URANO Yasuomi
Faculty of Life and Medical Sciences Department of Medical Life Systems
Associate Professor
Last Updated :2021/10/24

Researcher Profile and Settings

Research Interests

  • oxysterol

Research Areas

  • Life sciences/Cell biology

Academic & Professional Experience

  • Faculty of Life and Medical Sciences, Doshisha University, 2009 - 2018
  • Research Center for Advanced Science and Technology, The University of Tokyo, 2004 - 2005

Education

  • The University of Tokyo, 2004
  • Chiba University, 2000
  • Chiba University, Faculty of Pharmaceutical Sciences, 1998

Academic Degrees

  • 博士(工学), 東京大学
  • 修士(薬学), 千葉大学

Association Memberships

  • THE JAPANESE BIOCHEMICAL SOCIETY
  • THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
  • The American Society for Biochemistry and Molecular Biology

Published Papers

  • 24(S)-Hydroxycholesterol induces ER dysfunction-mediated unconventional cell death.
    Urano Y, Ho Vo DK, Hirofumi A, Noguchi N
    Cell death discovery, 5113 , 2019
  • Tocopherol suppresses 24(S)-hydroxycholesterol-induced cell death via inhibition of CaMKII phosphorylation.
    Kimura Y, Asa M, Urano Y, Saito Y, Nishikawa K, Noguchi N
    Biochimie, 153203 - 209, Oct. 2018
  • 6-Hydroxydopamine induces secretion of PARK7/DJ-1 via autophagy-based unconventional secretory pathway.
    Urano Y, Mori C, Fuji A, Konno K, Yamamoto T, Yashirogi S, Ando M, Saito Y, Noguchi N
    Autophagy, 1 - 16, Aug. 2018
  • Decrease of Amyloid-beta Levels by Curcumin Derivative via Modulation of Amyloid-beta Protein Precursor Trafficking
    Rina Kotani, Yasuomi Urano, Hachiro Sugimoto, Noriko Noguchi
    JOURNAL OF ALZHEIMERS DISEASE, IOS PRESS, 56(2)529 - 542, 2017, English, Research paper (scientific journal)
  • A beta induces oxidative stress in senescence-accelerated (SAMP8) mice
    Kurara Takagane, Jun Nojima, Hiroaki Mitsuhashi, Satoshi Suo, Dai Yanagihara, Fumio Takaiwa, Yasuomi Urano, Noriko Noguchi, Shoichi Ishiura
    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, TAYLOR & FRANCIS LTD, 79(6)912 - 918, Jun. 2015, English, Research paper (scientific journal)
  • Suppression of amyloid-β production by 24S-hydroxycholesterol via inhibition of intracellular amyloid precursor protein trafficking
    Yasuomi Urano, Sachika Ochiai, Noriko Noguchi
    FASEB Journal, FASEB, 27(10)4305 - 4315, 01 Oct. 2013, English, Research paper (scientific journal)
  • Neutralization of the gamma-secretase activity by monoclonal antibody against extracellular domain of nicastrin
    I. Hayashi, S. Takatori, Y. Urano, Y. Miyake, J. Takagi, M. Sakata-Yanagimoto, H. Iwanari, S. Osawa, Y. Morohashi, T. Li, P. C. Wong, S. Chiba, T. Kodama, T. Hamakubo, T. Tomita, T. Iwatsubo
    ONCOGENE, NATURE PUBLISHING GROUP, 31(6)787 - 798, Feb. 2012, English, Research paper (scientific journal)
  • Different functions of vitamin E homologues in the various types of cell death induced by oxysterols.
    Atsuki Suzuki, Yasuomi Urano, Tomohisa Ishida, Noriko Noguchi
    Free radical biology & medicine, 176356 - 365, 12 Oct. 2021, English, Research paper (scientific journal)
  • Identification of a novel endogenous long non-coding RNA that inhibits selenoprotein P translation.
    Yuichiro Mita, Risa Uchida, Sayuri Yasuhara, Kohei Kishi, Takayuki Hoshi, Yoshitaka Matsuo, Tadashi Yokooji, Yoshino Shirakawa, Takashi Toyama, Yasuomi Urano, Toshifumi Inada, Noriko Noguchi, Yoshiro Saito
    Nucleic acids research, 49(12)6893 - 6907, 09 Jul. 2021, English, Research paper (scientific journal)
  • Astrocytes release glutamate via cystine/glutamate antiporter upregulated in response to increased oxidative stress related to sporadic amyotrophic lateral sclerosis.
    Miku Kazama, Yoichiro Kato, Akiyoshi Kakita, Noriko Noguchi, Yasuomi Urano, Kenta Masui, Motoko Niida-Kawaguchi, Tomoko Yamamoto, Kazuhiko Watabe, Kazuo Kitagawa, Noriyuki Shibata
