| OKUMURA Naoki | |
| Faculty of Life and Medical Sciences Department of Biomedical Engineering | |
| Professor |
Last Updated :2021/10/24
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I have been developing both pharmaceutical and tissue engineering treatment for corneal endothelial dysfunction. The corneal endothelium is critical for maintaining homeostatic corneal transparency, which it accomplishes by pump and barrier functions. When corneal endothelial cell density decreases to a critical level, the cornea exhibits haziness, with edema, due to decompensation of the corneal endothelial function.
We showed that a Rho-associated kinase (ROCK) inhibitor can be useful in treating corneal endothelial dysfunction. In 2009, we demonstrated that the selective ROCK inhibitor, Y-27632, showed unique effects on cultured CECs: 1) promotion of proliferation; 2) enhancement of cell adhesion; and 3) suppression of apoptosis. Our subsequent studies revealed that administration of ROCK inhibitors in the form of eye drops promotes CEC proliferation in rabbit and monkey in vivo models. In addition to animal experiments, we have started a clinical trial of ROCK inhibitor eye drops in combination for treatment of human corneal endothelial dysfunction patients.
We also demonstrated that in rabbit and monkey corneal endothelial dysfunction models, corneal transparency was restored via the injection of cultivated CECs with the selective ROCK inhibitor into the anterior chamber. One technical obstacle that currently exists is the difficulty of the in vitro expansion of CECs, as they exhibit fibroblastic phenotypes with loss of pump and barrier functions while under the culture conditions. However, we successfully established a CEC culture protocol for clinical use. This protocol enables the efficient in vitro expansion of CECs and may ultimately provide clinicians with a new therapeutic modality in regenerative medicine. Of note, our team has started the first in man clinical trial of cultivated CEC-injection therapy in Japan.Research funding number
10581499
Research Interests
Research Areas
Academic & Professional Experience
- Visiting Professor, Department of Ophthalmology, Kyoto Prefectural University of Medicine, 2020/04 - Today
- Professor, Graduate School of Life and Medical Science, Doshisha University, 2020/04 - Today
- Associate Professor, Department of Biomedical Engineering, Doshisha University, 2015/04 - 2020/03
- Assistant professor, Doshisha university, 2011/04 - 2015/03
- Assistant professor, Kyoto Prefectural University of Medicine, 2010/04 - 2011/03
- PhD course student, Kyoto Prefectural University of Medicine, 2006/05 - 2010/03
- Ophthalomologist, Machida hospital, 2003/04 - 2006/03
- Resident, Kyoto Prefectural University of Medicine, 2001/04 - 2003/03
Education
- Kyoto Prefectural University of Medicine PhD course, 2006/04 - 2010/03
- Kyoto Prefectural University of Medicine, 1995/04 - 2001/03
Academic Degrees
Association Memberships
- Association for Research in Vision and Ophthalmology
- JAPAN CORNEA SOCIETY
- JAPANESE SOCIETY OF OPHTHALMIC SURGEONS
- JAPANESE OPHTHALMOLOGICAL SOCIETY
Awards & Honors
- Association for Research in Vision and Ophthalmology (ARVO) Kowa Travel Grant
2011, “ROCK Inhibitor Regulates the G1-S Progression of Corneal Endothelial Cells” - Association for Research in Vision and Ophthalmology (ARVO) International Travel Grant
2010, "The Effect of a ROCK Inhibitor on Corneal Endothelial Cell Migration in an In Vitro Wound-Healing Model" - Gordon Research Conference Biology & Pathobiology Of The Cornea Travel Grant
2010, "Therapeutic Potential of a Rho Kinase (ROCK) Inhibitor for the Treatment of Corneal Endothelial Dysfunction" - Association for Research in Vision and Ophthalmology (ARVO) International Travel Grant
2009, "A ROCK Inhibitor Enhances Corneal Endothelial Wound Healing in Both an In vitro and in vivo Model"
Published Papers
- Potential Functional Restoration of Corneal Endothelial Cells in Fuchs Endothelial Corneal Dystrophy by ROCK Inhibitor (Ripasudil)
Ursula Schlötzer-Schrehardt, Matthias Zenkel, Maria Strunz, Andreas Gießl, Hannah Schondorf, Heather da Silva, Gregory A. Schmidt, Mark A. Greiner, Naoki Okumura, Noriko Koizumi, Shigeru Kinoshita, Theofilos Tourtas, Friedrich E. Kruse
American Journal of Ophthalmology, Elsevier BV, 224185 - 199, Apr. 2021, English, Research paper (scientific journal) - Radial Endothelial Striae Over 360 Degrees in Fuchs Corneal Endothelial Dystrophy
Gilles Thuret, Anthony Ain, Noriko Koizumi, Naoki Okumura, Philippe Gain, Zhiguo He
Cornea, Ovid Technologies (Wolters Kluwer Health), Publish Ahead of Print, 15 Feb. 2021, English, Research paper (scientific journal) - Regeneration of the Corneal Endothelium.
Okumura N, Koizumi N
Current eye research, 45(3)1 - 10, Dec. 2019, English, Research paper (scientific journal) - Association of rs613872 and Trinucleotide Repeat Expansion in the TCF4 Gene of German Patients With Fuchs Endothelial Corneal Dystrophy.
Okumura N, Hayashi R, Nakano M, Tashiro K, Yoshii K, Aleff R, Butz M, Highsmith EW, Wieben ED, Fautsch MP, Baratz KH, Komori Y, Ueda E, Nakahara M, Weller J, Tourtas T, Schlötzer-Schrehardt U, Kruse F, Koizumi N
Cornea, 38(7)799 - 805, Jul. 2019, English, Research paper (scientific journal) - Stability, safety, and pharmacokinetics of ganciclovir eye drops prepared from ganciclovir for intravenous infusion.
Okumura N, Tanaka T, Fukui Y, Koizumi N
Japanese journal of ophthalmology, 63(3)289 - 296, May 2019 - Effect of Trinucleotide Repeat Expansion on the Expression of TCF4 mRNA in Fuchs' Endothelial Corneal Dystrophy.
Okumura N, Hayashi R, Nakano M, Yoshii K, Tashiro K, Sato T, Blake DJ, Aleff R, Butz M, Highsmith EW, Wieben ED, Fautsch MP, Baratz KH, Komori Y, Nakahara M, Tourtas T, Schlötzer-Schrehardt U, Kruse F, Koizumi N
Investigative ophthalmology & visual science, 60(2)779 - 786, Feb. 2019, English, Research paper (scientific journal) - Cell Based Therapy for Corneal Endothelial Regeneration: Therapy and Surgery. Corneal Regeneration. January 2019. pp.455-462. DOI: 10.1007/978-3-030-01304-2_30.
Koizumi N, Okumura N
Jan. 2019 - Feasibility of a cryopreservation of cultured human corneal endothelial cells.
Okumura N, Kagami T, Watanabe K, Kadoya S, Sato M, Koizumi N
PloS one, 14(6)e0218431 , 2019 - Development of Cell Analysis Software to Evaluate Fibroblastic Changes in Cultivated Corneal Endothelial Cells for Quality Control.
Okumura N, Kobayashi K, Ishida N, Kagami T, Hiwa S, Hiroyasu T, Koizumi N
Cornea, 37(12)1572 - 1578, Dec. 2018 - Effect of a p38 Mitogen-Activated Protein Kinase Inhibitor on Corneal Endothelial Cell Proliferation.
Nakahara M, Okumura N, Nakano S, Koizumi N
Investigative ophthalmology & visual science, 59(10)4218 - 4227, Aug. 2018 - Effect of Posterior Corneal Vesicles on Corneal Endothelial Cell Density and Anisometropic Amblyopia.
Noguchi A, Okumura N, Sotozono C, Kinoshita S
Cornea, 37(7)813 - 817, Jul. 2018 - Involvement of Nectin-Afadin in the Adherens Junctions of the Corneal Endothelium.
Okumura N, Kagami T, Fujii K, Nakahara M, Koizumi N
Cornea, 37(5)633 - 640, May 2018 - Perspective of Future Potent Therapies for Fuchs Endothelial Corneal Dystrophy.
