NOGUCHI Noriko
Faculty of Life and Medical Sciences Department of Medical Life Systems
Professor
Last Updated :2022/11/28

Researcher Profile and Settings

Research Interests

  • 遺伝情報発現・制御
  • 生物学
  • gene expression and regulation
  • Biochemistry

Research Areas

  • Life sciences / Molecular biology
  • Life sciences / Functional biochemistry

Research History

  • 1987-1990 The mechanisms of cytotoxicity of paraquat
  • 1990-1991 Damages of mitochondrial DNA induced by g-irradiation
  • 1991-2001 The mechanisms of free radical mediated damages and its protection by antioxidants
  • 2001- Regulation of gene expression by free radicals and antioxidants

Research Experience

  • The University of Tokyo, Research Center for Advanced Science and Technology, 2002 - 2005
  • - 同志社大学工学部 教授, 2005 -
  • The University of Tokyo, Research Center for Advanced Science and Technology, 1993 - 2002
  • The University of Tokyo, The Faculty of Engineering, 1991 - 1993
  • National Institute of Standards and Technology (U.S.A.) 客員研究員, 1990 - 1991
  • Teikyo University, School of Medicine, 1987 - 1990

Education

  • University of Tsukuba, 医学研究科, - 1987
  • University of Tsukuba, Graduate School, Division of Medicine, - 1987
  • University of Tsukuba, 医学研究科, - 1983
  • University of Tsukuba, Graduate School, Division of Medicine, - 1983
  • University of Tsukuba, 第二学群, 生物学類, - 1981
  • University of Tsukuba, Second Cluster of College, - 1981

Degree

  • Doctor of Medicine, University of Tsukuba
  • Master of Medical Science, University of Tsukuba

Association Memberships

  • 日本酸化ストレス学会
  • 日本生化学会
  • 日本油化学会
  • 日本ビタミン学会
  • 国際フリーラジカル学会
  • International Society for Free Radical Research

Committee Memberships

  • (公社)ビタミン・バイオファクター協会 参与, 2021/06 - Today
  • 代議員, 2017/04 - Today, 日本ビタミン学会
  • 理事, 2014 - , 日本酸化ストレス学会, Society, 日本酸化ストレス学会
  • アジア支部代表, - , 国際フリーラジカル学会, Society, 国際フリーラジカル学会
  • representative, - , International Society for Free Radical Research, Society, International Society for Free Radical Research

Awards

  • 日本フリーラジカル学会学会賞
    2007
  • 日本油化学会進歩賞
    1997, Japan
  • Young Investigation Award
    1994, International Society for Free Radical Research
  • Outstanding Paper Presentation
    1993, The American Oil Chemists' Society

