, 1(2) 333 - 337, 2012, Scientific journal
  

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• Recent advances in the adaptations of adipose tissue to physical activity: Morphology and adipose tissue cellularity.
  Izawa T; Ogasawara J; Sakurai T; Bomura S; Kizaki T; Ohno H
  Journal of Physical Fitness and Sports Medicine, The Japanese Society of Physical Fitness and Sports Medicine, 1(3) 381 - 387, 2012, Scientific journal
  

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• Effect of exercise training on the density of endothelial cells in the white adipose tissue of rats
  D. Hatano; J. Ogasawara; S. Endoh; T. Sakurai; S. Nomura; T. Kizaki; H. Ohno; T. Komabayashi; T. Izawa
  Scandinavian Journal of Medicine & Science in Sports, WILEY-BLACKWELL, 21(6) E115 - E121, Dec. 2011, Scientific journal
  

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• Involvement of leucine zipper transcription factor-like protein 1 (Lztfl1) in the attenuation of cognitive impairment by exercise training
  Takuya Sakurai; Junetsu Ogasawara; Takako Kizaki; Yoshinaga Ishibashi; Tomonori Fujiwara; Kimio Akagawa; Tetsuya Izawa; Shuji Oh-ishi; Shukoh Haga; Hideki Ohno
  Biochemical and Biophysical Research Communications, ACADEMIC PRESS INC ELSEVIER SCIENCE, 416(1-2) 125 - 129, Dec. 2011, Scientific journal
  

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• Voluntary exercise attenuates obesity-associated inflammation through ghrelin expressed in macrophages
  Takako Kizaki; Taketeru Maegawa; Takuya Sakurai; Jun-etsu Ogasawara; Tomomi Ookawara; Shuji Oh-ishi; Tetsuya Izawa; Shukoh Haga; Hideki Ohno
  Biochemical and Biophysical Research Communications, ACADEMIC PRESS INC ELSEVIER SCIENCE, 413(3) 454 - 459, Sep. 2011, Scientific journal
  

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• Comparison of the Effect of Oligonol, A New Lychee Fruit-derived Low Molecular Form of Polyphenol, and Epigallocatechin-3-gallate on Lipolysis in Rat Primary Adipocytes
  Junetsu Ogasawara; Kentaro Kitadate; Hiroshi Nishioka; Hajime Fujii; Takuya Sakurai; Takako Kizaki; Tetsuya Izawa; Hitoshi Ishida; Hideki Ohno
  Phytotherapy Research, WILEY, 25(3) 467 - 471, Mar. 2011, Scientific journal
  

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• Effects of exercise training on adipogenesis of stromal-vascular fraction cells in rat epididymal white adipose tissue
  T. Sakurai; S. Endo; D. Hatano; J. Ogasawara; T. Kizaki; S. Oh-ishi; T. Izawa; H. Ishida; H. Ohno
  Acta Physiologica, WILEY-BLACKWELL PUBLISHING, INC, 200(4) 325 - 338, Dec. 2010, Scientific journal
  

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• Oligonol, an oligomerized lychee fruit-derived polyphenol, activates the Ras/Raf-1/MEK1/2 cascade independent of the IL-6 signaling pathway in rat primary adipocytes
  Junetsu Ogasawara; Kentaro Kitadate; Hiroshi Nishioka; Hajime Fujii; Takuya Sakurai; Takako Kizaki; Tetsuya Izawa; Hitoshi Ishida; Masataka Tanno; Hideki Ohno
  Biochemical and Biophysical Research Communications, ACADEMIC PRESS INC ELSEVIER SCIENCE, 402(3) 554 - 559, Nov. 2010, Scientific journal
  

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• Hormone-sensitive lipase is critical mediators of acute exercise-induced regulation of lipolysis in rat adipocytes
  Junetsu Ogasawara; Sachiko Nomura; Nazibur Rahman; Takuya Sakurai; Takako Kizaki; Tetsuya Izawa; Hitoshi Ishida; Shukoh Haga; Hideki Ohno
  Biochemical and Biophysical Research Communications, ACADEMIC PRESS INC ELSEVIER SCIENCE, 400(1) 134 - 139, Sep. 2010, Scientific journal
  

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• Effect of exercise training on adipocyte-size-dependent expression of leptin and adiponectin
  Satoko Miyazaki; Tetsuya Izawa; Jun-etsu Ogasawara; Takuya Sakurai; Sachiko Nomura; Takako Kizaki; Hideki Ohno; Takao Komabayashi
  Life Sciences, PERGAMON-ELSEVIER SCIENCE LTD, 86(17-18) 691 - 698, Apr. 2010, Scientific journal
  

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• Possible mechanisms underlying effects of Oligonol, a new lychee fruit-derived low molecular from of polyphenol, on fat metabolism in primary adipocytes
  小笠原 準悦; 北舘 健太郎; 西岡 浩; 藤井 創; 櫻井 拓也; 木崎 節子; 井澤 鉄也; 長澤 純一; 斉藤 大蔵; 今泉 和彦; 大野 秀樹
  人間科学研究, 早稲田大学人間科学学術院, 23(1) 132 - 132, Mar. 2010
• 運動トレーニングによる肥満・生活習慣病および認知症予防効果とそのメカニズム
  櫻井 拓也; 小笠原 準悦; 木崎 節子; 石橋 義永; 白土 健; 井澤 鉄也; 今泉 和彦; 鈴木 健二; 野口 いづみ; 芳賀 脩光; 大野 秀樹
  人間科学研究, 23(1) 131 - 131, Mar. 2010
• Oligomerized grape seed polyphenols attenuate inflammatory changes due to antioxidative properties in coculture of adipocytes and macrophages
  Takuya Sakurai; Kentaro Kitadate; Hiroshi Nishioka; Hajime Fujii; Takako Kizaki; Yasumasa Kondoh; Tetsuya Izawa; Hitoshi Ishida; Zsolt Radak; Hideki Ohno
  Journal of Nutritional Biochemistry, ELSEVIER SCIENCE INC, 21(1) 47 - 54, Jan. 2010, Scientific journal
  

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• Oligonol, A New Lychee Fruit-derived Low-molecular Form of Polyphenol, Enhances Lipolysis in Primary Rat Adipocytes through Activation of the ERK1/2 pathway
  Junetsu Ogasawara; Kentaro Kitadate; Hiroshi Nishioka; Hajime Fujii; Takuya Sakurai; Takako Kizaki; Tetsuya Izawa; Hitoshi Ishida; Hideki Ohno
  Phytotherapy Research, JOHN WILEY & SONS LTD, 23(11) 1626 - 1633, Nov. 2009, Scientific journal
  

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• 脂肪細胞サイズとアディポカイン遺伝子発現との関係に及ぼす運動トレーニングの影響
  井澤 鉄也; 櫻井 拓也; 小笠原 準悦; 木崎 節子; 大野 秀樹
  人間科学研究, 22(1) 55 - 55, May 2009
• beta(2)-Adrenergic receptor regulate Toll-like receptor 4-induced late-phase NF-kappa B activation
  Takako Kizaki; Ken Shirato; Takuya Sakurai; Jun-etsu Ogasawara; Shuji Oh-ishi; Takeshi Matsuoka; Tetsuya Izawa; Kazuhiko Imaizumi; Shukoh Haga; Hideki Ohno
  Molecular Immunology, PERGAMON-ELSEVIER SCIENCE LTD, 46(6) 1195 - 1203, Mar. 2009, Scientific journal
  

  DOI URL
• Exercise training decreases expression of inflammation-related adipokines through reduction of oxidative stress in rat white adipose tissue
  Takuya Sakurai; Tetsuya Izawa; Takako Kizaki; Jun-Etsu Ogasawara; Ken Shirato; Kazuhiko Imaizumi; Kazuto Takahashi; Hitoshi Ishida; Hideki Ohno
  Biochemical and Biophysical Research Communications, ACADEMIC PRESS INC ELSEVIER SCIENCE, 379(2) 605 - 609, Feb. 2009, Scientific journal
  

  DOI URL
• beta(2)-Adrenergic receptor regulates Toll-like receptor-4-induced nuclear factor-kappa B activation through beta-arrestin 2
  Takako Kizaki; Tetsuya Izawa; Takuya Sakurai; Shukoh Haga; Naoyuki Taniguchi; Hisao Tajiri; Kenji Watanabe; Noorbibi K. Day; Kenji Toba; Hideki Ohno
  Immunology, WILEY-BLACKWELL, 124(3) 348 - 356, Jul. 2008, Scientific journal
  

  DOI URL
• Adaptation of macrophages to exercise training improves innate immunity
  Takako Kizaki; Tohru Takemasa; Takuya Sakurai; Tetsuya Izawa; Tomoko Hanawa; Shigeru Kamiya; Shukoh Haga; Kazuhiko Imaizumi; Hideki Ohno
  Biochemical and Biophysical Research Communications, ACADEMIC PRESS INC ELSEVIER SCIENCE, 372(1) 152 - 156, Jul. 2008, Scientific journal
  

  DOI URL
• 肥満予防に対する骨格筋と脂肪組織の役割 : 脂肪組織と骨格筋の脂肪分解反応(シンポジウム1:体力科学における骨格筋研究の展開と展望)
  井澤 鉄也; 櫻井 拓也; 木崎 節子; 大野 秀樹; 駒林 隆夫
  体力科學, 日本体力医学会, 57(1) 22 - 22, 01 Feb. 2008
  

  DOI URL
• Antioxidative effects of a new lychee fruit-derived polyphenol mixture, Oligonol, converted into a low-molecular form in adipocytes
  Takuya Sakurai; Hiroshi Nishioka; Hajime Fujii; Norihiko Nakano; Takako Kizaki; Zsolt Radak; Tetsuya Izawa; Shukoh Haga; Hideki Ohno
  Bioscience Biotechnology and Biochemistry, TAYLOR & FRANCIS LTD, 72(2) 463 - 476, Feb. 2008, Scientific journal
  

  DOI URL
• 358. ライチ由来新規低分子化ポリフェノールOligonolによる疲労改善効果(生活・健康,第62回日本体力医学大会)
  櫻井, 拓也; 北舘, 健太郎; 藤井, 創; 久島, 達也; 安部, 茂; 木崎, 節子; 井澤, 鉄也; 長澤, 純一; 武政, 徹; 芳賀, 脩光; 大野, 秀樹
  Japanese Journal of Physical Fitness and Sports Medicine, The Japanese Society of Physical Fitness and Sport Medicine, 56(6) 757 - 757, Dec. 2007, Scientific journal
• Functional roles of Fli-1, a member of the Ets family of transcription factors, in human breast malignancy
  Takuya Sakurai; Nobuo Kondoh; Masaaki Arai; Jun-Ichi Hamada; Toshiyuki Yamada; Fumiko Kihara-Negishi; Tetsuya Izawa; Hideki Ohno; Mikio Yamamoto; Tsuneyuki Oikawa
  Cancer Science, BLACKWELL PUBLISHING, 98(11) 1775 - 1784, Nov. 2007, Scientific journal
  

  DOI URL
• Exercise before or after refeeding prevents refeeding-induced recovery of cell size after fasting with a different pattern of metabolic gene expressions in rat epididymal adipocytes
  Takuya Sakurai; Megumi Takei; Junetsu Ogasawara; Hiroshi Ueda; Takako Kizaki; Hideki Ohno; Tetsuya Izawa
  Metabolism-Clinical and Experimental, W B SAUNDERS CO-ELSEVIER INC, 56(9) 1270 - 1278, Sep. 2007, Scientific journal
  

  DOI URL
• Transcription regulation of gene expression in rat brown adipose tissue in response to unloading or 2G loading during growing period
  S. Watanabe; Y. Hitomi; F. Kawano; Y. Ohira; T. Kizaki; N. Nakano; T. Sakurai; T. Izawa; K. Suzuki; M. Sudoh; R. R. Roy; H. Ohno
  Acta Astronautica, PERGAMON-ELSEVIER SCIENCE LTD, 60(10-11) 889 - 898, May 2007, Scientific journal
  

  DOI URL
• Antioxidative effect of new lychee-derived polyphenol Oligonol converted into a low-molecular form in adipocytes
  SAKURAI Takuya
  日本衞生學雜誌, (一社)日本衛生学会, 62(2) 672 - 672, Mar. 2007, Scientific journal
  

  PermalinkURL
• beta-Adrenergic receptor trafficking by exercise in rat adipocytes: roles of G-protein-coupled receptor kinase-2, beta-arrestin-2, and the ubiquitin-proteasome pathway
  Junetsu Ogasawara; Minori Sanpei; Nazibur Rahman; Tomonobu Sakurai; Takako Kizaki; Yoshiaki Hitomi; Hideki Ohno; Tetsuya Izawa
  FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, 20(2) 350 - 352, Feb. 2006, Scientific journal
  

  DOI URL
• Exercise training enhances tumor necrosis factor-alpha-induced expressions of anti-apoptotic genes without alterations in caspase-3 activity in rat epididymal adipocytes
  T Sakurai; M Takei; J Ogasawara; N Watanabe; M Sanpei; M Yoshida; D Nakae; T Sakurai; N Nakano; T Kizaki; H Ohno; T Izawa
  JAPANESE JOURNAL OF PHYSIOLOGY, CENTER ACADEMIC PUBL JAPAN, 55(3) 181 - 189, Jun. 2005, Scientific journal
  

  DOI URL
• Changes in nitric oxide and inducible nitric oxide synthase following stretch-induced injury to the tibialis anterior muscle of rabbit
  T Sakurai; J Hollander; SL Brickson; H Ohno; LL Ji; T Izawa; TM Best
  Japanese Journal of Physiology, CENTER ACADEMIC PUBL JAPAN, 55(2) 101 - 107, Apr. 2005, Scientific journal
  

  DOI URL
• タンパク質脱リン酸化酵素カルシニューリンは，骨格筋肥大に関与するか？
  人見嘉哲; 木崎節子; 中野法彦; 武政 徹; 芳賀脩光; 桜井智野風; 井澤鉄也; 谷口直之; 大野秀樹
  体力科学, 54(1) 60 - 61, 2005, Scientific journal
  

  DOI URL
• Seven skeletal muscles rich in slow muscle fibers may function to sustain neutral position in the rodent hindlimb
  Y Hitomia; T Kizaki; S Watanabe; G Matsumura; Y Fujioka; S Haga; T Izawa; N Taniguchi; H Ohno
  Comparative Biochemistry and Physiology B-Biochemistry & Molecular Biology, ELSEVIER SCIENCE INC, 140(1) 45 - 50, Jan. 2005, Scientific journal
  

  DOI URL
• Iron deficiency decreases lipid accumulation but, paradoxically, enhances the expression of sterol regulatory element binding protein-1c in rat epididymal adipose tissue.
  Rahman N; Ogasawara J; Sanpei M; Sakurai T; Komabayashi T; Izawa T
  Adipocytes (New Century Health Publishers), 1(4) 249 - 256, 2005, Scientific journal
• Is angiotensin I-converting enzyme I/D polymorphism associated with endurance performance and/or high altitude adaptation?
  Ohno H; Kizaki T; Suzuki K; Hitomi Y; Nakano N; Sakurai T; Ogiwara R; Sakurai T; Izawa T; Noguchi I; Nagasawa J; Ohnuki Y; Takemasa T; Nukita M; Haga S
  Advances in Exercise and Sports Physiology, Japan Society of Exercise and Sports Physiology, 11(2) 41 - 54, 2005, Scientific journal
• Desensitization of the inhibitory effect of norepinephrine on insulin secretion from pancreatic islets of exercise-trained rats
  Y Urano; T Sakurai; H Ueda; J Ogasawara; T Sakurai; M Takei; T Izawa
  Metabolism-Clinical and Experimental, W B SAUNDERS CO, 53(11) 1424 - 1432, Nov. 2004, Scientific journal
  

  DOI URL
• Acute exercise alters G alpha i2 protein expressions through the ubiquitin-proteasome proteolysis pathway in rat adipocytes
  J Ogasawara; T Sakurai; N Rahman; T Kizaki; Y Hitomi; H Ohno; T Izawa
  Biochemical and Biophysical Research Communications, ACADEMIC PRESS INC ELSEVIER SCIENCE, 323(3) 1109 - 1115, Oct. 2004, Scientific journal
  

  DOI URL
• Down-regulation of beta(2)-adrenergic receptor expression by exercise training increases IL-12 production by macrophages following LPS stimulation
  CE Itoh; T Kizaki; Y Hitomi; T Hanawa; S Kamiya; T Ookawara; K Suzuki; T Izawa; D Saitoh; S Haga; H Ohno
  Biochemical and Biophysical Research Communications, ACADEMIC PRESS INC ELSEVIER SCIENCE, 322(3) 979 - 984, Sep. 2004, Scientific journal
  