Okumura N, Hayashi R, Koizumi N
The open ophthalmology journal, 12154 - 163, 2018 - Activation of TGF-beta signaling induces cell death via the unfolded protein response in Fuchs endothelial corneal dystrophy
Naoki Okumura, Keisuke Hashimoto, Miu Kitahara, Hirokazu Okuda, Emi Ueda, Kyoko Watanabe, Makiko Nakahara, Takahiko Sato, Shigeru Kinoshita, Theofilos Tourtas, Ursula Schloetzer-Schrehardt, Friedrich Kruse, Noriko Koizumi
SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, 7(1)6801 , Jul. 2017, English, Research paper (scientific journal) - Rho kinase inhibitor enables cell-based therapy for corneal endothelial dysfunction
Naoki Okumura, Yuji Sakamoto, Keita Fujii, Junji Kitano, Shinichiro Nakano, Yuki Tsujimoto, Shin-ichiro Nakamura, Morio Ueno, Michio Hagiya, Junji Hamuro, Akifumi Matsuyama, Shingo Suzuki, Takashi Shiina, Shigeru Kinoshita, Noriko Koizumi
SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, 626113 , May 2016, English, Research paper (scientific journal) - Effect of the Rho-Associated Kinase Inhibitor Eye Drop (Ripasudil) on Corneal Endothelial Wound Healing
Naoki Okumura, Yugo Okazaki, Ryota Inoue, Kazuya Kakutani, Shinichiro Nakano, Shigeru Kinoshita, Noriko Koizumi
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 57(3)1284 - 1292, Mar. 2016, English, Research paper (scientific journal) - Rho-Associated Kinase Inhibitor Eye Drop (Ripasudil) Transiently Alters the Morphology of Corneal Endothelial Cells
Naoki Okumura, Yugo Okazaki, Ryota Inoue, Shinichiro Nakano, Nigel J. Fullwood, Shigeru Kinoshita, Noriko Koizumi
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 56(12)7560 - 7567, Nov. 2015, English, Research paper (scientific journal) - Involvement of ZEB1 and Snail1 in excessive production of extracellular matrix in Fuchs endothelial corneal dystrophy
Naoki Okumura, Ryuki Minamiyama, Leona T. Y. Ho, EunDuck P. Kay, Satoshi Kawasaki, Theofilos Tourtas, Ursula Schloetzer-Schrehardt, Friedrich E. Kruse, Robert D. Young, Andrew J. Quantock, Shigeru Kinoshita, Noriko Koizumi
LABORATORY INVESTIGATION, NATURE PUBLISHING GROUP, 95(11)1291 - 1304, Nov. 2015, English, Research paper (scientific journal) - Effect of the Rho Kinase Inhibitor Y-27632 on Corneal Endothelial Wound Healing
Naoki Okumura, Ryota Inoue, Yugo Okazaki, Shinichiro Nakano, Hiroko Nakagawa, Shigeru Kinoshita, Noriko Koizumi
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 56(10)6067 - 6074, Sep. 2015, English, Research paper (scientific journal) - Trinucleotide Repeat Expansion in the TCF4 Gene in Fuchs' Endothelial Corneal Dystrophy in Japanese
Masakazu Nakano, Naoki Okumura, Hiroko Nakagawa, Noriko Koizumi, Yoko Ikeda, Morio Ueno, Kengo Yoshii, Hiroko Adachi, Ross A. Aleff, Malinda L. Butz, W. Edward Highsmith, Kei Tashiro, Eric D. Wieben, Shigeru Kinoshita, Keith H. Baratz
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 56(8)4865 - 4869, Jul. 2015, English, Research paper (scientific journal) - Laminin-511 and-521 Enable Efficient In Vitro Expansion of Human Corneal Endothelial Cells
Naoki Okumura, Kazuya Kakutani, Ryohei Numata, Makiko Nakahara, Ursula Schloetzer-Schrehardt, Friedrich Kruse, Shigeru Kinoshita, Noriko Koizumi
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 56(5)2933 - 2942, May 2015, English, Research paper (scientific journal) - Synthetic Molecules that Protect Cells from Anoikis and Their Use in Cell Transplantation
Heidie L. Frisco-Cabanos, Mizuki Watanabe, Naoki Okumura, Kosuke Kusamori, Naohiro Takemoto, Junichiro Takaya, Shin-ichi Sato, Sayumi Yamazoe, Yoshinobu Takakura, Shigeru Kinoshita, Makiya Nishikawa, Noriko Koizumi, Motonari Uesugi
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, WILEY-V C H VERLAG GMBH, 53(42)11208 - 11213, Oct. 2014, English, Research paper (scientific journal) - R-spondin1 Regulates Cell Proliferation of Corneal Endothelial Cells via the Wnt3a/beta-Catenin Pathway
Naoki Okumura, Takahiro Nakamura, EunDuck P. Kay, Makiko Nakahara, Shigeru Kinoshita, Noriko Koizumi
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 55(10)6861 - 6869, Oct. 2014, English, Research paper (scientific journal) - Cultivation of Corneal Endothelial Cells on a Pericellular Matrix Prepared from Human Decidua-Derived Mesenchymal Cells
Ryohei Numata, Naoki Okumura, Makiko Nakahara, Morio Ueno, Shigeru Kinoshita, Daisuke Kanematsu, Yonehiro Kanemura, Yoshiki Sasai, Noriko Koizumi
PLOS ONE, PUBLIC LIBRARY SCIENCE, 9(2)e88169 , Feb. 2014, English, Research paper (scientific journal) - Involvement of Cyclin D and p27 in Cell Proliferation Mediated by ROCK Inhibitors Y-27632 and Y-39983 During Corneal Endothelium Wound Healing
Naoki Okumura, Shinichiro Nakano, EunDuck P. Kay, Ryohei Numata, Aya Ota, Yoshihiro Sowa, Toshiyuki Sakai, Morio Ueno, Shigeru Kinoshita, Noriko Koizumi
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 55(1)318 - 329, Jan. 2014, English, Research paper (scientific journal) - Cell Segmentation Using Binarization and Growing Neural Gas
Tomoyuki HIROYASU, Shunsuke SEKIYA, Noriko KOIZUMI, Naoki OKUMURA, Utako YAMAMOTO
Proceedings of the 18th Asia Pacific Symposium on Intelligent and Evolutionary Systems, Vol. 2179 - 190, 2014 - Corneal Endothelial Expansion Promoted by Human Bone Marrow Mesenchymal Stem Cell-Derived Conditioned Medium
Makiko Nakahara, Naoki Okumura, EunDuck P. Kay, Michio Hagiya, Kiwamu Imagawa, Yuuki Hosoda, Shigeru Kinoshita, Noriko Koizumi
PLOS ONE, PUBLIC LIBRARY SCIENCE, 8(7)e69009 , Jul. 2013, English, Research paper (scientific journal) - Inhibition of TGF-β Signaling Enables Human Corneal Endothelial Cell Expansion In Vitro for Use in Regenerative Medicine
Naoki Okumura, EunDuck P. Kay, Makiko Nakahara, Junji Hamuro, Shigeru Kinoshita, Noriko Koizumi
PLoS ONE, 8(2)e58000 , 25 Feb. 2013, English, Research paper (scientific journal) - Ferret animal model of corneal endothelial dysfunction for evaluation of drug effect on corneal endothelial wound healing．Anim Eye Res．32:15-21，2013.
Sakamoto Y, Okumura N, Koizumi N, Numata R, Kitano J, Yamamoto M, Komada T, Hoshi N
2013 - Ferret as a New Experimental Animal Model for Corneal Endothelial Research．Anim．Eye Res．31:3-11，2013．
Sakamoto Y, Okumura N, Koizumi N, Yamasaki K, Kitano J, Numata R, Komada T, Hoshi N
2013 - A Study of Host Corneal Endothelial Cells After Non-Descemet Stripping Automated Endothelial Keratoplasty
Hiroki Hatanaka, Noriko Koizumi, Naoki Okumura, Hiroaki Takahashi, Hidetoshi Tanioka, Robert D. Young, Frances E. Jones, Andrew J. Quantock, Shigeru Kinoshita
CORNEA, LIPPINCOTT WILLIAMS & WILKINS, 32(1)76 - 80, Jan. 2013, English, Research paper (scientific journal) - Extracting Rules for Cell Segmentation in Corneal Endothelial Cell Images using GP
Tomoyuki Hiroyasu, Shunsuke Sekiya, Sakito Nunokawa, Noriko Koizumi, Naoki Okumura, Utako Yamamoto
2013 IEEE INTERNATIONAL CONFERENCE ON SYSTEMS, MAN, AND CYBERNETICS (SMC 2013), IEEE, 1811 - 1816, 2013, English, Research paper (international conference proceedings) - Epithelial-Mesenchymal Transition-Like Phenotypic Changes of Retinal Pigment Epithelium Induced by TGF-beta Are Prevented by PPAR-gamma Agonists
Hiroki Hatanaka, Noriko Koizumi, Naoki Okumura, EunDuck P. Kay, Eri Mizuhara, Junji Hamuro, Shigeru Kinoshita
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 53(11)6955 - 6963, Oct. 2012, English, Research paper (scientific journal) - Algorithms for Automatic Extraction of Feature Values of Corneal Endothelial Cells using Genetic Programming
Tomoyuki Hiroyasu, Sakito Nunokawa, Hiroaki Yamaguchi, Noriko Koizumi, Naoki Okumura, Hisatake Yokouchi
6TH INTERNATIONAL CONFERENCE ON SOFT COMPUTING AND INTELLIGENT SYSTEMS, AND THE 13TH INTERNATIONAL SYMPOSIUM ON ADVANCED INTELLIGENT SYSTEMS, IEEE, 1388 - 1392, 2012, English, Research paper (international conference proceedings) - Comparison Study of Controlling Bloat Model of GP in Constructing Filter for Cell Image Segmentation Problems
Hiroaki Yamaguchi, Tomoyuki Hiroyasu, Sakito Nunokawa, Noriko Koizumi, Naoki Okumura, Hisatake Yokouchi, Mitsunori Miki, Masato Yoshimi
2012 IEEE CONGRESS ON EVOLUTIONARY COMPUTATION (CEC), IEEE, 1 - 8, 2012, English, Research paper (international conference proceedings) - A ROCK inhibitor enhances survival of primate corneal endothelial cells in vitro．Invest Ophthalmol Vis Sci．50（8）:3680-3687，2009．
Okumura N, Ueno M, Koizumi N, Sakamoto Y, Hirata K, Hamuro J, Kinoshita S
2009 - Pharmacokinetic analysis of platelet-activating factor in the tears of guinea pigs with allergic conjunctivitis
Naoki Okumura, Atsuki Fukushima, Atsushi Igarashi, Tamaki Sumi, Tetsuya Yamagishi, Hisayuki Ueno
JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS, MARY ANN LIEBERT INC, 22(5)347 - 352, Oct. 2006, English, Research paper (scientific journal) - Platelet-activating factor in human normal tears
N Okumura, K Kojima, M Hashida, Y Koura, A Fukushima, H Ueno
CURRENT EYE RESEARCH, TAYLOR & FRANCIS INC, 30(10)891 - 896, Oct. 2005, English, Research paper (scientific journal) - Corneal endothelial cell therapy: feasibility of cell culture from corneas stored in organ culture
Zhiguo He, Naoki Okumura, Masakazu Sato, Yuya Komori, Makiko Nakahara, Philippe Gain, Noriko Koizumi, Gilles Thuret
Cell and Tissue Banking, Springer Science and Business Media LLC, 16 Apr. 2021, English, Research paper (scientific journal) - Analysis of Immune Cells on Donor Corneal Endothelium After Corneal Transplantation Using the HRT-Rostock Cornea Module
Naoki Okumura, Thenmozhi Velumani, Farhath Hadiya, Vasanthi Padmanaban, Yuya Komori, Naoya Hanada, Taisuke Hirono, Sangly P. Srinivas, Noriko Koizumi, Prema Padmanabhan
Cornea, Ovid Technologies (Wolters Kluwer Health), Publish Ahead of Print, 09 Apr. 2021, English, Research paper (scientific journal) - Transcriptome dataset of human corneal endothelium based on ribosomal RNA-depleted RNA-Seq data
Yuichi Tokuda, Naoki Okumura, Yuya Komori, Naoya Hanada, Kei Tashiro, Noriko Koizumi, Masakazu Nakano
Scientific Data, Springer Science and Business Media LLC, 7(1)407 - 407, Dec. 2020, English, Research paper (scientific journal) - Five-Year Follow-up of First Eleven Cases Undergoing Injection of Cultured Corneal Endothelial Cells for Corneal Endothelial Failure.
Kohsaku Numa, Kojiro Imai, Morio Ueno, Koji Kitazawa, Hiroshi Tanaka, John D Bush, Satoshi Teramukai, Naoki Okumura, Noriko Koizumi, Junji Hamuro, Chie Sotozono, Shigeru Kinoshita
Ophthalmology, 05 Sep. 2020, English, Research paper (scientific journal) - Trinucleotide repeat expansion in the transcription factor 4 (TCF4) gene in Thai patients with Fuchs endothelial corneal dystrophy.
Naoki Okumura, Vilavun Puangsricharern, Raina Jindasak, Noriko Koizumi, Yuya Komori, Hayashi Ryousuke, Makiko Nakahara, Masakazu Nakano, Hiroko Adachi, Kei Tashiro, Kengo Yoshii, Patchima Chantaren, Rungnapa Ittiwut, Vorasuk Shotelersuk, Kanya Suphapeetiporn
Eye (London, England), 34(5)880 - 885, May 2020, English, Research paper (scientific journal) - Immune Cells on the Donor Corneal Endothelium After Corneal Transplantation.
Naoki Okumura, Ryota Inoue, Shinichiro Nakano, Hirofumi Imai, Daiki Matsumoto, Kanae Kayukawa, Koichi Wakimasu, Koji Kitazawa, Noriko Koizumi, Shigeru Kinoshita
Cornea, 37(9)1081 - 1086, Sep. 2018, English, Research paper (scientific journal) - Endothelial cell loss and graft survival after penetrating keratoplasty for laser iridotomy-induced bullous keratopathy.
Naoki Okumura, Ayaka Kusakabe, Noriko Koizumi, Koichi Wakimasu, Kanae Kayukawa, Masami Kondo, Kazuhiko Mori, Chie Sotozono, Shigeru Kinoshita
Japanese journal of ophthalmology, 62(4)438 - 442, Jul. 2018, English - Wide-field contact specular microscopy analysis of corneal endothelium post trabeculectomy.
Naoki Okumura, Daiki Matsumoto, Yugo Okazaki, Noriko Koizumi, Chie Sotozono, Shigeru Kinoshita, Kazuhiko Mori
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 256(4)751 - 757, Apr. 2018, English - Injection of Cultured Cells with a ROCK Inhibitor for Bullous Keratopathy.