    Neuropathology : official journal of the Japanese Society of Neuropathology, 40(6)587 - 598, Dec. 2020, English, Research paper (scientific journal)
  • Curcumin Derivative GT863 Inhibits Amyloid-Beta Production via Inhibition of Protein N-Glycosylation.
    Yasuomi Urano, Mina Takahachi, Ryo Higashiura, Hitomi Fujiwara, Satoru Funamoto, So Imai, Eugene Futai, Michiaki Okuda, Hachiro Sugimoto, Noriko Noguchi
    Cells, 9(2), 03 Feb. 2020, English
  • Brain Targeting of Acyl-CoA:Cholesterol O-Acyltransferase-1 Inhibitor K-604 via the Intranasal Route Using a Hydroxycarboxylic Acid Solution.
    Kimiyuki Shibuya, Shigeru Morikawa, Masayoshi Miyamoto, Shin-Ichiro Ogawa, Yoshihiko Tsunenari, Yasuomi Urano, Noriko Noguchi
    ACS omega, 4(16)16943 - 16955, 15 Oct. 2019, English
  • Effect of vitamin E on 24(S)-hydroxycholesterol-induced necroptosis-like cell death and apoptosis
    Takaya Nakazawa, Yuta Miyanoki, Yasuomi Urano, Madoka Uehara, Yoshiro Saito, Noriko Noguchi
    JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, PERGAMON-ELSEVIER SCIENCE LTD, 16969 - 76, May 2017, English, Research paper (scientific journal)
  • Esterification of 24S-OHC induces formation of atypical lipid droplet-like structures, leading to neuronal cell death
    Wakako Takabe, Yasuomi Urano, Diep-Khanh Ho Vo, Kimiyuki Shibuya, Masaki Tanno, Hiroaki Kitagishi, Toyoshi Fujimoto, Noriko Noguchi
    JOURNAL OF LIPID RESEARCH, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 57(11)2005 - 2014, Nov. 2016, English, Research paper (scientific journal)
  • Synthesis of 24(S)-hydroxycholesterol esters responsible for the induction of neuronal cell death
    Kimiyuki Shibuya, Toshiaki Watanabe, Yasuomi Urano, Wakako Takabe, Noriko Noguchi, Hiroaki Kitagishi
    BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON-ELSEVIER SCIENCE LTD, 24(11)2559 - 2566, Jun. 2016, English, Research paper (scientific journal)
  • Lysophosphatidylcholine promotes SREBP-2 activation via rapid cholesterol efflux and SREBP-2-independent cytokine release in human endothelial cells
    Mayuko Morita, Azusa Sekine, Yasuomi Urano, Taki Nishimura, Wakako Takabe, Hiroyuki Arai, Takao Hamakubo, Tatsuhiko Kodama, Noriko Noguchi
    JOURNAL OF BIOCHEMISTRY, OXFORD UNIV PRESS, 158(4)331 - 338, Oct. 2015, English, Research paper (scientific journal)
  • New aspects of 24(S)-hydroxycholesterol in modulating neuronal cell death
    Noriko Noguchi, Yasuomi Urano, Wakako Takabe, Yoshiro Saito
    FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, 87366 - 372, Oct. 2015, English
  • 24(S)-Hydroxycholesterol induces RIPK1-dependent but MLKL-independent cell death in the absence of caspase-8
    Diep-Khanh Ho Vo, Yasuomi Urano, Wakako Takabe, Yoshiro Saito, Noriko Noguchi
    STEROIDS, ELSEVIER SCIENCE INC, 99(Pt B)230 - 237, Jul. 2015, English, Research paper (scientific journal)
  • Diverse functions of 24(S)-hydroxycholesterol in the brain
    Noriko Noguchi, Yoshiro Saito, Yasuomi Urano
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, 446(3)692 - 696, Apr. 2014, English
  • Induction of apoptosis and necroptosis by 24(S)-hydroxycholesterol is dependent on activity of acyl-CoA: cholesterol acyltransferase 1
    K. Yamanaka, Y. Urano, W. Takabe, Y. Saito, N. Noguchi
    CELL DEATH & DISEASE, NATURE PUBLISHING GROUP, 5e990 , Jan. 2014, English, Research paper (scientific journal)
  • Adaptive responses induced by 24S-hydroxycholesterol through liver X receptor pathway reduce 7-ketocholesterol-caused neuronal cell death
    Akishi Okabe, Yasuomi Urano, Sayoko Itoh, Naoto Suda, Rina Kotani, Yuki Nishimura, Yoshiro Saito, Noriko Noguchi
    REDOX BIOLOGY, ELSEVIER SCIENCE BV, 228 - 35, 2014, English, Research paper (scientific journal)
  • 24(S)-Hydroxycholesterol Induces Neuronal Cell Death through Necroptosis, a Form of Programmed Necrosis