  DOI URL
• Effects of nitric oxide in recovery from structural damage in skeletal muscle
  Tomonobu Sakurai; Yutaka Kano; Hideki Ohno; Li Li Ji; Thomas M Best; Tetsuya Izawa
  Experimental Biology, Apr. 2004, International conference proceedings
• Induction of MCIP1 mRNA in rat skeletal muscle indicates the activation of the calcineurin signaling pathway during exercise
  Y Hitomi; T Kizaki; S Watanabe; T Katsumura; K Esaki; T Takemasa; T Kinugasa; S Haga; M Mizuno; T Izawa; H Ohno
  Japanese Journal of Physical Fitness and Sports Medicine, JAPANESE SOC PHYSICAL FITNESS SPORTS MEDICINE, 53(1) 68 - 68, Feb. 2004, Scientific journal
• Effect of acute exercise on ANP-induced inhibition of aldosterone release in rat adrenals.
  Suda K; Hagiwara H; Komabayashi T; Izawa T; Imai H; Hayashi T; Era S
  Advances in Exercise and Sports Physiology, Japan Society of Exercise and Sports Physiology, 10(2) 43 - 47, 2004, Scientific journal
• Distribution of facial motoneurons innervating the common facial muscles of the rabbit and rat
  Rui Furutani; Tetsuya Izawa; Shoei Sugita
  Okajimas Folia Anatomica Japonica, Okajima Foria Anatomica Yaponika Henshubu, 81(5) 101 - 108, 2004, Scientific journal
  

  DOI URL
• Extracellular superoxide dismutaze and lifestyle related diseases.
  Ohno H; Ookawara T; Kizaki T; Hitomi Y; Oh-ishi S; Saitoh D; Kimoto K; Itoh C; Izawa T; Haga S; Suzuki K; Radak Z
  Current Topics in Pharmacology, 8(1) 1 - 15, 2004, Scientific journal
• Enhanced expression of neuronal nitric oxide synthase in islets of exercise-trained rats
  H Ueda; Y Urano; T Sakurai; T Kizaki; Y Hitomi; H Ohno; T Izawa
  Biochemical and Biophysical Research Communications, ACADEMIC PRESS INC ELSEVIER SCIENCE, 312(3) 794 - 800, Dec. 2003, Scientific journal
  

  DOI URL
• Role of nitric oxide in recovery from lengthening contractions in rat skeletal muscle.
  Tomonobu Sakurai; Yutaka Kano; Hideki Ohno; L.L.Ji; T. M. Best; Tetsuya Izawa
  Medicine and Science in Sport and Exercise, 35, S241 , Jun. 2003, International conference proceedings
• Effects of overexpression of the Ets family transcription factor TEL on cell growth and differentiation of K562 cells
  T Sakurai; T Yamada; F Kihara-Negishi; S Teramoto; Y Sato; T Izawa; T Oikawa
  International Journal of Oncology, PROFESSOR D A SPANDIDOS, 22(6) 1327 - 1333, Jun. 2003, Scientific journal
• Physiological sceince of leptin: Recent findings.
  Komabayashi T; Suda K; Izawa T
  Advances in Exercise and Sports Physiology, Japan Society of Exercise and Sports Physiology, 9(3) 77 - 90, 2003, Scientific journal
• Possible role of nitric oxide on adipocyte lipolysis in exercise-trained rats
  H Kawanami; S Nomura; T Sakurai; T Sakurai; H Yamagishi; T Komabayashi; T Izawa
  Japanese Journal of Physiology, CENTER ACADEMIC PUBL JAPAN, 52(4) 343 - 352, Aug. 2002, Scientific journal
  

  DOI URL
• Possible mechanisms by which adipocyte lipolysis is enhanced in exercise-trained rats
  S Nomura; H Kawanami; H Ueda; T Kizaki; H Ohno; T Izawa
  Biochemical and Biophysical Research Communications, ACADEMIC PRESS INC ELSEVIER SCIENCE, 295(2) 236 - 242, Jul. 2002, Scientific journal
  

  DOI URL
• Exercise training increases membrane bound form of tumor necrosis factor-alpha receptors with decreases in the secretion of soluble forms of receptors in rat adipocytes
  Y Ito; S Nomura; H Ueda; T Sakurai; T Kizaki; H Ohno; T Izawa
  Life Sciences, PERGAMON-ELSEVIER SCIENCE LTD, 71(5) 601 - 609, Jun. 2002, Scientific journal
  

  DOI URL
• Relation between fat distributions and several plasma adipocytokines after exercise training in premenopausal and postmenopausal women
  Hideki Hayase; Sachiko Nomura; Takashi Abe; Tetsuya Izawa
  Journal of Physiological Anthropology and Applied Human Science, 21(2) 105 - 113, Mar. 2002, Scientific journal
  

  DOI URLScopus URLScopus Citedby URL
• Effect of acute exercise on the calcinerrin/NFAT signaling pathway in mouse skeletal muscle
  Y, Hitomi; K, Suzuki; T, Kizaki; C, Itoh; K, Murakami; T, Kinugasa; T, Takemasa; K, Esaki; S, Haga; S, Oh-ishi; T, Katsumura; M, Mizuno; T, Izawa; Z, Radak; H, Ohno
  4th International congress of pathophysiology, Budapest, Hungary. June29-July 5, 2002. Organaized by International Society for Pathophysiology, Jan. 2002, International conference proceedings
• Stress- and aging-associated modulation of macrophage functions
  Takako Kizaki; Kenji Suzuki; Tomomi Ookawara; Tetsuya Izawa; Daizoh Saitoh; Shuji Oh-Ishi; Keiichiro Suzuki; Shukoh Haga; Hideki Ohno
  Environmental Health and Preventive Medicine, Japanese Society for Hygiene, 6(4) 218 - 228, 2002, Scientific journal
  

  DOI URL
• 1.Effect of acute exercise on the expression of genes in the calcineurin-NFAT signaling pathway in human skeletal muscle
  HITOMI,YOSHIAKI; SUZUKI,KENJI; KIZAKI,TAKAKO; OHNO,HIDEKI; TAKEMASA,TOHRU; ESAKI,KAZUKI; HAGA,SHUKOH; KATSUMURA,TOSHIHITO; OH-ISHI,SHUJI; MIZUNO,MASAO; NAGASAWA,JUNICHI; IZAWA,TETSUYA
  Japanese Journal of Physical Fitness and Sports Medicine, The Japanese Society of Physical Fitness and Sport Medicine, 50(5) 671 - 671, Oct. 2001, Scientific journal
• Activation and apoptosis of murine peritoneal macrophages by acute cold stress
  T Kizkai; K Suzuki; Y Hitomi; K Iwabuchi; K Onoe; H Ishida; T Izawa; LL Ji; H Ohno
  Biochemical and Biophysical Research Communications, ACADEMIC PRESS INC ELSEVIER SCIENCE, 283(3) 700 - 706, May 2001, Scientific journal
  

  DOI URL
• マクロファージの一酸化窒素産生制御機構
  木崎節子; 鈴木健二; 井澤鉄也; 人見嘉哲; 芳賀脩光; 渡辺憲治; 大野秀樹
  運動生化学, (11+12) 67 - 73, 2001
• 核移行型extracellular superoxide dismutase (EC-SOD) の解析
  大河原知水; 木崎節子; 大石修司; 中尾千登世; 佐藤祐造; 井澤鉄也; 桜井智野風; 長澤純一; 宮崎裕美; 芳賀脩光; 鈴木敬一郎; 大野秀樹
  運動生化学, (11+12) 39 - 41, 2001
• Physical exercise and uncoupling protein family.
  Ohno H; Suzuki K; Hitomi Y; Kimoto K; Itoh C; Miyazawa N; Ookawara T; Suzuki K; Haga S; Sakurai T; Izawa T; Noguchi I; Kizaki T
  Advances in Exercise and Sports Physiology, 7(1) 1 - 15, 2001, Scientific journal
• Relationships among serum triacylglycerol, fat pad weight, and lipolysis in iron-deficient rats
  H Yamagishi; H Okazaki; M Shimizu; T Izawa; T Komabayashi
  Journal of Nutritional Biochemistry, ELSEVIER SCIENCE INC, 11(9) 455 - 460, Sep. 2000, Scientific journal
  

  DOI URL
• Inhibition of adipocyte lipolysis by papaverine: Papaverine can inhibit the redistribution of hormone-sensitive lipase
  T Izawa; S Nomura; T Kizaki; S Oh-ishi; T Ookawara; H Ohno
  Life Sciences, PERGAMON-ELSEVIER SCIENCE LTD, 66(25) PL359 - PL364, May 2000, Scientific journal
  

  DOI URL
• 運動は脂肪細胞の脂肪分解反応を増強させる：その再評価、in vivoとin vitroでなぜ違う？
  野村幸子; 伊藤幸彦; 上田浩司; 川波一美; 井澤鉄也
  第15回明治生命研究助成金論文集, (公財)明治安田厚生事業団, (15) 74 - 82, 2000
• beta-adrenergic receptors and adenylate cyclase activity in the parotid acinar cells from acute streptozotocin-induced diabetic rats
  T Komabayashi; T Ikeda; K Suda; T Izawa
  Research Communications in Molecular Pathology and Pharmacology, P J D PUBLICATIONS LTD, 107(3-4) 311 - 322, 2000, Scientific journal
• Effect of exercise training on ANP receptors
  K Suda; H Hagiwara; Y Kotani; K Kato; M Sasaki; T Izawa; T Komabayashi
  Research Communications in Molecular Pathology and Pharmacology, P J D PUBLICATIONS LTD, 108(3-4) 227 - 235, 2000, Scientific journal
• Swimming training prevents generation of suppressor macrophages during acute cold stress
  T Kizaki; S Haga; Sakata, I; T Ookawara; M Segawa; T Sakurai; T Izawa; H Ohno
  Medicine and Science in Sports and Exercise, LIPPINCOTT WILLIAMS & WILKINS, 32(1) 143 - 148, Jan. 2000, Scientific journal
• 運動誘発性酸化ストレスによる組織傷害‐食細胞の関与と役割‐
  大石修司; 大河原知水; 木崎節子; 十枝内厚次; 宮崎裕美; 芳賀脩光; 井澤鉄也; 桜井智野風; 駒林隆夫; 長澤純一; 大野秀樹
  第14回明治生命研究助成金論文集, 29 - 38, 1999
• Effect of running training on brown adipose tissue activity in rats: A reevaluation
  M Segawa; S Oh-Ishi; T Kizaki; T Ookawara; T Sakurai; T Izawa; J Nagasawa; T Kawada; T Fushiki; H Ohno
  Research Communications in Molecular Pathology and Pharmacology, P J D PUBLICATIONS LTD, 100(1) 77 - 82, Apr. 1998, Scientific journal
• 運動と老化と食細胞
  大石修司; 瀬川雅彦; 木崎節子; 大河原知水; 宮崎裕美; 芳賀脩光; 井澤鉄也; 桜井智野風; 中尾千登世; 佐藤祐造; 大野秀樹
  運動生化学, (10) 20 - 22, 1998
• Application of microdialysis techniques for the study of exercise and environment physiology.
  Aihara Y; Yasumatsu M; Hasegawa H; Izawa T
  Advances in Exercise and Sports Physiology, Japan Society of Exercise and Sports Physiology, 4(1) 1 - 10, 1998, Scientific journal
• Endurance training improves the resistance of rat diaphragm to exercise-induced oxidative stress
  S OhIshi; T Kizaki; T Ookawara; T Sakurai; T Izawa; N Nagata; H Ohno
  American Journal of Respiratory and Critical Care Medicine, AMER LUNG ASSOC, 156(5) 1579 - 1585, Nov. 1997, Scientific journal
• Relationship between cold tolerance and generation of suppressor macrophages during acute cold stress
  T Kizaki; T Ookawara; T Izawa; J Nagasawa; S Haga; Z Radak; H Ohno
  Journal of Applied Physiology, AMER PHYSIOLOGICAL SOC, 83(4) 1116 - 1122, Oct. 1997, Scientific journal
• Effects of endurance training on superoxide dismutase activity, content and mrna expression in rat muscle
  S Ohishi; T Kizaki; J Nagasawa; T Izawa; T Komabayashi; N Nagata; K Suzuki; N Taniguchi; H Ohno
  Clinical and Experimental Pharmacology and Physiology, BLACKWELL SCIENCE, 24(5) 326 - 332, May 1997, Scientific journal
  

  DOI URL
• 脂肪細胞と細胞内Ca²⁺の動き
  井澤鉄也; 桜井智野風; 木崎節子; 大河原知水; 大野秀樹; 駒林隆夫
  運動生化学, (9) 77 - 84, 1997
• マウスextracellular superoxide dismutase (EC-SOD) の精製と組織分布
  大河原知水; 木崎節子; 瀬川雅彦; 若月 徹; 長澤純一; 井澤鉄也; 桜井智野風; 駒林隆夫; 芳賀修光; 大野秀樹
  運動生化学, (9) 109 - 111, 1997
• Glucocorticoid-mediated generation of suppressor macrophages with high density Fc gamma RII during acute cold stress
  T Kizaki; S OhIshi; T Ookawara; M Yamamoto; T Izawa; H Ohno
  Endocrinology, ENDOCRINE SOC, 137(10) 4260 - 4267, Oct. 1996, Scientific journal
  

  DOI URL
• Decreased vascular sensitivity after acute exercise and chronic exercise training in rat thoracic aorta
  T Izawa; M Morikawa; T Mizuta; J Nagasawa; T Kizaki; S OhIshi; H Ohno; T Komabayashi
  Research Communications in Molecular Pathology and Pharmacology, P J D PUBLICATIONS LTD, 93(3) 331 - 342, Sep. 1996, Scientific journal
• Altered intracellular Ca2+ regulation in pancreatic acinar cells from acute streptozotocin-induced diabetic rats
  T Komabayashi; H Sawada; T Izawa; H Kogo
  European Journal of Pharmacology, ELSEVIER SCIENCE BV, 298(3) 299 - 306, Mar. 1996, Scientific journal
  

  DOI URL
• 寒冷適応と運動と生体防御能
  木崎節子; 大石修司; 瀬川雅彦; 若月徹; 福田孝一; 長澤純一; 井澤鉄也; 桜井智野風; 駒林隆夫; 十枝内厚次; 芳賀修光; 大野秀樹
  運動生化学, (8) 17 - 23, 1996
• A single bout of exercise brings about capillary growth in skeletal muscle through basic fibroblast growth factor (bFGF)
  Shuji Oh-Ishi; Hitoshi Yamashita; Takako Kizaki; Naokazu Nagata; Chandan K. Sen; Osmo Hänninen; Tetsuya Izawa; Tomonobu Sakurai; Hideki Ohno
  Pathophysiology, Elsevier B.V., 3(3) 197 - 201, 1996, Scientific journal
  

  DOI URL
• Hypoxia, oxygen stress, and exercise.
  Ohno H; Radak Z; Kizaki T; Ookawara T; Karasawa F; Sato T; Sakurai T; Nagasawa J; Izawa T; Kim CK; Ueno N; Nishida M; Fukawatari Y; Haga S
  Proceedings '96 Knupe International Symposium, 1 - 9, 1996, International conference proceedings
• 環境変化と褐色脂肪組織
  山下 均; 木崎節子; 大石修司; 瀬川雅彦; 大平充宣; 若月徹; 山本三毅夫; 長澤純一; 井澤鉄也; 駒林隆夫; 大野秀樹
  運動生化学, (7) 103 - 105, 1995
• Acute or chronic exercise alters angiotensin II-induced contraction of rat aorta
  T Izawa; M Morikawa; M Inoue; T Mizuta; H Yamashita; H Ohno; T Komabayashi
  Japanese Journal of Physiology, CENTER ACAD PUBL JAPAN, 45(6) 1093 - 1100, 1995, Scientific journal
  

  DOI URL
• Physical exercise and superoxide dismutase isoenzymes in rat skeletal muscle.
  Oh-ishi S; Yamashita H; Kizaki T; Nagasawa J; Sagawa M; Nagata N; Izawa T; Komabayashi T; Suzuki K; Taniguchi N; Ohno H
  Proceedings FISU/CESU Conference, 444 - 445, 1995, International conference proceedings
• Differential effects of physical training and acute exercise on insulin action.
  Nagasawa J; Oh-ishi S; Sagawa M; Kizaki T; Izawa T; Sakurai T; Sato Y; Muraoka I; Ohno H
  Proceedings FISU/CESU Conference, 446 - 447, 1995, International conference proceedings
• Ca2+ and lipolysis in adipocytes from exercise-trained rats
  Izawa T; Komabayashi T
  Journal of Applied Physiology, AMER PHYSIOLOGICAL SOC, 77(6) 2618 - 2624, Dec. 1994, Scientific journal
• Increase in cytosolic-free ca2+ in corticotropin-stimulated white adipocytes
  Izawa T; Mochizuki T; Komabayashi T; Suda K; Tsuboi M
  American Journal of Physiology, AMER PHYSIOLOGICAL SOC, 266(3) E418 - E426, Mar. 1994, Scientific journal
• ラット骨格筋の Mn-SOD 活性，濃度及び mRNA 発現に対する持久走トレーニングと急性運動負荷の影響
  大石修司; 木崎節子; 山下 均; 井澤鉄也; 駒林隆夫; 永田直一; 上野伸正; 中村健一; 大野秀樹
  防衛医科大学校雑誌, (19) 267 - 269, 1994
• Physical exercise and angiogenesis in skeletal muscle.
  Yamashita H; Oh-ishi S; Kizaki T; Sato N; Izawa T; Komabayashi T; Ohno H
  Asian Sports Sciences Congress, Proceedings, 96 - 97, 1994, Scientific journal
• Physical training and Mn-SOD in rat skeletal muscle.
  Nagasawa J; Oh-ishi S; Kizaki T; Yamashita H; Radak Z; Asano K; Izawa T; Komabayashi T; Sato Y; Suzuki K; Taniguchi N; Ohno H
  Asian Sports Sciences Congress, Proceedings, 134 - 135, 1994, Scientific journal
• Lack of the stimulatory effect of guanine-nucleotide on diacylglycerol generation in permeabilized adipocytes from diabetic rats
  Izawa T; Saitou S; Mochizuki T; Komabayashi T
  Research Communications in Molecular Pathology and Pharmacology, P J D PUBLICATIONS LTD, 82(3) 307 - 316, Dec. 1993, Scientific journal
• Mechanism of isoprenaline-stimulated diacylglycerol formation in rat parotid acinar-cells
  Komabayashi T; Noguchi M; Izawa T; Suda K; Tsuboi M
  Japanese Journal of Pharmacology, JAPANESE PHARMACOLOGICAL SOC, 62(4) 379 - 385, Aug. 1993, Scientific journal
  