Shigeru Kinoshita, Noriko Koizumi, Morio Ueno, Naoki Okumura, Kojiro Imai, Hiroshi Tanaka, Yuji Yamamoto, Takahiro Nakamura, Tsutomu Inatomi, John Bush, Munetoyo Toda, Michio Hagiya, Isao Yokota, Satoshi Teramukai, Chie Sotozono, Junji Hamuro
The New England journal of medicine, 378(11)995 - 1003, 15 Mar. 2018, English, Research paper (scientific journal) - Feasibility of cell-based therapy combined with descemetorhexis for treating Fuchs endothelial corneal dystrophy in rabbit model
Naoki Okumura, Daiki Matsumoto, Yuya Fukui, Masataka Teramoto, Hirofumi Imai, Tetta Kurosawa, Tomoki Shimada, Friedrich Kruse, Ursula Schlötzer-Schrehardt, Shigeru Kinoshita, Noriko Koizumi
PLoS ONE, Public Library of Science, 13(1)e0191306 , 01 Jan. 2018, English, Research paper (scientific journal) - The existence of dead cells in donor corneal endothelium preserved with storage media
Koji Kitazawa, Tsutomu Inatomi, Hidetoshi Tanioka, Satoshi Kawasaki, Hiroko Nakagawa, Osamu Hieda, Hideki Fukuoka, Naoki Okumura, Noriko Koizumi, Bernie Iliakis, Chie Sotozono, Shigeru Kinoshita
BRITISH JOURNAL OF OPHTHALMOLOGY, BMJ PUBLISHING GROUP, 101(12)1725 - 1730, Dec. 2017, English, Research paper (scientific journal) - Development of Cell Analysis Software for Cultivated Corneal Endothelial Cells
Naoki Okumura, Naoya Ishida, Kazuya Kakutani, Akane Hongo, Satoru Hiwa, Tomoyuki Hiroyasu, Noriko Koizumi
Cornea, Lippincott Williams and Wilkins, 36(11)1387 - 1394, 01 Nov. 2017, English, Research paper (scientific journal) - Corneal Endothelial Cells Have an Absolute Requirement for Cysteine for Survival
Naoki Okumura, Ryota Inoue, Kazuya Kakutani, Makiko Nakahara, Shigeru Kinoshita, Junji Hamuro, Noriko Koizumi
CORNEA, LIPPINCOTT WILLIAMS & WILKINS, 36(8)988 - 994, Aug. 2017, English, Research paper (scientific journal) - The Effect of a p38 Mitogen-Activated Protein Kinase Inhibitor on Cellular Senescence of Cultivated Human Corneal Endothelial Cells
Akane Hongo, Naoki Okumura, Makiko Nakahara, EunDuck P. Kay, Noriko Koizumi
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 58(9)3325 - 3334, Jul. 2017, English, Research paper (scientific journal) - Laminin-511 and-521-based matrices for efficient ex vivoexpansion of human limbal epithelial progenitor cells
Naresh Polisetti, Lydia Sorokin, Naoki Okumura, Noriko Koizumi, Shigeru Kinoshita, Friedrich E. Kruse, Ursula Schloetzer-Schrehardt
SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, 7(1)5152 , Jul. 2017, English, Research paper (scientific journal) - Sustained Activation of the Unfolded Protein Response Induces Cell Death in Fuchs' Endothelial Corneal Dystrophy
Naoki Okumura, Miu Kitahara, Hirokazu Okuda, Keisuke Hashimoto, Emi Ueda, Makiko Nakahara, Shigeru Kinoshita, Robert D. Young, Andrew J. Quantock, Theofilos Tourtas, Ursula Schloetzer-Schrehardt, Friedrich Kruse, Noriko Koizumi
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 58(9)3697 - 3707, Jul. 2017, English, Research paper (scientific journal) - Panoramic view of human corneal endothelial cell layer observed by a prototype slit-scanning wide-field contact specular microscope
Hiroshi Tanaka, Naoki Okumura, Noriko Koizumi, Chie Sotozono, Yasuhiro Sumii, Shigeru Kinoshita
BRITISH JOURNAL OF OPHTHALMOLOGY, BMJ PUBLISHING GROUP, 101(5)655 - 659, May 2017, English, Research paper (scientific journal) - Effect of Trabeculotomy on Corneal Endothelial Cell Loss in Cases of After Penetrating-Keratoplasty Glaucoma.
Ayaka Kusakabe, Naoki Okumura, Koichi Wakimasu, Kanae Kayukawa, Masami Kondo, Noriko Koizumi, Chie Sotozono, Shigeru Kinoshita, Kazuhiko Mori
Cornea, 36(3)317 - 321, Mar. 2017, English - The Role of Rho Kinase Inhibitors in Corneal Endothelial Dysfunction
Naoki Okumura, Shigeru Kinoshita, Noriko Koizumi
CURRENT PHARMACEUTICAL DESIGN, BENTHAM SCIENCE PUBL LTD, 23(4)660 - 666, 2017, English - Immune Cells on the Corneal Endothelium of an Allogeneic Corneal Transplantation Rabbit Model
Elena Koudouna, Naoki Okumura, Yugo Okazaki, Shinichiro Nakano, Ryota Inoue, Nigel J. Fullwood, Junko Hori, Shigeru Kinoshita, Noriko Koizumi
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 58(1)242 - 251, Jan. 2017, English, Research paper (scientific journal) - A Surgical Cryoprobe for Targeted Transcorneal Freezing and Endothelial Cell Removal
Alina Akhbanbetova, Shinichiro Nakano, Stacy L. Littlechild, Robert D. Young, Madara Zvirgzdina, Nigel J. Fullwood, Ian Weston, Philip Weston, Shigeru Kinoshita, Naoki Okumura, Noriko Koizumi, Andrew J. Quantock
JOURNAL OF OPHTHALMOLOGY, HINDAWI LTD, 20175614089 , 2017, English, Research paper (scientific journal) - Application of Rho Kinase Inhibitors for the Treatment of Corneal Endothelial Diseases
Naoki Okumura, Shigeru Kinoshita, Noriko Koizumi
JOURNAL OF OPHTHALMOLOGY, HINDAWI LTD, 20172646904 , 2017, English - Rho Kinase in Eye Disease
Naoki Okumura, Shintaro Nakao, Toshihiro Inoue, Padmanabhan Pattabiraman
JOURNAL OF OPHTHALMOLOGY, HINDAWI LTD, 20179281745 , 2017, English - Development of Poly Lactic/Glycolic Acid (PLGA) Microspheres for Controlled Release of Rho-Associated Kinase Inhibitor
Sho Koda, Naoki Okumura, Junji Kitano, Noriko Koizumi, Yasuhiko Tabata
JOURNAL OF OPHTHALMOLOGY, HINDAWI LTD, 20171598218 , 2017, English, Research paper (scientific journal) - Activation of the Rho/Rho Kinase Signaling Pathway Is Involved in Cell Death of Corneal Endothelium
Naoki Okumura, Keita Fujii, Takato Kagami, Nakahara Makiko, Miu Kitahara, Shigeru Kinoshita, Noriko Koizumi
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 57(15)6843 - 6851, Dec. 2016, English, Research paper (scientific journal) - Generation and Feasibility Assessment of a New Vehicle for Cell-Based Therapy for Treating Corneal Endothelial Dysfunction
Naoki Okumura, Kazuya Kakutani, Ryota Inoue, Daiki Matsumoto, Tomoki Shimada, Makiko Nakahara, Yumiko Kiyanagi, Takehiro Itoh, Noriko Koizumi
PLOS ONE, PUBLIC LIBRARY SCIENCE, 11(6)e0158427 , Jun. 2016, English, Research paper (scientific journal) - Density-gradient centrifugation enables the purification of cultured corneal endothelial cells for cell therapy by eliminating senescent cells
Naoki Okumura, Ayaka Kusakabe, Hiroatsu Hirano, Ryota Inoue, Yugo Okazaki, Shinichiro Nakano, Shigeru Kinoshita, Noriko Koizumi
SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, 515005 , Oct. 2015, English, Research paper (scientific journal) - Morphological Changes of Human Corneal Endothelial Cells after Rho-Associated Kinase Inhibitor Eye Drop (Ripasudil) Administration: A Prospective Open-Label Clinical Study
Hiroko Nakagawa, Noriko Koizumi, Naoki Okumura, Hideki Suganami, Shigeru Kinoshita
PLOS ONE, PUBLIC LIBRARY SCIENCE, 10(9)e0136802 , Sep. 2015, English, Research paper (scientific journal) - Derivation of Mesenchymal Stromal Cells from Pluripotent Stem Cells through a Neural Crest Lineage using Small Molecule Compounds with Defined Media
Makoto Fukuta, Yoshinori Nakai, Kosuke Kirino, Masato Nakagawa, Kazuya Sekiguchi, Sanae Nagata, Yoshihisa Matsumoto, Takuya Yamamoto, Katsutsugu Umeda, Toshio Heike, Naoki Okumura, Noriko Koizumi, Takahiko Sato, Tatsutoshi Nakahata, Megumu Saito, Takanobu Otsuka, Shigeru Kinoshita, Morio Ueno, Makoto Ikeya, Junya Toguchida
PLOS ONE, PUBLIC LIBRARY SCIENCE, 9(12)e112291 , Dec. 2014, English, Research paper (scientific journal) - Cell-Based Approach for Treatment of Corneal Endothelial Dysfunction
Naoki Okumura, Shigeru Kinoshita, Noriko Koizumi
CORNEA, LIPPINCOTT WILLIAMS & WILKINS, 33S37 - S41, Nov. 2014, English, Research paper (scientific journal) - New Therapeutic Modality for Corneal Endothelial Disease Using Rho-Associated Kinase Inhibitor Eye Drops
Noriko Koizumi, Naoki Okumura, Morio Ueno, Shigeru Kinoshita
CORNEA, LIPPINCOTT WILLIAMS & WILKINS, 33S25 - S31, Nov. 2014, English, Research paper (scientific journal) - Cell Surface Markers of Functional Phenotypic Corneal Endothelial Cells
Naoki Okumura, Hiroatsu Hirano, Ryohei Numata, Makiko Nakahara, Morio Ueno, Junji Hamuro, Shigeru Kinoshita, Noriko Koizumi
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 55(11)7610 - 7618, Nov. 2014, English, Research paper (scientific journal) - Rho-Associated Kinase Inhibitor Eye Drop Treatment as a Possible Medical Treatment for Fuchs Corneal Dystrophy
Noriko Koizumi, Naoki Okumura, Morio Ueno, Hiroko Nakagawa, Junji Hamuro, Shigeru Kinoshita
CORNEA, LIPPINCOTT WILLIAMS & WILKINS, 32(8)1167 - 1170, Aug. 2013, English, Research paper (scientific journal) - Corneal Endothelial Cell Fate Is Maintained by LGR5 Through the Regulation of Hedgehog and Wnt Pathway
Kana Hirata-Tominaga, Takahiro Nakamura, Naoki Okumura, Satoshi Kawasaki, Eunduck P. Kay, Yann Barrandon, Noriko Koizumi, Shigeru Kinoshita
STEM CELLS, WILEY-BLACKWELL, 31(7)1396 - 1407, Jul. 2013, English, Research paper (scientific journal) - The ROCK Inhibitor Eye Drop Accelerates Corneal Endothelium Wound Healing
Naoki Okumura, Noriko Koizumi, EunDuck P. Kay, Morio Ueno, Yuji Sakamoto, Shinichiro Nakamura, Junji Hamuro, Shigeru Kinoshita
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 54(4)2493 - 2502, Apr. 2013, English, Research paper (scientific journal) - Author response: Human corneal endothelium regeneration: Effect of ROCK inhibitor
Noriko Koizumi, Naoki Okumura, Shigeru Kinoshita
Investigative Ophthalmology and Visual Science, 54(8)5594 - 5595, 2013, English - ROCK Inhibitor Converts Corneal Endothelial Cells into a Phenotype Capable of Regenerating In Vivo Endothelial Tissue