Published Papers

  • Integrated stress response is involved in the 24(S)-hydroxycholesterol-induced unconventional cell death mechanism
    Yasuomi Urano; Shoya Osaki; Ren Chiba; Noriko Noguchi
    Cell Death Discovery, Oct. 2022
  • Redox-sensitive DJ-1 protein: An insight into physiological roles, secretion, and therapeutic target.
    Biplab K. Dash; Yasuomi Urano; Yoshiro Saito; Noriko Noguchi
    Redox Experimental Medicine, 1(1) 96 - 115, Aug. 2022
  • Role of selenoprotein P expression in the function of pancreatic b cells: Prevention of ferroptosis-like cell death and stress-induced nascent granule degradation.
    Nanako Kitabayashi; Shohei Nakao; Yuichiro Mita; Kotoko Arisawa; Takayuki Hoshi; Takashi Toyama; Kiyo-aki Ishii; Toshinari Takamura; Noriko Noguchi; Yoshiro Saito
    Free Radic Biol Med., Apr. 2022
  • Therapeutic effect of a novel curcumin derivative GT863 on a mouse model of amyotrophic lateral sclerosis
    Hajime Kato; Hiroyasu Sato; Michiaki Okuda; Jun Wu; Shingo Koyama; Yasuhiko Izumi; Tomonori Waku; Mitsuyoshi Iino; Masashi Aoki; Shigeki Arawaka; Yasuyuki Ohta; Kenichi Ishizawa; Kanan Kawasaki; Yasuomi Urano; Tomohiro Miyasaka; Noriko Noguchi; Toshiaki Kume; Akinori Akaike; Hachiro Sugimoto; Takeo Kato
    Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Informa UK Limited, 1 - 7, Dec. 2021, Scientific journal
  • Different functions of vitamin E homologues in the various types of cell death induced by oxysterols
    Atsuki Suzuki; Yasuomi Urano; Tomohisa Ishida; Noriko Noguchi
    Free Radical Biology and Medicine, 176 356 - 365, Oct. 2021
  • NRF3 upregulates gene expression in SREBP2-dependent mevalonate pathway with cholesterol uptake and lipogenesis inhibition
    Tsuyoshi Waku, Toru Hagiwara, Natsuko Tamura, Yuri Atsumi, Yasuomi Urano, Mikiko Suzuki, Takuya Iwami, Katsuya Sato, Masayuki Yamamoto, Noriko Noguchi, Akira Kobayashi
    iScience, Elsevier BV, 24 103180 - 103180, Sep. 2021, Scientific journal
  • Identification of a novel endogenous long non-coding RNA that inhibits selenoprotein P translation.
    Yuichiro Mita; Risa Uchida; Sayuri Yasuhara; Kohei Kishi; Takayuki Hoshi; Yoshitaka Matsuo; Tadashi Yokooji; Yoshino Shirakawa; Takashi Toyama; Yasuomi Urano; Toshifumi Inada; Noriko Noguchi; Yoshiro Saito
    Nucleic acids research, 49(12) 6893 - 6907, 09 Jul. 2021, Scientific journal
  • Curcumin Derivative GT863 Inhibits Amyloid-Beta Production via Inhibition of Protein N-Glycosylation.
    Yasuomi Urano; Mina Takahachi; Ryo Higashiura; Hitomi Fujiwara; Satoru Funamoto; So Imai; Eugene Futai; Michiaki Okuda; Hachiro Sugimoto; Noriko Noguchi
    Cells, 9(2), 03 Feb. 2020, Scientific journal
  • Antioxidant action of vitamin E in vivo as assessed from its reaction products with multiple biological oxidants.
    Etsuo Niki; Noriko Noguchi
    Free Radic Res, 1 - 33, 2020
  • Astrocytes release glutamate via cystine/glutamate antiporter upregulated in response to increased oxidative stress related to sporadic amyotrophic lateral sclerosis.
    Miku Kazama; Yoichiro Kato; Akiyoshi Kakita; Noriko Noguchi; Yasuomi Urano; Kenta Masui; Motoko Niida-Kawaguchi; Tomoko Yamamoto; Kazuhiko Watabe; Kazuo Kitagawa; Noriyuki Shibata
    Neuropathology, 40(6) 587 - 598, 2020, Scientific journal
  • Soluble iron accumulation induces microglial glutamate release in the spinal cord of sporadic amyotrophic lateral sclerosis.
    Motoko Niida-Kawaguchi; Akiyoshi Kakita; Noriko Noguchi; Miku Kazama; Kenta Masui; Yoichiro Kato; Tomoko Yamamoto; Tatsuo Sawada; Kazuo Kitagawa; Kazuhiko Watabe; Noriyuki Shibata
    Neuropathology : official journal of the Japanese Society of Neuropathology, 28 Dec. 2019
  • 角層DJ-1を用いた体内の酸化ストレス評価
    高橋 理子; 鈴木 民恵; 石渡 潮路; 村上 礼一; 秋田 美季; 宮川 泰子; 三上 正治; 八代 壇; 斎藤 芳郎; 野口 範子; 松熊 祥子
    加齢皮膚医学セミナー, 加齢皮膚医学研究会, 14(2) 70 - 70, Dec. 2019
  • Brain Targeting of Acyl-CoA:Cholesterol O-Acyltransferase-1 Inhibitor K-604 via the Intranasal Route Using a Hydroxycarboxylic Acid Solution.
    Kimiyuki Shibuya; Shigeru Morikawa; Masayoshi Miyamoto; Shin-Ichiro Ogawa; Yoshihiko Tsunenari; Yasuomi Urano; Noriko Noguchi
    ACS omega, 4(16) 16943 - 16955, 15 Oct. 2019
  • 角層DJ-1を用いた体内の酸化ストレス評価
    高橋 理子; 鈴木 民恵; 石渡 潮路; 村上 礼一; 秋田 美季; 宮川 泰子; 三上 正治; 八代 壇; 斎藤 芳郎; 野口 範子; 松熊 祥子
    加齢皮膚医学セミナー, 加齢皮膚医学研究会, 14(1) 49 - 57, Jun. 2019
  • 24(S)-Hydroxycholesterol induces ER dysfunction-mediated unconventionall cell death.
    Yasuomi Urano; Diep-Khanh Ho Vo; Hirofumi Araki; Noriko Noguchi
    Cell Death Discov, 5 113 , 2019
  • Polymerization of oxidized DJ-1 via noncovalent and covalent binding: Significance of disulfide bond formation.
    Mayuka Kobayashi; Kana Muramatsu; Takamitsu Haruyama; Haruka Uesugi; Ai Kikuchi; Hiroki Konno; Noriko Noguchi; Yoshiro Saito
    ACS Omega, 4 9603 - 9614, 2019
  • Comparison of Human Selenoprotein P Determinants in Serum between Our Original Methods and Commercially Available Kits
    Yoshiro Saito; Hirofumi Misu; Hiroaki Takayama; Shin-ichiro Takashima; Soichiro Usui; Masayuki Takamura; Shuichi Kaneko; Toshinari Takamura; Noriko Noguchi
    Biological and Pharmaceutical Bulletin, Pharmaceutical Society of Japan, 41(5) 828 - 832, 01 May 2018, Scientific journal
  • Serenoprotein P中和抗体を用いた糖尿病治療の開発
    三田 雄一郎; 中山 華穂; 稲荷 尚吾; 野口 範子; 斎藤 芳郎
    日本内分泌学会雑誌, (一社)日本内分泌学会, 94(1) 360 - 360, Apr. 2018
  • Diagnosis of Parkinson's disease and the level of oxidized DJ-1 protein.
    Yuko Yamagishi; Kazumasa Saigoh; Yoshiro Saito; Ikuko Ogawa; Yoshiyuki Mitsui; Yukihiro Hamada; Makoto Samukawa; Hidekazu Suzuki; Motoi Kuwahara; Makito Hirano; Noriko Noguchi; Susumu Kusunoki
    Neuroscience research, 128 58 - 62, Mar. 2018, Scientific journal
  • 6-Hydroxydopamine induces secretion of PARK7/DJ-1 via autophagy-based unconventional secretory pathway.
    Yasuomi Urano; Chinatsu Mori; Ayano Fuji; Keito Konno; Takayuki Yamamoto; Shohei Yashirogi; Mayu Ando; Yoshiro Saito; Noriko Noguchi
    Autophagy, 14 1943 - 1958, 2018
  • Tocopherol suppresses 24(S)-hydroxycholesterol-induced cell death via inhibition of CaMKII phosphorylation.
    Yuki Kimura; Minori Asa; Yasuomi Urano; Yoshiro Saito; Kiyotaka Nishikawa; Noriko Noguchi
    Biochimie, 153 203 - 209, 2018
  • Distribution of oxidized DJ-1 in Parkinson’s disease-related sites in the brain and in the peripheral tissues: effects of aging and a neurotoxin.
    Yuichiro Mita; Yuto Kataoka; Yoshiro Saito; Takuma Kashi; Kojiro Hayashi; Asa Iwasaki; Takanori Imanishi; Tomohiro Miyasaka; Noriko Noguchi
    Scientific Reports, 8 12056 , 2018
  • Hydrogen peroxide-reducing factor released by PC12D cells increases cell tolerance against oxidative stress.
    Asami Muraishi; Emi Haneta; Yoshiro Saito; Yutaka Hitomi; Mamoru Sano; Noriko Noguchi
    Biol.Pharm.Bull., Note,41(5) 777 - 785, 2018, Scientific journal
  • Pleckstrin homology domain of p210 BCR-ABL interacts with cardiolipin to regulate its mitochondrial translocation and subsequent mitophagy
    Kentaro Shimasaki; Miho Watanabe-Takahashi; Masato Umeda; Satoru Funamoto; Yoshiro Saito; Noriko Noguchi; Keigo Kumagai; Kentaro Hanada; Fujiko Tsukahara; Yoshiro Maru; Norihito Shibata; Mikihiko Naito; Kiyotaka Nishikawa
    Genes to Cells, Wiley, 23(1) 22 - 34, Jan. 2018, Scientific journal
  • 膵β細胞モデルMIN6はセレノプロテインP発現を介して抗酸化システムを維持する
    中尾 昌平; 三田 雄一郎; 斎藤 芳郎; 野口 範子
    生命科学系学会合同年次大会, 生命科学系学会合同年次大会運営事務局, 2017年度 [2P - 0374], Dec. 2017
  • 膵β細胞モデルMIN6における過剰Selenoprotein Pによるセレン運搬作用を介したERストレス誘導メカニズムの解析
    長村 尭浩; 稲荷 尚吾; 三田 雄一郎; 野口 範子; 斎藤 芳郎
    生命科学系学会合同年次大会, 生命科学系学会合同年次大会運営事務局, 2017年度 [2P - 1003], Dec. 2017
  • non-coding RNAによるSelenoprotein P翻訳抑制メカニズムの解析
    三田 雄一郎; 斎藤 芳郎; 内田 理沙; 安原 小百合; 横大路 将; 野口 範子
    生命科学系学会合同年次大会, 生命科学系学会合同年次大会運営事務局, 2017年度 [3P - 0671], Dec. 2017
  • 糖尿病関連タンパク質Selenoprotein Pの翻訳を抑制する内在性long non-coding RNAの発現変化
    内田 理沙; 三田 雄一郎; 横大路 将; 安原 小百合; 斎藤 芳郎; 野口 範子
    生命科学系学会合同年次大会, 生命科学系学会合同年次大会運営事務局, 2017年度 [3P - 0672], Dec. 2017
  • ヒト皮膚細胞モデルHaCaTにおけるDJ-1誘導因子の同定および酸化ストレス防御効果の評価
    安藤 万由; 斎藤 芳郎; 石渡 潮路; 松熊 祥子; 野口 範子
    生命科学系学会合同年次大会, 生命科学系学会合同年次大会運営事務局, 2017年度 [4AT18 - 0506)], Dec. 2017
  • Selenoprotein P-neutralizing antibodies improve insulin secretion and glucose sensitivity in type 2 diabetes mouse models
    Yuichiro Mita; Kaho Nakayama; Shogo Inari; Yukina Nishito; Yuya Yoshioka; Naoko Sakai; Kanade Sotani; Takahiro Nagamura; Yuki Kuzuhara; Kumi Inagaki; Miki Iwasaki; Hirofumi Misu; Masaya Ikegawa; Toshinari Takamura; Noriko Noguchi; Yoshiro Saito
    NATURE COMMUNICATIONS, NATURE PUBLISHING GROUP, 8 1658 , Nov. 2017, Scientific journal
  • Effect of vitamin E on 24(S)-hydroxycholesterol-induced necroptosis-like cell death and apoptosis
    Takaya Nakazawa; Yuta Miyanoki; Yasuomi Urano; Madoka Uehara; Yoshiro Saito; Noriko Noguchi
    JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, PERGAMON-ELSEVIER SCIENCE LTD, 169 69 - 76, May 2017, Scientific journal
  • Deficiency of the hepatokine selenoprotein P increases responsiveness to exercise in mice through upregulation of reactive oxygen species and AMP-activated protein kinase in muscle
    Hirofumi Misu; Hiroaki Takayama; Yoshiro Saito; Yuichiro Mita; Akihiro Kikuchi; Kiyo-aki Ishii; Keita Chikamoto; Takehiro Kanamori; Natsumi Tajima; Fei Lan; Yumie Takeshita; Masao Honda; Mutsumi Tanaka; Seiji Kato; Naoto Matsuyama; Yuya Yoshioka; Kaito Iwayama; Kumpei Tokuyama; Nobuhiko Akazawa; Seiji Maeda; Kazuhiro Takekoshi; Seiichi Matsugo; Noriko Noguchi; Shuichi Kaneko; Toshinari Takamura
    NATURE MEDICINE, NATURE PUBLISHING GROUP, 23(4) 508 - +, Apr. 2017, Scientific journal
  • Interleukin-27 Enhances the Potential of Reactive Oxygen Species Generation from Monocyte-derived Macrophages and Dendritic cells by Induction of p47(phox)
    Bharatwaj Sowrirajan; Yoshiro Saito; Deepak Poudyal; Qian Chen; Hongyan Sui; Suk See DeRavin; Hiromi Imamichi; Toyotaka Sato; Douglas B. Kuhns; Noriko Noguchi; Harry L. Malech; H. Clifford Lane; Tomozumi Imamichi
    SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, 7 43441 , Feb. 2017, Scientific journal
  • Decrease of Amyloid-beta Levels by Curcumin Derivative via Modulation of Amyloid-beta Protein Precursor Trafficking
    Rina Kotani; Yasuomi Urano; Hachiro Sugimoto; Noriko Noguchi
    JOURNAL OF ALZHEIMERS DISEASE, IOS PRESS, 56(2) 529 - 542, 2017, Scientific journal
  • Esterification of 24S-OHC induces formation of atypical lipid droplet-like structures, leading to neuronal cell death
    Wakako Takabe; Yasuomi Urano; Diep-Khanh Ho Vo; Kimiyuki Shibuya; Masaki Tanno; Hiroaki Kitagishi; Toyoshi Fujimoto; Noriko Noguchi
    JOURNAL OF LIPID RESEARCH, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 57(11) 2005 - 2014, Nov. 2016, Scientific journal
  • Oxidized Lipoprotein as a Major Vessel Cell Proliferator in Oxidized Human Serum
    Yoshiro Saito; Noriko Noguchi
    PLOS ONE, PUBLIC LIBRARY SCIENCE, 11(8), Aug. 2016, Scientific journal
  • Oxidation and interaction of DJ-1 with 20S proteasome in the erythrocytes of early stage Parkinson's disease patients
    Yoshiro Saito; Yoko Akazawa-Ogawa; Akihiro Matsumura; Kazumasa Saigoh; Sayoko Itoh; Kenta Sutou; Mayuka Kobayashi; Yuichiro Mita; Mototada Shichiri; Shin Hisahara; Yasuo Hara; Harutoshi Fujimura; Hiroyuki Takamatsu; Yoshihisa Hagihara; Yasukazu Yoshida; Takao Hamakubo; Susumu Kusunoki; Shun Shimohama; Noriko Noguchi
    SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, 6 30793 , Jul. 2016, Scientific journal
  • Synthesis of 24(S)-hydroxycholesterol esters responsible for the induction of neuronal cell death
    Kimiyuki Shibuya; Toshiaki Watanabe; Yasuomi Urano; Wakako Takabe; Noriko Noguchi; Hiroaki Kitagishi
    BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON-ELSEVIER SCIENCE LTD, 24(11) 2559 - 2566, Jun. 2016, Scientific journal
  • The protective role of DJ-1 in ultraviolet-induced damage of human skin: DJ-1 levels in the stratum corneum as an indicator of antioxidative defense
    Shioji Ishiwatari; Minako Takahashi; Chie Yasuda; Maho Nakagawa; Yoshiro Saito; Noriko Noguchi; Shoko Matsukuma
    ARCHIVES OF DERMATOLOGICAL RESEARCH, SPRINGER, 307(10) 925 - 935, Dec. 2015, Scientific journal
  • Enhancement of lipid peroxidation and its amelioration by vitamin E in a subject with mutations in the SBP2 gene
    Yoshiro Saito; Mototada Shichiri; Takashi Hamajima; Noriko Ishida; Yuichiro Mita; Shohei Nakao; Yoshihisa Hagihara; Yasukazu Yoshida; Kazuhiko Takahashi; Etsuo Niki; Noriko Noguchi
    JOURNAL OF LIPID RESEARCH, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 56(11) 2172 - 2182, Nov. 2015, Scientific journal
  • New aspects of 24(S)-hydroxycholesterol in modulating neuronal cell death
    Noriko Noguchi; Yasuomi Urano; Wakako Takabe; Yoshiro Saito
    FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, 87 366 - 372, Oct. 2015
  • Lysophosphatidylcholine promotes SREBP-2 activation via rapid cholesterol efflux and SREBP-2-independent cytokine release in human endothelial cells
    Mayuko Morita; Azusa Sekine; Yasuomi Urano; Taki Nishimura; Wakako Takabe; Hiroyuki Arai; Takao Hamakubo; Tatsuhiko Kodama; Noriko Noguchi
    JOURNAL OF BIOCHEMISTRY, OXFORD UNIV PRESS, 158(4) 331 - 338, Oct. 2015, Scientific journal
  • 24(S)-Hydroxycholesterol induces RIPK1-dependent but MLKL-independent cell death in the absence of caspase-8
    Diep-Khanh Ho Vo; Yasuomi Urano; Wakako Takabe; Yoshiro Saito; Noriko Noguchi
    STEROIDS, ELSEVIER SCIENCE INC, 99 230 - 237, Jul. 2015, Scientific journal
  • Functional interaction between cyclooxygenase-2 and p53 in response to an endogenous electrophile