  DOI URL
• In-vivo adaptative regulation of muscarinic receptors and muscarinic stimulation-induced Ca2+ mobilization during short-term heat exposure in rat parotid-glands
  Fujinami H; Komabayashi T; Izawa T; Suda K; Tsuboi M
  Comparative Biochemistry and Physiology C-Pharmacology Toxicology & Endocrinology, PERGAMON-ELSEVIER SCIENCE LTD, 105(3) 451 - 457, Jul. 1993, Scientific journal
• Effect of insulin on adipocyte lipolysis in exercise-trained rats
  Suda K; Izawa T; Komabayashi T; Tsuboi M; Era S
  Journal of Applied Physiology, AMER PHYSIOLOGICAL SOC, 74(6) 2935 - 2939, Jun. 1993, Scientific journal
• Intralysosomal pH and release of lysosomal-enzymes in the rat-liver after exhaustive exercise
  Tsuboi M; Harasawa K; Izawa T; Komabayashi T; Fujinami H; Suda K
  Journal of Applied Physiology, AMER PHYSIOLOGICAL SOC, 74(4) 1628 - 1634, Apr. 1993, Scientific journal
• Effect of running training on uncoupling protein messenger-rna expression in rat brown adipose-tissue
  Yamashita H; Yamamoto M; Sato Y; Izawa T; Komabayashi T; Saito D; Ohno H
  International Journal of Biometeorology, SPRINGER VERLAG, 37(1) 61 - 64, Feb. 1993, Scientific journal
• Effect of exercise on insulin resistance in adipocytes and the relationship between this effect and aging
  T. Izawa; T. Komabayashi; K. Suda; M. Tsuboi
  Bulletin of the Physical Fitness Research Institute, (83) 181 - 192, 1993, Scientific journal
• In vivo adaptative regulation of muscarinic receptors and muscarinic stimulation-induced Ca2+ mobilization during short-term heat exposure in rat parotid glands
  H. Fujinami; K. Komabayashi; T. Izawa; K. Suda; M. Tsuboi
  Comparative Biochemistry and Physiology. Part C, Comparative, 105(3) 451 - 457, 1993, Scientific journal
  

  DOI URL
• 運動と血管新生
  山下 均; 井澤鉄也; 駒林隆夫; 大河原知水; 木崎節子; 大野秀樹
  運動生化学, (5) 90 - 95, 1993
• 脂肪細胞におけるインスリン抵抗性の身体運動による改善効果と加齢現象との関係
  井澤鉄也; 駒林隆夫; 須田和裕; 坪井実
  体力研究（第８回明治生命研究助成金論文集）, 83 181 - 192, 1993
• Effect of endurance training on angiogenic activity in skeletal-muscles
  Yamashita H; Sato N; Yamamoto M; Gasa S; Izawa T; Komabayashi T; Ishikawa M; Sato Y; Ohno H
  Pflugers Archiv-European Journal of Physiology, SPRINGER VERLAG, 422(4) 332 - 338, Jan. 1993, Scientific journal
• Recovery of β-receptors and adenylate cyclase from desensitization induced by short term heat exposure in rat parotid glands
  Fujinami H; Komabayashi T; Izawa T; Nakamura T; Suda K; Tsuboi M
  General Pharmacology, PERGAMON-ELSEVIER SCIENCE LTD, 24(1) 205 - 210, Jan. 1993, Scientific journal
  

  DOI URL
• Phorbol ester alters carbachol-stimulated diacylglycerol formation in parotid acinar-cells through the hydrolysis of phosphoinositides and phosphatidylcholine
  Komabayashi T; Noguchi M; Izawa T; Suda K; Sawada H; Tsuboi M
  Research Communications in Molecular Pathology and Pharmacology, P J D PUBLICATIONS LTD, 77(3) 285 - 298, Sep. 1992, Scientific journal
• Ca2+ potentiates corticotropin-induced, but not isoproterenol-induced, [H-3] guanosine diphosphate release in rat adipocyte membranes
  Izawa T; Mochizuki T; Komabayashi T; Suda K; Tsuboi M
  Metabolism-Clinical and Experimental, W B SAUNDERS CO, 41(5) 462 - 464, May 1992, Scientific journal
• Ca2+ ionophore and phorbol ester stimulate diacylglycerol formation and phosphatidylcholine hydrolysis in rat parotid acinar-cells
  Komabayashi T; Yakata A; Izawa T; Noguchi M; Suda K; Tsuboi M
  Japanese Journal of Pharmacology, JAPANESE PHARMACOLOGICAL SOC, 59(1) 97 - 103, May 1992, Scientific journal
  

  DOI URL
• Mechanism of carbachol-stimulated diacylglycerol formation in rat parotid acinar-cells
  Komabayashi T; Yakata A; Izawa T; Fujinami H; Suda K; Tsuboi M
  European Journal of Pharmacology-Molecular Pharmacology Section, ELSEVIER SCIENCE BV, 225(3) 209 - 216, Mar. 1992, Scientific journal
• 脂肪分解に関わる細胞内情報伝達系と身体運動
  井澤 鉄也
  運動生化学, (3+4) 100 - 109, 1992
• 寒冷，運動，老化と褐色脂肪組織
  大野秀樹; 山下 均; 大河原知水; 木崎節子; 長澤純一; 斉藤大蔵; 井澤鉄也; 駒林隆夫; 山本三毅夫; 上野伸正; 中村健一
  登山医学, (12) 97 - 103, 1992, Scientific journal
• Substance-p-induced diacylglycerol formation in rat parotid acinar-cells
  Komabayashi T; Yakata A; Izawa T; Suda K; Noguchi M; Tsuboi M
  European Journal of Pharmacology-Molecular Pharmacology Section, ELSEVIER SCIENCE BV, 207(4) 329 - 335, Aug. 1991, Scientific journal
• Enhanced coupling of adenylate-cyclase to lipolysis in permeabilized adipocytes from trained rats
  Izawa T; Komabayashi T; Mochizuki T; Suda K; Tsuboi M
  Journal of Applied Physiology, AMER PHYSIOLOGICAL SOC, 71(1) 23 - 29, Jul. 1991, Scientific journal
• Protein-kinase C-dependent diacylglycerol formation is mediated via ca2+ calmodulin in parotid cells
  Komabayashi T; Yakata A; Izawa T; Suda K; Rubin RP; Tsuboi M
  European Journal of Pharmacology-Molecular Pharmacology Section, ELSEVIER SCIENCE BV, 207(3) 175 - 181, Jul. 1991, Scientific journal
• Enhanced coupling of adenylate cyclase to lipolysis in permeabilized adipocytes from trained rats
  T. Izawa; T. Komabayashi; T. Mochizuki; K. Suda; M. Tsuboi
  Journal of Applied Physiology, 71(1) 23 - 29, 1991, Scientific journal
• INVIVO ADAPTIVE-CONTROL OF BETA-RECEPTORS AND ADENYLATE-CYCLASE DURING SHORT-TERM HEAT EXPOSURE IN RAT PAROTID-GLANDS
  H FUJINAMI; T KOMABAYSHI; T IZAWA; T NAKAMURA; K SUDA; M TSUBOI
  Comparative Biochemistry and Physiology [C]-Pharmacology Toxicology & Endocrinology, PERGAMON-ELSEVIER SCIENCE LTD, 98(2-3) 411 - 416, 1991, Scientific journal
• Diacylglycerol accumulation is involved in the potentiating effect of A23187 on carbachol-stimulated amylase secretion from parotid-gland
  Komabayashi T; Yakata A; Izawa T; Suda K; Tsuboi M
  Research Communications in Molecular Pathology and Pharmacology, P J D PUBLICATIONS LTD, 70(3) 297 - 305, Dec. 1990, Scientific journal
• A protein kinase-c-dependent mechanism(s) is involved in atropine-resistant accumulation of diacylglycerol in rat parotid-gland
  Komabayashi T; Yakata A; Izawa T; Suda K; Tsuboi M
  Research Communications in Molecular Pathology and Pharmacology, P J D PUBLICATIONS LTD, 70(1) 11 - 20, Oct. 1990, Scientific journal
• ラット脂肪細胞膜の膜流動性に及ぼす身体トレーニングの影響
  井澤 鉄也
  東京薬科大学一般教育研究紀要, (11) 1 - 8, 1990
• 身体運動とカテコールアミン受容体
  井澤鉄也; 駒林隆夫
  運動生化学, (2) 30 - 31, 1990
• Effects of adenosine and pertussis toxin on lipolysis in adipocytes from exercise-trained male-rats
  Shinoda S; Izawa T; Komabayashi T; Suda K; Tsuboi M; Iwane H
  Research Communications in Molecular Pathology and Pharmacology, P J D PUBLICATIONS LTD, 66(3) 397 - 410, Dec. 1989, Scientific journal
• A possible mechanism of regulation of β-adrenergic receptor-cyclic AMP system in rat myocardium during and after acute dynamic exercise
  T. Izawa; T. Komabayashi; M. Tsuboi
  Bulletin of the Physical Fitness Research Institute, (72) 1 - 8, 1989, Scientific journal
• 運動時の突然死の発生機序に関する基礎的研究：運動時およびその回復期におけるラット心筋細胞膜のβ－アドレナリン受容体－cyclic AMP 系の調節機序
  井澤鉄也; 駒林隆夫; 坪井実
  体力研究 （第４回明治生命研究助成金論文集）, 72 1 - 8, 1989
• An acute exercise-induced translocation of β-adrenergic receptors in rat myocardium.
  Izawa T; Komabayashi T; Suda K; Kunisada Y; Shinoda S; Tsuboi M
  Journal of Biochemistry, JAPANESE BIOCHEMICAL SOC, 105(1) 110 - 113, Jan. 1989, Scientific journal
• BETA-ADRENERGIC-RECEPTOR ADAPTATION AFTER AN ACUTE EXERCISE IN RAT MYOCARDIUM
  T IZAWA; T KOMABAYASHI; K SUDA; S SHINODA; M TSUBOI
  JAPANESE JOURNAL OF PHYSIOLOGY, CENTER ACADEMIC PUBL JAPAN, 39(3) 447 - 454, 1989, Scientific journal
  

  DOI URL
• Effects of exercise training on the amylase activity and glycogen-content in rat submandibular-gland
  Komabayashi T; Izawa T; Suda K; Maruyama K; Tsuboi M
  Journal of Sports Medicine and Physical Fitness, EDIZIONI MINERVA MEDICA, 28(3) 293 - 297, Sep. 1988, Scientific journal
• SOME CHARACTERISTICS OF THE BETA-ADRENERGIC SYSTEM IN RAT ADIPOCYTE MEMBRANES AFTER THE CHRONIC ADMINISTRATIONS OF ISOPROTERENOL
  T IZAWA; T KOMABAYASHI; K SUDA; Y KUNISADA; S SHINODA; M TSUBOI
  RESEARCH COMMUNICATIONS IN CHEMICAL PATHOLOGY AND PHARMACOLOGY, P J D PUBLICATIONS LTD, 60(2) 253 - 256, May 1988, Scientific journal
• Effects of cyclic-nucleotide derivatives on the Na+ pump activity and the release of sialic-acid in dog submandibular glands
  Komabayashi T; Izawa T; Nakamura T; Suda K; Shinoda S; Tsuboi M
  Research Communications in Molecular Pathology and Pharmacology, P J D PUBLICATIONS LTD, 60(1) 137 - 140, Apr. 1988, Scientific journal
• Possible mechanism of regulating adenylate-cyclase activity in adipocyte membranes from exercise-trained male-rats
  Izawa T; Komabayashi T; Shinoda S; Suda K; Tsuboi M; Koshimizu E
  Biochemical and Biophysical Research Communications, ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS, 151(3) 1262 - 1268, Mar. 1988, Scientific journal
  

  DOI URL
• Effects of exercise training on rat submandibular glands
  Komabayashi T; Izawa T; Suda K; Tsuboi M
  Journal of Sports Medicine and Physical Fitness, EDIZIONI MINERVA MEDICA, 28(1) 99 - 103, Mar. 1988, Scientific journal
• Effects of adrenaline and NaF on glycogenolysis in rat submandibular gland slices.
  Tsuboi M; Komabayashi T; Izawa T; Suda K; Shinoda S
  Jikeikai Medical Journal, 35(1) 41 - 49, 1988, Research institution
• Does calmodulin participate as an intermediate in the process of glycogenolysis in rat submandibular-gland
  Komabayashi T; Izawa T; Suda K; Shinoda S; Tsuboi M
  Research Communications in Molecular Pathology and Pharmacology, P J D PUBLICATIONS LTD, 58(3) 401 - 404, Dec. 1987, Scientific journal
• 041309 ラット膵灌流のインスリン分泌に及ぼすトレーニングの影響(4.運動生理学,一般研究B)
  須田 和裕; 駒林 隆夫; 井沢 鉄也; 丸山 和容; 坪井 実
  日本体育学会大会号, 社団法人日本体育学会, (38) 550 - 550, 15 Aug. 1987
  

  DOI URL
• Effects of Ca-2+ and calmodulin antagonists on the Na-+ pump activity induced by pilocarpine in dog submandibular-gland
  Komabayashi T; Izawa T; Suda K; Shinoda S; Tsuboi M
  Research Communications in Molecular Pathology and Pharmacology, P J D PUBLICATIONS LTD, 57(2) 273 - 276, Aug. 1987, Scientific journal
• Effects of monensin on the Na+ pump activity and the release of amylase and sialic-acid in dog submandibular glands
  Komabayashi T; Izawa T; Suda K; Tsuboi M
  Research Communications in Molecular Pathology and Pharmacology, P J D PUBLICATIONS LTD, 55(1) 141 - 144, Jan. 1987, Scientific journal
• EFFECTS OF CHRONIC IN VIVO β-ADRENERGIC STIMULATION ON RAT ADIPOCYTES : LIPOLYSIS AND THE CHARACTERISTICS OF β-ADRENERGIC RECEPTORS IN EXERCISE-TRAINED AND CHRONIC ISOPROTERENOL-TREATED RATS
  IZAWA TETSUYA; KOMABAYASHI TAKAO; SUDA KAZUHIRO; KOSHIMIZU EIZI; TSUBOI MINORU
  Japanese Journal of Physical Fitness and Sports Medicine, The Japanese Society of Physical Fitness and Sport Medicine, 36(3) 147 - 155, 1987, Scientific journal
  

  DOI URL
• 043219 ラット脂肪細胞に及ぼすトレーニングならびに連続的なイソプロテレノール刺激の影響(4.運動生理学,一般研究B)
  井沢 鉄也; 駒林 隆夫; 小清水 英司; 須田 和裕; 坪井 実
  日本体育学会大会号, 社団法人日本体育学会, (37) 701 - 701, 01 Oct. 1986
  

  DOI URL
• P-31-nmr studies of energy metabolites in rat pancreas treated with trypsin-inhibitor
  Komabayashi T; Watanabe K; Izawa T; Tsuboi M
  Research Communications in Molecular Pathology and Pharmacology, P J D PUBLICATIONS LTD, 53(2) 249 - 252, Aug. 1986, Scientific journal
• Relationship between oxygen uptake and secretion in salivary gland
  Komabayashi T; Izawa T; Nakano K; Tsuboi M
  Biomedical Research, 7(s2) 61 - 63, 1986, Scientific journal
• Augmentation of catecholamine-stimulated [H-3] GDPrelease in adipocyte membranes from exercise-trained rats
  Izawa T; Komabayashi T; Tsuboi M; Koshimizu E; Suda K
  Japanese Journal of Physiology, CENTER ACADEMIC PUBL JAPAN, 36(5) 1039 - 1045, 1986, Scientific journal
  