Naoki Okumura, Noriko Koizumi, Morio Ueno, Yuji Sakamoto, Hiroaki Takahashi, Hideaki Tsuchiya, Junji Hamuro, Shigeru Kinoshita
AMERICAN JOURNAL OF PATHOLOGY, ELSEVIER SCIENCE INC, 181(1)268 - 277, Jul. 2012, English, Research paper (scientific journal) - A selective inhibitor of the Rho kinase pathway, Y-27632, and its influence on wound healing in the corneal stroma
Mayumi Yamamoto, Andrew J. Quantock, Robert D. Young, Naoki Okumura, Morio Ueno, Yuji Sakamoto, Shigeru Kinoshita, Noriko Koizumi
MOLECULAR VISION, MOLECULAR VISION, 18(178-80)1727 - 1739, Jun. 2012, English, Research paper (scientific journal) - Development of new therapeutic modalities for corneal endothelial disease focused on the proliferation of corneal endothelial cells using animal models
Noriko Koizumi, Naoki Okumura, Shigeru Kinoshita
EXPERIMENTAL EYE RESEARCH, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 95(1)60 - 67, Feb. 2012, English, Research paper (scientific journal) - The New Therapeutic Concept of Using a Rho Kinase Inhibitor for the Treatment of Corneal Endothelial Dysfunction
Naoki Okumura, Noriko Koizumi, Morio Ueno, Yuji Sakamoto, Hiroaki Takahashi, Junji Hamuro, Shigeru Kinoshita
CORNEA, LIPPINCOTT WILLIAMS & WILKINS, 30S54 - S59, Oct. 2011, English, Research paper (scientific journal) - Enhancement of corneal endothelium wound healing by Rho-associated kinase (ROCK) inhibitor eye drops
Naoki Okumura, Noriko Koizumi, Morio Ueno, Yuji Sakamoto, Hiroaki Takahashi, Kana Hirata, Ryuzo Torii, Junji Hamuro, Shigeru Kinoshita
BRITISH JOURNAL OF OPHTHALMOLOGY, BMJ PUBLISHING GROUP, 95(7)1006 - 1009, Jul. 2011, English, Research paper (scientific journal) - Enhancement on Primate Corneal Endothelial Cell Survival In Vitro by a ROCK Inhibitor
Naoki Okumura, Morio Ueno, Noriko Koizumi, Yuji Sakamoto, Kana Hirata, Junji Hamuro, Shigeru Kinoshita
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 50(8)3680 - 3687, Aug. 2009, English, Research paper (scientific journal) - Cultivated corneal endothelial transplantation in a primate: Possible future clinical application in corneal endothelial regenerative medicine
Noriko Koizumi, Yuji Sakamoto, Naoki Okumura, Hideaki Tsuchiya, Ryuzo Torii, Leanne J. Cooper, Yuriko Ban, Hidetoshi Tanioka, Shigeru Kinoshita
CORNEA, LIPPINCOTT WILLIAMS & WILKINS, 27(8)S48 - S55, Sep. 2008, English, Research paper (scientific journal) - Cultivated corneal endothelial cell sheet transplantation in a primate model
Noriko Koizumi, Yuji Sakamoto, Naoki Okumura, Norio Okahara, Hideaki Tsuchiya, Ryuzo Torii, Leanne J. Cooper, Yuriko Ban, Hidetoshi Tanioka, Shigeru Kinoshita
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 48(10)4519 - 4526, Oct. 2007, English, Research paper (scientific journal)
Misc
- Rhoキナーゼ阻害薬（リパスジル）の角膜内皮創傷治癒に対する影響．日本眼科学会雑誌 120（7）： 503，2016.6.
奥村直毅, 岡崎友吾, 井上亮太, 角谷和哉, 中野新一郎, 木下茂, 小泉範子
Jun. 2016 - 角膜内皮細胞研究のための新たな実験動物としてのフェレット(Ferrets as a New Experimental Animal Model for Corneal Endothelial Research)
坂本 雄二, 奥村 直毅, 小泉 範子, 山崎 健太, 北野 絢嗣, 沼田 諒平, 駒田 孝文, 星 信彦
比較眼科研究, 比較眼科学会, 313 - 11, Dec. 2012, English - 圧力駆動柔軟マイクロアクチュエータを用いた角膜移植マイクロマシンの開発
寺町 有未, 松下 佳史, 北野 絢嗣, 奥村 直毅, 小泉 範子, 木下 茂, 小西 聡
日本コンピュータ外科学会誌, (一社)日本コンピュータ外科学会, 14(3)268 - 269, Oct. 2012, Japanese - 結膜扁平上皮癌におけるGPR49の発現の検討
平田香菜, 中村隆宏, 外園千恵, 稲富勉, 奥村直毅, 小泉範子, 横井則彦, 木下茂
日本角膜学会総会・日本角膜移植学会プログラム・抄録集, 36th-28th67 , 2012, Japanese - 輪部デルモイドに対する表層角膜移植術の有効性の検討
中山琴美, 奥村直毅, 外園千恵, 稲富勉, 横井則彦, 木下茂
日本角膜学会総会・日本角膜移植学会プログラム・抄録集, 35th-27th46 , 2011, Japanese - 角膜疾患の未来医療
木下 茂, 小泉 範子, 外園 千恵, 中村 隆宏, 稲富 勉, 上田 真由美, 川崎 諭, 山田 潤, 横井 則彦, 上野 盛夫, 丸山 和一, 奥村 直毅, 伴 由利子, 西崎 暁子, 関山 英一, 永田 真帆, 中司 美奈, 東原 尚代, 鈴木 智, 佐野 洋一郎, 山崎 健太, 谷岡 秀敏, 高橋 浩昭, 岡野 明, 羽室 淳爾, Quantock Andrew J, Fullwood Nigel J, 西田 幸二, 田代 啓, 中野 正和, 八木 知人, 不破 正博, 鳥居 隆三, 成宮 周, 松岡 俊行, 審良 静男
日本眼科学会雑誌, (公財)日本眼科学会, 114(3)161 - 201, Mar. 2010, Japanese - アミノ酸組成の培養ヒト角膜上皮細胞機能に及ぼす影響
外園千恵, 山崎健太, 中司美奈, 奥村直毅, 伴由利子, 羽室淳爾, 木下茂
日本眼科学会雑誌, 113(臨増)206 - 206, 15 Mar. 2009, Japanese - Association of rs613872 and trinucleotide repeat expansion in the TCF4 gene in Fuchs endothelial corneal dystrophy in Germany
Yuya Komori, Naoki Okumura, Ryosuke Hayashi, Masakazu Nakano, Kei Tashiro, Kengo Yoshii, Ross Aleff, Malinda Butz, Edward W. Highsmith, Eric Wieben, Michael P. Fautsch, Keith H. Baratz, Theofilos Tourtas, Ursula Schlotzer-Schrehardt, Friedrich E. Kruse, Noriko Koizumi
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 59(9), Jul. 2018, English, Research paper, summary (international conference) - The role of TCF4 in the pathophysiology of Fuchs endothelial corneal dystrophy
Masakazu Sato, Naoki Okumura, Makiko Nakahara, Takahiko Sato, Koji Kitazawa, Ursula Schlotzer-Schrehardt, Friedrich E. Kruse, Noriko Koizumi
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 59(9), Jul. 2018, English, Research paper, summary (international conference) - Trinucleotide repeat expansion and TCF4 gene expression in Fuchs endothelial corneal dystrophy
Keisuke Ogata, Naoki Okumura, Ryosuke Hayashi, Makiko Nakahara, Masakazu Nakano, Kei Tashiro, Shigeru Kinoshita, Ursula Schloetzer-Schrehardt, Theofilos Tourtas, Friedrich E. Kruse, Noriko Koizumi
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 57(12), Sep. 2016, English, Research paper, summary (international conference) - The effect of p38 mitogen-activated protein kinase inhibitor on cell density and phenotype of cultivated human corneal endothelial cells
Akane Hongo, Naoki Okumura, Makiko Nakahara, Noriko Koizumi
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 57(12), Sep. 2016, English, Research paper, summary (international conference) - p38 mitogen-activated protein kinase inhibitor suppresses apoptosis in a Fuchs endothelial corneal dystrophy cellular model
Takako Onishi, Naoki Okumura, Ayaka Kusakabe, Miu Kitahara, Keisuke Hashimoto, Makiko Nakahara, Emi Ueda, Theofilos Tourtas, Ursula Schloetzer-Schrehardt, Friedrich E. Kruse, Noriko Koizumi
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 57(12), Sep. 2016, English, Research paper, summary (international conference) - Unfolded protein accumulation induced endoplasmic reticulum stress of corneal endothelial cells in Fuchs endothelial corneal dystrophy
Naoki Okumura, Keisuke Hashimoto, Miu Kitahara, Makiko Nakahara, Shigeru Kinoshita, Theofilos Tourtas, Ursula Schloetzer-Schrehardt, Friedrich E. Kruse, Noriko Koizumi
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 57(12), Sep. 2016, English, Research paper, summary (international conference) - Profiles of cytokines in the aqueous humor and serum of bullous keratopathy patients
Morio Ueno, Munetoyo Toda, Asako Hiraga, Koichi Wakimasu, Noriko Koizumi, Naoki Okumura, Kazuko Asada, Chie Sotozono, Junji Hamuro, Shigeru Kinoshita
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 57(12), Sep. 2016, English, Research paper, summary (international conference) - A Surgical Cryoprobe for Targeted Transcorneal Freezing to Treat Corneal Endothelial Dysfunction
Alina Akhbanbetova, Shinichiro Nakano, Stacy L. Littlechild, Robert D. Young, Madara Zvirgzdina, Nigel J. Fullwood, Shigeru Kinoshita, Naoki Okumura, Noriko Koizumi, Andrew J. Quantock
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 57(12), Sep. 2016, English, Research paper, summary (international conference) - Effect of rho -associated kinase inhibitor eye drop (ripasudil) on morphology of corneal endothelial cells in humans and rabbits
Noriko Koizumi, Naoki Okumura, Yugo Okazaki, Ryota Inoue, Shinichiro Nakano, Hideki Suganami, Nigel J. Fullwood, Hiroko Nakagawa, Shigeru Kinoshita
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 57(12), Sep. 2016, English, Research paper, summary (international conference) - Feasibility of cell preservation as a form of cell suspension for a cell-based therapy in a rabbit corneal endothelial dysfunction model
Daiki Matsumoto, Naoki Okumura, Ryota Inoue, Yuge Okazaki, Shigeru Kinoshita, Noriko Koizumi
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 57(12), Sep. 2016, English, Research paper, summary (international conference) - Effect of the rho-associated kinase inhibitor eye drop ripasudil on corneal endothelial wound healing in a rabbit corneal endothelial damage model
Tomoki Shimada, Naoki Okumura, Ryota Inoue, Yugo Okazaki, Shinichiro Nakano, Shigeru Kinoshita, Noriko Koizumi
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 57(12), Sep. 2016, English, Research paper, summary (international conference) - The different binding properties of cultured human corneal endothelial cell subpopulations to Descemet's membrane components
Munetoyo Toda, Morio Ueno, Asako Hiraga, Kazuko Asada, Takahiro Nakamura, Michio Hagiya, Naoki Okumura, Noriko Koizumi, Junji Hamuro, Shigeru Kinoshita
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 56(7), Jun. 2015, English, Research paper, summary (international conference) - Investigation of the donor tissue information on the phenotypes of cultivated human corneal endothelium
Hiroshi Tanaka, Morio Ueno, Munetoyo Toda, Junji Hamuro, Kengo Yoshii, Noriko Koizumi, Naoki Okumura, Shigeru Kinoshita, Monty Montoya, Bernie Iliakis
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 56(7), Jun. 2015, English, Research paper, summary (international conference) - Morphological and functional evaluation of mitochondria in a Fuchs' endothelial corneal dystrophy cell model
Miu Kitahara, Naoki Okumura, Ursula Schlotzer-Schrehardt, Friedrich E. Kruse, Robert D. Young, Andrew J. Quantock, Shigeru Kinoshita, Noriko Koizumi