    Takeshi Kumagai; Hiroko Usami; Nao Matsukawa; Fumie Nakashima; Miho Chikazawa; Takahiro Shibata; Noriko Noguchi; Koji Uchida
    REDOX BIOLOGY, ELSEVIER SCIENCE BV, 4 74 - 86, Apr. 2015, Scientific journal
  • Aβ induces oxidative stress in senescence-accelerated (SAMP8) mice.
    Takagane K; Nojima J; Mitsuhashi H; Suo S; Yanagihara D; Takaiwa F; Urano Y; Noguchi N; Ishiura S
    Bioscience, biotechnology, and biochemistry, 79(6) 912 - 918, 2015
  • A? induces oxidative stress in senescence-accelerated (SAMP8) mice.
    Kurara Takagane; Jun Nojima; Hiroaki Mitsuhashi; Satoshi Suo; Dai Yanagihara; Fumio Takaiwa; Yasuomi Urano; Noriko Noguchi; Shoichi Ishiura
    Biosci. Biotech. Biochem., 23 1 - 7, 2015
  • Immunostaining of Oxidized DJ-1 in Human and Mouse Brains
    Yoshiro Saito; Tomohiro Miyasaka; Hiroyuki Hatsuta; Kazuko Takahashi-Niki; Kojiro Hayashi; Yuichiro Mita; Osamu Kusano-Arai; Hiroko Iwanari; Hiroyoshi Ariga; Takao Hamakubo; Yasukazu Yoshida; Etsuo Niki; Shigeo Murayama; Yasuo Ihara; Noriko Noguchi
    JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, LIPPINCOTT WILLIAMS & WILKINS, 73(7) 714 - 728, Jul. 2014, Scientific journal
  • 7-Hydroxycholestrol as a possible biomarker of cellular lipid peroxidation: Difference between cellular and plasma lipid peroxidation
    Yoshiro Saito; Noriko Noguchi
    Biochemical and Biophysical Research Communications, 446 741 - 744, 11 Apr. 2014
  • Diverse functions of 24(S)-hydroxycholesterol in the brain
    Noriko Noguchi; Yoshiro Saito; Yasuomi Urano
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, 446(3) 692 - 696, Apr. 2014
  • パーキンソン病における酸化DJ-1測定のバイオマーカーとしての意義の検討
    小川郁子; 斎藤芳郎; 西郷和真; 細井幸恵; 三井良之; 野口範子; 楠 進
    Brain and Nerve, 66 471 - 477, 2014, Scientific journal
  • The significance of oxidized DJ-1 protein (oxDJ-1) as a biomarker for parkinson's disease
    Ikuko Ogawa; Yoshiro Saito; Kazumasa Saigoh; Yoshie Hosoi; Yoshiyuki Mitsui; Noriko Noguchi; Susumu Kusunoki
    Brain and Nerve, Igaku-Shoin Ltd, 66(4) 471 - 477, 2014, Scientific journal
  • Induction of apoptosis and necroptosis by 24(S)-hydroxycholesterol is dependent on activity of acyl-CoA: cholesterol acyltransferase 1
    K. Yamanaka; Y. Urano; W. Takabe; Y. Saito; N. Noguchi
    CELL DEATH & DISEASE, NATURE PUBLISHING GROUP, 5 e990 , Jan. 2014, Scientific journal
  • Adaptive responses induced by 24S-hydroxycholesterol through liver X receptor pathway reduce 7-ketocholesterol-caused neuronal cell death
    Akishi Okabe; Yasuomi Urano; Sayoko Itoh; Naoto Suda; Rina Kotani; Yuki Nishimura; Yoshiro Saito; Noriko Noguchi
    REDOX BIOLOGY, ELSEVIER SCIENCE BV, 2 28 - 35, 2014, Scientific journal
  • Suppression of amyloid-β production by 24S-hydroxycholesterol via inhibition of intracellular amyloid precursor protein trafficking
    Yasuomi Urano; Sachika Ochiai; Noriko Noguchi
    FASEB Journal, FASEB, 27(10) 4305 - 4315, 01 Oct. 2013, Scientific journal
  • Suppression of amyloid-beta production by 24S-hydroxycholesterol via inhibition of intracellular amyloid precursor protein trafficking
    Yasuomi Urano; Sachika Ochiai; Noriko Noguchi
    FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, 27(10) 4305 - 4315, Oct. 2013, Scientific journal
  • Deficiency of p62/Sequestosome 1 Causes Hyperphagia Due to Leptin Resistance in the Brain
    Harumi Harada; Eiji Warabi; Taizo Matsuki; Toru Yanagawa; Kosuke Okada; Junya Uwayama; Akira Ikeda; Kazuhiro Nakaso; Kyoko Kirii; Noriko Noguchi; Hiroki Bukawa; Richard C. M. Siow; Giovanni E. Mann; Junichi Shoda; Tetsuro Ishii; Takeshi Sakurai
    JOURNAL OF NEUROSCIENCE, SOC NEUROSCIENCE, 33(37) 14767 - 14777, Sep. 2013, Scientific journal
  • Oxidized DJ-1 Inhibits p53 by Sequestering p53 from Promoters in a DNA-Binding Affinity-Dependent Manner
    Izumi Kato; Hiroshi Maita; Kazuko Takahashi-Niki; Yoshiro Saito; Noriko Noguchi; Sanae M. M. Iguchi-Ariga; Hiroyoshi Ariga
    MOLECULAR AND CELLULAR BIOLOGY, AMER SOC MICROBIOLOGY, 33(2) 340 - 359, Jan. 2013, Scientific journal
  • Nrf2 in bone marrow-derived cells positively contributes to the advanced stage of atherosclerotic plaque formation
    Nobuhiko Harada; Koichi Ito; Tomonori Hosoya; Junsei Mimura; Atsushi Maruyama; Noriko Noguchi; Ken-ichi Yagami; Naoki Morito; Satoru Takahashi; Jon M. Maher; Masayuki Yamamoto; Ken Itoh
    FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, 53(12) 2256 - 2262, Dec. 2012, Scientific journal
  • Enhanced CD36 expression changes the role of Nrf2 activation from anti-atherogenic to pro-atherogenic in apoE-deficient mice
    Hirotaka Sawada; Yoshiro Saito; Noriko Noguchi
    ATHEROSCLEROSIS, ELSEVIER IRELAND LTD, 225(1) 83 - 90, Nov. 2012, Scientific journal
  • Cytoprotective effects of geraniin against peroxynitrite- and peroxyl radical-induced cell death via free radical scavenging activity
    Lai Teng Ling; Yoshiro Saito; Uma D. Palanisamy; Hwee Ming Cheng; Noriko Noguchi
    FOOD CHEMISTRY, ELSEVIER SCI LTD, 132(4) 1899 - 1907, Jun. 2012, Scientific journal
  • A novel fluorescent probe with high sensitivity and selective detection of lipid hydroperoxides in cells
    Kazunori Yamanaka; Yoshiro Saito; Junji Sakiyama; Yuya Ohuchi; Fumio Oseto; Noriko Noguchi
    RSC ADVANCES, ROYAL SOC CHEMISTRY, 2(20) 7894 - 7900, 2012, Scientific journal
  • 赤血球画分を用いた酸化DJ-1定量の検討
    松村 晃寛; 久原 真; 齊藤 正樹; 川又 純; 今井 富裕; 下濱 俊; 斎藤 芳郎; 野口 範子; 二木 鋭雄
    臨床神経学, (一社)日本神経学会, 51(12) 1266 - 1266, Dec. 2011
  • Oxidation of DJ-1 Induced by 6-Hydroxydopamine Decreasing Intracellular Glutathione
    Akiko Miyama; Yoshiro Saito; Kazunori Yamanaka; Kojiro Hayashi; Takao Hamakubo; Noriko Noguchi
    PLOS ONE, PUBLIC LIBRARY SCIENCE, 6(11) e27883 , Nov. 2011, Scientific journal
  • Analyses of marine-derived tocopherol in processed foods containing fish
    Naohiro Gotoh; Daisuke Mashimo; Tomiko Oka; Kaori Sekiguchi; Mikiko Tange; Hiroyuki Watanabe; Noriko Noguchi; Shun Wada
    FOOD CHEMISTRY, ELSEVIER SCI LTD, 129(2) 279 - 283, Nov. 2011, Scientific journal
  • Anti-Atherogenic Effect of Laminar Shear Stress via Nrf2 Activation
    Wakako Takabe; Eiji Warabi; Noriko Noguchi
    ANTIOXIDANTS & REDOX SIGNALING, MARY ANN LIEBERT, INC, 15(5) 1415 - 1426, Sep. 2011
  • Redox Going with Vascular Shear Stress
    Noriko Noguchi; Hanjoong Jo
    ANTIOXIDANTS & REDOX SIGNALING, MARY ANN LIEBERT INC, 15(5) 1367 - 1368, Sep. 2011
  • 24(S)-Hydroxycholesterol Induces Neuronal Cell Death through Necroptosis, a Form of Programmed Necrosis
    Kazunori Yamanaka; Yoshiro Saito; Tohru Yamamori; Yasuomi Urano; Noriko Noguchi
    JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 286(28) 24666 - 24673, Jul. 2011, Scientific journal
  • Actual ratios of triacylglycerol positional isomers consisting of saturated and highly unsaturated fatty acids in fishes and marine mammals
    Naohiro Gotoh; Yumiko Matsumoto; Toshiharu Nagai; Hoyo Mizobe; Ikuko Otake; Kenji Ichioka; Ikuma Kuroda; Hiroyuki Watanabe; Noriko Noguchi; Shun Wada
    FOOD CHEMISTRY, ELSEVIER SCI LTD, 127(2) 467 - 472, Jul. 2011, Scientific journal
  • alpha-Tocopheryl phosphate: Uptake, hydrolysis, and antioxidant action in cultured cells and mouse
    Keiko Nishio; Noriko Ishida; Yoshiro Saito; Yoko Ogawa-Akazawa; Mototada Shichiri; Yasukazu Yoshida; Yoshihisa Hagihara; Noriko Noguchi; John Chirico; Jeffrey Atkinson; Etsuo Niki
    FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, 50(12) 1794 - 1800, Jun. 2011, Scientific journal
  • Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction
    Akira Kobayashi; Takako Tsukide; Tomohiro Miyasaka; Tomoko Morita; Tatsuya Mizoroki; Yoshiro Saito; Yasuo Ihara; Akihiko Takashima; Noriko Noguchi; Akiyoshi Fukamizu; Yosuke Hirotsu; Makiko Ohtsuji; Fumiki Katsuoka; Masayuki Yamamoto
    GENES TO CELLS, WILEY-BLACKWELL, 16(6) 692 - 703, Jun. 2011, Scientific journal
  • Phosphorylation of p66shc mediates 6-hydroxydopamine cytotoxicity
    Tohru Yamamori; Ayano Mizobata; Yoshiro Saito; Yasuomi Urano; Osamu Inanami; Kaikobad Irani; Noriko Noguchi
    FREE RADICAL RESEARCH, INFORMA HEALTHCARE, 45(3) 342 - 350, Mar. 2011, Scientific journal
  • Cytoprotective effects of vitamin E homologues against glutamate-induced cell death in immature primary cortical neuron cultures: Tocopherols and tocotrienols exert similar effects by antioxidant function
    Yoshiro Saito; Keiko Nishio; Yoko Ogawa Akazawa; Kazunori Yamanaka; Akiko Miyama; Yasukazu Yoshida; Noriko Noguchi; Etsuo Niki
    FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, 49(10) 1542 - 1549, Nov. 2010, Scientific journal
  • Elevation of oxidized DJ-1 in the brain and erythrocytes of Parkinson disease model animals
    Yoko Ogawa Akazawa; Yoshiro Saito; Takao Hamakubo; Yoshinori Masuo; Yasukazu Yoshida; Keiko Nishio; Mototada Shichiri; Tomohiro Miyasaka; Hiroko Iwanari; Yasuhiro Mochizuki; Tatsuhiko Kodama; Noriko Noguchi; Etsuo Niki
    NEUROSCIENCE LETTERS, ELSEVIER IRELAND LTD, 483(3) 201 - 205, Oct. 2010, Scientific journal
  • Enhanced neointimal hyperplasia and carotid artery remodelling in sequestosome 1 deficient mice
    Rika Sugimoto; Eiji Warabi; Satoru Katayanagi; Satoshi Sakai; Junya Uwayama; Toru Yanagawa; Ayaka Watanabe; Harumi Harada; Kiyoshi Kitamura; Noriko Noguchi; Hiroshi Yoshida; Richard C. M. Siow; Giovanni E. Mann; Tetsuro Ishii
    JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, WILEY-BLACKWELL, 14(6B) 1546 - 1554, Jun. 2010, Scientific journal
  • Characterization of Non-endcapped Polymeric ODS Column for the Separation of Triacylglycerol Positional Isomers
    Naohiro Gotoh; Yumiko Matsumoto; Hiromi Yuji; Toshiharu Nagai; Hoyo Mizobe; Kenji Ichioka; Ikuma Kuroda; Noriko Noguchi; Shun Wada
    JOURNAL OF OLEO SCIENCE, JAPAN OIL CHEMISTS SOC, 59(2) 71 - 79, Feb. 2010, Scientific journal
  • An Orally Applicable Shiga Toxin Neutralizer Functions in the Intestine To Inhibit the Intracellular Transport of the Toxin
    Miho Watanabe-Takahashi; Toshio Sato; Taeko Dohi; Noriko Noguchi; Fumi Kano; Masayuki Murata; Takashi Hamabata; Yasuhiro Natori; Kiyotaka Nishikawa
    INFECTION AND IMMUNITY, AMER SOC MICROBIOLOGY, 78(1) 177 - 183, Jan. 2010, Scientific journal
  • Preparation and application of monoclonal antibodies against oxidized DJ-1. Significant elevation of oxidized DJ-1 in erythrocytes of early-stage Parkinson disease patients
    Yoshiro Saito; Takao Hamakubo; Yasukazu Yoshida; Yoko Ogawa; Yasuo Hara; Harutoshi Fujimura; Yasuharu Imai; Hiroko Iwanari; Yasuhiro Mochizuki; Mototada Shichiri; Keiko Nishio; Tomoya Kinumi; Noriko Noguchi; Tatsuhiko Kodama; Etsuo Niki
    NEUROSCIENCE LETTERS, ELSEVIER IRELAND LTD, 465(1) 1 - 5, Nov. 2009, Scientific journal
  • Dietary Marine-Derived Tocopherol has a Higher Biological Availability in Mice Relative to Alpha-Tocopherol
    Naohiro Gotoh; Hiroyuki Watanabe; Tomiko Oka; Daisuke Mashimo; Noriko Noguchi; Kazuhiko Hata; Shun Wada
    LIPIDS, SPRINGER HEIDELBERG, 44(2) 133 - 143, Feb. 2009, Scientific journal
  • Regulation of GCL activity and cellular glutathione through inhibition of ERK phosphorylation
    Zhi-Hua Chen; Yoshiro Saito; Yasukazu Yoshida; Noriko Noguchi; Etsuo Niki
    BIOFACTORS, IOS PRESS, 33(1) 1 - 11, 2008, Scientific journal
  • Chronic oxidative stress causes amplification and overexpression of ptprz1 protein tyrosine phosphatase to activate beta-catenin pathway
    Yu-Ting Liu; Donghao Shang; Shinya Akatsuka; Hiroki Ohara; Khokon Kumar Dutta; Katsura Mizushima; Yuji Naito; Toshikazu Yoshikawa; Masashi Izumiya; Kouichiro Abe; Hitoshi Nakagama; Noriko Noguchi; Shinya Toyokuni
    AMERICAN JOURNAL OF PATHOLOGY, AMER SOC INVESTIGATIVE PATHOLOGY, INC, 171(6) 1978 - 1988, Dec. 2007, Scientific journal
  • Protective effects of 15-deoxy-Delta(12,14)-prostaglandin J(2) against glutamate-induced cell death in primary cortical neuron cultures: induction of adaptive response and enhancement of cell tolerance primarily through up-regulation of cellular glutathione
    Yoshiro Saito; Keiko Nishio; Yumiko Numakawa; Yoko Ogawa; Yasukazu Yoshida; Noriko Noguchi; Etsuo Niki
    JOURNAL OF NEUROCHEMISTRY, BLACKWELL PUBLISHING, 102(5) 1625 - 1634, Sep. 2007, Scientific journal
  • Nrf2-dependent and -independent induction of ABC transporters ABCC1, ABCC2, and ABCG2 in HepG2 cells under oxidative stress
    Tatsuhiko Adachi; Hiroshi Nakagawa; Ivy Chung; Yuichiro Hagiya; Kazuyuki Hoshijima; Noriko Noguchi; Macus Tien Kuo; Toshihisa Ishikawa
    Journal of Experimental Therapeutics and Oncology, 6(4) 335 - 348, 2007, Scientific journal
  • Shear stress stabilizes NF-E2-related factor 2 and induces antioxidant genes in endothelial cells: Role of reactive oxygen/nitrogen species
    Eiji Warabi; Wakako Takabe; Takashi Minami; Kenji Inoue; Ken Itoh; Masayuki Yamamoto; Tetsuro Ishii; Tatsuhiko Kodama; Noriko Noguchi
    FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, 42(2) 260 - 269, Jan. 2007, Scientific journal
  • alpha-Tocopherol induces calnexin in renal tubular cells: Another protective mechanism against free radical-induced cellular damage
    Wen-Hua Lee; Shinya Akatsuka; Tomoyuki Shirase; Khokon Kumar Dutta; Li Jiang; Yu-Ting Liu; Janice Onuki; Yoshihiro Yamada; Katsuya Okawa; Youichiro Wada; Akira Watanabe; Takahide Kohro; Noriko Noguchi; Shinya Toyokuni
    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, ELSEVIER SCIENCE INC, 453(2) 168 - 178, Sep. 2006, Scientific journal
  • Turning point in apoptosis/necrosis induced by hydrogen peroxide
    Yoshiro Saito; Keiko Nishio; Yoko Ogawa; Junko Kimata; Tomoya Kinumi; Yasukazu Yoshida; Noriko Noguchi; Etsuo Niki