  DOI URL
• 043128 ラット脂肪細胞β-アドレナリン受容体に及ぼすin vivoの連続的なカテコールアミン刺激の影響(4.運動生理学,一般研究)
  井沢 鉄也; 駒林 隆夫; 小清水 英司; 坪井 実
  日本体育学会大会号, 社団法人日本体育学会, (36) 333 - 333, 20 Aug. 1985
  

  DOI URL
• 043129 トレーニングラットの唾液腺について(4.運動生理学,一般研究)
  駒林 隆夫; 井沢 鉄也; 小清水 英司; 坪井 実
  日本体育学会大会号, 社団法人日本体育学会, (36) 334 - 334, 20 Aug. 1985
  

  DOI URL
• Studies on the relationship between the oxygen uptake and the release of amylase and sialic acid
  K. Nakano; S. Ichikawa; T. Komabayashi; T. Izawa; M. Tsuboi
  Journal of the Physiological Society of Japan, 47(11) 718 - 726, 1985, Scientific journal
• Effect of exercise-training on β-adrenergic receptors of rat fat cells
  井澤鉄也; 小清水英司; 駒林隆夫; 坪井実
  体力科学, 34(2) 119 - 127, 1985, Scientific journal
• イヌ顎下腺における酸素摂取の亢進とアミラーゼおよびシアル酸分泌との関連について
  中野慶子; 市河三太; 駒林隆夫; 井澤鉄也; 坪井実
  日本生理学雑誌, 47(11) 718 - 726, 1985, Scientific journal
• Characterization of adrenergic and muscarinic receptors of submandibular glands of rats treated with isoproterenol.
  Tsuboi M; Komabayashi T; Kawajiri Y; Nakano K; Izawa T
  Jikeikai Medical Journal, 32(3) 375 - 382, 1985, Research institution
• Stimulation of the oxygen uptake by histamine in dog submandibular gland slices.
  Tsuboi M; Komabayashi T; Nakano K; Izawa T
  Jikeikai Medical Journal, 32(3) 383 - 388, 1985, Research institution
• Comparison Between Lipolysis in Adipose Tissue From Exercise-Trained Rats and from Chronic Isoproterenol-Treated Rats
  Tetsuya Izawa; Eiji Koshimizu; Takao Komabayashi; Minoru Tsuboi
  Japanese Journal of Physical Fitness and Sports Medicine, 33(1) 8 - 16, 1984, Scientific journal
  

  DOI URL
• Effects of Ca2+ and calmodulin antagonists on the oxygen-uptake induced by acetylcholine or substance-p in rat submandibular-gland slices
  Komabayashi T; Nakano K; Izawa T; Nakamura T; Tsuboi M
  Japanese Journal of Pharmacology, JAPANESE PHARMACOLOGICAL SOC, 36(4) 441 - 447, 1984, Scientific journal
  

  DOI URL
• クリティカル・パワー（ＣＰ）による持久性能力の評価
  小清水英司; 室 増男; 与那正栄; 井澤鉄也
  体育の科学, 杏林書院, 33(12) 947 - 949, 1983
• クリティカル・パワー（Critical Power）法によるVO2 maxの簡易的間接測定
  小清水英司; 室 増男; 与那正栄; 井澤鉄也
  東京体育学研究, (10) 75 - 76, 1983, Scientific journal
• ラット副睾丸脂肪組織におけるエピネフン，ノルエピネフリン，カフェインおよびＡＣＴＨの脂肪動員作用に及ぼすCa²⁺ならびにカルモデュリン阻害剤の影響
  井澤鉄也; 小清水英司; 駒林隆夫; 坪井実
  日本生理学雑誌, 日本生理学会, 45(1) 36 - 44, 1983, Scientific journal

MISC

• The influence of endurance training on content of myoglobin localized to muscle mitochondria
  KOMA Rikuhide; SHIBAGUCHI Tsubasa; PEREZ-LOPEZ Claudia; TAKAKURA Hisashi; IZAWA Tetsuya; OKA Toshihiko; MASUDA Kazumi
  Journal of Physical Fitness and Sports Medicine, 9(6), 2020
• 運動による脂肪組織のリモデリング
  井澤 鉄也; 加藤久詞
  New Diet Therapy ニュー ダイエット セラピー, 33(3) 37 - 44, Dec. 2017, Introduction scientific journal
• 肥満による脂肪組織のプロサイモシンα発現増加は運動によって減弱される
  櫻井 拓也; 小笠原 準悦; 白土 健; 石橋 義永; 井澤 鉄也; 大石 修司; 芳賀 脩光; 大野 秀樹; 木崎 節子
  日本衛生学雑誌, 日本衛生学会, 72(Suppl.) S211 - S211, Mar. 2017
• 肥満による脂肪組織のプロサイモシンα発現増加は運動によって減弱される
  櫻井 拓也; 小笠原 準悦; 白土 健; 石橋 義永; 井澤 鉄也; 大石 修司; 芳賀 脩光; 大野 秀樹; 木崎 節子
  日本衛生学雑誌, 日本衛生学会, 72(Suppl.) S211 - S211, Mar. 2017
• 時計遺伝子の発現リズムに基づいた運動トレーニングが脂肪分解反応に及ぼす影響
  加藤久詞; 田中剛貴; 増田慎也; 高倉久志; 小笠原準悦; 櫻井拓也; 木崎節子; 大野秀樹; 井澤鉄也
  体力科学, 64(6) 665 , 01 Dec. 2015
  

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• 運動トレーニングが脂肪組織のポジティブリモデリングにおよぼす影響
  田中剛貴; 加藤久詞; 柴原拓哉; 増田慎也; 小笠原準悦; 櫻井拓也; 木崎節子; 大野秀樹; 井澤鉄也
  体力科学, 64(2) 281 , 01 Apr. 2015
  

  URL
• PGC‐1αの発現抑制がミオグロビン発現量に及ぼす影響について
  高倉久志; 田中誠智; 田中剛貴; 加藤久詞; 柴原拓哉; 増田慎也; 岩中伸壮; 北條達也; 稗田睦子; 井澤鉄也; 増田和実
  体力科学, (一社)日本体力医学会, 63(6) 571 - 571, Dec. 2014
  

  URL
• Pgc-1 alpha Expression Is Not Essential For Endurance Training-induced Increase In Myoglobin Expression In Skeletal Muscle
  Hisashi Takakura; Goki Tanaka; Seichi Tanaka; Hisashi Kato; Takuya Shibahara; Shinya Masuda; Nobumasa Iwanaka; Toshimichi Hata; Tetsuya Izawa; Thomas Jue; Kazumi Masuda
  MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, LIPPINCOTT WILLIAMS & WILKINS, 46(5) 758 - 758, May 2014, Summary international conference
  

  DOI URL
• 1D04-1 Creatine analogue reduces adipose tissue mass via increased secretion of myostatin(The Proceedings of the 22nd Annual Meetings of Japan Society of Exercise and Sports Physiology July 19・20, (Okayama)) :
  Masuda Shinya; Kato Hisashi; Ohira Yoshinobu; Takakura Hisashi; Izawa Tetsuya
  Advances in exercise and sports physiology, Japan Society of Exercise and Sports Physiology, 20(4) 96 - 96, 2014
• 持久的トレーニングが筋細胞内酸素運搬タンパクを増加させる分子機序の解明
  高倉久志; 増田慎也; 加藤久詞; 田中剛貴; 岩中伸壮; 井澤鉄也; 増田和実
  体力科学, (一社)日本体力医学会, 62(6) 578 - 578, Dec. 2013
  

  DOI URL
• O-35 Signaling in the differentiation from myoblast to brown adipocyte is stimulated by swimming exercise(The Proceedings of the 20th Annual Meetings of Japan Society of Exercise and Sports Physiology July 28・29,(Tsukuba)) :
  OGASAWARA Junetsu; SAKURAI Takuya; KIZAKI Takako; IZAWA Tetsuya; TAKEMASA Toru; HAGA Shukoh; NAGASAWA Junichi; OHNO Hideki
  Advances in exercise and sports physiology, Japan Society of Exercise and Sports Physiology, 18(4) 99 - 99, 2013
• 脂肪分解反応を制御する新しいプレーヤーと運動の影響（総説）
  井澤鉄也
  医学のあゆみ, 244(12) 1068 - 1073, 2013, Introduction commerce magazine
• Effects of Exercise Training-Induced Hormonal Changes on Body Composition
  井澤鉄也; 小笠原準悦; 櫻井拓也; 木崎節子; 大野秀樹
  第6回 栄養とエイジング国際会議 講演録, 日本国際生命科学協会, (110) 93 - 103, 2012, Introduction international proceedings
  

  URL
• Training-induced hormonalchanges on body composition
  Izawa T; Ogasawara J; Sakurai T; Kizaki T; Ohno H
  (110) 93 - 103, 2012
• 2-B-02 Exercise has preventive effects on cognitive impairment in senescence-accelerated mice(The Proceedings of the 19th Annual Meetings of Japan Society of Exercise and Sports Physiology August 25・26, (Tokushima)) :
  SAKURAI Takuya; OGASAWARA Junetsu; KIZAKI Takako; IZAWA Tetsuya; NAGASAWA Junichi; HAGA Shukoh; OHNO Hideki
  Advances in exercise and sports physiology, Japan Society of Exercise and Sports Physiology, 17(2) 64 - 64, 2011
• Effects of an acute exercise on mRNA expressions related with survival of adipocytes in mature adipocytes and those related with adipogenesis and angiogenesis in stromal vascular fraction cells
  井澤 鉄也
  人間科学研究, 早稲田大学人間科学学術院, 23(1) 124 - 124, 25 Mar. 2010
• 2B-O-1 The mechanisms underlying prolonged exercise training : induced alterations in levels of adipose triglyceride lipase (ATGL) in rat primary adipocytes(The Proceedings of the 18th Annual Meetings of Japan Society Exercise and Sports Physiology Jury 31 August 1, (Kagoshima)) :
  OGASAWARA Junetsu; SAKURAI Takuya; KIZAKI Takako; NAGASAWA Junichi; HAGA Shukoh; IZAWA Tetsuya; OHNO Hideki
  Advances in exercise and sports physiology, Japan Society of Exercise and Sports Physiology, 16(2) 56 - 56, 2010
• 1-O-12 Exercise training suppresses adipogenesis of adipose tissue-derived stem cells(The Proceedings of the 17th Annual Meetings of Japan Society of Exercise and Sports Physiology Jury 25-26, (Tokyo)) :
  SAKURAI Takuya; IZAWA Tetsuya; KIZAKI Takako; OGASAWARA Junetsu; MAEGAWA Taketeru; HAGA Shukoh; OHNO Hideki
  Advances in exercise and sports physiology, Japan Society of Exercise and Sports Physiology, 15(2) 54 - 54, 2009
• 2-P-34 The possible mechanisms underlying acute exercise-induced alterations in lipolysis in rat primary adipocytes(The Proceedings of the 17th Annual Meetings of Japan Society of Exercise and Sports Physiology Jury 25-26, (Tokyo)) :
  MAEGAWA Taketeru; OGASAWARA Junetsu; IZAWA Tetsuya; SAKURAI Takuya; KIZAKI Takako; NAGASAWA Junichi; HAGA Shukoh; OHNO Hideki
  Advances in exercise and sports physiology, Japan Society of Exercise and Sports Physiology, 15(2) 87 - 87, 2009
• Plum Extracts Inhibit the Renin-Angiotensin System : Experimental Evidence in vivo
  櫻井拓也; 北館健太郎; 西岡浩; 藤井創; 久島達也; 安部茂; 木崎節子; 小笠原準悦; 白土健; 石橋義永; 井澤鉄也; 今泉和彦; 鈴木健二; 中野法彦; 大野秀樹
  Food function, 国際食品機能学会, 5(1) 2 - 7, 2009, Introduction scientific journal
• Antioxidative effects of oligonol, converted into alow-molecular form.
  Food Function, 5(1) 2 - 7, 2009
• 240. 運動負荷パターンの差異が酸化ストレスにおよぼす影響(代謝,一般口演,第63回日本体力医学会大会)
  長澤 純一; 高井 俊英; 坂口 明; 井澤 鉄也; 木崎 節子; 大野 秀樹
  体力科學, 日本体力医学会, 57(6) 752 - 752, 01 Dec. 2008
• 280. 急性運動と脂肪細胞のホルモン感受性リパーゼの発現変化(代謝,一般口演,第63回日本体力医学会大会)
  小笠原 準悦; 櫻井 拓也; 白土 健; 木崎 節子; 井澤 鉄也; 長澤 純一; 今泉 和彦; 大野 秀樹
  体力科學, 日本体力医学会, 57(6) 772 - 772, 01 Dec. 2008
• Adaptation of macrophages to exercise training improves innate immunity (vol 372, pg 152, 2008)
  Takako Kizaki; Tohru Takemasa; Takuya Sakurai; Tetsuya Izawa; Tomoko Hanawa; Shigeru Kamiya; Shukoh Haga; Kazuhiko Imaizumi; Hideki Ohno
  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, 376(1) 244 - 244, Nov. 2008, Others
  

