NOGUCHI Noriko
Faculty of Life and Medical Sciences Department of Medical Life Systems
Professor
Last Updated :2021/10/23

Researcher Profile and Settings

Research Interests

  • gene expression and regulation
  • Biochemistry

Research Areas

  • Life sciences/Molecular biology
  • Life sciences/Functional biochemistry

Research History

  • 1987-1990 The mechanisms of cytotoxicity of paraquat
  • 1990-1991 Damages of mitochondrial DNA induced by g-irradiation
  • 1991-2001 The mechanisms of free radical mediated damages and its protection by antioxidants
  • 2001- Regulation of gene expression by free radicals and antioxidants

Academic & Professional Experience

  • Research Center for Advanced Science and Technology, The University of Tokyo, 2002 - 2005
  • Research Center for Advanced Science and Technology, The University of Tokyo, 1993 - 2002
  • The Faculty of Engineering, The University of Tokyo, 1991 - 1993
  • School of Medicine, Teikyo University, 1987 - 1990

Education

  • University of Tsukuba, 1987
  • University of Tsukuba, Graduate School, Division of Medicine, 1987
  • University of Tsukuba, 1983
  • University of Tsukuba, Graduate School, Division of Medicine, 1983
  • University of Tsukuba, 1981
  • University of Tsukuba, Second Cluster of College, 1981

Academic Degrees

  • Doctor of Medicine, University of Tsukuba
  • Master of Medical Science, University of Tsukuba

Association Memberships

  • International Society for Free Radical Research

Committee Memberships

  • representative, International Society for Free Radical Research, Academic society, International Society for Free Radical Research

Awards & Honors

  • Young Investigation Award
    1994, International Society for Free Radical Research
  • Outstanding Paper Presentation
    1993, The American Oil Chemists' Society