    FREE RADICAL RESEARCH, TAYLOR & FRANCIS LTD, 40(6) 619 - 630, Jun. 2006, Scientific journal
  • Activation of mitogen-activated protein kinases by lysophosphatidylcholine-induced mitochondrial reactive oxygen species generation in endothelial cells
    N Watanabe; JW Zmijewski; W Takabe; M Umezu-Goto; C Le Goffe; A Sekine; A Landar; A Watanabe; J Aoki; H Arai; T Kodama; MP Murphy; R Kalyanaraman; VM Darley-Usmar; N Noguchi
    AMERICAN JOURNAL OF PATHOLOGY, AMER SOC INVESTIGATIVE PATHOLOGY, INC, 168(5) 1737 - 1748, May 2006, Scientific journal
  • Induction of Adaptive Response and Enhancement of PC12 Cell Tolerance by 7-Hydroxycholesterol and 15-Deoxy-Delta(12,14)-Prostaglandin J(2) through Up-regulation of Cellular Glutathione via Different Mechanisms
    Zhi-Hua Chen; Yasukazu Yoshida; Yoshiro Saito; Azusa Sekine; Noriko Noguchi; Etsuo Niki
    JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 281(20) 14440 - 14445, May 2006, Scientific journal
  • Interface of Antioxidant Function and Gene Expression Function
    Noguchi Noriko
    VITAMINS, THE VITAMIN SOCIETY OF JAPAN, 80(10) 499 - 506, 2006
  • Quantification Method for Triglyceride Molecular Species in Fish Oil with High Performance Liquid Chromatography - Ultraviolet Detector - Evaporative Light Scattering Detector
    GOTOH Naohiro; AOKI Tomoko; NAKAYASU Kyoko; TOKAIRIN Shigeru; NOGUCHI Noriko; WADA Shun
    Journal of Oleo Science, Japan Oil Chemists' Society, 55(9) 457 - 463, 2006
  • Adaptive response induced by lipid peroxidation products in cell cultures
    ZH Chen; Y Yoshida; Y Saito; N Noguchi; E Niki
    FEBS LETTERS, ELSEVIER SCIENCE BV, 580(2) 479 - 483, Jan. 2006, Scientific journal
  • Chemical structure-dependent gene expression of proteasome subunits via regulation of the antioxidant response element
    W Takabe; N Matsukawa; T Kodama; K Tanaka; N Noguchi
    FREE RADICAL RESEARCH, TAYLOR & FRANCIS LTD, 40(1) 21 - 30, Jan. 2006, Scientific journal
  • 4-Hydroxynonenal induces adaptive response and enhances PC12 cell tolerance primarily through induction of thioredoxin reductase 1 via activation of Nrf2
    ZH Chen; Y Saito; Y Yoshida; A Sekine; N Noguchi; E Niki
    JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 280(51) 41921 - 41927, Dec. 2005, Scientific journal
  • Lipid peroxidation: Mechanisms, inhibition, and biological effects
    E Niki; Y Yoshida; Y Saito; N Noguchi
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, 338(1) 668 - 676, Dec. 2005
  • Tumor suppressive effects of tocotrienol in vivo and in vitro
    S Wada; Y Satomi; M Murakoshi; N Noguchi; T Yoshikawa; H Nishino
    CANCER LETTERS, ELSEVIER IRELAND LTD, 229(2) 181 - 191, Nov. 2005, Scientific journal
  • Inhibition of cholesterol biosynthesis by 25-hydroxycholesterol is independent of OSBP
    T Nishimura; T Inoue; N Shibata; A Sekine; W Takabe; N Noguchi; H Arai
    GENES TO CELLS, BLACKWELL PUBLISHING, 10(8) 793 - 801, Aug. 2005, Scientific journal
  • Differential responses of the Nrf2-Keap1 system to laminar and oscillatory shear stresses in endothelial cells
    T Hosoya; A Maruyama; MI Kang; Y Kawatani; T Shibata; K Uchida; K Itoh; M Yamamoto
    JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 280(29) 27244 - 27250, Jul. 2005, Scientific journal
  • A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis
    M Anai; N Shojima; H Katagiri; T Ogihara; H Sakoda; Y Onishi; H Ono; M Fujishiro; Y Fukushima; N Horike; A Viana; M Kikuchi; N Noguchi; S Takahashi; K Takata; Y Oka; Y Uchijima; H Kurihara; T Asano
    JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 280(18) 18525 - 18535, May 2005, Scientific journal
  • Tocotrienols reduce 25-hydroxycholesterol-induced monocyte-endothelial cell interaction by inhibiting the surface expression of adhesion molecules
    Y Naito; M Shimozawa; M Kuroda; N Nakabe; H Manabe; K Katada; S Kokura; H Ichikawa; N Yoshida; N Noguchi
    ATHEROSCLEROSIS, ELSEVIER IRELAND LTD, 180(1) 19 - 25, May 2005, Scientific journal
  • Association of active gamma-secretase complex with lipid rafts
    Y Urano; Hayashi, I; N Isoo; PC Reid; Y Shibasaki; N Noguchi; T Tomita; T Iwatsubo; T Hamakubo; T Kodama
    JOURNAL OF LIPID RESEARCH, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 46(5) 904 - 912, May 2005, Scientific journal
  • Expression of the LXR alpha protein in human atherosclerotic lesions
    Y Watanabe; SY Jiang; W Takabe; R Ohashi; T Tanaka; Y Uchiyama; K Katsumi; H Iwanari; N Noguchi; M Naito; T Hamakubo; T Kodama
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, LIPPINCOTT WILLIAMS & WILKINS, 25(3) 622 - 627, Mar. 2005, Scientific journal
  • Activation of map kinases by lysophosphatidylcholine-induced mitochondrial reactive oxygen species generation in endothelial cells
    N Watanabe; J Zmijewski; C Le Goffe; A Landar; W Takabe; M Murphy; R Kalyanaraman; N Noguchi; Darley-Usmar, V
    FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, 39 S80 - S80, 2005
  • 4-hydroxynonenal induces adaptive response and enhances PC12 cell tolerance primarily through induction of thioredoxin reductase 1 via activation of NRF2
    ZH Chen; Y Saito; Y Yoshida; A Sekine; N Noguchi; E Niki
    FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, 39 S69 - S69, 2005
  • Vascular endothelial growth factor-and thrombin-induced termination factor, down syndrome critical region-1, attenuates endothelial cell proliferation and angiogenesis
    T Minami; K Horiuchi; M Miura; MR Abid; W Takabe; N Noguchi; T Kohro; XJ Ge; H Aburatani; T Hamakubo; T Kodama; WC Aird
    JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 279(48) 50537 - 50554, Nov. 2004, Scientific journal
  • Inhibition of plasma lipid peroxidation by anti-atherogenic antioxidant BO-653, 2,3-dihydro-5-hydroxy-4,6-di-tert-butyl-2,2-dipentylbenzofuran
    N Itoh; Y Yoshida; M Hayakawa; N Noguchi; T Kodama; O Cynshi; E Niki
    BIOCHEMICAL PHARMACOLOGY, PERGAMON-ELSEVIER SCIENCE LTD, 68(5) 813 - 818, Sep. 2004, Scientific journal
  • Effect on endothelial cell gene expression of shear stress, oxygen concentration, and low-density lipoprotein as studied by a novel flow cell culture system
    E Warabi; Y Wada; H Kajiwara; M Kobayashi; N Koshiba; T Hisada; M Shibata; J Ando; M Tsuchiya; T Kodama; N Noguchi
    FREE RADICAL BIOLOGY AND MEDICINE, PERGAMON-ELSEVIER SCIENCE LTD, 37(5) 682 - 694, Sep. 2004, Scientific journal
  • Lysophosphatidylcholine enhances cytokine production of endothelial cells via induction of L-type amino acid transporter 1 and cell surface antigen 4F2
    W Takabe; Y Kanai; A Chairoungdua; N Shibata; S Toi; M Kobayashi; T Kodama; N Noguchi
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, LIPPINCOTT WILLIAMS & WILKINS, 24(9) 1640 - 1645, Sep. 2004, Scientific journal
  • Oxidative stress induces insulin resistance by activating the nuclear factor-kappa B pathway and disrupting normal subcellular distribution of phosphatidylinositol 3-kinase
    T Ogihara; T Asano; H Katagiri; H Sakoda; M Anai; N Shojima; H Ono; M Fujishiro; A Kushiyama; Y Fukushima; M Kikuchi; N Noguchi; H Aburatani; Y Gotoh; Komuro, I; T Fujita
    DIABETOLOGIA, SPRINGER-VERLAG, 47(5) 794 - 805, May 2004, Scientific journal
  • Quantification Method for Triglyceride Molecular Species in Fish Oil with High Performance Liquid Chromatography-Ultraviolet Detector
    Tomoko Aoki; Ikuko Otake; Naohiro Gotoh; Noriko Noguchi; Shun Wada
    Journal of Oleo Science, 53(6) 285 - 294, 2004, Scientific journal
  • Dynamics of antioxidant action of vitamin E
    E Niki; N Noguchi
    ACCOUNTS OF CHEMICAL RESEARCH, AMER CHEMICAL SOC, 37(1) 45 - 51, Jan. 2004
  • A novel method of following oxidation of low-density lipoprotein using a sensitive fluorescent probe, diphenyl-1-pyrenylphosphine
    Y Okimoto; E Warabi; Y Wada; E Niki; T Kodama; N Noguchi
    FREE RADICAL BIOLOGY AND MEDICINE, PERGAMON-ELSEVIER SCIENCE LTD, 35(6) 576 - 585, Sep. 2003, Scientific journal
  • Inhibition of THP-1 cell adhesion to endothelial cells by alpha-tocopherol and alpha-tocotrienol is dependent on intracellular concentration of the antioxidants
    N Noguchi; R Hanyu; A Nonaka; Y Okimoto; T Kodama
    FREE RADICAL BIOLOGY AND MEDICINE, PERGAMON-ELSEVIER SCIENCE LTD, 34(12) 1614 - 1620, Jun. 2003, Scientific journal
  • Comparative study on the action of tocopherols and tocotrienols as antioxidant: chemical and physical effects
    Y Yoshida; E Niki; N Noguchi
    CHEMISTRY AND PHYSICS OF LIPIDS, ELSEVIER SCI IRELAND LTD, 123(1) 63 - 75, Mar. 2003, Scientific journal
  • Angiotensin II-induced insulin resistance is associated with enhanced insulin signaling
    T Ogihara; T Asano; K Ando; Y Chiba; H Sakoda; M Anai; N Shojima; H Ono; Y Onishi; M Fujishiro; H Katagiri; Y Fukushima; M Kikuchi; N Noguchi; H Aburatani; Komuro, I; T Fujita
    HYPERTENSION, LIPPINCOTT WILLIAMS & WILKINS, 40(6) 872 - 879, Dec. 2002, Scientific journal
  • Novel insights into the molecular mechanisms of the antiatherosclerotic properties of antioxidants: The alternatives to radical scavenging
    N Noguchi
    FREE RADICAL BIOLOGY AND MEDICINE, PERGAMON-ELSEVIER SCIENCE LTD, 33(11) 1480 - 1489, Dec. 2002
  • Antioxidant action of 2,2,4,6-tetra-substituted 2,3-dihydro-5-hydroxybenzofuran against lipid peroxidation: Effects of substituents and side chain
    Y Yoshida; N Noguchi; A Watanabe; Y Iwaki; M Yanagisawa; T Kodama; O Cynshi; E Niki
    FREE RADICAL RESEARCH, TAYLOR & FRANCIS LTD, 36(11) 1171 - 1178, Nov. 2002, Scientific journal
  • Lipid accumulation in smooth muscle cells under LDL loading is independent of LDL receptor pathway and enhanced by hypoxic conditions
    Y Wada; A Sugiyama; T Yamamoto; M Naito; N Noguchi; S Yokoyama; M Tsujita; Y Kawabe; M Kobayashi; A Izumi; T Kohro; T Tanaka; H Taniguchi; H Koyama; K Hirano; S Yamashita; Y Matsuzawa; E Niki; T Hamakubo; T Kodama
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, LIPPINCOTT WILLIAMS & WILKINS, 22(10) 1712 - 1719, Oct. 2002, Scientific journal
  • Effects of antioxidants against atherosclerosis
    E Niki; N Noguchi
    MOLECULAR AND CELLULAR BIOCHEMISTRY, KLUWER ACADEMIC PUBL, 234(1) 19 - 25, May 2002, Scientific journal
  • 15-deoxy-Delta(12,14)-prostaglandin J(2): The endogenous electrophile that induces neuronal apoptosis
    M Kondo; T Shibata; T Kumagai; T Osawa; N Shibata; M Kobayashi; S Sasaki; M Iwata; N Noguchi; K Uchida
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, 99(11) 7367 - 7372, May 2002, Scientific journal
  • The specificity of lipoxygenase-catalyzed lipid peroxidation and the effects of radical-scavenging antioxidants
    N Noguchi; H Yamashita; J Hamahara; A Nakamura; H Kuhn; E Niki
    BIOLOGICAL CHEMISTRY, WALTER DE GRUYTER & CO, 383(3-4) 619 - 626, Mar. 2002, Scientific journal
  • Oxidized low density lipoprotein-induced LFA-1-dependent adhesion and transendothelial migration of monocytes via the protein kinase C pathway
    S Mine; T Tabata; Y Wada; T Fujisaki; T Iida; N Noguchi; E Niki; T Kodama; Y Tanaka
    ATHEROSCLEROSIS, ELSEVIER SCI IRELAND LTD, 160(2) 281 - 288, Feb. 2002, Scientific journal
  • Specificity and inhibition by antioxidant of lipid peroxidation by lipoxygenase: effects of substrate, lipoxygenase and milieu
    N Noguchi; H Yamashita; H Kuhn; E Niki
    OXYGEN AND LIFE: OXYGENASES, OXIDASE AND LIPID MEDIATORS, ELSEVIER SCIENCE BV, 1233 355 - 356, 2002, International conference proceedings
  • Ebselen, a glutathione peroxidase mimetic seleno-organic compound, as a multifunctional antioxidant - Implication for inflammation-associated carcinogenesis
    Y Nakamura; Q Feng; T Kumagai; K Torikai; H Ohigashi; T Osawa; N Noguchi; E Niki; K Uchida
    JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 277(4) 2687 - 2694, Jan. 2002, Scientific journal
  • Formation of active oxygen species and lipid peroxidation induced by hypochlorite
    N Noguchi; A Nakada; Y Itoh; A Watanabe; E Niki
    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, ACADEMIC PRESS INC ELSEVIER SCIENCE, 397(2) 440 - 447, Jan. 2002, Scientific journal
  • In vivo complex formation of oxidized alpha(1)-antitrypsin and LDL
    S Mashiba; Y Wada; M Takeya; A Sugiyama; T Hamakubo; A Nakamura; N Noguchi; E Niki; A Izumi; M Kobayashi; K Uchida; T Kodama
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, LIPPINCOTT WILLIAMS & WILKINS, 21(11) 1801 - 1808, Nov. 2001, Scientific journal
  • Anti-atherogenic antioxidants regulate the expression and function of proteasome alpha-type subunits in human endothelial cells
    W Takabe; T Kodama; T Hamakubo; K Tanaka; T Suzuki; H Aburatani; N Matsukawa; N Noguchi
    JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 276(44) 40497 - 40501, Nov. 2001, Scientific journal
  • Oxidative stress promotes the development of transformation: involvement of a potent mutagenic lipid peroxidation product, acrolein
    W Takabe; E Niki; K Uchida; S Yamada; K Satoh; N Noguchi
    CARCINOGENESIS, OXFORD UNIV PRESS, 22(6) 935 - 941, Jun. 2001, Scientific journal
  • New Functions of 20-Hydroxyecdysone in Lipid Peroxidation
    Alexander I. Kuzmenko; Etsuo Niki; Noriko Noguchi
    Journal of Oleo Science, 50(6) 497 - 506, 2001, Scientific journal
  • Role of myeloperoxidase in the neutrophil-induced oxidation of low density lipoprotein as studied by myeloperoxidase-knockout mouse
    N Noguchi; K Nakano; Y Aratani; H Koyama; T Kodama; E Niki
    JOURNAL OF BIOCHEMISTRY, JAPANESE BIOCHEMICAL SOC, 127(6) 971 - 976, Jun. 2000, Scientific journal