  DOI URL
• 4 Exercise training reduces oxidative stress in rat adipose tissue
  SAKURAI TAKUYA; KIZAKI TAKAKO; OHNO HIDEKI; IZAWA TETSUYA; HAGA SHUKOH
  Japanese Journal of Physical Fitness and Sports Medicine, The Japanese Society of Physical Fitness and Sport Medicine, 57(1) 185 - 185, 01 Feb. 2008
• スポーツと燃焼系サプリメント
  櫻井拓也; 井澤 鉄也; 大野秀樹
  Functional Food, 2(3) 257 - 261, 2008, Introduction scientific journal
• sports and burning supplement
  Functional Food, 2(3) 257 - 261, 2008
• 192. 運動の強度および時間と酸化ストレス(代謝,第62回日本体力医学会大会)
  長澤 純一; 井澤 鉄也; 櫻井 拓也; 木崎 節子; 大野 秀樹
  体力科學, 日本体力医学会, 56(6) 674 - 674, 01 Dec. 2007
• 495. 脂肪組織由来幹細胞に及ぼす運動トレーニングの影響(遺伝子,第62回日本体力医学会大会)
  井澤 鉄也; 櫻井 拓也; 木崎 節子; 長澤 純一; 大野 秀樹
  体力科學, 日本体力医学会, 56(6) 826 - 826, 01 Dec. 2007
• New lychee-derived polyphenol Oligonol converted into a low-molecular form reduces oxidative stress in adipocytes
  Takuya Sakurai; Hiroshi Nishioka; Hajime Fujii; Norihiko Nakano; Takako Kizaki; Tetsuya Izawa; Shukoh Haga; Hitoshi Ishida; Zsolt Raldak; Hideki Ohno
  INTERNATIONAL JOURNAL OF OBESITY, NATURE PUBLISHING GROUP, 31 S47 - S47, May 2007, Summary international conference
• 4. Oxidative stress in rat white adipose tissue is decreased by exercise training(The Proceedings of the 15th Annual Meetings of Japan Society of Exercise and Sports Physiology July 26-27, (Hirosaki)) :
  SAKURAI Takuya; IZAWA Tetsuya; KIZAKI Takako; HAGA Shukoh; OHNO Hideki
  Advances in exercise and sports physiology, Japan Society of Exercise and Sports Physiology, 13(3) 56 - 56, 2007
• 246. 脂肪由来前駆細胞の血管新生に関わる遺伝子発現に及ぼす運動の影響(代謝, 第61回 日本体力医学会大会)
  畑野 大輔; 遠藤 聖宗; 櫻井 拓也; 木崎 節子; 芳賀 脩光; 大野 秀樹; 井澤 鉄也
  体力科學, 日本体力医学会, 55(6) 701 - 701, 01 Dec. 2006
• 249. ライチ由来新規低分子化ポリフェノール Oligonol の脂肪細胞における抗酸化作用(代謝, 第61回 日本体力医学会大会)
  櫻井 拓也; 木崎 節子; 井澤 鉄也; 桜井 智野風; 長澤 純一; 武政 徹; 芳賀 脩光; 大野 秀樹
  体力科學, 日本体力医学会, 55(6) 703 - 703, 01 Dec. 2006
• 247. 前駆脂肪細胞の分化・増殖機構に及ぼす運動の影響(代謝, 第61回 日本体力医学会大会)
  遠藤 聖宗; 畑野 大輔; 櫻井 拓也; 木崎 節子; 芳賀 脩光; 大野 秀樹; 井澤 鉄也
  体力科學, 日本体力医学会, 55(6) 702 - 702, 01 Dec. 2006
• 209. 運動強度と抗酸化能の変動(代謝, 第61回 日本体力医学会大会)
  長澤 純一; 畑野 大輔; 井澤 鉄也; 櫻井 拓也; 木崎 節子; 大野 秀樹
  体力科學, 日本体力医学会, 55(6) 683 - 683, 01 Dec. 2006
• Role of Nitric Oxide in the Apoptosis of Structural Damage in Rat Skeletal Muscle
  Tomonobu Sakurai; Yutaka Kano; Hideki Ohno; Li Li Ji; Thomas M. Best; Tetsuya Izawa
  MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, LIPPINCOTT WILLIAMS & WILKINS, 38(5) S124 - S124, May 2006, Summary international conference
• 運動と脂肪代謝
  井澤 鉄也
  ホルモンと臨床, 54 923 - 932, 2006, Introduction commerce magazine
• 84.骨格筋損傷における一酸化窒素とアポトーシスの関連(運動器,一般口演,第60回 日本体力医学会大会)
  桜井 智野風; 三瓶 みのり; 小笠原 準悦; 井澤 鉄也
  体力科學, 日本体力医学会, 54(6) 460 - 460, 01 Dec. 2005
• 218.ラット脂肪細胞のアポトーシスシグナルおよび生存シグナルの遺伝子発現に及ぼす運動の影響(代謝,一般口演,第60回 日本体力医学会大会)
  三瓶 みのり; 小笠原 準悦; 桜井 智野風; 井澤 鉄也
  体力科學, 日本体力医学会, 54(6) 527 - 527, 01 Dec. 2005
• 1A-10 Down-regulation of β_2-adrenergic receptor expression by exercise training increases IL-12 production by macrophages following LPS stimulation(Immunology and Endocrinology, The Proceedings of the 13th Annual Meetings of Japan Society of Exercise and Sports Physiology July 30-31, (Tokyo)) :
  KIZAKI Takako; SAKURAI Takuya; NAKANO Norihiko; SAKURAI Tomonobu; OGASAWARA Junetsu; IZAWA Tetsuya; NAGASAWA Junichi; SUDA Kazuhiro; TAKEMASA Tohru; HAGA Shukoh; OHNO Hideki
  Advances in exercise and sports physiology, Japan Society of Exercise and Sports Physiology, 11(4) 158 - 158, 2005
• 1B-03 Effect of exercise training on tumor necrosis factor-α-induced expressions of lipogenic genes in rat adipocytes(Sports Biochemistry, The Proceedings of the 13th Annual Meetings of Japan Society of Exercise and Sports Physiology July 30-31, (Tokyo)) :
  SAKURAI Takuya; OGASAWARA Junetsu; NAKANO Norihiko; KIZAKI Takako; OHNO Hideki; IZAWA Tetsuya
  Advances in exercise and sports physiology, Japan Society of Exercise and Sports Physiology, 11(4) 152 - 152, 2005
• 1B-02 Acute exercise induces alteration in β-adrenergic receptor-cAMP signal transduction system via ubiquitin-pro-teasome proteolysis pathway in rat adipocytes(Sports Biochemistry, The Proceedings of the 13th Annual Meetings of Japan Society of Exercise and Sports Physiology July 30-31, (Tokyo)) :
  OGASAWARA Junetsu; SANPEI Minori; SAKURAI Tomonobu; KIZAKI Takako; OHNO Hideki; IZAWA Tetsuya
  Advances in exercise and sports physiology, Japan Society of Exercise and Sports Physiology, 11(4) 152 - 152, 2005
• 過重力環境下で14世代育成したマウスの筋内NO生成反応
  桜井 智野風; 喜多 清; 柴田 茂貴; 青木 健; 井澤 鉄也; 岩崎 賢一; 伊藤 雅夫
  宇宙航空環境医学, 日本宇宙航空環境医学会, 41(4) 154 - 154, Dec. 2004
• 脂肪細胞の脂肪代謝に関わる遺伝子群の食事や運動による発現変化(代謝, 第59回日本体力医学会大会)
  櫻井 拓也; 小笠原 準悦; 井澤 鉄也
  体力科學, 日本体力医学会, 53(6) 732 - 732, 01 Dec. 2004
• 単回運動によるβ-アドレナリン受容体-cAMP生成系を構成する情報伝達タンパク分子発現変化機構 : ユビキチン-プロテアソーム系の役割(代謝, 第59回日本体力医学会大会)
  小笠原 準悦; 桜井 拓也; 井澤 鉄也
  体力科學, 日本体力医学会, 53(6) 739 - 739, 01 Dec. 2004
• We have two strategies to attain healthy aging
  OHNO Hideki; KIZAKI Takako; HITOMI Yoshiaki; WATANABE Sumiko; ISHIBASHI Yoshinaga; IZAWA Tetsuya; SAITOH Daizoh; KINUGASA Takashi; HAGA Shukoh
  Geriatrics & gerontology international, 4 S311 - S312, 01 Sep. 2004
• Changes in the sensitivity of rat aorta to NO donor by training, detraining, and inactivity
  T Tanabe; J Nagasawa; T Izawa; N Nakano; Y Ishibashi; H Ohno
  NITRIC OXIDE-BIOLOGY AND CHEMISTRY, ACADEMIC PRESS INC ELSEVIER SCIENCE, 11(1) 91 - 91, Aug. 2004, Summary international conference
• Effect of an acute exercise on the expression of inducible nitric oxide synthase in rat skeletal muscle
  T Sakurai; TM Best; H Ohno; LL Ji; T Izawa
  NITRIC OXIDE-BIOLOGY AND CHEMISTRY, ACADEMIC PRESS INC ELSEVIER SCIENCE, 11(1) 90 - 90, Aug. 2004, Summary international conference
• Exercise training enhances nitric oxide production in macrophages through beta(2)-adrenergic receptor
  H Ohno; Y Hitomi; T Sakurai; T Izawa; T Tanabe; J Nagasawa; D Saitoh; S Haga; T Kizaki
  NITRIC OXIDE-BIOLOGY AND CHEMISTRY, ACADEMIC PRESS INC ELSEVIER SCIENCE, 11(1) 97 - 97, Aug. 2004, Summary international conference
• Acute exercise induces alterations in beta-adrenergic-adenylate cyclase system through the proteasome pathway in rat adiopocytes
  Ogasawara Junetsu; Izawa Tetsuya
  Proceedings of Annual Meeting of the Physiological Society of Japan, PHYSIOLOGICAL SOCIETY OF JAPAN, 2004(0) S238 - S238, 2004
• 過重力負荷時における骨格筋損傷と筋内NO生成との関連
  桜井 智野風; 喜多 清; 柴田 茂貴; 金 慧徳; 塩澤 友規; 青木 健; 井澤 鉄也; 伊藤 雅夫; 岩崎 賢一
  宇宙航空環境医学, 日本宇宙航空環境医学会, 40(4) 189 - 189, Dec. 2003
• 405. 乳酸のフリーラジカルスカベンジング効果(代謝)
  長澤 純一; 井澤 鉄也; 大野 秀樹
  体力科學, 日本体力医学会, 52(6) 917 - 917, 01 Dec. 2003
• 291. 伸張性骨格筋損傷の治癒過程におけるNOの役割(運動器)
  桜井 智野風; 井澤 鉄也
  体力科學, 日本体力医学会, 52(6) 860 - 860, 01 Dec. 2003
• 396. Tumor necrosis factor α(TNF-α)の細胞内情報伝達経路に及ぼす運動トレーニングの影響(体液・内分泌)
  櫻井 拓也; 小笠原 準悦; 武井 愛美; 人見 嘉哲; 木崎 節子; 大野 秀樹; 井澤 鉄也
  体力科學, 日本体力医学会, 52(6) 912 - 912, 01 Dec. 2003
• 398. ノルアドレナリンによる膵ランゲルハンス島のインスリン分泌抑制作用の運動トレーニングによる脱感作(体液・内分泌)
  井澤 鉄也; 桜井 智野風; 上田 浩司; 桜井 拓也; 小笠原 準悦; 武井 愛実
  体力科學, 日本体力医学会, 52(6) 913 - 913, 01 Dec. 2003
• 442. 脂肪細胞の脂肪合成に関わる遺伝子群の発現変化 : 絶食と運動の影響(代謝)
  武井 愛美; 桜井 拓也; 小笠原 準悦; 上田 浩司; 井澤 鉄也
  体力科學, 日本体力医学会, 52(6) 935 - 935, 01 Dec. 2003
• 445. 脂肪細胞のβ-アドレナリン受容体-Gタンパク質を介する情報伝達系に及ぼす運動の影響(代謝)
  小笠原 準悦; 桜井 拓也; 武井 愛美; 上田 浩司; 井澤 鉄也
  体力科學, 日本体力医学会, 52(6) 937 - 937, 01 Dec. 2003
• 4. Role of Nitric Oxide to the damage of rat skeletal muscle by the over-gravity load
  SAKURAI TOMONOBU; AOKI KEN; IZAWA TETSUYA; KITA SAYAKA; SHIBATA SHIGEKI; KIN HEYTEOK; SHIOZAWA TOMOKI; IWASAKI KENICHI
  Japanese Journal of Physical Fitness and Sports Medicine, The Japanese Society of Physical Fitness and Sport Medicine, 52(3) 349 - 349, 01 Jun. 2003
• 1D08 The effect of exercise training and nitric oxide on the glucose-stimulated insulin secretion :
  UEDA Hiroshi; OGASAWARA Jun-etsu; TAKEI Megumi; SAKURAI Tomonobu; IZAWA Tetsuya
  Advances in exercise and sports physiology, Japan Society of Exercise and Sports Physiology, 9(4) 160 - 160, 2003
• 1D09 Effect of an acute exercise on the β-adrenergic receptor-adenylate cyclase system in rat adipocytes :
  OGASAWARA Jun-etsu; UEDA Hiroshi; IZAWA Tetsuya
  Advances in exercise and sports physiology, Japan Society of Exercise and Sports Physiology, 9(4) 161 - 161, 2003
• The effects of high-intensity runnig on inducible nitric oxide synthase expression in rat skeletal muscle
  T Sakurai; TM Best; H Ohno; LL Ji; T Izawa
  FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, 16(4) A446 - A446, Mar. 2002, Summary international conference
• 3P11 Effect of single bout exercise on adipocyte lipolysis(II) :
  OGASAWARA Jun-etsu; SAKURAI Takuya; UEDA Hiroshi; SAKURAI Tomonobu; IZAWA Tetsuya
  Advances in exercise and sports physiology, Japan Society of Exercise and Sports Physiology, 8(4) 198 - 198, 2002
• 3P14 The effect of exercise-training on the generation of nitric oxide in pancreatic islet of Langerhans :
  UEDA Hiroshi; URANO Yuriko; OGASAWARA Jun-etsu; SAKURAI Tomonobu; IZAWA Tetsuya
  Advances in exercise and sports physiology, Japan Society of Exercise and Sports Physiology, 8(4) 199 - 199, 2002
• 2E2 Effects of detraining and inactivity on antioxidant enzymes of rat skeletal muscle :
  NAGASAWA Junichi; IZAWA Tetsuya; SAKURAI Tomonobu; OHNO Hideki
  Advances in exercise and sports physiology, Japan Society of Exercise and Sports Physiology, 8(4) 159 - 159, 2002
• 2D3 Relationship between skeletal muscle damage and inducible nitric oxide synthase expression after running exercise :
  SAKURAI Tomonobu; SAKURAI Takuya; Ohno Hideki; Izawa Tetsuya
  Advances in exercise and sports physiology, Japan Society of Exercise and Sports Physiology, 8(4) 156 - 156, 2002
• 運動と脂肪代謝
  井澤 鉄也
  比較生理生化学, 19(1) 47 - 55, 2002, Introduction scientific journal
  

  DOI URL
• 105.高強度走運動後の骨格筋損傷がiNOS動態に及ぼす影響(【運動器】)
  桜井 智野風; 大野 秀樹; 井澤 鉄也
  体力科學, 日本体力医学会, 50(6) 785 - 785, 01 Dec. 2001
• 212.運動トレーニングによるインスリン分泌低下機構 : 一酸化窒素合成酵素及び一酸化窒素の関与の可能性(【体液・内分泌】)
  上田 浩司; 浦野 由里子; 川波 一美; 野村 幸子; 桜井 智野風; 井澤 鉄也
  体力科學, 日本体力医学会, 50(6) 838 - 838, 01 Dec. 2001
• 253.脂肪細胞におけるcAMP依存症タンパクキナーゼの細胞内分布 : 加齢変化と身体運動の影響(【代謝】)
  野村 幸子; 川波 一美; 上田 浩司; 井澤 鉄也
  体力科學, 日本体力医学会, 50(6) 859 - 859, 01 Dec. 2001
• 260.脂肪細胞の脂肪分解反応に及ぼす持久的身体トレーニングの影響 : 一酸化窒素の役割(【代謝】)
  川波 一美; 野村 幸子; 上田 浩司; 桜井 智野風; 井澤 鉄也
  体力科學, 日本体力医学会, 50(6) 862 - 862, 01 Dec. 2001
• 261.急性運動が脂肪細胞の脂肪分解反応に及ぼす影響(【代謝】)
  小笠原 準悦; 野村 幸子; 川波 一美; 井澤 鉄也
  体力科學, 日本体力医学会, 50(6) 863 - 863, 01 Dec. 2001
• Activation and apoptosis of murine peritoneal macrophages by acute cold stress (vol 283, pg 700, 2001)
  T Kizaki; K Suzuki; Y Hitomi; K Iwabuchi; K Onoe; H Ishida; T Izawa; LL Ji; H Ohno
  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC, 285(1) 158 - 158, Jul. 2001, Others
• PHYSICAL EXERCISE AND FREE RADICALS
  OHNO HIDEKI; SUZUKI KENJI; HITOMI YOSHIAKI; KIMOTO KIYOKO; ITOH CHOH-EI; MIYAZAWA NOBUKO; KIZAKI TAKAKO
  Japanese Journal of Physical Fitness and Sports Medicine, The Japanese Society of Physical Fitness and Sport Medicine, 50(4) 389 - 415, 2001
  