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 56(7), Jun. 2015, English, Research paper, summary (international conference) - Rho-associated protein kinase inhibitor suppresses corneal endothelial cell apoptosis by suppressing cell contraction via inhibiting myosin light chainphosphorylation
Keita Fujii, Naoki Okumura, Ai Odajima, Morio Ueno, Shigeru Kinoshita, Noriko Koizumi
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 56(7), Jun. 2015, English, Research paper, summary (international conference) - Effect of the cell density of cultivated corneal endothelial cells on tissue engineering for the treatment of corneal endothelial dysfunction
Naoki Okumura, Shinichiro Nakano, Ayaka Kusakabe, Ryota Inoue, Yugo Okazaki, Kazuya Kakutani, Shigeru Kinoshita, Noriko Koizumi
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 56(7), Jun. 2015, English, Research paper, summary (international conference) - Feasibility of Descemet's membrane removal during cultivated corneal endothelial cell injection in rabbit and monkey models
Noriko Koizumi, Naoki Okumura, Shinichiro Nakano, Junji Kitano, Shigeru Kinoshita
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 56(7), Jun. 2015, English, Research paper, summary (international conference) - The feasibility of recombinant human laminin-511 E8 fragments for human corneal endothelial cell cultivation
Kazuya Kakutani, Naoki Okumura, Ursula Schlotzer-Schrehardt, Friedrich E. Kruse, Shigeru Kinoshita, Noriko Koizumi
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 56(7), Jun. 2015, English, Research paper, summary (international conference) - Purification of high cell density cultured corneal endothelial cells by density-gradient centrifugation
Ayaka Kusakabe, Naoki Okumura, Hiroatsu Hirano, Noriko Koizumi, Shigeru Kinoshita
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 56(7), Jun. 2015, English, Research paper, summary (international conference) - Existence of inflammatory cells on donor corneal endothelium in a Descemet's stripping automated endothelial keratoplasty rabbit model
Elena Koudouna, Naoki Okumura, Shinichiro Nakano, Ryota Inoue, Nigel Fullwood, Yugo Okazaki, Shigeru Kinoshita, Noriko Koizumi
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 56(7), Jun. 2015, English, Research paper, summary (international conference) - The effect of ROCK inhibitor on corneal wound healing and the transformation of keratocytes
M. Yamamoto, N. Okumura, H. Takahashi, M. Ueno, Y. Sakamoto, M. Liles, R. D. Young, A. J. Quantock, S. Kinoshita, N. Koizumi
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, WILEY-BLACKWELL, 92(3)A15 - A15, Jun. 2011, English, Research paper, summary (international conference) - Mite antigen-induced perennial allergic conjunctivitis in mice
K Kojima, N Okumura, M Hashida, W Ishida, K Fukata, T Yamaguchi, A Fukushima, H Ueno
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 46, 2005, English, Research paper, summary (international conference)
Books etc
- Corneal Regeneration, Essentials in Ophthalmology
Koizumi N, Okumura N
Springer, Jan. 2019, Joint author, Cell based therapy for corneal endothelial regeneration
Conference Activities & Talks
- Rho-kinase Inhibitor Assisted Cell Therapy for the Treatment of Corneal Endothelial Decompensation.
Okumura, N
05 Feb. 2021, English - Immune Cells on the Donor Corneal Endothelium After Corneal Transplantation Immune Cells on the Donor Cornea.
Okumura, N
The Asia Cornea Society Biennial Scientific Meeting., Feb. 2021, English - Pathophysiology of Fuchs Endothelial Corneal Dystrophy
Okumura, N
Philippine Academy of Ophthalmology Annual Meeting, 06 Dec. 2019 - Fuchs Endothelial Corneal Dystrophy - Pathophysiology and Potential Future Therapies ROCK Inhibitor Eye Drops for the Treatment of Corneal Endothelial Disease Clinical Research and Future Perspectives of Cultured Corneal Endothelial Cell-Injection Therapy
Okumura, N
Philippine Cornea Society 20th Anniversary Meeting, 05 Dec. 2019 - Clinical Research and Future Perspectives of Cultured Corneal Endothelial Cell-Injection Therapy.
Okumura, N
The 122th Annual meeting of Korean Ophthalmological Society, 02 Nov. 2019 - Future therapies for the treatment of corneal endothelial disease.
Okumura, N
Lecture, Sankara Nethralaya, 27 Jul. 2019, Public lecture, seminar, tutorial, course, or other speech - Application of Rho Kinase Inhibitors for the Treatment of Corneal Endothelial Diseases.
Naoki Okumura
08 Mar. 2019 - Can cell-based therapy and eye-drop medication become future therapies for the treatment of corneal endothelial disease?
Okumura, N
ARVO-INDIA 2019, 28 Jul. 2019, Oral presentation (general) - Future pharmaceutical treatment for the treatment of Fuchs’ endothelial corneal dystrophy.
Naoki Okumura
BBSRC Japan Partnering Award Symposium, Eye Research in Japan and The UK and The Application of Stem Cell Technology., 07 Dec. 2018, Oral presentation (general) - Involvement of mitochondria-associated endoplasmic reticulum membrane in the pathophysiology of Fuchs endothelial corneal dystrophy.
Matsumoto S, Okumura N, Okuda H, Ursula Schlötzer-Schrehardt, Friedrich E. Kruse, Robert D. Young, Andrew J. Quantock, Koizumi N
The 11th Joint Meeting of Japan-China-Korea Ophthalmologists., 01 Dec. 2018, Oral presentation (general) - Feasibility of “stromal sandwich” for the treatment of keratoconus and keratectasia by using decellularized porcine corneal sheet.
The 11th Joint Meeting of Japan-China-Korea Ophthalmologists., 01 Dec. 2018, Poster presentation - Drug Development for the Treatment of Fuchs Endothelial Corneal Dystrophy.
30 Nov. 2018, Oral presentation (general) - Translational Research of Cultured Corneal Endothelial Cell Transplantation.
Naoki Okumura
2018 TERMIS World Congress., 07 Sep. 2018, Oral presentation (general) - The role of TCF4 in the pathophysiology of Fuchs endothelial corneal dystrophy.
Sato M, Okumura N, Nakahara M, Sato T, Kitazawa K, U. Schlotzer-Schrehardt, F. E. Kruse, Koizumi N
The Association for Research in Vision and Ophthalmology 2018., 02 May 2018, Oral presentation (general) - Feasibility of decellularized porcine corneal sheet implantation for a “stromal sandwich” for the treatment of keratoconus and keratectasia.
Fukui Y, Okumura N, Matsumoto D, Shimada T, Teramoto M, Imai H, Kurosawa T, F Tseng, D Hsieh, Koizumi N
The Association for Research in Vision and Ophthalmology 2018., 02 May 2018, Poster presentation - Future therapy: cell-based therapy and drug treatment.
Naoki Okumura
The Association for Research in Vision and Ophthalmology 2018., 02 May 2018, Oral presentation (general) - Comparison of subfoveal choroidal thickness with the difference between right and left eye in POAG patients.
Mengxue Zhou, Imai K, Mori K, Ikeda Y, Ueno M, Okumura N, Kinoshita S, Sotozono C, Koizumi N
The Association for Research in Vision and Ophthalmology 2018., 30 Apr. 2018, Poster presentation - Establishment of a drug screening system for Fuchs endothelial corneal dystrophy.
Oshima T, Okumura N, Onishi T, Ueda E, Watanabe K, T Tourtas, U Schlotzer-Schrehardt, F E Kruse, Koizumi N
The Association for Research in Vision and Ophthalmology 2018., 30 Apr. 2018, Poster presentation - Association of rs613872 and trinucleotide repeat expansion in the TCF4 gene in Fuchs endothelial corneal dystrophy in Germany.
Komori Y, Okumura N, Hayashi R, Nakano M, Tashiro K, Yoshii K, R Aleff, M Butz, E W Highsmith, E Wieben, M P Fautsch, K H Baratz, T Tourtas, U Schlotzer-Schrehardt, F E Kruse, Koizumi N
The Association for Research in Vision and Ophthalmology 2018., 30 Apr. 2018, Poster presentation - Involvement of p38 mitogen-activated protein kinase pathway in Fuchs endothelial corneal dystrophy. The Association for Research in Vision and Ophthalmology 2017, Baltimore, USA, 2017.5.10.(一般口演)
Onishi T, Okumura N, Hashimoto K, Koizumi N
May 2017 - Wide-field contact specular microscopy analysis of corneal endothelium post trabeculectomy. The Association for Research in Vision and Ophthalmology 2017, Baltimore, USA, 2017.5.8.（ポスター）
Matsumoto D, Okumura N, Okazaki Y, Shimada T, Koizumi N, Sotozono C, Kinoshita S, Mori K
May 2017 - Nectin-afadin and N-cadherin-catenin system is involved in the formation of adherens junctions in the corneal endothelium. The Association for Research in Vision and Ophthalmology 2017, Baltimore, USA, 2017.5.8.（ポスター）
Kagami T, Okumura N, Nakahara M, Koizumi N
May 2017 - Expression level of the TCF4 gene in the corneal endothelium of Fuchs endothelial corneal dystrophy patients. The Association for Research in Vision and Ophthalmology 2017, Baltimore, USA, 2017.5.8.（ポスター）
Hayashi R, Okumura N, Ogata K, Nakano M, Tourtas T, Schlötzer-Schrehardt U, Kruse FE, Koizumi N
May 2017 - Feasibility of caspase inhibitor to treat Fuchs endothelial corneal dystrophy. The Association for Research in Vision and Ophthalmology 2017, Baltimore, USA, 2017.5.8.（ポスター）
Endo M, Okumura N, Tourtas T, Schlötzer-Schrehardt U, Kruse FE, Koizumi N
May 2017 - Activation of an intrinsic pathway by endoplasmic reticulum stress in corneal endothelial cells. The Association for Research in Vision and Ophthalmology 2017, Baltimore, USA, 2017.5.8.（ポスター）
Okuda H, Okumura N, Kitahara M, Hashimoto K, Koizumi N
May 2017 - Feasibility of TGF-β inhibition for the treatment of Fuchs endothelial corneal dystrophy.The Association for Research in Vision and Ophthalmology 2017, Baltimore, USA, 2017.5.8.（ポスター）
Okumura N, Hashimoto K, Okuda H, Ueda E, Tourtas T, Schlötzer-Schrehardt U, Kruse FE, Koizumi N
May 2017 - The Long and Winding Road: From Novel Insights to Practical Application. 第121回日本眼科学会総会, 東京2017.4.7.