  • A novel fluorescent probe diphenyl-1-pyrenylphosphine to follow lipid peroxidation in cell membranes
    Y Okimoto; A Watanabe; E Niki; T Yamashita; N Noguchi
    FEBS LETTERS, ELSEVIER SCIENCE BV, 474(2-3) 137 - 140, Jun. 2000, Scientific journal
  • Stability and reactivity of aryloxyl radicals derived from a novel antioxidant BO-653 and related compounds. Effects of substituent and side chain in solution and membranes
    A Watanabe; N Noguchi; A Fujisawa; T Kodama; K Tamura; O Cynshi; E Niki
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMER CHEMICAL SOC, 122(23) 5438 - 5442, Jun. 2000, Scientific journal
  • Phenolic antioxidants: A rationale for design and evaluation of novel antioxidant drug for atherosclerosis
    Noriko Noguchi; Etsuo Niki
    Free Radical Biology and Medicine, 28(10) 1538 - 1546, 15 May 2000, International conference proceedings
  • Antioxidant action, of the antihypertensive drug, carvedilol, against lipid peroxidation
    N Noguchi; K Nishino; E Niki
    BIOCHEMICAL PHARMACOLOGY, PERGAMON-ELSEVIER SCIENCE LTD, 59(9) 1069 - 1076, May 2000, Scientific journal
  • Inhibition of c-jun expression induces antioxidant enzymes under serum deprivation
    YH Kim; M Takahashi; N Noguchi; E Suzuki; K Suzuki; N Taniguchi; E Niki
    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, ACADEMIC PRESS INC, 374(2) 339 - 346, Feb. 2000, Scientific journal
  • Diverse functions of antioxidants
    N. Noguchi; A. Watanabe; H. Shi
    Free Radical Research, 33(6) 809 - 817, 2000
  • Gene expression induced by BO-653, probucol and BHQ in human endothelial cells.
    W. Takabe; C. Mataki; Y. Wada; M. Ishii; A Izumi; H. Aburatani; T. Hamakubo; E. Niki; T. Kodama; N. Noguchi
    J. Atheroscler. Thromb., 7 223 - 230, 2000
  • 1-Methyl-4-phenyl-2,3-dihydropyridinium is transformed by ubiquinone to the selective nigrostriatal toxin 1-methyl-4-phenylpyridinium
    HL Shi; N Noguchi; YX Xu; E Niki
    FEBS LETTERS, ELSEVIER SCIENCE BV, 461(3) 196 - 200, Nov. 1999, Scientific journal
  • An in vitro coculture model of transmigrant monocytes and foam cell formation
    M Takaku; Y Wada; K Jinnouchi; M Takeya; K Takahashi; H Usuda; M Naito; H Kurihara; Y Yazaki; Y Kumazawa; Y Okimoto; M Umetani; N Noguchi; E Niki; T Hamakubo; T Kodama
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, LIPPINCOTT WILLIAMS & WILKINS, 19(10) 2330 - 2339, Oct. 1999, Scientific journal
  • Comparative study on dynamics of antioxidative action of alpha-tocopheryl hydroquinone, ubiquinol, and alpha-tocopherol, against lipid peroxidation
    HL Shi; N Noguchi; E Niki
    FREE RADICAL BIOLOGY AND MEDICINE, PERGAMON-ELSEVIER SCIENCE LTD, 27(3-4) 334 - 346, Aug. 1999, Scientific journal
  • Rate constants for hydrogen atom abstraction by alpha-tocopheroxyl radical from lipid, hydroperoxide and ascorbic acid
    A Watanabe; N Noguchi; M Takahashi; E Niki
    CHEMISTRY LETTERS, CHEMICAL SOC JAPAN, (7) 613 - 614, Jul. 1999, Scientific journal
  • Vitamin E protects against polymorphonuclear leukocyte-dependent adhesion to endothelial cells
    N Yoshida; T Yoshikawa; H Manabe; Y Terasawa; M Kondo; N Noguchi; E Niki
    JOURNAL OF LEUKOCYTE BIOLOGY, FEDERATION AMER SOC EXP BIOL, 65(6) 757 - 763, Jun. 1999, Scientific journal
  • Action of quinolinic and indolinonic aminoxyls as radical-scavenging antioxidants
    N Noguchi; E Damiani; L Greci; E Niki
    CHEMISTRY AND PHYSICS OF LIPIDS, ELSEVIER IRELAND LTD, 99(1) 11 - 19, May 1999, Scientific journal
  • Formation of phospholipid hydroperoxides and its inhibition by alpha-tocopherol in rat brain synaptosomes induced by peroxynitrite
    HL Shi; N Noguchi; YX Xu; E Niki
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, 257(3) 651 - 656, Apr. 1999, Scientific journal
  • Oxidation of low density lipoprotein and plasma by 15-lipoxygenase and free radicals
    H Yamashita; A Nakamura; N Noguchi; E Niki; H Kuhn
    FEBS LETTERS, ELSEVIER SCIENCE BV, 445(2-3) 287 - 290, Feb. 1999, Scientific journal
  • Action of Pyrroloquinolinequinol As an Antioxidant Against Lipid Peroxidation in Solution
    Kazuhiro Miyauchi; Teiji Urakami; Hiroyuki Abeta; Honglian Shi; Noriko Noguchi; Etsuo Niki
    Antioxidants and Redox Signaling, Mary Ann Liebert Inc., 1(4) 547 - 554, 1999, Scientific journal
  • Dynamics of action of bisphenol as radical-scavenging antioxidant against lipid peroxidation in solution and liposomal membranes
    K Nishino; N Noguchi; E Niki
    FREE RADICAL RESEARCH, HARWOOD ACAD PUBL GMBH, 31(6) 535 - 548, 1999, Scientific journal
  • Dynamics of antioxidant action of ubiquinol: a reappraisal
    HL Shi; N Noguchi; E Niki
    BIOFACTORS, IOS PRESS, 9(2-4) 141 - 148, 1999, Scientific journal
  • Antiatherogenic effects of the antioxidant BO-653 in three different animal models
    O Cynshi; Y Kawabe; T Suzuki; Y Takashima; H Kaise; M Nakamura; Y Ohba; Y Kato; K Tamura; A Hayasaka; A Higashida; H Sakaguchi; M Takeya; K Takahashi; K Inoue; N Noguchi; E Niki; T Kodama
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, 95(17) 10123 - 10128, Aug. 1998, Scientific journal
  • Acrolein is a product of lipid peroxidation reaction - Formation of free acrolein and its conjugate with lysine residues in oxidized low density lipoproteins
    K Uchida; M Kanematsu; Y Morimitsu; T Osawa; N Noguchi; E Niki
    JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 273(26) 16058 - 16066, Jun. 1998, Scientific journal
  • Protein-bound acrolein: Potential markers for oxidative stress
    K Uchida; M Kanematsu; K Sakai; T Matsuda; N Hattori; Y Mizuno; D Suzuki; T Miyata; N Noguchi; E Niki; T Osawa
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, 95(9) 4882 - 4887, Apr. 1998, Scientific journal
  • Action of 21-aminosteroid U74006F as an antioxidant against lipid peroxidation
    N Noguchi; M Takahashi; J Tsuchiya; H Yamashita; E Komuro; E Niki
    BIOCHEMICAL PHARMACOLOGY, PERGAMON-ELSEVIER SCIENCE LTD, 55(6) 785 - 791, Mar. 1998, Scientific journal
  • Inhibition of oxidative modifications of low density lipoprotein by antioxidants
    N Noguchi; E Niki
    PATHOPHYSIOLOGY OF LIPID PEROXIDES AND RELATED FREE RADICALS, KARGER, 91 - 101, 1998, International conference proceedings
  • Action of vitamin E as antioxidant against oxidative modification of low density lipoprotein
    Noriko Noguchi; Naohiro Gotoh; Etsuo Niki
    BIOFACTORS, WILEY, 7(1-2) 41 - 50, 1998, Scientific journal
  • Inhibition of oxidative modification of low density lipoprotein by novel antioxidant BO-653 prepared by theoretical design
    N Noguchi; Y Okimoto; O Cynshi; T Kodama; E Niki
    BIOLOGICAL OXIDANTS AND ANTIOXIDANTS: MOLECULAR MECHANISMS AND HEALTH EFFECTS, AMER OIL CHEMISTS SOC, 139 - 152, 1998, International conference proceedings
  • Oxidation of lipids in low density lipoprotein particles
    N Noguchi; R Numano; H Kaneda; E Niki
    FREE RADICAL RESEARCH, HARWOOD ACAD PUBL GMBH, 29(1) 43 - 52, 1998, Scientific journal
  • Dynamics of vitamin E action against LDL oxidation
    N Noguchi; E Niki
    FREE RADICAL RESEARCH, HARWOOD ACAD PUBL GMBH, 28(6) 561 - 572, 1998, Scientific journal
  • 2,2'-azobis (4-methoxy-2,4-dimethylvaleronitrile), a new lipid-soluble azo initiator: Application to oxidations of lipids and low-density lipoprotein in solution and in aqueous dispersions
    N Noguchi; H Yamashita; N Gotoh; Y Yamamoto; R Numano; E Niki
    FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, 24(2) 259 - 268, Jan. 1998, Scientific journal
  • Inhibition of oxidation of low-density lipoprotein by a novel antioxidant, BO-653, prepared by theoretical design
    N Noguchi; Y Okimoto; J Tsuchiya; O Cynshi; T Kodama; E Niki
    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, ELSEVIER SCIENCE INC, 347(1) 141 - 147, Nov. 1997, Scientific journal
  • Design, Synthesis and Evaluation of Novel Radical-Scavenging Antioxidant against Lipid Peroxidation
    NOGUCHI Noriko
    Journal of Oleo Science, Japan Oil Chemists' Society, 46(10) 1167 - 1175, 20 Oct. 1997
  • 2,3-dihydro-5-hydroxy-2,2-dipentyl-4,6-di-tert-butylbenzofuran: Design and evaluation as a novel radical-scavenging antioxidant against lipid peroxidation
    N Noguchi; Y Iwaki; M Takahashi; E Komuro; Y Kato; K Tamura; O Cynshi; T Kodama; E Niki
    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS, 342(2) 236 - 243, Jun. 1997, Scientific journal
  • Dynamics of oxidation of LDL and its inhibition by antioxidants
    E Niki; N Noguchi
    BIOFACTORS, WILEY, 6(2) 201 - 208, 1997, Scientific journal
  • イチョウ葉エキスの抗酸化作用.
    野口範子; 西野公大; 鷲尾英一; 石 紅朕; 陳 京生; 二木鋭雄
    J. Jpn. Oil Chem. Soc., 12 1481 - 1488, 1997
  • Inhibition of oxidation of low density lipoprotein by troglitazone
    N Noguchi; H Sakai; Y Kato; J Tsuchiya; Y Yamamoto; E Niki; H Horikoshi; T Kodama
    ATHEROSCLEROSIS, ELSEVIER SCI IRELAND LTD, 123(1-2) 227 - 234, Jun. 1996, Scientific journal
  • Inhibition of oxidation of low density lipoprotein by vitamin E and related compounds
    N Gotoh; N Noguchi; J Tsuchiya; K Morita; H Sakai; H Shimasaki; E Niki
    FREE RADICAL RESEARCH, TAYLOR & FRANCIS LTD, 24(2) 123 - 134, 1996, Scientific journal
  • INTERACTION AMONG VITAMIN-C, VITAMIN-E, AND BETA-CAROTENE
    E NIKI; N NOGUCHI; H TSUCHIHASHI; N GOTOH
    AMERICAN JOURNAL OF CLINICAL NUTRITION, AMER SOC NUTRITION-ASN, 62(6) 1322 - 1326, Dec. 1995, Scientific journal
  • ACTION OF NITRIC-OXIDE AS AN ANTIOXIDANT AGAINST OXIDATION OF SOYBEAN PHOSPHATIDYLCHOLINE LIPOSOMAL MEMBRANES
    K HAYASHI; N NOGUCHI; E NIKI
    FEBS LETTERS, ELSEVIER SCIENCE BV, 370(1-2) 37 - 40, Aug. 1995, Scientific journal
  • HEPATIC DAMAGE-INDUCED BY PERFUSION OF RADICAL GENERATING AZO COMPOUND AND ITS INHIBITION BY VITAMIN-E
    H YASUDA; N NOGUCHI; M MIKI; W MORINOBU; K HIRANO; T OGIHARA; T TANABE; M MINO; K TERAO; E NIKI
    CHEMICO-BIOLOGICAL INTERACTIONS, ELSEVIER SCI PUBL IRELAND LTD, 97(1) 11 - 23, Jun. 1995, Scientific journal
  • DYNAMICS OF FREE-RADICAL FORMATION FROM THE REACTION OF PEROXIDES WITH HAEMPROTEINS AS STUDIED BY STOPPED-FLOW CHEMILUMINESCENCE
    N NOGUCHI; E NIKI
    FREE RADICAL RESEARCH, HARWOOD ACAD PUBL GMBH, 23(4) 329 - 338, 1995, Scientific journal
  • EFFECTS OF EBSELEN AND PROBUCOL ON OXIDATIVE MODIFICATIONS OF LIPID AND PROTEIN OF LOW-DENSITY-LIPOPROTEIN INDUCED BY FREE-RADICALS
    N NOGUCHI; N GOTOH; E NIKI
    BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM, ELSEVIER SCIENCE BV, 1213(2) 176 - 182, Jul. 1994, Scientific journal
  • 2,2'-AZOBIS(4-METHOXY-2,4-DIMETHYLVALERONITRILE), A NEW LIPID-SOLUBLE AZO RADICAL INITIATOR
    N GOTOH; T YOSHINO; N NOGUCHI; E NIKI
    FRONTIERS OF REACTIVE OXYGEN SPECIES IN BIOLOGY AND MEDICINE, ELSEVIER SCIENCE PUBL B V, 1058 59 - 62, 1994, International conference proceedings
  • ANTIOXIDANT EFFECTS OF PROBUCOL AND EBSELEN AGAINST OXIDATIVE MODIFICATION OF LDL INDUCED BY FREE-RADICALS GENERATED AT DIFFERENT SITES
    N NOGUCHI; N GOTOH; T YOSHINO; E NIKI
    FRONTIERS OF REACTIVE OXYGEN SPECIES IN BIOLOGY AND MEDICINE, ELSEVIER SCIENCE PUBL B V, 1058 191 - 194, 1994, International conference proceedings
  • Action of curcumin as an antioxidant against lipid peroxidation.
    N. Noguchi; E. Komuro; E. Niki; R. L. Willson
    J. Jpn. Oil Chem. Soc., Japan Oil Chemists' Society, 43(12) 1045 - 1051, 1994
  • DYNAMICS OF THE OXIDATION OF LOW-DENSITY-LIPOPROTEIN INDUCED BY FREE-RADICALS
    N NOGUCHI; N GOTOH; E NIKI
    BIOCHIMICA ET BIOPHYSICA ACTA, ELSEVIER SCIENCE BV, 1168(3) 348 - 357, Jul. 1993, Scientific journal
  • DYNAMICS OF LIPID-PEROXIDATION AND ITS INHIBITION BY ANTIOXIDANTS
    E NIKI; N NOGUCHI; N GOTOH
    BIOCHEMICAL SOCIETY TRANSACTIONS, PORTLAND PRESS LTD, 21(2) 313 - 317, May 1993, Scientific journal
  • EFFECTS OF PARAQUAT ON MG2+-ATPASE ACTIVITY IN RAT-LIVER
    N NOGUCHI; HA YAMAMOTO; S MISAWA
    ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, SPRINGER VERLAG, 24(4) 483 - 486, May 1993, Scientific journal
  • INHIBITION OF OXIDATIVE MODIFICATION OF LOW-DENSITY-LIPOPROTEIN BY ANTIOXIDANTS
    E NIKI; N NOGUCHI; N GOTOH
    JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY, CENTER ACADEMIC PUBL JAPAN, 39 S1 - S8, 1993, Scientific journal
  • ANTIOXIDANT ACTIVITIES OF PROBUCOL AGAINST LIPID PEROXIDATIONS
    N GOTOH; K SHIMIZU; E KOMURO; J TSUCHIYA; N NOGUCHI; E NIKI
    BIOCHIMICA ET BIOPHYSICA ACTA, ELSEVIER SCIENCE BV, 1128(2-3) 147 - 154, Oct. 1992, Scientific journal
  • ACTION OF EBSELEN AS AN ANTIOXIDANT AGAINST LIPID-PEROXIDATION
    N NOGUCHI; Y YOSHIDA; H KANEDA; Y YAMAMOTO; E NIKI
    BIOCHEMICAL PHARMACOLOGY, PERGAMON-ELSEVIER SCIENCE LTD, 44(1) 39 - 44, Jul. 1992, Scientific journal
  • THE OXIDATIVE MODIFICATION OF LOW-DENSITY-LIPOPROTEIN INDUCED BY COPPER OR WATER-SOLUBLE RADICAL INITIATOR
    N NOGUCHI; N GOTOH; E KOMURO; Y YAMAMOTO; E NIKI; H SHIMASAKI
    OXYGEN RADICALS, ELSEVIER SCIENCE PUBL B V, 998 377 - 380, 1992, International conference proceedings
  • Initial accumulation of paraquat in the heart leading to acute death
    N. Noguchi; E. Tanaka; H. Yamamoto; S. Misawa
    Japanese Journal of Legal Medicine, 44(1) 6 - 11, 1990, Scientific journal
  • LARGE MYELINATED CLUB ENDINGS ON THE MAUTHNER CELL IN THE GOLDFISH - A STUDY WITH THIN SECTIONING AND FREEZE-FRACTURING
    K KOHNO; N NOGUCHI
    ANATOMY AND EMBRYOLOGY, SPRINGER VERLAG, 173(3) 361 - 370, 1986, Scientific journal
  • CARDIORESPIRATORY EFFECTS OF PARAQUAT WITH AND WITHOUT EMETICS ON WISTER RATS
    N NOGUCHI; S MISAWA; S TSUCHIYA; H YAMAMOTO; H NAITO
    VETERINARY AND HUMAN TOXICOLOGY, COMPARATIVE TOXICOLOGY LAB, 27(6) 508 - 510, 1985, Scientific journal