Published Papers

  • NRF3 upregulates gene expression in SREBP2-dependent mevalonate pathway with cholesterol uptake and lipogenesis inhibition
    Tsuyoshi Waku, Toru Hagiwara, Natsuko Tamura, Yuri Atsumi, Yasuomi Urano, Mikiko Suzuki, Takuya Iwami, Katsuya Sato, Masayuki Yamamoto, Noriko Noguchi, Akira Kobayashi
    Oct. 2021
  • Different functions of vitamin E homologues in the various types of cell death induced by oxysterols
    Atsuki Suzuki, Yasuomi Urano, Tomohisa Ishida, Noriko Noguchi
    Free Radical Biology and Medicine, 176356 - 365, Oct. 2021
  • Identification of a novel endogenous long non-coding RNA that inhibits selenoprotein P translation.
    Yuichiro Mita, Risa Uchida, Sayuri Yasuhara, Kohei Kishi, Takayuki Hoshi, Yoshitaka Matsuo, Tadashi Yokooji, Yoshino Shirakawa, Takashi Toyama, Yasuomi Urano, Toshifumi Inada, Noriko Noguchi, Yoshiro Saito
    Nucleic acids research, 49(12)6893 - 6907, 09 Jul. 2021
  • Antioxidant action of vitamin E in vivo as assessed from its reaction products with multiple biological oxidants.
    Etsuo Niki, Noriko Noguchi
    Free Radic Res, 1 - 33, 2020
  • Astrocytes release glutamate via cystine/glutamate antiporter upregulated in response to increased oxidative stress related to sporadic amyotrophic lateral sclerosis.
    Miku Kazama, Yoichiro Kato, Akiyoshi Kakita, Noriko Noguchi, Yasuomi Urano, Kenta Masui, Motoko Niida-Kawaguchi, Tomoko Yamamoto, Kazuhiko Watabe, Kazuo Kitagawa, Noriyuki Shibata
    Neuropathology, 40587 - 598, 2020
  • 24(S)-Hydroxycholesterol induces ER dysfunction-mediated unconventionall cell death.
    Yasuomi Urano, Diep-Khanh Ho Vo, Hirofumi Araki, Noriko Noguchi
    Cell Death Discov, 5113 , 2019
  • Polymerization of oxidized DJ-1 via noncovalent and covalent binding: Significance of disulfide bond formation.
    Mayuka Kobayashi, Kana Muramatsu, Takamitsu Haruyama, Haruka Uesugi, Ai Kikuchi, Hiroki Konno, Noriko Noguchi, Yoshiro Saito
    ACS Omega, 49603 - 9614, 2019
  • 6-Hydroxydopamine induces secretion of PARK7/DJ-1 via autophagy-based unconventional secretory pathway.
    Yasuomi Urano, Chinatsu Mori, Ayano Fuji, Keito Konno, Takayuki Yamamoto, Shohei Yashirogi, Mayu Ando, Yoshiro Saito, Noriko Noguchi
    Autophagy, 141943 - 1958, 2018
  • Tocopherol suppresses 24(S)-hydroxycholesterol-induced cell death via inhibition of CaMKII phosphorylation.
    Yuki Kimura, Minori Asa, Yasuomi Urano, Yoshiro Saito, Kiyotaka Nishikawa, Noriko Noguchi
    Biochimie, 153203 - 209, 2018
  • Distribution of oxidized DJ-1 in Parkinson’s disease-related sites in the brain and in the peripheral tissues: effects of aging and a neurotoxin.
    Yuichiro Mita, Yuto Kataoka, Yoshiro Saito, Takuma Kashi, Kojiro Hayashi, Asa Iwasaki, Takanori Imanishi, Tomohiro Miyasaka, Noriko Noguchi
    Scientific Reports, 812056 , 2018
  • Hydrogen peroxide-reducing factor released by PC12D cells increases cell tolerance against oxidative stress.
    Asami Muraishi, Emi Haneta, Yoshiro Saito, Yutaka Hitomi, Mamoru Sano, Noriko Noguchi
    Biol.Pharm.Bull., Note,41(5)777 - 785, 2018, Research paper (scientific journal)
  • Oxidation and interaction of DJ-1 with 20S proteasome in the erythrocytes of early stage Parkinson's disease patients
    Yoshiro Saito, Yoko Akazawa-Ogawa, Akihiro Matsumura, Kazumasa Saigoh, Sayoko Itoh, Kenta Sutou, Mayuka Kobayashi, Yuichiro Mita, Mototada Shichiri, Shin Hisahara, Yasuo Hara, Harutoshi Fujimura, Hiroyuki Takamatsu, Yoshihisa Hagihara, Yasukazu Yoshida, Takao Hamakubo, Susumu Kusunoki, Shun Shimohama, Noriko Noguchi
    SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, 630793 , Jul. 2016, English, Research paper (scientific journal)
  • Aβ induces oxidative stress in senescence-accelerated (SAMP8) mice.
    Takagane K, Nojima J, Mitsuhashi H, Suo S, Yanagihara D, Takaiwa F, Urano Y, Noguchi N, Ishiura S
    Bioscience, biotechnology, and biochemistry, 79(6)912 - 918, 2015
  • A? induces oxidative stress in senescence-accelerated (SAMP8) mice.
    Kurara Takagane, Jun Nojima, Hiroaki Mitsuhashi, Satoshi Suo, Dai Yanagihara, Fumio Takaiwa, Yasuomi Urano, Noriko Noguchi, Shoichi Ishiura
    Biosci. Biotech. Biochem., 231 - 7, 2015
  • 7-Hydroxycholestrol as a possible biomarker of cellular lipid peroxidation: Difference between cellular and plasma lipid peroxidation
    Yoshiro Saito, Noriko Noguchi
    Biochemical and Biophysical Research Communications, 446741 - 744, 11 Apr. 2014