Naoki Okumura
Apr. 2017 - Sustained Activation of Unfolded Protein Response Induces Cell Death in Fuchs Endothelial Corneal Dystrophy. The 5th Biennial Scientific Meeting Asia Cornea Society (ACS 2016) , Seoul,Korea, 2016.12.9.
Okumura N
Dec. 2016 - Translational Research for Corneal Endothelial Disease．Lecture in Cardiff university，Wales，UK，2016.8.10.
Naoki Okumura
Aug. 2016 - 再生医療で光を取り戻す、角膜再生医療の最前線．駿台予備学校 生命医科学特別講演会, 大阪, 2016.5.26.
Naoki Okumura
May 2016 - The effect of p38 mitogen-activated protein kinase inhibitor on cell density and phenotype of cultivated human corneal endothelial cells．The Association for Research in Vision and Ophthalmology 2016，Seattle，USA，2016.5.4．（ポスター）
Hongo A, Okumura N, Nakahara M, Koizumi N
May 2016 - Effect of the rho-associated kinase inhibitor eye drop ripasudil on corneal endothelial wound healing in a rabbit corneal endothelial damage model. The Association for Research in Vision and Ophthalmology 2016, Seattle, USA, 2016.5.4.
Shimada T, Okumura N, Inoue R, Okazaki Y, Nakano S, Kinoshita S, Koizumi N
May 2016 - p38 mitogen-activated protein kinase inhibitor suppresses apoptosis in a Fuchs endothelial corneal dystrophy cellular model．The Association for Research in Vision and Ophthalmology 2016，Seattle，USA，2016.5.4．（ポスター）
Onishi T, Okumura N, Kusakabe A, Kitahara M, Hashimoto K, Nakahara M, Ueda E, Tourtas T, Schlötzer-Schrehardt U, Kruse F, Koizumi N
May 2016 - Feasibility of cell preservation as a form of cell suspension for a cell-based therapy in a rabbit corneal endothelial dysfunction model．The Association for Research in Vision and Ophthalmology 2016，Seattle，USA，2016.5.4．（ポスター）
Matsumoto D, Okumura N, Inoue R, Okazaki Y, Kinoshita S, Koizumi N
May 2016 - Effect of rho-associated kinase inhibitor eye drop （ripasudil） on morphology of corneal endothelial cells in humans and rabbits．The Association for Research in Vision and Ophthalmology 2016，Seattle，USA，2016.5.4．（ポスター）
Koizumi N, Okumura N, Okazaki Y, Inoue R, Nakano S, Suganami H, Fullwood N, Nakagawa H, Kinoshita S
May 2016 - Trinucleotide repeat expansion and TCF4 gene expression in Fuchs endothelial corneal dystrophy．The Association for Research in Vision and Ophthalmology 2016，Seattle，USA，2016.5.3．
Ogata K, Okumura N, Hayashi R, Nakahara M, Nakano M, Tashiro K, Kinoshita S, Schlötzer-Schrehardt U, Tourtas T, Kruse F, Koizumi N
May 2016 - Unfolded protein accumulation induced endoplasmic reticulum stress of corneal endothelial cells in Fuchs endothelial corneal dystrophy．The Association for Research in Vision and Ophthalmology 2016，Seattle，USA，2016.5.3．
Okumura N, Hashimoto K, Kitahara M, Nakahara M, Kinoshita S, Tourtas T, Schlötzer-Schrehardt U, Kruse F, Koizumi N
May 2016 - Cultivaled Corneal Endothelial Cell Transplantation．The 31st Asia-Pacific Academy of Ophthalmology Congress （APAO 2016） Taipei，Taiwan，2016.3.24
Naoki Okumura
Mar. 2016 - Endotheial Cell Transplantation and Regeneration. DOG congress 2015, Berlin, Germany, 2015.10.4.
Naoki Okumura
Oct. 2015 - How to make cornea endothelial cells. 6th EuCornea Congress, XXXIII Congress of the ESCRS, Barcelona, Spain, 2015.9.5.
Naoki Okumura
Sep. 2015 - Development of Cell Therapy for the Treatment of Corneal Endothelial Dysfunction. Chulalongkorn Eye Center, Thailand.2015.8.19.
Naoki Okumura
Aug. 2015 - An allogeneic transplantation trial of cynomolgus monkey ipsc-derived corneal endothelial-like cells．The International Society for Stem Cell Research．Stockholm，Sweden，2015.6.24.
Yoshida S, Hatou S, Okumura N, Koizumi N, Kinoshita S, Tsujikawa M, Hayashi R, Nishida K, Tsubota K, Shimmura S
Jun. 2015 - Clinical research of cultured corneal endothelial transplantation. The Association for Research in Vision and Ophthalmology 2015, Colorado, USA, 2015.5.4.
Naoki Okumura
May 2015 - Existence of inflammatory cells on donor corneal endothelium in a Descemet’s stripping automated endothelial keratoplasty rabbit model．The Association for Research in Vision and Ophthalmology 2015．Colorado，USA，2015.5.6．（ポスター）
Koudouna E, Okumura N, Nakano S, Inoue R, Fullwood N, Okazaki S, Kinoshita S, Koizumi N
May 2015 - Rho-associated protein kinase inhibitor suppresses corneal endothelial cell apoptosis by suppressing cell contraction via inhibiting myosin light chain phosphorylation．The Association for Research in Vision and Ophthalmology 2015．Colorado，USA，2015.5.5.
Fujii K, Okumura N, Odajima A, Ueno M, Kinoshita S, Koizumi N
May 2015 - Morphological and functional evaluation of mitochondria in a Fuchs’ endothelial corneal dystrophy cell model．The Association for Research in Vision and Ophthalmology 2015．Colorado，USA，2015.5.3．（ポスター）
Kitahara M, Okumura N, Schlotzer-Schrehardt U, Kruse FE, Young RD, Quantock AJ, Kinoshita S, Koizumi N
May 2015 - Effect of the cell density of cultivated corneal endothelial cells on tissue engineering for the treatment of corneal endothelial dysfunction．The Association for Research in Vision and Ophthalmology 2015．Colorado，USA，2015.5.3．（ポスター）
Okumura N, Nakano S, Kusakabe A, Inoue R, Okazaki Y, Kakutani K, Kinoshita S, Koizumi N
May 2015 - Feasibility of Descemet’s membrane removal during cultivated corneal endothelial cell injection in rabbit and monkey models．The Association for Research in Vision and Ophthalmology 2015．Colorado，USA，2015.5.3．（ポスター）
Koizumi N, Okumura N, Nakano S, Kitano J, Kinoshita S
May 2015 - Purification of high cell density cultured corneal endothelial cell by density-gradient centrifugation．The Association for Research in Vision and Ophthalmology 2015．Colorado，USA，2015.5.3．（ポスター）
Kusakabe A, Okumura N, Hirano H, Koizumi N, Kinoshita S
May 2015 - Investigation of the donor tissue information on the phenotypes of cultivated human corneal endothelium．The Association for Research in Vision and Ophthalmology 2015．Colorado，USA，2015.5.3．（ポスター）
Tanaka H, Ueno M, Toda M, Hamuro J, Yoshii K, Koizumi N, Okumura N, Kinoshita S, Montoya M, Iliakis B
May 2015 - The feasibility of recombinant human laminin-511 E8 fragments for human corneal endothelial cell cultivation．The Association for Research in Vision and Ophthalmology 2015．Colorado，USA，2015.5.3．（ポスター）
Kakutani K, Okumura N, Schlotzer-Schrehardt U, Kruse FE, Kinoshita S, Koizumi N
May 2015 - The different binding properties of cultured human corneal endothelial cell subpopulations to Descemet’s membrane components．The Association for Research in Vision and Ophthalmology 2015．Colorado，USA，2015.5.3．（ポスター）
Toda M, Ueno M, Hiraga A, Asada K, Nakamura T, Hagiya M, Okumura N, Koizumi N, Hamuro J, Kinoshita S
May 2015 - 角膜内皮障害に対する新しい治療法の開発〜再生医療と薬物療法〜. 京滋眼科臨床懇話会, 京都, 2015.4.25.
Naoki Okumura
Apr. 2015 - R-spondin1の角膜内皮細胞増殖に対する影響．角膜カンファランス2015第39回日本角膜学会総会・第31回日本角膜移植学会，高知 ，2015.2.12.
Feb. 2015 - Cultivated corneal endothelial cell injection for the treatment of bullous keratopathy. Seminar in Kyungpook National University Hospital, 2014.9.27
Naoki Okumura
Sep. 2014 - Cell-injection therapy for the treatment of corneal endothelial dysfunction.第118回日本眼科学会総会，東京2014.4.3．（WOC2014 Otsuka morning seminar）
Okumura N
Apr. 2014 - 霊長類水疱性角膜症モデルを用いた培養角膜内皮細胞移植の有用性および安全性評価．第13回日本再生医療学会総会, 京都, 2014.3.6.
小泉範子, 奥村直毅, 椎名隆, 鈴木進悟, 中村紳一朗, 上野盛夫, 羽室淳爾, 松山晃文, 木下茂
Mar. 2014 - Involvement of transforming growth factor beta in extracellular matrix deposition and endoplasmic reticulum stress in FUCHS' corneal dystrophy．The International Society for Eye Research XXI Biennial Meeting，San Francisco，California，USA，2014.7.22.
Okumura N, Minamiyama R, Kay EP,Ho L, Kawasaki S, Young R, Quantock A, Schlotzer-Schrehardt U, Kruse F, Kinoshita S, Koizumi N
2014 - Modulating Cell Adhesion Property Enables Cell-based Therapy for Corneal Endothelial Dysfunction．The Association for Research in Vision and Ophthalmology 2014．Florida，USA，2014.5.7．
Okumura N
2014 - The efficiency of laminin-511 and laminin-521 as extracellular matrix for human corneal endothelial cell culture．The Association for Research in Vision and Ophthalmology 2014．Florida，USA，2014.5.5.（ポスター）
Kakutani K, Okumura N, Numata R, Schlotzer-Schrehardt U, Kruse F, Kinoshita S, Koizumi N
2014 - The effect of cell density on the adhesion and proliferation properties of cultivated corneal endothelial cells．The Association for Research in Vision and Ophthalmology 2014．Florida，USA，2014.5.5.（ポスター）
Kusakabe A, Okumura N, Hirano H, Kinoshita S, Koizumi N
2014 - The involvement of transforming growth factor beta on excessive extracellular matrix production of corneal endothelial cells in Fuchs’ endothelial corneal dystrophy．The Association for Research in Vision and Ophthalmology 2014．Florida，USA，2014.5.6.