MISC

  • 酸化障害と抗酸化防御機構
    野口 範子
    日本内分泌学会雑誌, 96 1 - 4, Jul. 2020
  • コレステロールメタボライト研究の新展開: 構造的・機能的多様性に迫る オキシステロール誘導性の新規細胞死機構
    浦野 泰臣; 野口 範子
    日本生化学会大会プログラム・講演要旨集, (公社)日本生化学会, 92回 [1S11a - 04], Sep. 2019
  • ビタミンE疎水部構造の違いと膜相分離
    中谷 祐将; 下川 直史; 浦野 泰臣; 野口 範子; 高木 昌宏
    日本生物工学会大会講演要旨集, (公社)日本生物工学会, 2019年 224 - 224, Aug. 2019
  • ステロールおよび脂質の代謝・代謝物と疾病に関する研究の最先端 コレステロール酸化物による神経細胞死とビタミンEの役割
    野口 範子; 浦野 泰臣
    日本栄養・食糧学会大会講演要旨集, (公社)日本栄養・食糧学会, 73回 176 - 176, Apr. 2019
  • 【レドックス疾患学 酸素・窒素・硫黄活性種はどう作用するのか、どこまで健康・疾患と関わるのか?】 (第2章)レドックスと疾患 セレノプロテインPによるレドックス制御と2型糖尿病
    斎藤 芳郎; 野口 範子; 御簾 博文; 篁 俊成
    実験医学, (株)羊土社, 36(5) 753 - 759, Mar. 2018
  • Decrease of Insulin Secretion is Induced by Excess Selenoprotein P-Improving Effects of Neutralizing Antibody
    Yoshiro Saito; Yuichiro Mita; Kaho Nakayama; Shogo Inari; Takahiro Nagamura; Noriko Noguchi
    FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, 112 156 - 156, Nov. 2017, Summary international conference
  • Interleukin-27 Induces p47(phox) in Monocyte-derived Macrophages and Dendritic cells and Enhances the Potential of Reactive Oxygen Species Generation
    Yoshiro Saito; Bharatwaj Sowrirajan; Deepak Poudyal; Noriko Noguchi; Harry L. Malech; H. Clifford Lane; Tomozumi Imamichi
    FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, 112 210 - 210, Nov. 2017, Summary international conference
  • P210型BCR‐ABL PHドメインのリガンド特性およびその病理的意義の解明
    島崎健太朗; 高橋美帆; 梅田真郷; 舟本聡; 斎藤芳郎; 野口範子; 熊谷圭吾; 花田賢太郎; 塚原富士子; 丸義朗; 柴田識人; 内藤幹彦; 内藤幹彦; 西川喜代孝
    日本生化学会大会(Web), 生命科学系学会合同年次大会運営事務局, 90th ROMBUNNO.1PT26‐07(2P‐0039) (WEB ONLY) - 0039)], 2017
  • セレノプロテインPの阻害抗体による糖尿病治療効果の解析 インスリン抵抗性および分泌能を改善する抗体医薬の開発
    三田 雄一郎; 中山 華穂; 稲荷 尚吾; 西藤 有希奈; 吉岡 佑弥; 曽谷 奏; 高部 稚子; 御簾 博文; 篁 俊成; 高橋 和彦; 野口 範子; 斎藤 芳郎
    糖尿病, (一社)日本糖尿病学会, 59(Suppl.1) S - 444, Apr. 2016
  • 4.神経細胞死メカニズムの違いとビタミンEの作用特異性について(研究発表,第348回会議研究発表要旨,脂溶性ビタミン総合研究委員会)
    野口 範子; 新井 洋由
    ビタミン, 日本ビタミン学会, 90(2) 85 - 86, 25 Feb. 2016
  • Selenoprotein Pの中和抗体による耐糖能異常及びインスリン分泌能の改善
    三田雄一郎; 三田雄一郎; 中山華穂; 稲荷尚吾; 吉岡佑弥; 高部稚子; 御簾博文; 篁俊成; 野口範子; 斎藤芳郎
    日本酸化ストレス学会学術集会プログラム・抄録集, 69th, 2016
  • セレノプロテインPの阻害抗体による糖尿病治療効果の解析-インスリン抵抗性および分泌能を改善する抗体医薬の開発
    三田雄一郎; 中山華穂; 稲荷尚吾; 西藤有希奈; 吉岡佑弥; 曽谷奏; 高部稚子; 御簾博文; 篁俊成; 高橋和彦; 野口範子; 斎藤芳郎
    糖尿病(Web), 59(Suppl), 2016
  • 膵臓β細胞モデルMIN6は過剰なSelenoprotein Pにより障害を受ける
    稲荷 尚吾; 高部 稚子; 三田 雄一郎; 御簾 博文; 篁 俊成; 野口 範子; 斎藤 芳郎
    日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, (公社)日本生化学会, 88回・38回 [4T特L - 10(3P1201)], Dec. 2015
  • SBP2変異によるセレン含有タンパク質欠乏患者におけるコレステロールの酸化-細胞膜と血漿リポタンパク質の酸化反応の違い
    齋藤 芳郎; 七里 元督; 濱島 崇; 萩原 義久; 吉田 康一; 野口 範子
    脂質生化学研究, 日本脂質生化学会, 57 146 - 149, May 2015
  • Novel Method for Suppression of Neuronal Cell Death by 24S-Hydroxycholesterol
    野口 範子; 斎藤 芳郎; 浦野 泰臣
    同志社大学理工学研究報告, 同志社大学理工学研究所, 55(4) 59 - 62, Jan. 2015
  • 1-I-11 血漿セレン含有タンパク質セレノプロテインPを標的とした2型糖尿病の抗体医薬の開発(一般演題要旨,ビタミン・バイオファクター研究のさらなる魅力~大和まほろぱからの発信~,第67回大会講演要旨)
    斎藤 芳郎; 中山 華穂; 三田 雄一郎; 野口 範子
    ビタミン, 公益社団法人 日本ビタミン学会, 89(4) 214 - 214, 2015
  • Identification of neuron-derived protecting factors against oxidative stress
    野口 範子; 斎藤 芳郎
    コスメトロジー研究報告, コスメトロジー研究振興財団, 23 61 - 64, 2015
  • Enhancement of Oxidative Stress and Its Amelioration by Vitamin E in a Subject with Mutations in the Selenocysteine Insertion Sequence-Binding Protein 2 (SBP2) Gene
    Yoshiro Saito; Mototada Shichiri; Takashi Hamajima; Noriko Noguchi
    FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, 76 S90 - S90, Nov. 2014, Summary international conference
  • 血中oxDJ-1の異常高値を示し、幻覚を認めたPDの4例
    西郷 和真; 斎藤 芳郎; 小川 郁子; 細井 幸恵; 三井 良之; 花田 一志; 上田 昌美; 石井 一成; 野口 範子; 楠 進
    Dementia Japan, (一社)日本認知症学会, 28(4) 504 - 504, Oct. 2014
  • 血中酸化型DJ‐1異常高値の臨床的意義
    西郷和真; 斎藤芳郎; 小川郁子; 細井幸恵; 三井良之; 花田一志; 上田昌美; 石井一成; 野口範子; 楠進
    日本酸化ストレス学会学術集会プログラム・抄録集, 67th 52 , 29 Aug. 2014
  • セレンタンパク質研究の最前線 血漿セレノプロテインPによるセレン代謝制御と2型糖尿病
    斎藤 芳郎; 吉岡 佑弥; 三田 雄一郎; 御簾 博文; 田中 睦; 篁 俊成; 野口 範子
    Biomedical Research on Trace Elements, 日本微量元素学会, 25(2) 50 - 50, Jun. 2014
  • 脳特異的オキシステロール24S-hydroxycholesterolによる細胞死メカニズムの解析
    浦野泰臣; 山中一哲; 高部稚子; 斎藤芳郎; 野口範子
    日本Cell Death学会学術集会プログラム抄録集, 23rd, 2014
  • アストロサイトに対する24S-hydroxycholesterolの細胞死誘導機序の解明
    西村祐貴; 浦野泰臣; 高部稚子; 野口範子
    日本酸化ストレス学会学術集会プログラム・抄録集, 67th, 2014
  • 酸化コレステロール24S-OHCにより誘導されるNecroptosisのメカニズム
    高部稚子; 山中一哲; 浦野泰臣; 斎藤芳郎; 野口範子
    日本酸化ストレス学会学術集会プログラム・抄録集, 67th, 2014
  • Study on Involvement of Reactive Oxygen Species in Neuronal Cell Death Induced by Oxidation Product of Cholesterol
    野口 範子; 斎藤 芳郎; 浦野 泰臣
    同志社大学理工学研究報告, 同志社大学理工学研究所, 54(4) 21 - 25, Jan. 2014
  • 脳特異的24(S)-ヒドロキシコレステロールにより誘導されるプログラムネクローシスおよび細胞保護作用の分子メカニズム
    斎藤 芳郎; 山中 一哲; 浦野 泰臣; 野口 範子
    脂質生化学研究, 55 9 - 9, 28 May 2013
  • Novel insights of brain-specific produced oxysterol in neurodegenerative diseases
    NOGUCHI Noriko; YAMANAKA Kazunori; TAKABE Wakako; URANO Yasuomi; SAITO Yoshiro
    日本生化学会大会(Web), 86th, 2013
  • 2-IV-13 セレン欠乏に伴う酸化ストレス障害に対するビタミンEの効果 : SBP2遺伝子異常に対する治療への応用(一般演題要旨,第65回大会講演要旨)
    斎藤 芳郎; 七里 元督; 濱島 崇; 萩原 義久; 吉田 康一; 野口 範子
    ビタミン, 公益社団法人 日本ビタミン学会, 87(4), 2013
  • パーキンソン病における酸化型DJ-1測定とMIBG心筋シンチグラフィーの関連について
    西郷 和真; 斎藤 芳郎; 池上 郁子; 細井 幸子; 高田 和男; 宮本 勝一; 三井 良之; 楠 進; 野口 範子
    臨床神経学, (一社)日本神経学会, 52(12) 1428 - 1428, Dec. 2012
  • アミロイド前駆体タンパク質細胞内輸送へのオキシステロールの関与機構の解明
    浦野 泰臣; 野口 範子
    脂質生化学研究, 54 118 - 120, 28 May 2012
  • 早期パーキンソン病患者の赤血球におけるDJ‐1の酸化
    斎藤芳郎; 浜窪隆雄; 下濱俊; 二木鋭雄; 野口範子
    日本酸化ストレス学会学術集会プログラム・抄録集, 64th 60 , 27 Jun. 2011
  • パーキンソン病における新たなバイオマーカーとしての酸化型DJ‐1測定の可能性
    西郷和真; 斎藤芳郎; 三井良之; 楠進; 野口範子
    パーキンソン病・運動障害疾患コングレスプログラム・抄録集, 5th 92 , 2011
  • 脂質酸化物により誘導される適応反応のメカニズム
    斎藤 芳郎; 野口 範子
    放射線生物研究, 放射線生物研究会, 45(2) 160 - 169, Jun. 2010
  • 24(S)-Hydroxycholesterol Induces SH-SY5Y Cell Death via Necroptosis, Programmed Necrosis
    Kazunori Yamanaka; Yoshiro Saito; Tohru Yamamori; Yasuomi Urano; Noriko Noguchi
    FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, 49 S137 - S137, 2010, Summary international conference
  • Cytoprotective Effect of Vitamin E Homologues Against Glutamate-induced Cell Death in Immature Primary Cortical Neuron Cultures: Tocopherols and Tocotrienols Exert Similar Effects by Antioxidant Function
    Yoshiro Saito; Yasukazu Yoshida; Noriko Noguchi; Etsuo Niki
    FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, 49 S196 - S196, 2010, Summary international conference
  • Elevation of Oxidized DJ-1 in the Erythrocytes of Parkinson Disease Patients and Animal Models
    Yoshiro Saito; Yoko O. Akazawa; Takao Hamakuho; Yasukazu Yoshida; Noriko Noguchi; Etsuo Niki
    FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, 49 S171 - S171, 2010, Summary international conference
  • 3.24(S)-HyDroxycholesterolによる神経細胞死の誘導メカニズム(第327回会議研究発表要旨,脂溶性ビタミン総合研究委員会)
    野口 範子; 山中 哲一; 斉藤 芳郎; 浦野 泰臣
    ビタミン, 公益社団法人 日本ビタミン学会, 84(9) 448 - 448, 2010
  • グルタミン酸誘導性の神経細胞死に対するビタミンE類の抑制効果
    斎藤芳郎; 西尾敬子; 赤澤(小川)陽子; 吉田康一; 野口範子; 二木鋭雄
    ビタミンE研究の進歩, 14 27 - 32, 2010
  • 24S-hydroxycholesterol による神経細胞傷害メカニズムの解析
    山中 一哲; 斎藤 芳郎; 山盛 徹; 浦野 泰臣; 野口 範子
    脂質生化学研究, 51 69 - 72, 10 Jul. 2009
  • 酸化DJ-1とパーキンソン病(1):抗体作成とELISA開発
    斎藤芳郎; 斎藤芳郎; 浜窪隆雄; 吉田康一; 小川陽子; 岩成宏子; 望月康弘; 七里元督; 西尾敬子; 絹見朋也; 野口範子; 児玉龍彦; 二木鋭雄
    日本酸化ストレス学会学術集会プログラム・抄録集, 62nd, 2009
  • 酸化DJ-1とパーキンソン病(2):臨床検体の測定
    小川陽子; 斎藤芳郎; 浜窪隆雄; 児玉龍彦; 原保夫; 藤村晴俊; 今井康陽; 岩成宏子; 七里元督; 西尾敬子; 野口範子; 吉田康一; 二木鋭雄
    日本酸化ストレス学会学術集会プログラム・抄録集, 62nd, 2009
  • Significant Elevation of Oxidized DJ-1 in Erythrocytes of Early-Stage Parkinson Disease Patients: Potential Application of Oxidized DJ-1 Levels for Diagnosis of PD at Early Stage
    Yoshiro Saito; Takao Hamakuba; Yasukazu Yoshida; Yoko Ogawa Akazawa; Mototado Shichiri; Noriko Noguchi; Etsuo Niki
    FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, 47 S80 - S80, 2009, Summary international conference
  • 酸化ストレスと老化・寿命を結びつけるタンパク質--p66shc
    山盛 徹; 野口 範子
    放射線生物研究, 放射線生物研究会, 43(3) 261 - 271, Sep. 2008
  • Induction of Adaptive Response and Enhancement of PC12 Cell Tolerance by Lipopolysaccharide Primarily Through the Upregulation of Glutathione S-Transferase A3 Via Nrf2 Activation
    Yoshiro Saito; Yo Omata; Yasukazu Yoshida; Noriko Noguchi; Etsuo Niki
    FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, 45 S37 - S37, 2008, Summary international conference
  • リポ多糖(LPS)により誘導される適応反応・酸化ストレス耐性メカニズムの解析
    斎藤芳郎; 小俣葉; 藤田克英; 吉田康一; 野口範子; 二木鋭雄
    生化学, 4P-0442 , 2008
  • Activity of shogaol derivatives as antioxidant and gene expression regulator
    野口 範子
    Cosmetology, コスメトロジー研究振興財団, 15 23 - 28, 2007
  • マクロファージの泡沫化に伴う遺伝子発現変化の網羅的解析
    島田 芽衣; 山田 知広; 高根沢 康一; 野口 範子; 新井 洋由
    脂質生化学研究, 日本脂質生化学会, 48 73 - 75, May 2006
  • Accumulation of Nrf2 due to its modification by oxidative stress and laminar share stress in endothelial cell
    TAKABE Wakako; WARABI Eiji; SEKINE Azusa; KODAMA Tatsuhiko; NOGUCHI Noriko; NOGUCHI Noriko
    生化学, 2006
  • 腹腔マクロファージの泡沫化に伴う遺伝子変動の解析
    山田知広; 高根沢康一; 関根あずさ; 高部稚子; 野口範子; 新井洋由
    衛生薬学・環境トキシコロジー講演要旨集, 2006, 2006
  • 25ハイドロキシコレステロールによるコレステロール生合成抑制作用はオキシステロール結合蛋白質(OSBP)非依存的である
    西村多喜; 西村多喜; 井上貴雄; 柴田識人; 関根あずさ; 高部稚子; 野口範子; 新井洋由
    脂質生化学研究, 48, 2006
  • 25ハイドロキシコレステロールによるコレステロール生合成抑制はオキシステロール結合タンパク質(OSBP)非依存的である
    西村多喜; 井上貴雄; 柴田識人; 関根あずさ; 高部稚子; TRIPUVANUNTAKUL Pearlta; 野口範子; 新井洋由
    日本薬学会年会要旨集, 126th(3), 2006
  • 流れストレスによる遺伝子の発現メカニズムにおける活性酸素の寄与
    高部稚子; 蕨栄治; 野口範子; 野口範子
    万有生命科学振興国際交流財団若手研究者のための生命科学セミナー, 9th, 2006
  • Induction of Lung Kruppel-Like Factor by lysophosphatidylcholine in human endothelial cell
    SHIRAHATA Satoshi; TAKABE Wakako; KOHRO Takahide; MINAMI Takashi; KODAMA Tatsuhiko; NOGUCHI Noriko
    生化学, 2006
  • Nitric oxide-independent expression of Nrf2-regulated genes by laminar shear stress in human endothelial cells
    Wakako Takabe; Eiji Warabi; Noriko Noguchi
    FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, 41 S43 - S43, 2006, Summary international conference
  • Differential responses of the Nrf2-Keap1 system to laminar and oscillatory shear stresses in endothelial cells. (vol 280, pg 27244, 2005)
    T Hosoya; A Maruyama; MI Kang; Y Kawatani; T Shibata; K Uchida; E Warabi; N Noguchi; K Itoh; M Yamamoto
    JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 280(33) 29988 - 29988, Aug. 2005, Others
  • Regulation of cell functions by redox signaling
    NOGUCHI Noriko
    生化学, 日本生化学会, 77(7) 659 - 663, 25 Jul. 2005
  • 酸化ストレスによる遺伝子発現変化のビタミンEによる修飾について
    李 文華; 野口 範子; 赤塚 慎也; 白瀬 智之; 鶴山 竜昭; 山田 義博; 豊國 伸哉
    日本病理学会会誌, (一社)日本病理学会, 94(1) 305 - 305, Mar. 2005
  • Cholesterol biosynthesis inhibition by 25-hydroxycholesterol is independent of OSBP
    NISHIMURA Taki; INOUE Takao; SHIBATA Norihito; SEKINE Azusa; TAKABE Wakako; TRIPUVANUNTAKUL Pearlta; NOGUCHI Noriko; ARAI Hiroyuki
    生化学, 77(8), 2005
  • Identification of genes that are up-regulated or down-regulated during foam cell formation in mouse peritoneal macrophage
    YAMADA Tomohiro; TAKANEZAWA Yasukazu; SEKINE Azusa; TAKABE Wakako; NOGUCHI Noriko; ARAI Hiroyuki
    生化学, 77(8), 2005
  • Lysophosphatidylcholine activates the promoter of solute carrier family 7 member 5 via induction Egr-1 in vascular endothelial cell
    W Takabe; T Minami; M Miura; T Kodama; N Noguchi
    FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, 39 S79 - S79, 2005, Summary international conference
  • Lysophosphatidylcholine increases cholesterol levels via SREBP pathway in endothelial cell
    N Noguchi; A Sekine; W Takabe; H Arai; T Kodama
    FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, 39 S76 - S76, 2005, Summary international conference
  • A turning point to apoptotic and necrotic cell death induced by hydrogen peroxide
    Y Saito; K Nishio; Y Ogawa; T Kinumi; Y Yoshida; N Noguchi; E Niki
    FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, 39 S147 - S147, 2005, Summary international conference
  • Gene expression profiles in human and mice endothelial cells exposed to laminar shear stress
    K Inoue; E Warabi; T Minami; N Noguchi; T Kodama
    CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, 110(17) 284 - 284, Oct. 2004, Summary international conference
  • NRF-2 regulated genes expression in endothelial cell exposed to shear stress regardless of oxygen concentration and low-density lipoprotein
    N Noguchi; E Warabi; Y Wada; H Kajiwara; M Kobayashi; M Tsuchiya; T Kodama
    FREE RADICAL BIOLOGY AND MEDICINE, PERGAMON-ELSEVIER SCIENCE LTD, 37 S68 - S68, 2004, Summary international conference
  • Vitamin E and BO-653: Natural vs. synthetic antioxidant
    E Niki; Y Yoshida; Y Saito; N Itoh; O Cynshi; N Noguchi; T Kodama
    FREE RADICAL BIOLOGY AND MEDICINE, PERGAMON-ELSEVIER SCIENCE LTD, 36 S7 - S7, 2004, Summary international conference
  • Oxidative stress induces insulin resistance by changing the subcellular IRS-1 distribution and NF-Kappa B activation
    T Ogihara; H Sakoda; N Shojima; M Anai; N Noguchi; M Kikuchi; T Fujita; T Asano
    DIABETES, AMER DIABETES ASSOC, 52 A292 - A292, Jun. 2003, Summary international conference
  • ビタミンE欠乏及び過剰状態における遺伝子発現の比較
    斎藤 尚子; 野口 範子; 藤原 葉子; 近藤 和雄; 新井 洋由
    ビタミン, (公社)日本ビタミン学会, 77(4) 229 - 229, Apr. 2003
  • トコトリエノールの生理作用
    二木 鋭雄; 野口 範子
    ビタミン, 日本ビタミン学会, 77(3) 172 - 175, 25 Mar. 2003
  • Exercise-related oxidative stress and antioxidant effects
    NOGUCHI Noriko
    Journal of exercise and sports physiology, 日本運動生理学会事務局, 10(1) 1 - 8, 2003
  • トコトリエノールによるコレステロール合成経路の新たな制御機構
    野口範子; 高部稚子; 新井洋由
    ビタミン, 77(4), 2003
  • LysoPCによるアミノ酸トランスポーター遺伝子発現と炎症における寄与
    高部稚子; 野口範子; 金井好克; 児玉龍彦
    脂質生化学研究, 45, 2003
  • Lysophosphatidylcholineによるアミノ酸トランスポーター遺伝子発現と炎症における寄与
    高部稚子; 金井好克; CHAIROUNGDUA A; 児玉龍彦; 野口範子
    日本分子生物学会年会プログラム・講演要旨集, 26th, 2003
  • Increase of cytokine production by lysophosphatidylcholine through induction of amino acid transporter in endothelial cell
    N Noguchi; W Takabe; T Kodama
    FREE RADICAL BIOLOGY AND MEDICINE, PERGAMON-ELSEVIER SCIENCE LTD, 35 S71 - S71, 2003, Summary international conference
  • Antioxidant action of vitamin E isoforms
    E Niki; Y Yoshida; Y Saito; R Piga; N Noguchi
    FREE RADICAL RESEARCH, TAYLOR & FRANCIS LTD, 37 40 - 40, 2003, Summary international conference
  • Gene regulation by oxidation products of LDL in endothelial cell
    N Noguchi; W Takabe; T Kodama
    FREE RADICAL RESEARCH, TAYLOR & FRANCIS LTD, 37 21 - 21, 2003, Summary international conference
  • 平成14年度日本油化学会エディター賞受賞によせて : 実を結んだ"日-ウクライナ国際共同研究"
    KUZMENKO A. I.; 二木 鋭雄; 野口 範子
    オレオサイエンス = / Japan oil chemists' society, 2(8) 447 - 447, 01 Aug. 2002
  • ビタミンE同族体の構造特異的な遺伝子発現制御
    野口範子; 沖本優子; 高部稚子; 児玉龍彦
    ビタミン, 76(3), 2002
  • Chemical structure-specific gene expression by phenolic compounds
    N Noguchi; W Takabe; T Kodama
    FREE RADICAL BIOLOGY AND MEDICINE, PERGAMON-ELSEVIER SCIENCE LTD, 33 S207 - S207, 2002, Summary international conference
  • Accumulation of lipids in smooth muscle cell with LDL loading under hypoxia
    N Noguchi; Y Wada; S Shimakawa; Y Yoshida; E Niki; T Kodama
    FREE RADICAL BIOLOGY AND MEDICINE, PERGAMON-ELSEVIER SCIENCE LTD, 33 S399 - S400, 2002, Summary international conference
  • Life Science of Human Stress
    NIKI Etsuo; NOGUCHI Noriko
    Oleoscience : Journal of Japan Oil Chemists' Society, 日本油化学会, 1(5) 509 - 513, 01 May 2001
  • 2-I-15 ビタミンE同族体の抗酸化活性と遺伝子発現調節を介する細胞機能制御に関する研究
    野口 範子; 野中 綾; 沖本 優子; 二木 鋭雄
    ビタミン, 日本ビタミン学会, 75(4) 225 - 225, 25 Apr. 2001
  • Scavenger receptors and pathogenesis of atherosclerosis
    KODAMA Tatsuhiko; HAMAKUBO Takao; WADA Yoichiro; NOGUCHI Noriko; NIKI Etsuo
    生化學, 日本生化学会, 73(3) 179 - 183, 25 Mar. 2001
  • Galvinoxyl method for standardizing electron and proton donation activity
    HL Shi; N Noguchi; E Niki
    FLAVONOIDS AND OTHER POLYPHENOLS, ELSEVIER ACADEMIC PRESS INC, 335 157 - 166, 2001, Book review
  • A novel method to follow lipid peroxidation in low-density lipoprotein using diphenyl-1-pyrenylphosphine
    Y Okimoto; Y Wada; E Niki; T Kodama; N Noguchi
    FREE RADICAL BIOLOGY AND MEDICINE, PERGAMON-ELSEVIER SCIENCE LTD, 31 S88 - S88, 2001, Summary international conference
  • Novel insights into the molecular mechanisms of the anti-atherogenic effects of antioxidants through genomic analysis; regulation of proteasome function
    W Takabe; T Kodama; K Tanaka; T Suzuki; H Aburatani; N Noguchi
    FREE RADICAL BIOLOGY AND MEDICINE, PERGAMON-ELSEVIER SCIENCE LTD, 31 S62 - S62, 2001, Summary international conference
  • Evaluation of antioxidant capacity. What capacity is being measured by which method?
    E Niki; N Noguchi
    IUBMB LIFE, TAYLOR & FRANCIS INC, 50(4-5) 323 - 329, Oct. 2000, Book review
  • 2-I-21 α-トコフェロール及び新規抗酸化物BO-653由来のラジカルの反応性について
    渡辺 亮; 野口 範子; 高橋 希之; 二木 鋭雄
    ビタミン, 日本ビタミン学会, 73(4) 274 - 274, 25 Apr. 1999
  • 2. α-トコフェリルヒドロキノンの抗酸化作用
    二木 鋭雄; 野口 範子; 石 紅聯
    ビタミン, 日本ビタミン学会, 73(1) 63 - 63, 23 Jan. 1999
  • The hyperlipidemia drug. The target for limited treatment. Treatment by the antioxidant and the significance.
    高部稚子; 野口範子; 児玉龍彦
    治療学, 33(10), 1999
  • Reactivity and stability of antioxidant-derived phenoxyl radical
    A Watanabe; N Noguchi; M Takahashi; HL Shi; E Niki
    FREE RADICAL BIOLOGY AND MEDICINE, PERGAMON-ELSEVIER SCIENCE LTD, 27 S45 - S45, 1999, Summary international conference
  • Antioxidant action of antihypertensive drug, carvedilol
    N Noguchi; K Nishino; E Niki
    FREE RADICAL BIOLOGY AND MEDICINE, PERGAMON-ELSEVIER SCIENCE LTD, 25 S35 - S35, 1998, Summary international conference
  • Inhibition of oxidation of low density lipoprotein by a novel antioxidant BO-653 prepared by theoretical design
    N Noguchi; Y Okimoto; O Cynshi; T Kodama; E Niki
    ATHEROSCLEROSIS, ELSEVIER SCI IRELAND LTD, 134(1-2) 206 - 206, Oct. 1997, Summary international conference
  • 生体の酸化傷害と防御機構 (特集 生体の酸化と抗酸化成分の開発と応用)
    野口 範子; 二木 鋭雄
    フレグランスジャーナル, フレグランスジャーナル社, 25(4) 9 - 16, Apr. 1997
  • Inhibition of plasma cholesterol ester hydroperoxide and phosphatidylcholine hydroperoxide formation as measures of antioxidant status
    N Noguchi; E Niki
    VITAMINS AND COENZYMES, PT L, ELSEVIER ACADEMIC PRESS INC, 282 271 - 278, 1997, Book review
  • 脂質の酸化と抗酸化における一酸化窒素(NO)の二面作用
    野口 範子; 林 克亘; 近藤 洋; 二木 鋭雄
    日本分子生物学会年会プログラム・講演要旨集, 19 502 - 502, 01 Aug. 1996
  • 3-III-14 ピロロキノリンキノール(PQQH_2)の抗酸化作用 : 第48回大会研究発表要旨 : 一般研究発表要旨
    宮内 一浩; 阿部田 浩之; 野口 範子; 二木 鋭雄; 浦上 貞治
    ビタミン, 日本ビタミン学会, 70(4) 214 - 215, 25 Apr. 1996
  • 2-II-41 LDLの酸化変性におけるビタミンCによるビタミンEとプロブコールの再生効率 : 第47回大会研究発表要旨
    野口 範子; 二木 鋭雄
    ビタミン, 日本ビタミン学会, 69(4) 291 - 292, 25 Apr. 1995
  • 1-II-23 脂質酸化に対するビタミンEと合成抗酸化剤の協同抑制作用 : ビタミンの発癌予防効果 : 第46回大会研究発表要旨
    野口 範子; 吉野 哲也; 後藤 直宏; 二木 鋭雄
    ビタミン, 日本ビタミン学会, 68(4) 222 - 222, 25 Apr. 1994
  • APOLIPOPROTEIN-B PROTEIN OXIDATION IN LOW-DENSITY LIPOPROTEINS
    N NOGUCHI; E NIKI
    OXYGEN RADICALS IN BIOLOGICAL SYSTEMS, PT C, ACADEMIC PRESS INC, 233 490 - 494, 1994, Book review
  • 2.LDLの酸化変性に対するビタミンEの防御作用の考察 : 脂溶性ビタミン総合研究委員会 第257回会議研究発表要旨
    二木 鋭雄; 野口 範子; 後藤 直宏; 吉田 康一
    ビタミン, 日本ビタミン学会, 67(12) 690 - 691, 25 Dec. 1993
  • G020021 Reduction of Vitamin E radical in Electron-beam-irradiated dl-α-Tocopherol-blended Ultra High Molecular Weight Polyethylene
    Iwade H; Kawasaki T; Tajima K; Sakurai Y; Noguchi N; Saito Y; Uetsuki K; Tomita N
    Mechanical Engineering Congress, Japan, The Japan Society of Mechanical Engineers, 2012 "G020021 - 1"-"G020021-4", 09 Sep. 2012
  • トランスクリプトーム解析から見た抗酸化薬剤開発の展望
    高部稚子; 野口範子
    日本動脈硬化学会総会プログラム・抄録集, 34th, 2002