    Kazunori Yamanaka, Yoshiro Saito, Tohru Yamamori, Yasuomi Urano, Noriko Noguchi
    JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 286(28)24666 - 24673, Jul. 2011, English, Research paper (scientific journal)
  • Phosphorylation of p66shc mediates 6-hydroxydopamine cytotoxicity
    Tohru Yamamori, Ayano Mizobata, Yoshiro Saito, Yasuomi Urano, Osamu Inanami, Kaikobad Irani, Noriko Noguchi
    FREE RADICAL RESEARCH, INFORMA HEALTHCARE, 45(3)342 - 350, Mar. 2011, English, Research paper (scientific journal)
  • Sterol-regulatory-element-binding protein 2 and nuclear factor Y control human farnesyl diphosphate synthase expression and affect cell proliferation in hepatoblastoma cells
    Kenji Ishimoto, Keisuke Tachibana, Ikuko Hanano, Daisuke Yamasaki, Hiroki Nakamura, Megumi Kawai, Yasuomi Urano, Toshiya Tanaka, Takao Hamakubo, Juro Sakai, Tatsuhiko Kodama, Takefumi Doi
    BIOCHEMICAL JOURNAL, PORTLAND PRESS LTD, 429(2)347 - 357, Jul. 2010, English, Research paper (scientific journal)
  • Intracellular transport of low-density lipoprotein-derived cholesterol
    Yasuomi Urano
    Seikagaku, 82(5)411 - 415, 2010, Japanese, Research paper (scientific journal)
  • Single Chain Variable Fragment against Nicastrin Inhibits the gamma-Secretase Activity
    Ikuo Hayashi, Sho Takatori, Yasuomi Urano, Hiroko Iwanari, Noriko Isoo, Satoko Osawa, Maiko A. Fukuda, Tatsuhiko Kodama, Takao Hamakubo, Tong Li, Philip C. Wong, Taisuke Tomita, Takeshi Iwatsubo
    JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 284(41)27838 - 27847, Oct. 2009, English, Research paper (scientific journal)
  • Acyl-coenzyme A: cholesterol acyltransferases
    Ta-Yuan Chang, Bo-Liang Li, Catherine C. Y. Chang, Yasuomi Urano
    AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, AMER PHYSIOLOGICAL SOC, 297(1)E1 - E9, Jul. 2009, English
  • Transport of LDL-derived cholesterol from the NPC1 compartment to the ER involves the trans-Golgi network and the SNARE protein complex
    Yasuomi Urano, Hiroshi Watanabe, Stephanie R. Murphy, Yohei Shibuya, Yong Geng, Andrew A. Peden, Catherine C. Y. Chang, Ta Yuan Chang
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, 105(43)16513 - 16518, Oct. 2008, English, Research paper (scientific journal)
  • Alzheimer's Disease: cholesterol, membrane rafts, isoprenoids and statins
    Patrick C. Reid, Yasuomi Urano, Tatsuhiko Kodama, Takao Hamakubo
    JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, BLACKWELL PUBLISHING, 11(3)383 - 392, May 2007, English
  • Association of active gamma-secretase complex with lipid rafts
    Y Urano, Hayashi, I, N Isoo, PC Reid, Y Shibasaki, N Noguchi, T Tomita, T Iwatsubo, T Hamakubo, T Kodama
    JOURNAL OF LIPID RESEARCH, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 46(5)904 - 912, May 2005, English, Research paper (scientific journal)
  • Selective reconstitution and recovery of functional gamma-secretase complex on budded baculovirus particles
    Hayashi, I, Y Urano, R Fukuda, N Isoo, T Kodama, T Hamakubo, T Tomita, T Iwatsubo
    JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 279(36)38040 - 38046, Sep. 2004, English, Research paper (scientific journal)
  • A novel method for viral display of ER membrane proteins on budded baculovirus
    Y Urano, M Yamaguchi, R Fukuda, K Masuda, K Takahashi, Y Uchiyama, H Iwanari, SY Jiang, M Naito, T Kodama, T Hamakubo
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, 308(1)191 - 196, Aug. 2003, English, Research paper (scientific journal)
  • Molecular cloning and functional characterization of cDNAs encoding cysteine synthase and serine acetyltransferase that may be responsible for high cellular cysteine content in Allium tuberosum
    Y Urano, T Manabe, M Noji, K Saito
    GENE, ELSEVIER SCIENCE BV, 257(2)269 - 277, Oct. 2000, English, Research paper (scientific journal)