Koizumi N, Okumura N, Ho L, Kay EP, Kawasaki S, Tourtas T, Schlotzer-Schrehardt U, Kruse F, Kinoshita S
2014 - The involvement of transforming growth factor beta in endoplasmic reticulum stress of corneal endothelial cells in Fuchs’ endothelial corneal dystrophy．The Association for Research in Vision and Ophthalmology 2014．Florida，USA，2014.5.5．（ポスター）
Okumura N, Minamiyama R, Kay EP, Kawasaki S, Young R, Quantock A, Schlotzer-Schrehardt U, Friedrich EK, Kinoshita S, Koizumi N
2014 - Cell-Based Approach for the Treatment of Corneal Endothelial Dysfunction．Gordon Research Conference．California，USA，2014.2.17．
Okumura N
2014 - The Effect of EMT-Related Genes on the Regulation of Excessive Production of Extracellular Matrix in a Cellular Model of Fuchs’ Corneal Dystrophy．Gordon Research Conference．California，USA，2014.2.17.
Okumura N, Leona Ho, EunDuck P.Kay, Kawasaki S, Theofilos Tourtas, Schlotzer-Schrehardt U, Kruse FE, Kinoshita S, Koizumi N
2014 - ROCK-inhibiter Suppressed Apoptosis of Corneal Endothelial Cells by Inhibiting Membrane Blebbing．The Association for Research in Vision and Ophthalmology 2014．Florida，USA，2014.5.6.
Fujii K, Okumura N, Kay EP, Nakahara M, Odajima A, Ueno M, Kinoshita S, Koizumi N
2014 - ROCK Inhibitor Suppresses Apoptosis of Corneal Endothelial Cells by Inhibiting MLC phosphorylation. 4th Biennial Scientific Meeting Asia Cornea Society. Taipei, Taiwan, 2014.12.11.
Naoki Okumura
2014 - Regenerative medicine for the treatment of corneal endothelial dysfunction. (Keynote lecture), TERMIS-AP 2014, Daegu, Korea, 2014.9.26
Naoki Okumura
2014 - Development of cell therapy for treating corneal endothelial dysfunction. Seminar in the Catholic University of Korea. Seoul, Korea, 2014.9.23
Naoki Okumura
2014 - Rhoキナーゼ阻害剤の角膜内皮細胞に対するアポトーシス抑制効果の検討．角膜カンファランス2013第37回日本角膜学会総会・第29回日本角膜移植学会，和歌山, 2013.2.14.
小田嶋愛, 奥村直毅, Eunduck P Kay, 陳文, 上野盛夫, 木下茂, 小泉範子
2013 - Effect of SAHA on Fibrotic Change in Primate Retinal Pigment Epithelium Cells and Vitreous Cells. The Association for Research in Vision and Ophthalmology 2013. Seattle, USA, 2013.5.9.
2013 - Integral Analysis of Gene Signatures and MicroRNA Expression of Cultured Human Corneal Endothelial Cells in Relation to Their Functions，Cell Senescence，Epithelial-Mesenchymal Transition，and Fibrosis．The Association for Research in Vision and Ophthalmology
Asada K, Toda M, Hagiya M, Nakata K, Ueno M, Okumura N, Koizumi N, Hamuro J, Kinoshita S
2013 - Development of a Human Cultivated Nasal Mucosal Epithelial Cell Sheet for the Treatment of Severe Ocular Surface Diseases．The Association for Research in Vision and Ophthalmology 2013．Seattle，USA，2013.5.6.（ポスター）
Kobayashi M, Nakamura T, Yasuda M, Hata Y, Okura S, Okumura N, Koizumi N, Yasu H, Kinoshita S
2013 - Activation of the Rho/ROCK Signaling Pathway in the Apoptosis of Corneal Endothelial Cells．The Association for Research in Vision and Ophthalmology 2013．Seattle，USA，2013.5.6.
Okumura N, Odajima A, EunDuck P.Kay, Chen W, Ueno M, Hamuro J, Kinoshita S, Koizumi N
2013 - Efficacy and Safety Evaluation of Cell-Injection Therapy using Cultivated Human Corneal Endothelial Cells．The Association for Research in Vision and Ophthalmology 2013．Seattle，USA，2013.5.6.
Koizumi N, Okumura N, Shiina T, Suzuki S, Nakamura S, Sakamoto Y, Yamasaki K, Ueno M, Hamuro J, Kinoshita S
2013 - Rho kinase inhibitor promotes cell adhesion of corneal endothelial cells through inhibiting phosphorylation of MLC．The Association for Research in Vision and Ophthalmology 2013．Seattle，USA，2013.5.6.（ポスター）
Tsujimoto Y, Okumura N, EunDuck P.Kay, Numata R, Kinoshita S, Koizumi N
2013 - Effect of ROCK inhibiter on Apoptosis in Corneal Endothelial Cells．The Association for Research in Vision and Ophthalmology 2013．Seattle，USA，2013.5.6.（ポスター）
Odajima A, Okumura N, EunDuck P.Kay, Chen W, Ueno M, Kinoshita S, Koizumi N
2013 - Cell-injection Therapy Using Rho Kinase Inhibitor in a Corneal Endothelial Dysfunction Rabbit Model．The Association for Research in Vision and Ophthalmology 2013．Seattle，USA，2013.5.6.（ポスター）
Kitano J, Okumura N, EunDuck P.Kay, Ueno M, Hamuro J, Kinoshita S, Koizumi N
2013 - Proliferation Propensity of Cultured Human Corneal Endothelial Cells and Their Plasticity Dictated by Culture Microenvironments．The Association for Research in Vision and Ophthalmology 2013．Seattle，USA，2013.5.6.（ポスター）
Toda M, Nakata K, Asada K, Hagiya M, Ueno M, Okumura N, Koizumi N, Hamuro J, Kinoshita S
2013 - Rho-kinase inhibitor enhances corneal endothelial cell proliferation via p27 degradation．The Association for Research in Vision and Ophthalmology 2013．Seattle，USA，2013.5.6.（ポスター）
Numata R, Okumura N, EunDuck P.Kay, Nakahara M, Nakano S, Ueno M, Kinoshita S, Koizumi N
2013 - Controlled Release of a Rho Kinase （ROCK）-Selective Inhibitor with Polylactic Acid Microspheres．The Association for Research in Vision and Ophthalmology 2013．Seattle，USA，2013.5.6.（ポスター）
Koda S, Saito T, Kitano J, Okumura N, Kinoshita S, Tabata Y, Koizumi N
2013 - Cell Line of Fuchs' Corneal Dystrophy Produces an Abnormal Extracellular Matrix．The Association for Research in Vision and Ophthalmology 2013.Seattle，USA，2013.5.6.（ポスター）
Leona Ho, Okumura N, EunDuck P.Kay, Yamasaki K, Kawasaki S, Tourtas T, Schlotzer-Schrehardt U, Kruse FE, Kinoshita S, Koizumi N
2013 - The establishment of human corneal endothelial cell culture for clinical application．第117回日本眼科学会総会，東京2013.4.4.
Okumura N
2013 - HDAC阻害薬による網膜色素上皮細胞および硝子体細胞の線維性変化への影響．第117回日本眼科学会総会，東京2013.4.4.（ポスター
畑中宏樹, 小泉範子, 奥村直毅, 平野浩惇, 水原英理, 羽室淳爾, 木下茂
2013 - Rhoキナーゼ阻害剤の角膜内皮創傷治癒に対する影響．第117回日本眼科学会総会，東京，2013.4.4.
小泉範子, 奥村直毅, 中野新一郎, 北野絢嗣, 太田礼, 坂本雄二, 羽室淳爾, 上野盛夫, 木下茂
2013 - Rhoキナーゼ阻害剤の角膜内皮細胞に対するアポトーシス抑制効果の検討．第117回日本眼科学会総会，東京，2013.4.4.
奥村直毅, 小田嶋愛, EunDuck Kay, 陳文, 上野盛夫, 羽室淳爾, 木下茂, 小泉範子
2013 - Rhoキナーゼ阻害剤を併用した培養角膜内皮細胞移植の開発．第12回日本再生医療学会総会，横浜，2013.3.21.
北野絢嗣, 奥村直毅, 上野盛夫, 中原マキコ, 沼田諒平, 坂本雄二, 羽室淳爾, 木下茂, 小泉範子
2013 - 選択的Rhoキナーゼ阻害剤徐放化ポリ乳酸粒子の作製．第12回日本再生医療学会総会，横浜，2013.3.21.
迎田生, 齋藤高志, 北野絢嗣, 奥村直毅, 小泉範子, 田畑泰彦
2013 - Rhoキナーゼ阻害剤の角膜内皮細胞に対する増殖促進作用機序の検討．第12回日本再生医療学会総会，横浜，2013.3.21.
沼田諒平, 奥村直毅, Kay EunDuck, 中原マキコ, 上野盛夫, 木下茂, 小泉範子
2013 - Rhoキナーゼ阻害剤の培養角膜内皮細胞に対する基質接着性促進機序の検討．第12回日本再生医療学会総会，横浜，2013.3.21.
奥村直毅, 辻本勇気, Kay EunDuck, 沼田諒平, 太田礼, 上野盛夫, 羽室淳爾, 木下茂, 小泉範子
2013 - 難治性眼表面疾患に対する培養鼻粘膜上皮シートの開発．角膜カンファランス2013第37回日本角膜学会総会・第29回日本角膜移植学会，和歌山，2013.2.14.
小林正和, 中村隆宏, 安田誠, 畑結衣子, 大倉翔貴, 奥村直毅, 小泉範子, 久育男, 木下茂
2013 - ROCK阻害剤Y-39983の角膜内皮細胞増殖に対する効果の検討．角膜カンファランス2013第37回日本角膜学会総会・第29回日本角膜移植学会，和歌山，2013.2.14.
中野新一郎, 奥村直毅, 北野絢嗣, 太田礼, 坂本雄二, 羽室淳爾, 上野盛夫, 木下茂, 小泉範子
2013 - ポリ乳酸粒子を用いた選択的Rhoキナーゼ阻害剤徐放化の検討．角膜カンファランス2013第37回日本角膜学会総会・第29回日本角膜移植学会，和歌山，2013.2.14.
迎田生, 齋藤高志, 北野絢嗣, 奥村直毅, 木下茂, 田畑泰彦, 小泉範子
2013 - Rhoキナーゼ阻害剤の培養角膜内皮細胞に対する接着促進機序の検討．角膜カンファランス2013第37回日本角膜学会総会・第29回日本角膜移植学会，和歌山，2013.2.14.
辻本勇気, 奥村直毅, Eunduck P Kay, 沼田諒平, 上野盛夫, 羽室淳爾, 木下茂, 小泉範子
2013 - Rhoキナーゼ阻害剤の霊長類角膜内皮細胞に対する増殖促進機序の解明．角膜カンファランス2013第37回日本角膜学会総会・第29回日本角膜移植学会，和歌山，2013.2.14.
沼田諒平, 奥村直毅, Eunduck P Kay, 中原マキ子, 上野盛夫, 木下茂, 小泉範子
2013 - 霊長類水疱性角膜症モデルを用いた培養角膜内皮細胞注入療法の有用性および安全性評価．角膜カンファランス2013第37回日本角膜学会総会・第29回日本角膜移植学会，和歌山，2013.2.14.
奥村直毅, 椎名隆, 鈴木進悟, 中村紳一朗, 坂本雄二, 上野盛夫, 羽室淳爾, 木下茂, 松山晃文
2013 - ウサギ水疱性角膜症モデルを用いた培養角膜内皮細胞注入療法の開発．角膜カンファランス2013第37回日本角膜学会総会・第29回日本角膜移植学会，和歌山，2013.2.14.