  DOI URL
• 副腎のANP情報伝達機構に対する一過性運動の影響
  須田和裕; 駒林隆夫; 井澤鉄也
  第５６回日本体力医学会予稿集, 216 , 2001
• 副腎のANP情報伝達機構に対する一過性運動の影響
  須田和裕; 駒林隆夫; 井沢鉄也
  体力科学, 50(6) 837 , 2001
• 脂肪細胞の脂肪分解反応と運動
  井澤 鉄也
  日本運動生理学雑誌, 8(1) 1 - 24, 2001, Introduction scientific journal
• ANPのアルドステロン放出抑制に対する一過性運動の影響
  須田和裕; 駒林隆夫; 井澤鉄也
  第５５回日本体力医学会大会予稿集, 154 , 2000
• ANPのアルドステロン放出抑制に対する一過性運動の影響
  須田和裕; 駒林隆夫; 井澤鉄也
  体力科学, 49(6) 739 , 2000
• 376.ラット膵島におけるインスリン分泌調節と持久的運動トレーニングの効果
  桜井 智野風; 野村 幸子; 井澤 鉄也
  体力科學, 日本体力医学会, 48(6) 900 - 900, 01 Dec. 1999
• 446.血中アディポサイトカインと体脂肪分布の関係に及ぼす運動トレーニングの影響
  早瀬 秀樹; 安部 孝; 桜井 智野風; 野村 幸子; 井澤 鉄也
  体力科學, 日本体力医学会, 48(6) 935 - 935, 01 Dec. 1999
• 469.ラット単離心筋細胞における脂肪分解反応と身体トレーニングの影響
  野村 幸子; 桜井 智野風; 井澤 鉄也
  体力科學, 日本体力医学会, 48(6) 947 - 947, 01 Dec. 1999
• 471.ラット脂肪細胞のCa2+/カルモジュリンによる脂肪分解調節とトレーニング効果
  野村 幸子; 桜井 智野風; 大野 秀樹; 駒林 隆夫; 井澤 鉄也
  体力科學, 日本体力医学会, 48(6) 948 - 948, 01 Dec. 1999
• (E61011) Effects of inactivity on Aortic Response in rat. :
  TANABE Takumi; NAGASAWA Junichi; KANO Yutaka; MIZUTA Takudo; SAKURAI Tomonobu; IZAWA Tetsuya; OHNO Hideki
  Advances in exercise and sports physiology, Japan Society of Exercise and Sports Physiology, 5(4) 178 - 178, 1999
• SHR脂肪細胞の脂肪分解に対するトレーニングの影響
  須田和裕; 駒林隆夫; 井沢鉄也
  第54回日本体力医学会大会予稿集, 316 , 1999
• SHR脂肪細胞の脂肪分解に対するトレーニングの影響
  須田和裕; 駒林隆夫; 井澤鉄也
  体力科学, 48(6) 947 , 1999
• 運動時の脂質代謝とホルモン
  井澤 鉄也
  体育の科学, 49 974 - 982, 1999, Introduction commerce magazine
• 90.活性酸素と血管新生
  宮崎 裕美; 大石 修司; 芳賀 脩光; 木崎 節子; 中尾 千登世; 佐藤 祐造; 長澤 純一; 桜井 智野風; 井澤 鉄也; 大野 秀樹
  体力科學, 日本体力医学会, 47(6) 747 - 747, 01 Dec. 1998
• 361.血清Leptinと内臓脂肪量および皮下脂肪量分布
  安部 孝; 早瀬 秀樹; 桜井 智野風; 倉田 順子; 楠原 慶子; 井澤 鉄也
  体力科學, 日本体力医学会, 47(6) 883 - 883, 01 Dec. 1998
• 311.鉄欠乏ラットにおける脂肪細胞の機能特性に関する研究
  駒林 隆夫; 山岸 博之; 須田 和裕; 井澤 鉄也; 大野 秀樹
  体力科學, 日本体力医学会, 47(6) 858 - 858, 01 Dec. 1998
• 492.腎ANP受容体に対するトレーニングの影響
  須田 和裕; 加藤 幸司; 佐々木 道子; 大形 純平; 高野 憲一; 田中 雄; 駒林 隆夫; 井沢 鉄也
  体力科學, 日本体力医学会, 46(6) 858 - 858, 01 Dec. 1997
• 250.長期エタノール摂取はラット血中ANP濃度を増加させる
  須田 和裕; 駒林 隆夫; 井沢 鉄也
  体力科學, 日本体力医学会, 45(6) 729 - 729, 01 Dec. 1996
• 526.脂肪細胞のホルモン感受性リパーゼ活性に及ぼす持久的身体トレーニングの影響
  井澤 鉄也; 長澤 純一; 水田 拓道; 大石 修司; 木崎 節子; 大野 秀樹
  体力科學, 日本体力医学会, 45(6) 867 - 867, 01 Dec. 1996
• 149.種々の血管作業薬の収縮特性に及ぼす持久的トレーニングの影響
  長澤 純一; 井澤 鉄也; 水田 拓道; 駒林 隆夫; 須田 和裕; 木崎 節子; 大野 秀樹
  体力科學, 日本体力医学会, 45(6) 679 - 679, 01 Dec. 1996
• 5.Contractile sensitivity of rat thoracic aorta after an acute exercise and chronic exercise training.
  IZAWA TETSUYA; KOMABAYASHI TAKAO; SAKURAI TOMONOBU
  Japanese Journal of Physical Fitness and Sports Medicine, The Japanese Society of Physical Fitness and Sport Medicine, 45(5) 558 - 558, 01 Oct. 1996
• 82. 運動トレーニングとインスリン反応性
  長澤 純一; 村岡 功; 井沢 鉄也; 桜井 智野風; 佐藤 祐造; 大野 秀樹
  日本運動生理学雑誌, 日本運動生理学会事務局, 3(1) 64 - 64, 1996
• 運動時の体液因子としての内分泌機能動態
  井澤 鉄也; 大野秀樹
  骨・関節・靭帯, 9(3) 299 - 308, 1996, Introduction commerce magazine
• 運動と脂肪組織のアドレナリン受容体
  井澤 鉄也
  臨床スポーツ医学, 13(6) 695 , 1996, Introduction commerce magazine
• 酸化ストレスと栄養･運動
  大野秀樹; 木崎節子; 大河原知水; 井澤鉄也
  臨床スポーツ医学, 13 166 - 170, 1996, Introduction commerce magazine
• 73.急性運動と骨格筋の血管新生
  長澤 純一; 山下 均; 大石 修司; 木崎 節子; 井澤 鉄也; 桜井 智野風; 駒林 隆夫; 佐藤 祐造; 大野 秀樹
  体力科學, 日本体力医学会, 44(6) 643 - 643, 01 Dec. 1995
• 485.運動による心臓のANP放出と標的臓器情報伝達系へのトレーニングの影響
  須田 和裕; 駒林 隆夫; 井沢 鉄也
  体力科學, 日本体力医学会, 44(6) 849 - 849, 01 Dec. 1995
• 129. 持久的トレーニングと脂肪細胞の脂肪分解能におけるCa^<2+>の役割 (第三報)
  井澤 鉄也; 水田 拓道; 駒林 隆夫; 須田 和裕
  日本運動生理学雑誌, 日本運動生理学会事務局, 2(1) 96 - 96, 1995
• 45.アンギオテンシンに対するラット胸部大動脈の収縮特性に及ぼす運動の影響
  井沢 鉄也; 水田 拓道; 駒林 隆夫; 須田 和裕
  体力科學, 日本体力医学会, 43(6) 529 - 529, 01 Dec. 1994
• 62.ANP受容体に対するトレーニングの影響
  須田 和裕; 駒林 隆夫; 井沢 鉄也
  体力科學, 日本体力医学会, 43(6) 537 - 537, 01 Dec. 1994
• 運動とラット骨格筋および肝臓の抗酸化酵素システム
  大石修司; 木崎節子; 山下 均; 瀬川雅彦; 井澤鉄也; 駒林隆夫; 鈴木敬一郎; 谷口直之; 永田直一; 大野秀樹
  第４回健康スポーツ医科学フォーラム集：健康スポーツ核医学研究会編, 89 - 93, 1994
• 74. 持久的トレーニングと脂肪分解能 : Ca^<2+>ならびにカルモジュリン阻害剤の影響
  井沢 鉄也; 水田 拓道; 駒林 隆夫; 須田 和裕
  日本運動生理学雑誌, 日本運動生理学会事務局, 1(1) 76 - 76, 1994
• 363.運動トレーニングとラットMn-SOD
  大野 秀樹; 大河原 知水; 山下 均; 木崎 節子; 井澤 鉄也; 駒林 隆夫; 大平 充宣
  体力科學, 日本体力医学会, 42(6) 748 - 748, 01 Dec. 1993
• 270.持久的トレーニングと脂肪細胞の脂肪分解能におけるCa^<2+>の役割
  井沢 鉄也; 水田 拓道; 駒林 隆夫; 須田 和裕
  体力科學, 日本体力医学会, 42(6) 701 - 701, 01 Dec. 1993
• 18.脂肪分解のインスリンに対する反応性に及ぼす身体トレーニングの影響 第4報
  須田 和裕; 駒林 隆夫; 井沢 鉄也; 坪井 実; 中原 凱文
  体力科學, 日本体力医学会, 41(6) 659 - 659, 01 Dec. 1992
• 311.運動時のACTHによる脂肪動員作用に関する基礎的研究 I
  井沢 鉄也; 水田 拓道; 駒林 隆夫; 坪井 実; 須田 和裕
  体力科學, 日本体力医学会, 41(6) 806 - 806, 01 Dec. 1992
• Effect of exercise training on the sensitivity of insulin III
  SUDA KAZUHIRO; IZAWA TETSUYA; KOMABAYASHI TAKAO; MOCHIZUKI TAKEHITO; TSUBOI MINORU
  Japanese Journal of Physical Fitness and Sports Medicine, The Japanese Society of Physical Fitness and Sport Medicine, 40(6) 914 - 914, 01 Dec. 1991
• Effect of exercise training on the sensitivity of adipocytes to insulin I
  MOCHIZUKI TAKEHITO; IZAWA TETSUYA; KOMABAYASHI TAKAO; SUDA KAZUHIRO; TSUBOI MINORU
  Japanese Journal of Physical Fitness and Sports Medicine, The Japanese Society of Physical Fitness and Sport Medicine, 40(6) 912 - 912, 01 Dec. 1991
• Effect of exercise training on the sensitivity of adiposytes to insulin II
  IZAWA TETSUYA; MOCHIZUKI TAKEHITO; KOMABAYASHI TAKAO; SUDA KAZUHIRO; TSUBOI MINORU
  Japanese Journal of Physical Fitness and Sports Medicine, The Japanese Society of Physical Fitness and Sport Medicine, 40(6) 913 - 913, 01 Dec. 1991
• 17. An increase in intralysosomal pH is involved in the release of lysosomal enzymes induced by exhaustive exercise
  HARASAWA KATSUYA; TSUBOI MINORU; KOMABAYASHI TAKAO; FUJINAMI. HIROYUKI; IZAWA TETSUYA; SUDA KAZUHIRO
  Japanese Journal of Physical Fitness and Sports Medicine, The Japanese Society of Physical Fitness and Sport Medicine, 40(2) 243 - 243, 01 Apr. 1991
• 18. In vivo adaptative control of β-receptor and adenylate cyclase during short term heat expo-sure in rat parotid glands
  FUJINAMI HIROYUKI; KOMABAYASHI TAKAO; TSUBOI. MINORU; IZAWA TETSUYA; SUDA KAZUHIRO
  Japanese Journal of Physical Fitness and Sports Medicine, The Japanese Society of Physical Fitness and Sport Medicine, 40(2) 243 - 244, 01 Apr. 1991
• A possible mechanisme of exercise-induced release of lysosomal enzymes is increased intralysosomal pH
  HARASAWA KATSUYA; TSUBOI MINORU; KOMABAYASHI TAKAO; FUJINAMI HIROYUKI; IZAWA TETSUYA; SUDA KAZUHIRO
  Japanese Journal of Physical Fitness and Sports Medicine, The Japanese Society of Physical Fitness and Sport Medicine, 40(1) 132 - 133, 01 Feb. 1991
• Exercise training enhances the coupling of adenylate cyclase activity to lipolysis in rat adipocytes
  IZAWA TETSUYA; KOMABAYASHI TAKAO; FUJINAMI HIROYUKI; HARASAWA KATSUYA; TSUBOI MINORU; SUDA KAZUHIRO
  Japanese Journal of Physical Fitness and Sports Medicine, The Japanese Society of Physical Fitness and Sport Medicine, 40(1) 132 - 132, 01 Feb. 1991
• Relationship betewwn adenylate cyclase and lipolysis in adipocytes from exercise-trained rats
  IZAWA Tetsuya; SUDA Kazuhiro; KOMABAYASHI Takao; TSUBOI Minoru
  Japanese Journal of Physical Fitness and Sports Medicine, The Japanese Society of Physical Fitness and Sport Medicine, 39(6) 822 - 822, 01 Dec. 1990
• Relationship between training effect on insulin action and adenosine
  SUDA Kazuhiro; KOMABAYASHI Takao; IZAWA Tetsuya; TSBOI Minoru
  Japanese Journal of Physical Fitness and Sports Medicine, The Japanese Society of Physical Fitness and Sport Medicine, 39(6) 845 - 845, 01 Dec. 1990
• Effect of training on insulin-induced antilipolytic action in rat adipocytes
  SUDA KAZUHIRO; IZAWA TETSUYA; KOMABAYASHI TAKAO; TSUBOI MINORU; FUJINAMI HIROYUKI
  Japanese Journal of Physical Fitness and Sports Medicine, The Japanese Society of Physical Fitness and Sport Medicine, 38(6) 364 - 364, 01 Dec. 1989
• Inhibitory pathway in lipolytic cascade in adipocytes from exercise-trained male rats.
  IZAWA TETSUYA; KOMABAYASHI TAKAO; SUDA KAZUHIRO; SHINODA SHOUHACHIROU; KOSHIMIZU EIZI; TSUBOI MINORU
  Japanese Journal of Physical Fitness and Sports Medicine, The Japanese Society of Physical Fitness and Sport Medicine, 38(6) 363 - 363, 01 Dec. 1989
• 19.Does exercise training decrease sensitivity of adipocyte IipoIysis to adenosine in rats?
  IZAWA TETSUYA; KOSHIMIZU EIZI; TSUBOI MINORU
  Japanese Journal of Physical Fitness and Sports Medicine, The Japanese Society of Physical Fitness and Sport Medicine, 38(2) 81 - 82, 01 Apr. 1989
• Changes in lysosomal enzymes by the severe exercise
  Tsuboi Minoru; Hattori Ryuichi; Fujinami Hiroyuki; Izawa Tetsuya; Suda Kazuhiro; Shinoda Shohachiro; Kobune Katsutosh; Koshimizu Eiji; Kunisada Yukjnori
  Japanese Journal of Physical Fitness and Sports Medicine, The Japanese Society of Physical Fitness and Sport Medicine, 37(6) 556 - 556, 01 Dec. 1988
• トレーニングラットの脂肪細胞におけるカテコールアミンによる脂肪分解反応に及ぼすアデノシンディアミナーゼの影響
  井澤鉄也; 小清水英司
  東京薬科大学一般教育研究紀要, (9) 141 - 145, 1988
• The movement of the lysosomal enzymes during exhaustive exercise
  TSUBOI MINORU; MARUYAMA KAZUHIRO; HATTORI RYUICHIROU; KOMABAYASHI TAKAO; IZAWA TETSUYA; SUDA KAZUHIRO; SHINODA SHOHACHIROU; KOFUNE KATSUTOSHI; KOSHIMIZU EIJI
  Japanese Journal of Physical Fitness and Sports Medicine, The Japanese Society of Physical Fitness and Sport Medicine, 36(6) 433 - 433, 01 Dec. 1987
• Effect of an acute exercise on β-adrenergic receptors in rat heart
  IZAWA TETSUYA; KOMABAYASHI TAKAO; SUDA KAZUHIRO; KATOU HIROSHI; MARUYAMA KAZUYASU; HATTORI RYUICHIROU; TSUBOI MINORU; KOSHIMIZU EIJI; SHINODA SHOHACHIROU
  Japanese Journal of Physical Fitness and Sports Medicine, The Japanese Society of Physical Fitness and Sport Medicine, 36(6) 339 - 339, 01 Dec. 1987
• Effect of exercise training on amylase and glycogen contents of rat submandibular glands
  KOMABAYASHI TAKAO; IZAWA TETSUYA; KOSHIMIZU EIJI; SUDA KAZUHIRO; SHINODA SHOHACHIROU; MARUYAMA KAZUYASU; HATTORI RYUICHIROU; TSUBOI MINORU
  Japanese Journal of Physical Fitness and Sports Medicine, The Japanese Society of Physical Fitness and Sport Medicine, 36(6) 459 - 459, 01 Dec. 1987
• 12. Effect of exercise-training on the release of[^3H]GDP in rat adipocyte membranes
  IZAWA TETSUYA; KOSHIMIZU EIZI; KOMABAYASHI TAKAO; TSUBOI MINORU; SUDA KAZUHIRO
  Japanese Journal of Physical Fitness and Sports Medicine, The Japanese Society of Physical Fitness and Sport Medicine, 36(1) 49 - 50, 01 Feb. 1987
• 心拍数からみた壁テニスの運動強度
  小清水英司; 井澤鉄也
  東京薬科大学一般教育研究紀要, (8) 23 - 28, 1987
• Effect of chronic administration of isoproterenol on rat adipocytes. III
  井沢 鉄也; 駒林 隆夫; 小清水 英司; 須田 和裕; 坪井 実
  Japanese Journal of Physical Fitness and Sports Medicine, The Japanese Society of Physical Fitness and Sport Medicine, 35(6) 460 - 460, 01 Dec. 1986
• Comparison between salivary glands from exercise-trained rats and from chronic reserpine-treated rats
  Komabayashi Takao; Sakamoto Seiya; Murohashi Masako; Endo Shiro; Izawa Tetsuya; Koshimizu Eiji; Tsuboi Minoru
  Japanese Journal of Physical Fitness and Sports Medicine, The Japanese Society of Physical Fitness and Sport Medicine, 33(6) 459 - 459, 01 Dec. 1984
• Effect of exercise-training on β-adrenergic receptors of rat fat cells II
  Izawa Tetsuya; Koshimizu Eiji; Komabayashi Takao; Tsuboi Minoru
  Japanese Journal of Physical Fitness and Sports Medicine, The Japanese Society of Physical Fitness and Sport Medicine, 33(6) 456 - 456, 01 Dec. 1984
• 16. Effect of exercise-training on rat epididymal adipose tissue : II. Effects of repeated injections of reserpine
  IZAWA TETSUYA; KOSHIMIZU EIJI; KOMABAYASHI TAKAO; TSUBOI MINORU
  Japanese Journal of Physical Fitness and Sports Medicine, The Japanese Society of Physical Fitness and Sport Medicine, 32(6) 389 - 389, 01 Dec. 1983
• トレーニング中止が呼吸機能の最大酸素摂取量および Anaerobic Threshold に及ぼす影響
  井澤鉄也; 小清水英司; 室 増男; 与那正栄
  東京薬科大学一般教育研究紀要, (6) 41 - 43, 1983
• 低体力者に対する体力トレーニング処方の一試案
  与那正栄; 小清水英司; 室 増男; 井澤鉄也
  東京薬科大学一般教育研究紀要, (6) 45 - 48, 1983
• 126.全身反応時間と下肢筋群の相助・拮抗作用について : 運動生理学的研究II : 第36回日本体力医学会大会
  与那 正栄; 室 増男; 小清水 英司; 井沢 鉄也
  体力科學, 日本体力医学会, 30(6) 364 - 364, 01 Dec. 1981
• 3. Echocardiographic study of left ventricular response to supine bicycle exercise. A study on distant runners.
  KATO HIROSHI; OGAWA SHINKICHI; KORO TSUNEO; NODA HIROSHI; IZAWA TETSUYA
  Japanese Journal of Physical Fitness and Sports Medicine, The Japanese Society of Physical Fitness and Sport Medicine, 30(5) 271 - 272, 01 Oct. 1981