Books etc

  • サイエンスとインテリジェンスーサイエンスコミュニケーター養成副専攻受講生論文集-
    佐藤 優; 野口 範子
    K&Kプレス, Sep. 2020, Editor
  • (Vitamin E: Chemistry and Nutritional Benefits.) Action of Vitamin E Against Lipid Peroxidation and Cell Death
    Noriko Noguchi
    Royal Society of Chemistry, 2018, Contributor, pp. 165-172
  • 脳のコレステロール代謝と神経変性疾患, 生物の科学遺伝
    エヌティーエス, 2016
  • 酸化ストレスと疾患
    ストレスシグナルと疾患 医学のあゆみ 医歯薬出版, 2015
  • パーキンソン病と酸化ストレス
    医歯薬出版, 2014
  • Necroptosis 医学のあゆみ
    医歯薬出版, 2011
  • HDAC
    朝日書店, 2011
  • Nrf 血管生物学事典
    朝日書店, 2011
  • 抗酸化ビタミンの相互作用 「ビタミン・ミネラルの科学(五十嵐修、 江指隆年編集)
    朝倉書店, 2011
  • Uptake, Distribution, and Antioxidant Actions of Tocotrienol in Cultured Cells. Tocotrienols:Vitamin E Beyond Tocopherols
    CRC Press, 2008
  • 動脈硬化症と酸化ストレス「酸化ストレスの医学(吉川敏一編集)」
    診断と治療社, 2008
  • 酸化ストレス 「ストレスの科学と健康(二木鋭雄編著)」
    共立出版, 2008
  • 抗酸化ビタミンの大規模臨床試験 「酸化ストレスと心血管病
    日本医学出版, 2007
  • 抗酸化ビタミン 「酸化ストレスと心血管病(横山光宏、藤田敏郎編 集)」
    日本医学出版, 2007
  • DNAマイクロアレイを用いた遺伝子発現解析 レドックス/ストレス防御の医学(谷口直之監)医学のあゆ
    医歯薬出版, 2005
  • Specificity and inhibition by antioxidant of lipid peroxidation by lipoxygenase: effects of substrate, lipoxygenase and milieu
    International Congress Series, 2002
  • Natural antioxidants
    Antioxidants in food, 2001
  • Galvinoxyl method for standardizing electron and proton donation activity
    Methods in Enzymology, 2001
  • Action of ginkgo biloba extract as an antioxidant.
    Antioxidants & Disease, CAB International, Oxford, 1999
  • Chemistry of oxygen species and antioxidant.
    Antioxidant Status, Diet, Nutrition and Health, CRC press, FL, 1998
  • Inhibition of oxidation of low density lipoprotein by antioxidants.
    Pathophysiology of lipid peroxides and related free radicals, 1998
  • Inhibition of oxidative modification of low density lipoprotein by novel antioxidant BO-653 prepared by theoretical design.
    Nutrition, Lipids, Health, and Disease, 1998
  • Protection of human low-density lipoprotein from oxidative modification by vitamin C.
    Vitamin C in health and disease, 1997
  • Antioxidand properties of ebselen
    Hand book of synthetic antioxidants, 1997
  • Antioxidant properties of probucol
    Hand book of synthetic antioxidants, 1997
  • Noguchi N., Action of vitamin E against lipid peroxidation and cell death, Niki E. ed. Vitamin E, chemistry and nutritional benefits, pp. 165-174, 2019, Royal Society of Chemistry, UK
  • 山中一哲,斉藤芳郎,山盛 徹, 浦野泰臣, 野口範子, 24S-OHC誘導性細胞死に対するビタミンE類の添加効果,ビタミンE研究の進歩XV (ビタミンE研究会編), pp. 20-25, 2012, 共立出版株式会社 (ビタミンE研究会, Jan. 2011, 京都)
  • 斎藤芳郎, 西尾敬子, 小川陽子, 吉田康一, 野口範子, 二木鋭雄, グルタミン酸誘導性神経細胞死に対するビタミンE類の抑制効果,ビタミンE研究の進歩XIV (ビタミンE研究会編), pp. 27-32, 2010, 共立出版株式会社 (ビタミンE研究会, Jan. 2009, 奈良)
  • 野口範子, 脂質酸化生成物に対する内皮細胞の遺伝子発現応答,放射線の固体影響?機構研究からのアプローチ, pp. 135-140, 2005, 独立行政法人放射線医学総合研究所(放医研シンポジウム, Dec., 2004, 千葉)
  • 野口範子, 抗酸化機能と遺伝子制御機能の接点,ビタミン誌 79, 225-226, 2005
  • 野口範子, 伊藤靖浩, 二木鋭雄, 新井洋由, 柴田亮行, α-TTPノックアウトマウスにみられる酸化傷害,ビタミンE研究の進歩X (ビタミンE研究会編), pp. 45-49, 2001, 共立出版株式会社 (ビタミンE研究会, Jan. 2001, 東京)
  • 野口範子, 二木鋭雄, α-トコフェロールの化学構造を基に設計合成した新規抗酸化物質の抗酸化作用,ビタミンE研究の進歩VIII (ビタミンE研究会編), pp. 59-65, 1998, 共立出版株式会社 (ビタミンE研究会, Feb.1997, 京都)
  • N. Noguchi, N. Gotoh, E. Niki, Action of vitamin E as antioxidant against oxidative modification of low density lipoprotein. Biofactors, 7, 41-50, 1998. (International Conference on Vitamin E, Feb., 1997, Kyoto)
  • N. Noguchi, E. Niki, Inhibition of oxidation of low density lipoprotein by antioxidants. Pathophysiology of lipid peroxides and related free radicals (K. Yagi, ed), pp. 91-101, 1998, Jpn. Sci. Soc. Press, Tokyo (International Conference on Lipid Peroxide
  • N. Noguchi, E. Niki, Cooperative antioxidant action of probucol, ?-tocopherol and ascorbic acid against the oxidation of LDL of human and rabbit. BioFactors, 6, 259-260, 1997 (Lipid and Thrombosis, Aug., 1996, Marstricht)
  • E. Niki, N. Noguchi, Dynamics of oxidation of LDL and its inhibition by antioxidants. BioFactors, 6, 201-208, 1997 (Workshop Oxidative Stress, July, 1996, Graz)
  • 野口範子,山本裕子,二木鋭雄, 低比重リポ蛋白質の酸化におけるアポリポ蛋白Bの変性に対するビタミンEの抑制作用,ビタミンE研究の進歩VII (ビタミンE研究会編), pp. 84-88, 1997, 共立出版株式会社 (ビタミンE研究会, Mar. 1996, 浜松)
  • N. Gotoh, T. Yoshino, N. Noguchi, E. Niki, 2,2'-Azobis(4-methoxy- 2,4-dimethylvaleronitrile), a new lipid-soluble azo radical initiator. (K. Asada, T. Yoshikawa eds.) pp. 59-62, 1994, Elsevier Science Publisher, Amsterdam (SOD meeting, Oct., 1993, Kyoto)
  • N. Noguchi, N. Gotoh, T. Yoshino, E. Niki, Antioxidant effects of probucol and ebselen against oxidative modification of LDL induced by free radicals generated at different sites. (K. Asada, T. Yoshikawa eds.), pp.191-194, 1994, Elsevier Science Publisher
  • 野口範子,保田 浩,二木鋭雄,三木正之,美濃 真, 脳脂質の酸化に対するビタミンEの抗酸化作用,ビタミンE研究の進歩IV (ビタミンE研究会編), pp. 80-84, 1994, 共立出版株式会社(ビタミンE研究会, Feb. 1993, 京都)
  • 後藤直宏,野口範子,土屋順一,二木鋭雄,島崎弘幸, LDLの酸化に対するビタミンEの抗酸化作用,ビタミンE研究の進歩III (ビタミンE研究会編), pp. 57-62, 1993, 共立出版株式会社(ビタミンE研究会, Feb. 1992, 東京)
  • N. Noguchi, N. Gotoh, E. Komuro, Y. Yamamoto, E. Niki, H. Shimasaki, The oxidative modification of low density lipoprotein induced by copper or water-soluble radical initiator. Oxygen Radicals ( K. Yagi, M. Kondo, E. Niki, T. Yoshikawa, eds.), pp. 377-380
  • 野口範子, 酸化ストレスと疾患 医学のあゆみ別冊, ストレスシグナルと疾患?細胞恒常性維持機構の破綻と病態, pp. 347-352, 2015, 医歯薬出版, 東京
  • 斎藤芳郎,野口範子, 神経変性とレドックスーパーキンソン病関連分子DJ-1のレドックス制御機能 レドックスUPDATE, 第4章, 224-228, 2015
  • 斎藤芳郎,野口範子, Parkinson病と酸化ストレス 酸化ストレスの医学, pp. 264-271, 2014, 診断と治療社,東京
  • 西尾敬子, 石田規子, 斉藤芳郎, 赤澤陽子, 七里基督, 吉田康一, 萩原義久,野口範子, John Chirico, Jefferey Atkinson, 二木鋭雄, ビタミン ?-トコフェロールリン酸の細胞および生体への取り込みと抗酸化作用, ビタミンEの進歩, pp. 15-19, 2012, ビタミンE研究会
  • 山中一哲, 斉藤芳郎, 山盛徹, 浦野泰臣, 野口範子, 24S-0HC誘導性細胞死に対するビタミンE類の添加効果, ビタミンEの進歩, pp. 20-25, 2012, ビタミンE研究会
  • 野口範子, Necroptosis医学のあゆみ別冊, pp. 142-144, 2011, 医歯薬出版, 東京
  • 野口範子, HDAC,血管生物医学事典,pp. 386-387, 2011, 朝日書店,東京
  • 野口範子, Nrf,血管生物医学事典,pp. 397-398, 2011, 朝日書店,東京
  • 二木鋭雄,野口範子, 抗酸化ビタミンの相互作用 「ビタミン・ミネラルの科学(五十嵐修,江指隆年編集)」pp.157-165, 2011, 朝倉書店、東京
  • Noguchi N, Saito, Y. Niki E, Uptake, Distribution, and Antioxidant Actions of Tocotrienol in Cultured Cells. Tocotrienols: Vitamin E Beyond Tocopherols, pp 159-167, CRC Press, UK, 2008
  • 野口範子, 動脈硬化症と酸化ストレス「酸化ストレスの医学(吉川敏一編集)」pp.240-247, 2008,診断と治療社,東京
  • 野口範子, 酸化ストレス 「ストレスの科学と健康(二木鋭雄編著)」,pp.38-43,2008 共立出版,東京
  • 太田好次、阿部皓一、野口範子, 抗酸化ビタミンの大規模臨床試験 「酸化ストレスと心血管病(横山光宏、藤田敏郎編集)」,pp.275-279, 2007,日本医学出版,東京
  • 野口範子, 抗酸化ビタミン 「酸化ストレスと心血管病(横山光宏、藤田敏郎編 集)」,pp.255-258, 2007,日本医学出版,東京
  • 野口範子, DNAマイクロアレイを用いた遺伝子発現解析,レドックス/ストレス防御の医学(谷口直之監)医学のあゆみ別冊,151-156,2005, 医師薬出版
  • 二木鋭雄,野口範子,内田浩ニ編集, 酸化ストレスマーカー、2005. 5, 学会出版センター,東京
  • 野口範子, 抗酸化物質の新規機能の追究,酸化ストレス/フリーラジカル医学生物学の最前線 (吉川敏一監) 医学のあゆみ別冊, pp. 142-144, 2001, 医歯薬出版, 東京
  • H. Shi, N. Noguchi, E. Niki, Natural antioxidants,Antioxidants in food. (F. Dodds ed.), Chapter 3, 2001, Woodhead Publishing Limited
  • 野口範子, 老化の制御方法,老化に対する防御機構 (吉川敏一監) pp. 61-68, 2001, シーエムシー, 東京
  • H. Shi, N. Noguchi, E. Niki, Galvinoxyl method for standardizing electron and proton donation activity. Methods in Enzymology, 335, 157-166, 2001, Academic Press, New York
  • 野口範子, 血管の老化とフリーラジカル,老化予防食品の開発 (吉川敏一監) pp. 79-85,1999, シーエムシー, 東京
  • N. Noguchi, K. Nishino, E. Washio, H. Shi, E. Niki, Action of ginkgo biloba extract as an antioxidant. Antioxidants & Disease (N. J. Temple ed.), pp. 131-140, 1999, CAB International, Oxford
  • 野口範子, 動脈硬化,抗酸化物質のすべて(吉川敏一編), pp. 241-247, 1998, 先端医学社, 東京
  • 野口範子, プロブコール,抗酸化物質のすべて(吉川敏一編), pp. 200-205, 1998, 先端医学社, 東京
  • N. Noguchi, E. Niki, Chemistry of oxygen species and antioxidant. Antioxidant Status, Diet, Nutrition and Health (A.M. Papas ed.), pp. 3-20, 1998, CRC press, FL
  • N. Noguchi, Y. Okimoto, O. Cynshi, T. Kodama, E. Niki, Inhibition of oxidative modification of low density lipoprotein by novel antioxidant BO-653 prepared by theoretical design. Nutirition, Lipids, Health, and Disease (L. Packer, ed.), pp. 139-152, 1998,
  • E. Niki, N. Noguchi, Protection of human low-density lipoprotein from oxidative modification by vitamin C. Vitamin C in health and disease, (L. Packer, E. Cadenas, eds), pp. 183-192, 1997, Marcel Dekker, New York
  • N. Noguchi, E. Niki, Inhibition of plasma cholesterol ester hydroperoxide and phosphatidylcholine hydroperoxide formation as measures of antioxidant status. Methods in Enzymology (D.B. MacCormick, J.W. Suttie, C. Wagner eds.), 282, 271-278, 1997, Academic
  • N. Noguchi, E. Niki, Antioxidant properties of ebselen. Handbook of Synthetic Antioxidants (L. Packer, E. Cadenas, eds), pp. 285-303, 1997, Marcel Dekker, New York
  • E. Niki, N. Noguchi, Antioxidant properties of probucol,Handbook of Synthetic Antioxidants (L. Packer, E. Cadenas, eds), pp.225-239, 1997, Marcel Dekker, New York
  • 二木鋭雄,野口範子, フリーラジカルによる各種疾病の発症と抗酸化物による予防新食品機能材料の開発 (太田明一監) ,pp. 28-36,1996, シーエムシー, 東京
  • E. Niki, N. Noguchi, M. Iwatsuki, Antioxidant Activities of Phenolic Compounds in Solutions, Membranes, and Lipoproteins. Nutrition, Lipids, Health, and Disease (A. S. H. Ong., E. Niki, L. Packer,eds.) pp. 1-7, 1995, AOCS Press, Champaign, IL
  • 野口範子, 細胞分画法,過酸化脂質 フリーラジカル実験法 生物化学実験法34(島崎弘幸,五十嵐脩編)pp.192-198,1995, 学会出版センター, 東京
  • E. Niki, N. Noguchi, N. Gotoh, H. Sakai,
  • N. Noguchi, E. Niki, Apo B protein oxidation in LDL. Oxygen radicals in biological systems, part C, Methods in Enzymology (L. Packer ed.) 233, 490-494, 1994, Academic Press, Calif.
  • 野口範子,後藤直宏,二木鋭雄, LDLの酸化とその抑制,フリーラジカルの臨床 7(近藤元治監,大柳善彦,吉川敏一編)pp. 49-54, 1993, 日本医学館, 東京
  • 二木鋭雄,野口範子, 生体内に生じるフリーラジカル,体内動態と生体傷害機序(近藤元治編)最新医学からのアプローチ4 「フリーラジカル」分担執筆,pp. 7-26, 1992, メジカルビュー社, 東京
  • 河野邦雄,大野良樹,野口範子, 神経細胞の構造的研究法,
  • Noriko Noguchi, Ebselen, a useful tool for understanding cellular redox biology and a promissing drug candidate for use in human diseases. Arc. Biochem. Biophys. 595, 109-112, 2016
  • 野口範子, 脳のコレステロール代謝と神経変性疾患,生物の科学,70, 225-229, 2016
  • 山中一哲,野口範子, 新しい細胞死ネクロトーシス?プログラムされたネクローシス?,DOJINDO NEWS, 145, 1-6, 2012
  • 斎藤,野口, 脂質酸化物により誘導される適応反応のメカニズム,放射線生物研究 45, 160-169, 2010
  • 山盛、野口, 酸化ストレスと老化/寿命を結びつけるタンパク質―p66shc 放射線生物研究 43, 261-271, 2008
  • Noriko Noguchi, Role of oxidative stress in adaptive responses in special reference to atherogenesis, J. Clin. Nutr. Biol. 43, 131-138 , 2008
  • 野口範子, 生体の酸化傷害とその防御機構,フレグランスジャーナル, 2, 12-17, 2008, フレグランスジャーナル社
  • 野口範子, 遺伝子で応える細胞のストレス応答,日本薬理学雑誌、129, 85-88, 2007, 日本薬理学会
  • 野口範子, 過酸化物調整機構としての肝,The Lipid, 17: 28-32, 2006, メディカルレビュー社
  • 野口範子, 酸化ストレスと遺伝子発現,アンチ・エイジング医学, 2: 97-101, 2006, メディカルレビュー社
  • 野口範子, 酸化脂質はどのように動脈硬化を進行させるか?,Vascular Medicine, 2: 33-39, 2006, 先端医学社
  • J.W. Zmijewski, A. Landar, N Watanabe, D.A. Dickinson, N. Noguchi, V.M. Darley-Usmar,Cell signalling by oxidized lipids and the role of reactive oxygen species in the endothelium. Review Biochem. Soc. Trans., 33, 1385-1389, 2005.
  • 野口範子, 酸化?還元による細胞機能の制御,生化学ミニレビュー,日本生化学会, 77: 659-663, 2005
  • 野口範子, 酸化ストレスによる血管内皮細胞の遺伝子応答プロファイリング,血管医学, 6: 41-45, 2005, メジカルビュー社
  • 野口範子, オキシステロールの生物活性と血管,血管医学, 5: 13-18, 2004, メジカルビュー社
  • 野口範子, 酸化脂質の生成メカニズムと生物学的作用,The Lipid, 15: 33-38, 2004,メディカルレビュー社
  • E. Niki, N. Noguchi, Dynamics of antioxidant action of vitamin E. Accounts of Chemical Research, 37: 45-51, 2004
  • 野口範子, 運動に関連する酸化ストレスと抗酸化作用,日本運動生理学雑誌, 10: 1-8, 2003
  • 二木鋭雄, 野口範子, トコトリエノールの生理作用,ビタミン, 77: 172-175, 2003
  • E. Niki, N. Noguchi, Effects of antioxidants against atherosclerosis. Mol. Cell. Biochem., 234: 19-25, 2002
  • 野口範子, 抗酸化物質による血管障害の防御,血管医学, 3:41-47, 2002 , メジカルビュー社
  • 野口範子, 酸化ストレスと動脈硬化,
  • 二木鋭雄, 野口範子, ストレスの生命科学,オレオサイエンス、1(5), 509-514, 2001
  • N. Noguchi, E. Niki, Evaluation of antioxidant capacity. What capacity is being measured by which method? IUBMB Life, 50, 323-329, 2001
  • 二木鋭雄, 野口範子, CHAOS [Cambridge Heart Antioxidant Study],日本臨床, 高脂血症(下巻), 59,3, 448-451, 2001
  • 野口範子, ラジカル消去を作用機序とする疾患治療薬,日本病院薬剤師会雑誌, 37,29(205)-31(207), 2001
  • 野口範子, Gombergのフリーラジカル発見から100年,ISOTOPE NEWS, No. 559, 24-28, 2000
  • N. Noguchi, A. Watanabe, H. Shi, Diverse functions of antioxidants. Free Rad. Res., 33, 809-817, 2000
  • N. Noguchi, E. Niki, Phenolic antioxidants: A rationale for design and evaluation of novel antioxidant drug for atherosclerosis. Free Rad. Biol. Med., 28, 1538-1546, 2000
  • 野口範子, 生体にとってフリーラジカルとは何か,ヒューマンサイエンス, 10, 16-18, 1999, ヒューマンサイエンス振興財団
  • N. Noguchi, E. Niki, Dynamics of vitamin E action against LDL oxidation.Free Rad. Res., 28, 561-572, 1998
  • 野口範子, 二木鋭雄, 酸化変性のメカニズム, 治療学, 32, 9-15, 1998, ライフサエンス出版
  • 野口範子, 新規抗酸化物質の設計・合成とその活性評価, 日本油化学会誌, 46, 1167-1174, 1997
  • 野口範子,二木鋭雄, 生体の酸化傷害と防御機構, FRAGNANCE JOURNAL , April, 9-16, 1997
  • 野口範子, 酸化LDL,臨床栄養, 85, NO.7, 802-808, 1994, 医歯薬出版
  • 野口範子, 動脈硬化と過酸化脂質,Geriatric Medicine, 32, No.9, 1047-1053, 1994, ライフサイエンス出版
  • 野口範子, 血管とフリーラジカル, フリーラジカルの臨床, Mebio 11, No.4, 36-42, 1993, メジカルビュー社
  • E. Niki, N. Noguchi, N. Goto, Inhibition of oxidative modification of low dinsity lipoprotein by antioxidants. J. Nutr. Sci. Vitaminol., 39, S1-S8, 1993
  • 野口範子, 動脈硬化, Up date フリーラジカルー基礎と臨床 現代医療 25, 89-95, 1993, 現代医療社
  • E. Niki, N. Noguchi, N. Gotoh, Dynamics of lipid peroxidation and its inhibition by antioxidants. Mechanisms of free radical damage in the vascular and central nervous systems and control by antioxidant intervention, Biochem. Soc. Transact., 21, 313-317,
  • 野口範子,二木鋭雄, LDLの酸化とその抑制,実験医学 10, 42-47, 1992, 羊土社

Works

  • トコフェロールの抗酸化作用
    2000 -2001
  • Antioxidant activity of α-, β-, γ-, δ-tocopherol
    2000 -2001
  • α, γ-トコフェロールとトコトリエノールの抗酸化作用と遺伝子発現制御に関する研究
    2001
  • Study of antioxidant activity and gene expression of α, γ-tocopherol and tocotrienol
    2001
  • にんにく抽出物の抗酸化作用
    1999 -2000
  • Antioxidant activity of extract of garlic
    1999 -2000

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    2013-175612
  • Patent right
    細胞死抑制剤
    2012-242950
  • Patent right
    生体の抗酸化能測定方法
    2011-181963
  • Patent right
    過酸化脂質の測定方法
    2011-260819
  • Patent right
    含硫アミノ残基を含むポリペプチドに対する抗体
    2012-028138
  • Patent right
    内皮細胞防御剤および抗アテローム性動脈硬化剤
    特許2004-11月出願
  • Patent right
    低比重リポタンパクの酸化変性防止剤および抗アテローム性動脈硬化剤
    特許2004-089925
  • Patent right
    低比重リポタンパクの酸化変性防止剤および抗アテローム性動脈硬化剤
    特許2004-150811
  • Patent right
    抗酸化力増強剤
    特許2002-83138
  • Patent right
    細胞の過酸化の分析方法
    特許2000-311821
  • Patent right
    細胞死抑制剤
    第6143435号
  • Patent right
    過酸化脂質の測定方法
    2011-260819
  • Patent right
    含硫アミノ残基を含むポリペプチドに対する抗体
    2012-028138

Research Projects

  • 皮膚細胞を保護するタンパク質の分泌機構の解明と分泌促進因子の探索
    野口 範子
    公益財団法人コスメトロジー研究振興財団, コスメトロジー研究振興財団研究助成, 2017/12 -2019/03, Principal investigator, Competitive research funding
  • コレステロール酸化物が誘導する神経細胞死に対するビタミンEの抑制機構
    野口 範子
    独立法人日本学術振興会, 科学研究費基盤C, 2016 -2019, Principal investigator, Competitive research funding
  • 抗酸化物貭による遺伝子発現制御
    Competitive research funding
  • 活性酵素フリーラジカルによる生体の傷害とその防御機構
    Competitive research funding
  • regulation of gene expression by antioxidants
    Competitive research funding
  • Mechanisms of damage induced by free radicals in vivo and its prevention
    Competitive research funding

Social Contribution

  • World Student Environment Summit, 同志社大学, サミット, 2018/08/26-2018/08/30, Others

Research cooperation among industry, academia and government

  • Joint Research Theme:Regulation of gene expression by vitamin E
    Remarks:Cooperative research with other research organization of universities, etc.
  • Joint Research Theme:Effects of anti-atherogenic drag on different animal species
    Remarks:Cooperative research with other research organization including private (industrial) sectors