北野絢嗣, 奥村直毅, 山崎健太, 中原マキ子, 上野盛夫, 羽室淳爾, 木下茂, 小泉範子
2013 - Cultivation of human corneal endothelial cells on a pericellular matrix prepared from human decidua-derived mesenchymal cells．The Association for Research in Vision and Ophthalmology 2012．Florida，USA，2012.5.10.
Numata R, Okumura N, Nakahara M, Ueno M, Kinoshita S, Kanemura Y, Sasai Y, Koizumi N
2012 - Rock inhibitor eye drops accelerate corneal endothelium wound healing in a primate model．The Association for Research in Vision and Ophthalmology 2012．Florida，USA，2012.5.10.
Okumura N, Koizumi N, Ueno M, Sakamoto Y, Takahashi H, Yamasaki K, Torii R, Hamuro J, Kinoshita S
2012 - Effect of the PPARγ agonist on the fibrotic change in primate retinal pigment epithelial cells．The Association for Research in Vision and Ophthalmology 2012．Florida，USA，2012.5.9.
Hatanaka H, Okumura N, Koizumi N, Mizuhara E, Hamuro J, Kinoshita S
2012 - Cell-injection therapy using cultivated human corneal endothelial cells in a primate model．The Association for Research in Vision and Ophthalmology 2012．Florida，USA，2012.5.7.
Koizumi N, Okumura N, Sakamoto Y, Yamasaki K, Nakahara M, Torii R, Ueno M, Hamuro J, Kinoshita S
2012 - New Therapeutic Modality of Using ROCK Inhibitor for Corneal Endothelial Disease，27th Asia-Pacific Academy of Ophthalmology Congress．2012.4.
Okumura N
2012 - Elevated keratan sulphate in the corneal stroma cultured at low oxygen tension，角膜カンファランス2012第36回日本角膜学会総会・第28回日本角膜移植学会，東京，2012.2.23．
Leona T.Y.Ho, Bruce Caterson, Keith M.Meek, Andrew, J.Quantock, Okumura N, Koizumi N
2012 - The New Therapeutic Modality of Using a Rho Kinase （ROCK） Inhibitor for the Treatment of Corneal Endothelial Dysfunction．TERMIS Singapore．2011.8.5.
Okumura N
Aug. 2011 - New strategy for corneal endothelial tissue engineering, Schepens Eye Research Institute 27th Biennial Cornea Conference.2011.
Koizumi N, Okumura N, Kinoshita S
2011 - ROCK Inhibition Regulates the Cell Adhesion of Corneal Endothelial Cells．Annual Meeting of the Association for Research in Vision and Ophthalmology，Fort Lauderdale，Florida，USA．2011.5.5.（ポスター）
Kumagai K, Koizumi N, Okumura N, Yamazaki K, Ueno M, Sakamoto Y, Yoshimura N, Hamuro J, Kinoshita S
2011 - Cell-Injection Therapy using Cultivated Corneal Endothelial Cells Combined with a ROCK Inhibitor in a Primate Model．Annual Meeting of the Association for Research in Vision and Ophthalmology，Fort Lauderdale，Florida，USA．2011.5.5.
Koizumi N, Okumura N, Yamasaki K, Ueno M, Sakamoto Y, Takahashi H, Torii R, Hamuro J, Kinoshita S
2011 - ROCK Inhibitor Regulates the G1-S Progression of Corneal Endothelial Cells．Annual Meeting of the Association for Research in Vision and Ophthalmology，Fort Lauderdale，Florida，USA．2011.5.5.
Okumura N, Koizumi N, Yamasaki K, Ueno M, Sakamoto Y, Sowa Y, Sakai T, Hamuro J, Kinoshita S
2011 - Effect of PPARγ agonist on the fibrotic change in retinal pigment epithelium and vitreous cells．Annual Meeting of the Association for Research in Vision and Ophthalmology，Fort Lauderdale，Florida，USA．2011.5.3.（ポスター）
Hatanaka H, Okumura N, Koizumi N, Hamuro J, Kinoshita S
2011 - A New Pharmaceutical Treatment for Corneal Endothelial DysfunctionAsia-ARVO 2011. Singapore. 2011.1.20.
Okumura N
2011 - ROCK inhibitor as a new therapeutic modality for corneal endothelial dysfunction．5th International Symposium of the UCSD-Doshisha Medical Imaging Research Center，San Diego，USA，2011.12.5.
Okumura N
2011 - A ROCK Inhibitor Eye Drop Enhances Corneal Endothelial Cell Proliferation.The 2nd Asia Cornea Society Biennial Scientific Meeting. Kyoto, Japan.2010.12.2.
Okumura N
2010 - The Efficacy of A ROCK Inhibitor Containing Corneal Storage Medium for Corneal Endothelial Cells．Annual Meeting of the Association for Research in Vision and Ophthalmology，Fort Lauderdale，Florida，USA．2010.5.4.
Takahashi H, Koizumi N, Okumura N, Ueno M, Sakamoto Y, Hamuro J, Kinoshita S
2010 - The Existence of Dead Cells in Corneal Endothelium Preserved with Storage Media．Annual Meeting of the Association for Research in Vision and Ophthalmology，Fort Lauderdale，Florida，USA．2010.5.4.
Tanioka H, Kawasaki S, Adachi H, Inatomi T, Hieda O, Fukuoka H, Okumura N, Koizumi N, Iliakis B, Kinoshita S
2010 - Cell-Injection Therapy Using Cultivated Corneal Endothelial Cells Combined With a ROCK Inhibitor in a Rabbit Model．Annual Meeting of the Association for Research in Vision and Ophthalmology，Fort Lauderdale，Florida，USA．2010.5.5.
Koizumi N, Okumura N, Takahashi H, Ueno M, Sakamoto Y, Hirata K, Hamuro J, Kinoshita S
2010 - Feasibility Evaluation of Non-Descemet Stripping Automated Endothelial Keratoplasty by Using an In Vivo Animal Model．Annual Meeting of the Association for Research in Vision and Ophthalmology，Fort Lauderdale，Florida，USA．2010.5.4.
Hatanaka H, Koizumi N, Okumura N, Takahashi H, Tanioka H, Kinoshita S
2010 - The Effect of a ROCK Inhibitor on Corneal Endothelial Cell Migration in an In Vitro Wound-Healing Model．Annual Meeting of the Association for Research in Vision and Ophthalmology，Fort Lauderdale，Florida，USA．2010.5.4.
Okumura N, Koizumi N, Ueno M, Sakamoto Y, Takahashi H, Hirata K, Hamuro J, Kinoshita S
2010 - Therapeutic Potential of a Rho Kinase （ROCK） Inhibitor for the Treatment of Corneal Endothelial Dysfunction．Gordon Reserch Conference Biology & Pathobiology Of The Cornea，Ventura，USA，2010.3.7.
Okumura N, Koizumi N, Ueno M, Sakamoto Y, Takahashi H, Hirata K, Hamuro J, Kinoshita S
2010 - The New Therapeutic Concept of Using a Rho Kinase (ROCK) Inhibitor for the Treatment of Corneal Endothelial DysfunctionKyoto Cornea Club 2010, Kyoto, Japan.2010.12.3.
Okumura N
2010 - Effect of a ROCK inhibitor on corneal endothelial wound healing in an animal model. 2nd KPUM & Friedrich Alexander nurmberg Erlangen Univ Collaborating Conference. Erlangen, Germany, 2009.
Okumura N, Koizumi N, Ueno M, Sakamoto Y, Takahashi H, Hirata K, Hamuro J, Kinoshita S
2009 - The Effect of Insulin and Ascorbic Acid on Rabbit Keratocyte Culture, The 9th Corneal Conference, Cardiff, UK, 2009. 7.14.
Yamamoto M, Okumura N, Hirata K, Takahashi H, Yuri Tsukahara, Toshie Isobe, Koizumi N
2009 - A ROCK inhibitor Enhances Corneal Endothelial Wound Healing in an Animal Model, The 9th Corneal Conference, Cardiff, UK, 2009. 7.15.
Okumura N, Koizumi N, Ueno M, Sakamoto Y, Takahashi H, Hirata K, Hamuro J, Kinoshita S
2009 - Cultivated monkey corneal endothelial cell transplantation using a corneal lamellar graft. ARVO, Florida, USA, 2009.5.6.
Koizumi N, Okumura N, Sakamoto Y, Takahashi H, Hirata K, Okahara N
2009 - A ROCK Inhibitor Enhances Corneal Endothelial Wound Healing in Both an In vitro and in vivo Model, ARVO, Florida, USA, 2009.5.6.
Okumura N, Koizumi N, Ueno M, Sakamoto Y, Takahashi H, Hirata K, Hamuro J, Kinoshita S
2009 - Increase in Fluoroquinolone Resistance Following Long-Term Topical Use，American Academy of Opthalmology，Atlanta，USA，2008.10.
Okumura N, Sotozono C, Hashida M, Kojima K, Urabe K, Kinoshita S
2008 - Corneal endothelial cell proliferation is enhanced by a single injection of connexin43 siRNA in a primate endothelial injury．ARVO．2008.
Koizumi N, Nakano Y, Sakamoto Y, Okumura N, Dai P, Tsuchiya H
2008 - A ROCK Inhibitor Enhances Primate Corneal Endothelial Cells Culture In Vitro，ARVO，Florida，USA，2008.5.
Okumura N, Ueno M, Koizumi N, Hitora H, Kinoshita S
2008 - Expression of Cell Cycle Molecules in Primate Corneal Endothelial Cells and Primate Cultivated Corneal Endothelial Cells，ARVO，Florida，USA，2007.5.
Okumura N, Koizumi N, Matsuda A, Sakamoto Y, Funayama R, Ishikawa F, Kinoshita S
2007 - A ROCK inhibitor enhances survival of primate corneal endothelial cells in vitro，2nd KPUM & Friedrich Alexander nurmberg Erlangen Univ Collaborating Conference．Kyoto，Japan，2007．
Okumura N, Koizumi N, Ueno M, Kinoshita S
2007 - Deep neural network system for the analysis of guttae by using transfer learning.
Narimoto K, Okumura N, Yamada S, Hiwa S, Hiroyasu T, Tourtas T, Friedrich E. Kruse, Koizumi N
The Association for Research in Vision and Ophthalmology (ARVO), Feb. 2021, English - Development of AI for analyzing severe corneal endothelial images in the Fuchs endothPelial corneal dystrophy mouse model using semi-supervised learning.
Nishikawa T, Okumura N, Yamada S, Hiroyasu T, Koizumi N
The Association for Research in Vision and Ophthalmology (ARVO), Feb. 2021, English - Potential Pathophysiology of Fuchs Endothelial Corneal Dystrophy.
Okumura, N
The 7th Asia Cornea Society Biennial Scientific Meeting., 07 Dec. 2020, English - Effect of CTG repeat expansion in TCF4 on the pathophysiology of Fuchs endothelial corneal dystrophy.
Matsuo H, Okumura N, Komori Y, Tokunaga A, Nakayama G, Nakahara M, Blake DJ, Tourtas T, Schlötzer-Schrehardt U, Kruse FE, Koizumi N
The Association for Research in Vision and Ophthalmology (ARVO), May 2020, English - Development of a deep neural network system for the analysis of specular microscopy images.
Yamada S, Okumura N, Okamoto M, Hishinuma K, Hiwa S, Hiroyasu, Koizumi N
The Association for Research in Vision and Ophthalmology (ARVO), May 2020, English