Books etc

• 運動と内分泌 ホルモン受容体 In ニュー運動生理学
  真興交易医書出版部, 2014
• 「褐色脂肪細胞の起源、増殖、分化」，「褐色脂肪組織は安眠をもたらすか」 In 『ここまでわかった燃える褐色脂肪の不思議』
  ナップ, 2013
• 運動を制御する内分泌系の機能と適応. In スポーツ指導者に必要な生理学と運動生理学の知識
  市村出版, 2012
• 脂肪組織のエクササイズバイオロジー
  ナップ, 2011
• 細胞内シグナル伝達系と運動
  真興交易医書出版部・運動生理学のニューエビデンス 宮村実晴 編集, 2010
• アディポカイン
  真興交易医書出版部・運動生理学のニューエビデンス 宮村実晴 編集, 2010
• トレーニングと内分泌・ホルモン受容体
  真興交易医書出版部・身体トレーニング 宮村実晴 編集, 2009
• 運動と内分泌系と免疫
  ナップ・運動と免疫 大野秀樹 木崎節子 編集, 2009
• 内分泌と運動：健康運動指導士養成講習会テキスト
  健康体力つくり事業団, 2008
• 脂肪と体力
  ナップ・：体力とは何か 長澤純一 編集, 2007
• Cellular adaptations of adipocytes to exercise training
  Cooper Publishing Group: Exercise, Nutrition, and Environmental Stress, Nose H, Spriet LL, and Imaizumi K eds, 2002
• Cellular adaptations of adipocytes to exercise training
  Cooper Publishing Group: Exercise, Nutrition, and Environmental Stress, Nose H, Spriet LL, and Imaizumi K eds, 2002
• からだを動かすしくみ
  杏林書院, 2001
• 「副腎皮質刺激放出ホルモン（ＣＲＦ）の反応は？」「ビタミンＤの反応は？」「運動は骨を丈夫にするのか？」
  大修館書店・運動と遺伝 大野秀樹 及川恒之 石井直方 編集, 2001
• 運動とホルモン
  ナップ, 2001
• 代謝(概要)、脂質代謝
  真興交易医書出版部」・新運動生理学（下巻） 宮村実晴 編集, 2001
• 運動生理・生化学辞典
  大修館書店, 2001
• 「呼吸商って何？」「脂肪の使われ方が何故わかるの？」「リバウンドを防ぐにはどうすればいいのか」「体脂肪を効果的にとるための具体的な運動処方は？」
  杏林書院・身体運動・栄養・生命環境科学Q&Aシリーズ「栄養と運動」 伏木 亨 跡見順子 大野秀樹 編集, 1999
• 高強度運動時の代謝応答，長時間運動時の代謝応答，トレーニングに対する代謝応答
  メディカル・サイエンス・インタ－ナショナル・：スポーツとトレーニングの生化学 谷口正子、大野秀樹、谷口直之 監訳, 1999
• 内分泌（ホルモン）
  杏林書院・スポーツ医科学 中野昭一 編集, 1999
• カテコールアミン受容体の測定法
  大修館書店・運動生理学実験法 今泉和彦・石原昭彦 編集, 1998
• 「一酸化窒素（ＮＯ）の反応は？」「サイトカインの反応は？」「高密度リポタンパク質（ＨＤＬ）コレステロールの役割は？」「活性酸素発生系とその防御系」
  杏林書院・身体運動・栄養・生命環境科学Q&Aシリーズ「活性酸素と運動」 大野秀樹 跡見順子 伏木 亨 編集, 1998
• 運動とホルモン
  真興交易医書出版部・最新運動生理学 宮村実晴 編集, 1996
• 「内分泌と代謝」「生命誕生のしくみ」「発育と発達」
  評伝社・保母試験講座第6巻 坪井 實 編集, 1990
• 「呼吸器系」「内分泌系」「代謝生理」
  廣川書店・カラースケッチ生理学 坪井 實 監訳, 1990

Presentations

• 脂肪組織の質と量を転換させる運動療法の分子基盤
  井澤鉄也
  第74回日本体力医学会大会．, 20 Sep. 2019, 19 Sep. 2019, 21 Sep. 2019, Invited oral presentation
• 運動による脂肪組織のリモデリング
  井澤 鉄也
  2017年度日本臨床栄養協会・サプリメントアドバイザーレベルアップセミナー, May 2016, Invited oral presentation
• 運動トレーニングによるホルモン変化とボディコンポジション（body composition）の変容
  井澤 鉄也
  国際生命科学研究機構Japan３０周年記念 第６回「栄養とエイジング」国際会議, Sep. 2011, Invited oral presentation
• 脂肪細胞の脂肪分解反応に及ぼす新規カテキン型ポリフェノール複合体01igonolの効果
  井澤 鉄也
  第21回体力・栄養・免疫学会大会, 2011, 北里大学
• 運動は老化促進モデルマウスの認知機能障害を予防する
  井澤 鉄也
  第18回日本運動生理学会, 2011, 鹿児島大学
• Oligonol, a new lychee fruit-derived low molecular form of polyphenol, enhances lipolysis in primary rat adipocytes via activation of the ERK1/2 pathway.
  IZAWA Tetsuya
  11th ICO （International Congress on Obesity）, 2011, Stockholm Sweden.
• Effects of exercise-training-induced hormonal changes on body composition.
  IZAWA Tetsuya
  The 6th International Conference on Nutrition and Aging, 2011, Tokyo, Japan.
• 肥満抑制効果を有する01igOn01による脂肪分解反応の調節機構の解明
  井澤 鉄也
  第81回日本衛生学会学術総会（東京），※東日本大震災のため開催中止（発表抄録のみ）, 2010
• 老化促進モデルマウスの認知機能障害に対する運動トレーニングの予防効果
  井澤 鉄也
  第65回日本体力医学会, 2010, 千葉
• 持久的トレーニングによる脂肪細胞のATGL発現の変化と調節メカニズム
  井澤 鉄也
  第18回日本運動生理学会, 2010, 鹿児島大学
• 運動トレーニングによる脂肪細胞の脂肪分解反応とAdipose Triglyceride Lipaseの役割
  井澤 鉄也
  第80回日本衛生学会学術総会, 2010, 仙台
• 運動トレーニングは脂肪組織由来幹細胞の脂肪細胞への分化を抑制する
  井澤 鉄也
  第6回日本予防医学会総会, 2009, 東京医科大学
• 運動トレーニングによる脂肪細胞の脂肪分解反応の亢進にはadipose triglyceride lipase (ATGL) の発現変化が関与する
  井澤 鉄也
  第64回日本体力医学会, 2009, 新潟
• 脂肪組織由来幹細胞の脂肪細胞分化に及ぼす運動トレーニングの影響
  井澤 鉄也
  第64回日本体力医学会, 2009, 新潟
• 脂肪細胞サイズとアディポカイン遺伝子発現との関係に及ぼす運動トレーニングの影響
  井澤 鉄也
  第64回日本体力医学会, 2009, 新潟
• 急性運動と脂肪細胞のホルモン感受性リパーゼの発現変化
  井澤 鉄也
  第64回日本体力医学会, 2009, 新潟
• 脂肪組織由来幹細胞の脂肪細胞への分化は運動トレーニングによって抑制される
  井澤 鉄也
  第17回日本運動生理学会, 2009, 東京慈恵会医科大学
• 脂肪組織リモデリングとアディポサイトカイン発現に及ぼす運動の影響：動物実験からみた分子制御機構
  井澤 鉄也
  第16回 日本運動生理学会, Aug. 2008, Invited oral presentation, 奈良
• 脂肪組織由来幹細胞の脂肪および血管内皮細胞への分化に対する運動トレーニングの影響
  井澤 鉄也
  第79回日本衛生学会総会, 2008, 北里大学
• 急性運動による脂肪細胞の脂肪分解反応のメカニズム
  井澤 鉄也
  第79回日本衛生学会総会, 2008, 北里大学
• 運動や運動トレーニングによるβ-アドレナリン受容体の適応機構
  井澤 鉄也
  第23回日本体力医学会近畿地方会, 2008, 大阪学院大学
• 運動負荷パターンの差異が酸化ストレスにおよぼす影響
  井澤 鉄也
  第63回日本体力医学会, 2008, 別府市
• 運動トレーニングによって脂肪細胞内酸化ストレスは軽減される
  井澤 鉄也
  第78回日本衛生学会総会, 2008, 熊本市
• Oxidative stress in adipocytes is reduced by new lychee-derived polyphenol oligonol converted into a low-molecular form
  IZAWA Tetsuya
  Biomarkers of Oxidative Stress in Haelth and Diseases, 2008, Osaka, Japan.
• 肥満予防に対する骨格筋と脂肪組織の役割：脂肪組織と骨格筋の脂肪分解反応
  井澤 鉄也
  第62回 日本体力医学会, Sep. 2007, Invited oral presentation, 秋田
• 脂肪細胞の増殖・分化に対するグリクラジドの機能の解析
  井澤 鉄也
  第30回日本分子生物学会総会・第80回日本生化学会大会, 2007, 横浜
• 運動トレーニングの脂肪組織内酸化ストレス軽減効果
  井澤 鉄也
  第5回日本予防医学会学術総会, 2007, 大阪
• 脂肪組織由来幹細胞に及ぼす運動トレーニングの影響
  井澤 鉄也
  第60回日本体力医学会, 2007, 秋田
• シンポジウム1 体力科学における骨格筋研究の展開と展望：肥満予防に対する骨格筋と脂肪組織の役割「脂肪組織と骨格筋の脂肪分解反応」
  井澤 鉄也
  第62回日本体力医学会, 2007, 秋田
• 脂肪細胞の酸化ストレスはライチ由来新規低分子化ポリフェノールOligonolによって軽減される
  井澤 鉄也
  国際食品機能学会2007, 2007
• ライチ由来新規低分子化ポリフェノールOligonolによる脂肪細胞内酸化ストレス減少効果
  井澤 鉄也
  第77回日本衛生学会総会, 2007
• New lychee-derived polyphenol oligonol converted into a low-molecular form reduces oxidative stress in adipocyte.
  IZAWA Tetsuya
  15th European Congress on Obesity, 2007, Budapest, Hungary
• Antioxidative/antiinflammatory effects of the new lychee-derived polyphenol oligonol converted into a low-molecular form in white adipose tissue.
  IZAWA Tetsuya
  3rd International Conference on Polyphenols and Health, 2007, Kyoto, Japan
• 持久運動時のエネルギー基質とその動き‐糖・脂質・タンパク質‐：運動と脂肪
  井澤 鉄也
  第57回 日本体育学会, Aug. 2006, Invited oral presentation, 弘前
• 脂質代謝と運動
  井澤 鉄也
  第10回日本運動生理学会, Jul. 2002, Invited oral presentation, 筑波
• Cellular adaptations of adipocytes to exercise training.
  IZAWA Tetsuya
  GSSI-Sports Science Network Forum in Nagano 2000, Jul. 2000, Invited oral presentation, 長野
• 運動と脂肪細胞の脂肪分解反応
  井澤 鉄也
  日本栄養・食糧学会中部支部シンポジウム, May 1998, Invited oral presentation, 名古屋
• 脂肪細胞と細胞内Ca2+の動き
  井澤 鉄也
  第9回 運動生化学研究会シンポジウム, Dec. 1996, Invited oral presentation
• 脂肪細胞と細胞内Ca²⁺の動き
  井澤 鉄也
  第9回 運動生化学研究会シンポジウム, 1996, 東京
• 細胞内情報伝達系と運動
  井澤 鉄也
  第3回 日本運動生理学会, Jul. 1995, Invited oral presentation, 東京