Misc

  • Study on Involvement of Reactive Oxygen Species in Neuronal Cell Death Induced by Oxidation Product of Cholesterol
    野口 範子, 斎藤 芳郎, 浦野 泰臣
    同志社大学理工学研究報告, 同志社大学理工学研究所, 54(4)21 - 25, Jan. 2014, Japanese
  • SREBP‐2とNF‐Yによるヒトファルネシルピロリン酸合成酵素の遺伝子発現調節と細胞増殖への影響
    石本憲司, 橘敬祐, 花野郁子, 山崎大典, 中村太樹, 河井恵, 浦野泰臣, 田中十志也, 浜窪隆雄, 酒井寿郎, 児玉龍彦, 土井健史
    生化学, ROMBUNNO.1P-0004 , 2010, Japanese
  • ヒトファルネシルピロリン酸合成酵素の遺伝子発現解析
    石本憲司, 橘敬祐, 花野郁子, 山崎大典, 住友美賀子, 中村太樹, 浦野泰臣, 田中十志也, 浜窪隆雄, 酒井寿郎, 児玉龍彦, 土井健史
    生化学, 2P-1076 , 2007, Japanese
  • Alzheimer's disease and Lipid rafts
    Yasuomi Urano
    The Lipid, 17335 - 340, 2006
  • コレステロールメタボライト研究の新展開: 構造的・機能的多様性に迫る オキシステロール誘導性の新規細胞死機構
    浦野 泰臣, 野口 範子
    日本生化学会大会プログラム・講演要旨集, (公社)日本生化学会, 92回[1S11a - 04], Sep. 2019, English

Conference Activities & Talks

  • 25-Hydroxycholesterol induces ferroptosis via downregulation of mevalonate pathway in Schwann cells
    Yasuomi Urano, Anan Iwagaki, Noriko Noguchi
    10th ENOR SYMPOSIUM, 17 Sep. 2021, English, Oral presentation (general)

Patents

  • Therapeutic agents for Alzheimer's disease and cancer.
    PCT/US13/276,501
  • Method of expressing activated membrane protease protein complex using budding baculovirus.
    PCT/JP2004/015668
  • Therapeutic agents for Alzheimer's disease and cancer.
    PCT/JP2007/000438

Research Grants & Projects

  • Effects of food-derived substances on secretory autophagy
    2020/08 -2021/07, Yasuomi Urano

Research Seeds

  • Acyl-CoA:cholesterol acyltransferase as a drug target for Alzheimer's disease
    Research Fields: Medical and Pharmaceutical Sciences, Life Sciences
    Patent Information: 特許第6143435号