Research Projects

• 運動療法が影響する細胞外マトリックスのダイナミクスに制御される脂肪由来幹細胞機能
  井澤 鉄也; 高倉 久志; 土屋 吉史
  日本学術振興会, 科学研究費助成事業, 2023/04 -2026/03, Principal investigator, 基盤研究(B), 同志社大学
• Possible mechanism underlying exercise training-mediated the differentiation of adipose-derived stem cells: roles of intracellular amino acid metabolism
  Izawa Tetsuya
  This study clarified the mechanism of exercise training (TR)-induced change in the differentiation ability of adipose-derived stem cells (ADSCs) to adipocytes by investigating amino acid-mediated signal transduction. TR inhibited adipogenic differentiation of ADSCs with reduced expression of PPARγ protein. TR also affected L-leucine-induced changes in the protein expression of Sestrin2 and mTORC1. However, these responses to TR differed between subcutaneous and visceral adipose tissue ADSCs. In particular, bioinformatics analysis revealed that the down-regulation of branched-chain amino acid degradation pathways was enriched in adipocytes differentiated from ADSCs derived from subcutaneous adipose tissue. The findings obtained in this study would be extremely significant in constructing new exercise therapy for obesity, focusing on the effects of amino acids., Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2019/04 -2023/03, Principal investigator, Grant-in-Aid for Scientific Research (B), Doshisha University
• Clarification of mechanism(s) underlying exercise training-induced possible change(s) in the differentiation potential of adipose tissue-derived stem cells
  Izawa Tetsuya; KATO Hisashi; TAKAKURA Hisashi; OGASAWARA Junetsu; SAKURAI Takuya
  Both visceral and subcutaneous adipose tissues are composed of several types of cells. Of these cells, adipose tissue-derived stem cells (ADSC) from either visceral or subcutaneous adipose tissue can be differentiated into each fat depot-specific adipocytes. The aim of the present project was to establish the effect of exercise training on the ability of ADSC into adipocytes and other type of cells. The main findings were as follows. First, fat depot-specific differences in developmental genes were found in the expressions, and some of developmental genes expressions were associated with exercise training-induced changes in adipose tissue weight. Second, exercise training affected intracellular metabolism, probably being associated with the changes in the ability of ADSC into mature adipocytes. Finally, high-fat diet impaired the differentiation ability of ADSC into neuron-like cells, but exercise training ameliorated such the high-fat diet-induced impairment of neurogenesis in ADSC., Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2016/04 -2019/03, Principal investigator, Grant-in-Aid for Scientific Research (B), Doshisha University
• The analysis for mechanism of exercise-induced adipose tissue remodeling on developmental genes
  Kato Hisashi; IZAWA Tetsuya; TAKAKURA Hisashi
  Recent studies indicate that developmental genes are differentially expressed in subcutaneous adipose tissue (scWAT) and visceral adipose tissue (vWAT), and that some of these genes exhibit changes in expressions which closely correlate with the extent obesity and the pattern of fat distribution. The purpose of the current study was to investigate the effect of exercise training (TR) and high-fat diet (HFD) on developmental genes in three depots: inguinal, epididymal, and brown fat from rats. The fat depot-specific differences in mRNA levels of developmental genes were observed in three fat depots. TR and HFD induced the changes in the expression levels of some of these genes, i.e., HoxA5, HoxC9, and HoxC10. Moreover, the depression of HoxC10 in inguinal and brown adipocytes increases the expressions of brown fat genes, Ucp1 and Pgc1α. These data suggest that HoxC10 modulates adaptation of exercise training on adipose tissues., Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2016/08 -2018/03, Coinvestigator, Grant-in-Aid for Research Activity Start-up, Doshisha University
• Response and adaptation of skeletal muscle to endurance training based on circadian rhythms of clock gene expression.
  Takakura Hisashi; IZAWA Tetsuya; MASUDA Shinya; HIEDA Mutsuko; KATOU Hisashi
  The purpose of this study was to determine whether exercise timing enhanced exercise training (TR)-induced increase in the levels of mitochondrial proteins in skeletal muscles. The treadmill TR for 9 weeks was conducted at two time points (TR@zeitgeber time 0 (ZT0) and TR@ZT10). Both of per2 and pgc-1α mRNA expression showed the highest level at ZT0 and lowest level at ZT10. Additionally, the rats underwent acute exercise at the same time points (Ex@ZT0 and Ex@ZT10). The TR significantly increased levels of the mitochondrial protein (COXIV) in the deep portion of gastrocnemius muscle. Moreover, COXIV level in the TR@ZT10 group increased significantly compared to those in the TR@ZT0 group. Indeed, pgc-1α mRNA expression increased significantly immediately after acute exercise only at Ex@ZT10. The timing of TR influenced TR-induced adaptation. This differential adaptation might be caused by the differential PGC-1α expression upon acute exercise., Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2014/04 -2017/03, Coinvestigator, Grant-in-Aid for Young Scientists (B), Doshisha University
• Establishment of the Evidence of Thermal Therapy before Exercise Protecting Articular Degeneration
  HOJO TATSUYA; IZAWA Tetsuya
  Cultured human articular chondrocytes were subjected to the 1st HS in a thermal bath (37, 39, 41, 43 °C for 20 min) after 48 h of differentiation. Then, 24 h after the 1st HS, half of them were exposed to fatal stress (2nd HS at 45 °C) for 15 min. Cell viability was measured 8 h after 2nd HS. Twenty-four hours after each HS, Hsp70, proteoglycan, and type II collagen mRNA expressions were quantified by rt-PCR. After the 1st HS, Hsp70 expression gradually increased with increase in temperature of the HS. Proteoglycan and type II collagen gradually increased until HS at 41 °C. HSP70 expression level significantly increased 24 h after the 1st HS at 41 °C compared with that in untreated chondrocytes. Moreover, chondrocytes pretreated at 41 °C showed increased cartilage matrix gene expression and the most tolerance to the 2nd HS. Appropriate HS caused increase in HSP70 expression, leading to enhancement of chondrocytes’ tolerance to heat stress., Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2013/04 -2016/03, Coinvestigator, Grant-in-Aid for Scientific Research (C), Doshisha University
• Exercise prescription based on the circadian rhythm of adipocyte clock genes : The significance of chrono-exercise prescription
  IZAWA Tetsuya
  The mRNA levels of both adipokines and metabolic genes were strongly correlated with those of clock genes. The mRNA expressions of adipokines and metabolic genes, which were obtained after the exercise performed at the peak of Bmal1 mRNA expression, differed from those obtained after the exercise performed at the bottom of Bmal1 mRNA expression. Melatonin affected the mRNA expressions of several genes regulating adipocyte metabolism and adipokines. The findings indicate that the circadian rhythm of adipokines genes and metabolic genes should be considered when the exercise is used for preventing and improving metabolic syndrome due to obesity., Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2011 -2013, Principal investigator, Grant-in-Aid for Scientific Research (B), Doshisha University
• Optimal exercise intensity for defense ability to oxidative stress
  NAGASAWA Junichi; IZAWA Tetsuya; OHNO Hideki
  The purpose of the study was to evaluate the effects of physical exercise to antioxidation power in plasma. Six male subjects (21-25 years old) performed maximal exercise by a gradual increase load using a bicycle ergometer. Exercise load was raised by 25W every four minutes to exhaustion. Blood samples were obtained from the antecubital vein at rest, each load stage, and 10 minutes, 1-hour and 1-day after exercise. As antioxidation power, we measured iron reduction power (Fe^<3+>→Fe^<2+>). The quantity of hydroxyl radical generation was measured by a spin trap method. The lactic acid and the pyruvic acid were measured by an enzyme method. Six another subjects exercised with a physical work as equivalence. The iron reduction power in plasma rose with an increase in exercise intensity. On the contrary, the quantity of generation of a hydroxyl radical decreased with a rise of exercise intensity. This shows that antioxidation power of plasma increases by a rise of exercise intensity. In addition, there were negative relations to lactic acid and ESR signal intensity. These data supported that the plasma lactic acid which increased by exercise has a role of a scavenger of active oxygen., Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2004 -2006, Coinvestigator, Grant-in-Aid for Scientific Research (C), The University of Electro-Communications
• キレート化合物による骨格筋遺伝子導入法の開発:スポーツ科学への応用
  大野 秀樹; 人見 嘉哲; 木崎 節子; 井澤 鉄也
  われわれは、骨格筋細胞や組織に大きなダメージを与えることなく、遺伝子導入の効率を高めることができる遺伝子導入促進剤およびそれを含む遺伝子導入用組成物の国際特許取得のため、2004年9月10日に国際公開した。 すなわち、カルシウムイオンおよび/あるいはマグネシウムイオンを捕足する物質が、遺伝子導入効率を高めることを見出した。さらに、本研究は、遺伝子導入を望む外来遺伝子を含み、遺伝子導入される動物の骨格筋細胞中で外来遺伝子を発現することができる組み換えベクターと遺伝子導入促進剤とを媒体中に含む遺伝子導入用組成物を提供する。遺伝子導入促進剤は、カルシウムイオン/マグネシウムイオンを捕足する物質からなる。つまり、カルシウムイオン/マグネシウムイオンのキレート化剤が好ましい。たとえば、EDTA、CyDTA、DTPA-OH、EDDP、およびHDTA、ならびにこれらの塩(好ましいのは、ナトリウムやカリウムのようなアルカリ金属塩、複数のカルボキシル基の一部が塩になっているものを含有するもの)である。これらのうち、EDTAは細胞や組織へのダメージが軽微であり、医薬品としてすでに認可されているものでもあるので、最も望ましい。なお、カルシウムイオン/マグネシウムイオンを捕足する物質としてキレート剤は好ましいが、必ずしもキレート剤に限定されず、両イオンを捕足できる物質であれば他のものでもよい。 本研究により、遺伝子導入促進剤は、骨格筋細胞や組織に大きなダメージを与えることなく、遺伝子導入の効率を高めることができる。遺伝子導入促進剤の存在下に遺伝子導入を行うことにより、細胞や組織に大きなダメージを与えることなく細胞への遺伝子導入効率を向上させることができるので、本研究は、遺伝子治療の効率を高めることができ、遺伝子治療に有用な遺伝子導入用組成物を提供することが可能である。, 日本学術振興会, 科学研究費助成事業, 2003 -2004, Coinvestigator, 萌芽研究, 杏林大学
• Clarification of the molecular mechanism(s) behind exercise training-induced suppression of fat mass
  IZAWA Tetsuya
  In order to clarify the mechanism(s) behind either exercise- or exercise training-induced suppression of fat mass, the following studies were performed in rat adipocytes : (1)effects of exercise on apoptotic and anti-apoptotic signals, (2)effects of exercise and diet on several genes related with lipid metabolism, (3)effects of exercise on tumor necrosis factor-α (TNF-α)-induced apoptotic and anti-apoptotic signals, (4)effect of exercise training on insulin secretion from pancreatic islets, (5)alterations in exercise-induced β-adrenergic receptors and G proteins. As a result, the following findings were obtained. Exercise increased the Bcl2/Bax ratio in retroperitoneal and inguinal adipose tissue, but decreased its ratio in epididymal adipose tissue. Starvation reduced the expressions of some lipogenic genes, and re-feeding enhanced these expressions. Exercise after re-feeding blocked re-feeding-induced enhancement of some lipogenic genes expressions. Exercise training enhanced TNF-α signaling directed toward the expressions of survival signals and the suppression of fatty acid synthase gene expression. The mechanism behind exercise training-induced reduction of insulin secretion may involve an enhanced expression of neuronal nitric oxide synthase and a decreased expression of Gαi-2 protein. Acute exercise altered the expression of Giα2 protein via the ubiquitin-proteasome pathway, and the mechanism underlying the increased density of β_2-AR after exercise may involve alterations in a multi-step event involving the coordinate interaction among proteins mediating β_2-AR trafficking, e.g. G-protein-coupled receptor kinase-2 and β-arrestin-2. Thus, the data obtained in this grant will become helpful to understand more exact mechanism behind exercise training-induced suppression of fat mass., Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2003 -2004, Principal investigator, Grant-in-Aid for Scientific Research (B), Tokyo Metropolitan University
• Possible role of nitric oxide in lipolysis in exercise-trained rats.
  IZAWA Tetsuya
  A possible role of nitric oxide (NO) on adipocyte lipolysis was studied in exercise-trained (9 weeks of running) rats. Lipolysis in adipose tissue tended to be greater in trained rats than in control rats. Treatment of adipose tissue with 5 mM N^G -nitro-L-arginine methyl ester (L-NAME) showed that both basal and isoproterenol-stimulated lipolysis were significantly greater in trained rats than in control rats. In contrast, in isolated adipocytes, L-NAME had no effect on lipolysis in either group of rats, although the lipolysis of isolated adipocytes was significantly greater in trained rats than in control rats. Training significantly reduced nitrite/nitrate production in adipocytes but not in tissue. On the other hand, training increased the protein expression of endothelial nitric oxide synthase (eNOS) but not that of inducible NOS (iNOS) in the extracts of tissue homogenates. In tissue homogenates, eNOS activity but not iNOS activity was significantly greater in trained rats than in control rats. In cellular extracts, training significantly reduced the activites of both NOSs, but the mRNA expressions of both NOSs were not different between groups. The NO donor, S-nitroso-N-acetyl-penicillamine (SNAP), significantly inhibited adipocyte lipolysis in response to isoproterenol in both groups. This inhibitory effect of SNAP was greater in the adipocytes of trained rats than in those of the control rats. Thus, it is possible that NO is involved in the regulation of lipolysis and that exercise training enhances the responsiveness of adipocytes to extracellular NO with the reduced production of nitrite/nitrate in adipocytes due to decreased activites of NOSs. On the other hand, it is also possible that exercise increases either the activity or protein expression of eNOS in adipose tissue., Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2001 -2002, Principal investigator, Grant-in-Aid for Scientific Research (C), Tokyo Metropolitan University
• Possible role of adipocytokines in exercise-induced improvement of obesity and insulin-resistance.
  IZAW Tetsuya
  This research project examined possible role of adipocytokines in exercise-induced improvement of obesity and insulin-resistance. The increase in plasma concentrations of tumor necrosis factor (TNF)- α has been shown to result in insulin resistance. It is unclear, however, whether endurance exercise training can reduce the ability of adipocytes to secrete TNF- α. Therefore, we examined the effects of endurance training on the secretions of TNF- α and soluble TNF- α receptor (sTNFR) from isolated adipocytes. The expressions of menbrane-p55 TNF receptor (TNFR) in adipocytes were also examined. Male Wistar rats were divided into two groups, sedentary control and exercise-trained group. The rats of exercise-trained group were exercised on a rodent treadmill for 9 weeks. Adipocytes were isolated from the epididymal adipose tissue at least 36 hours after the last bout of exercise. The adipocytes (250000 per tube) were incubated in 5ml of DMEM/Ham's F12 medium for 24 hours at 37℃. The amounts of TNF- α and sTNFR in the culture medium were measured by ELISA.TNFR was measured by Western blot analysis. Exercise training increased significantly the secretions of TNF- α from isolated adipocytes. This increase was completely blocked by indomethacin or ETYA, cyclooxygenase inhibitors, suggesting that the enhanced secretions could be mediated by a possible change in the activity of cyclooxygenase. On the other hand, exercise training could decrease the secretions of sTNFR.The concentrations of sTNFR tended to be less in exercise-trained than in control rats. In contrast, exercise training could increase the expressions of TNFR proteins in adipocytes. This result suggests that TR would enhance the autocrine effect of TNF- α on adipocytes., Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 1999 -2000, Principal investigator, Grant-in-Aid for Scientific Research (C), Tokyo Metropolitan University
• The study of exercise treatment for cardiovascular diseases
  IZAWA Tetsuya
  The effects of chronic physical exercise (ET) on the sensitivity of thoracic aorta to norepinephrine and on adipocyte lipolysis were investigated in spontaneously hypertensive rats (SHR). After ET, the attenuated sensitivity of aorta to norepinephrine was observed in SHR rats as well as in normotensive rats. This attenuated sensitivity of aorta to norepinephrine after ET was still evident in endothelium-denuded aorta, but to a lesser extent than in endothelium-intact aorta. No significant difference in 60 mM KC1-induced tension between control and trained SHR rats was observed with or without endothelium after ET.The results suggest that levels of endothelium-dependent releasing factor may increase in response to norepinephrine after ET in SHR rats as well as in normotensive rats. In the separate experiments, adipocyte lipolysis was investigated in SHR rats after ET.Adipocyte lipolysis stimulated by various agonists, such as isoproterenol, dobutamine, salbutamol, BRL37344 and dibutyryl cyclic AMP, was blunted in non-trained SHR rats compared with normotensive rats. However, ET significantly increased adipocyte lipolysis stimulated by each agonist, although the maximal responses were less in SHR rats than in normotensive exercise-trained rats. Thus, ET significantly alter the responses of aorta to norepinephrine and those of adipocyte lipolysis to various agonists in SHR rats., Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), 1995 -1997, Principal investigator, Competitive research funding, Grant-in-Aid for Scientific Research (C), The University of Electro-Communications-Tokyo Metropolitan University
• The role of Ca^<2+> and calmodulin in exercise trainining-enhanced lipolytic response.
  井澤 鉄也
  長期間の身体トレーニング(TR)は脂肪細胞の脂肪分解反応を増強させる.この現象は脂肪細胞のサイクリックAMP(cAMP)以降の酵素であるタンパクキナーゼ(PK)やホルモン感受性リパーゼ(HSL)の活性が増強するためであると考えられている.しかしながら,PKやHSL自身の活性はTRによって増強せず,未だその実体は捉えられていない.脂肪分解反応はcAMP以外にもCa^<2+>やカルモジュリン(CaM)によっても修飾されている.本研究においてはTRによる脂肪分解増強効果をCa^<2+>/CaM系とPKとの関係を検討した. TRによってラット脂肪細胞の脂肪分解反応は著明に増強した.TRラットおよびその対照群の脂肪分解反応はCaM阻害剤であるW-7で有意に抑制された.その抑制作用はTR群において有意に大きかった.このことからTRによる脂肪分解反応の増強機構にCa^<2+>/CaM系に大きく修飾されている可能性が示唆された.そこでさらにPK活性に及ぼすW-7の影響を検討した.細胞抽出液中のcAMPによるPK活性はTR群で低下する傾向にあった.このcAMPによるPK活性はW-7によって両群共に有意に抑制されたが,その抑制率はTR群(31.5%)で対照群(18.9%)に比較して有意に大きかった.このことから,TR群の脂肪細胞のcAMPによるPK活性の調節はCa^<2+>/CaM系に大きく依存していることが明らかになった.また,TRラットの脂肪細胞では細胞内Ca^<2+>濃度が有意に高く,これがCa^<2+>/CaMにより大きく修飾されているPK活性の調節に役だっている可能性も示唆された., Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for General Scientific Research (C), 1994 -1994, Principal investigator, Competitive research funding, Grant-in-Aid for General Scientific Research (C), The University of Electro-Communications
• Effects of long-term physical exercise on contractile properties of rat aorta
  井澤 鉄也
  ラット大動脈の収縮特性に及ぼす長期間の身体運動(TR)の影響を内皮細胞との関連性から検討した.実験動物としてWistar系雄ラットを用い、TRは9週間のトレッドミル走行を実施した.TR終了後,ラットを屠殺し胸部大動脈を摘出後,種々の薬物に対する収縮特性を検討した.ノルエピネフリンによる収縮において,内皮細胞存在下でTR群の濃度反応曲線は対照群と比較し有意に右側にシフトした(50%有効濃度(ED_<50>),対照群;9.5nM,TR群;30nM).内皮細胞非存在下においても同様の現象が観察されたが,その差は小さくなった(対照群;ED_<50>=4.2nM,TR群;ED_<50>=9.7nM).外液Ca^<2+>のノルエピネフリン収縮に及ぼす効果にTRの影響は認められなかった.アンギオテンシンIIによる収縮は内皮細胞存在下でTRラットの濃度反応曲線は対照ラットと比較し有意に右側にシフトした(対照群;ED_<50>=2.1nM,TR群;ED_<50>=5.6nM).内皮細胞非存在下においても同様の現象が観察された(対照群;ED_<50>=2.0nM,TR群;ED_<50>=6.6nM).アセチルコリンによる弛緩やカリウム拘縮はTRによる影響を受けなかった.さらに急性の運動負荷について検討した.運動負荷後,対照群のノルエピネフリン収縮は内皮細胞の有無に関わらず濃度反応曲線は有意に右側にシフトした.TR群においても同様の現象が観察されたが,濃度反応曲線の右側へのシフトが小さく,結果的に運動負荷直後に測定したノルエピネフリン収縮は対照群とTR群で有意な差が認められなかった.また,運動負荷後,対照群のアンギオテンシンII収縮は内皮細胞の有無に関わらず濃度反応曲線は有意に右側にシフトした.一方,TR群のアンギオテンシンII収縮は急性の運動負荷の影響は認められなかった., Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Encouragement of Young Scientists (A), 1993 -1994, Principal investigator, Competitive research funding, Grant-in-Aid for Encouragement of Young Scientists (A), The University of Electro-Communications
• The effect of exercise training on ageing-related increase in insulin resistance in adipocytes.
  井澤 鉄也
  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Encouragement of Young Scientists (A), 1992 -1992, Principal investigator, Competitive research funding, Grant-in-Aid for Encouragement of Young Scientists (A), The University of Electro-Communications
• Possible mechanism of sudden cardiac death during and after exercise.
  井澤 鉄也
  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Encouragement of Young Scientists (A), 1988 -1988, Principal investigator, Competitive research funding, Grant-in-Aid for Encouragement of Young Scientists (A), Tokyo University of Pharmacy and Life Science
• Effect of training on fat mobilization.
  井澤 鉄也
  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Encouragement of Young Scientists (A), 1984 -1984, Principal investigator, Competitive research funding, Grant-in-Aid for Encouragement of Young Scientists (A), Tokyo University of Pharmacy and Life Science
• Effect of training on beta-adrenergic receptors in rat adipocytes.
  井澤 鉄也
  Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Encouragement of Young Scientists (A), 1983 -1983, Principal investigator, Competitive research funding, Grant-in-Aid for Encouragement of Young Scientists (A), Tokyo University of Pharmacy and Life Science
• 脂肪細胞におけるインスリン抵抗性の身体運動による改善効果と加齢現象との関係
  財団法人 明治生命厚生事業団, 明治生命厚生事業団 「健康医科学」研究助成, 各種団体からの研究助成, Principal investigator, Competitive research funding
• 運動時の突然死の発生機序に関する基礎的研究：運動時およびその回復期におけるラット心筋細胞膜のβ－アドレナリン受容体－cyclic AMP 系の調節機序
  財団法人 明治生命厚生事業団, 明治生命厚生事業団 「健康医科学」研究助成, 各種団体からの研究助成, Competitive research funding