  • Chronic oxidative stress causes amplification and overexpression of ptprz1 protein tyrosine phosphatase to activate beta-catenin pathway
    Yu-Ting Liu, Donghao Shang, Shinya Akatsuka, Hiroki Ohara, Khokon Kumar Dutta, Katsura Mizushima, Yuji Naito, Toshikazu Yoshikawa, Masashi Izumiya, Kouichiro Abe, Hitoshi Nakagama, Noriko Noguchi, Shinya Toyokuni
    AMERICAN JOURNAL OF PATHOLOGY, AMER SOC INVESTIGATIVE PATHOLOGY, INC, 171(6)1978 - 1988, Dec. 2007, English, Research paper (scientific journal)
  • 15-deoxy-Delta(12,14)-prostaglandin J(2): The endogenous electrophile that induces neuronal apoptosis
    M Kondo, T Shibata, T Kumagai, T Osawa, N Shibata, M Kobayashi, S Sasaki, M Iwata, N Noguchi, K Uchida
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, 99(11)7367 - 7372, May 2002, English, Research paper (scientific journal)
  • Gene expression induced by BO-653, probucol and BHQ in human endothelial cells.
    W. Takabe, C. Mataki, Y. Wada, M. Ishii, A Izumi, H. Aburatani, T. Hamakubo, E. Niki, T. Kodama, N. Noguchi
    J. Atheroscler. Thromb., 7223 - 230, 2000
  • 2,2'-azobis (4-methoxy-2,4-dimethylvaleronitrile), a new lipid-soluble azo initiator: Application to oxidations of lipids and low-density lipoprotein in solution and in aqueous dispersions
    N Noguchi, H Yamashita, N Gotoh, Y Yamamoto, R Numano, E Niki
    FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, 24(2)259 - 268, Jan. 1998, English, Research paper (scientific journal)
  • イチョウ葉エキスの抗酸化作用.
    野口範子, 西野公大, 鷲尾英一, 石 紅朕, 陳 京生, 二木鋭雄
    J. Jpn. Oil Chem. Soc., 121481 - 1488, 1997
  • INTERACTION AMONG VITAMIN-C, VITAMIN-E, AND BETA-CAROTENE
    E NIKI, N NOGUCHI, H TSUCHIHASHI, N GOTOH
    AMERICAN JOURNAL OF CLINICAL NUTRITION, AMER SOC NUTRITION-ASN, 62(6)1322 - 1326, Dec. 1995, English, Research paper (scientific journal)
  • Action of curcumin as an antioxidant against lipid peroxidation.
    N. Noguchi, E. Komuro, E. Niki, R. L. Willson
    J. Jpn. Oil Chem. Soc., 431045 - 1051, 1994
  • Curcumin Derivative GT863 Inhibits Amyloid-Beta Production via Inhibition of Protein N-Glycosylation.
    Yasuomi Urano, Mina Takahachi, Ryo Higashiura, Hitomi Fujiwara, Satoru Funamoto, So Imai, Eugene Futai, Michiaki Okuda, Hachiro Sugimoto, Noriko Noguchi
    Cells, 9(2), 03 Feb. 2020, English
  • Soluble iron accumulation induces microglial glutamate release in the spinal cord of sporadic amyotrophic lateral sclerosis.
    Motoko Niida-Kawaguchi, Akiyoshi Kakita, Noriko Noguchi, Miku Kazama, Kenta Masui, Yoichiro Kato, Tomoko Yamamoto, Tatsuo Sawada, Kazuo Kitagawa, Kazuhiko Watabe, Noriyuki Shibata
    Neuropathology : official journal of the Japanese Society of Neuropathology, 28 Dec. 2019, English
  • Brain Targeting of Acyl-CoA:Cholesterol O-Acyltransferase-1 Inhibitor K-604 via the Intranasal Route Using a Hydroxycarboxylic Acid Solution.
    Kimiyuki Shibuya, Shigeru Morikawa, Masayoshi Miyamoto, Shin-Ichiro Ogawa, Yoshihiko Tsunenari, Yasuomi Urano, Noriko Noguchi
    ACS omega, 4(16)16943 - 16955, 15 Oct. 2019, English
  • Comparison of Human Selenoprotein P Determinants in Serum between Our Original Methods and Commercially Available Kits
    Yoshiro Saito, Hirofumi Misu, Hiroaki Takayama, Shin-ichiro Takashima, Soichiro Usui, Masayuki Takamura, Shuichi Kaneko, Toshinari Takamura, Noriko Noguchi
    Biological and Pharmaceutical Bulletin, Pharmaceutical Society of Japan, 41(5)828 - 832, 01 May 2018, Research paper (scientific journal)
  • Diagnosis of Parkinson's disease and the level of oxidized DJ-1 protein.
    Yuko Yamagishi, Kazumasa Saigoh, Yoshiro Saito, Ikuko Ogawa, Yoshiyuki Mitsui, Yukihiro Hamada, Makoto Samukawa, Hidekazu Suzuki, Motoi Kuwahara, Makito Hirano, Noriko Noguchi, Susumu Kusunoki
    Neuroscience research, 12858 - 62, Mar. 2018, English
  • Pleckstrin homology domain of p210 BCR-ABL interacts with cardiolipin to regulate its mitochondrial translocation and subsequent mitophagy
    Kentaro Shimasaki, Miho Watanabe-Takahashi, Masato Umeda, Satoru Funamoto, Yoshiro Saito, Noriko Noguchi, Keigo Kumagai, Kentaro Hanada, Fujiko Tsukahara, Yoshiro Maru, Norihito Shibata, Mikihiko Naito, Kiyotaka Nishikawa
    Genes to Cells, Wiley, 23(1)22 - 34, Jan. 2018, Research paper (scientific journal)
  • Selenoprotein P-neutralizing antibodies improve insulin secretion and glucose sensitivity in type 2 diabetes mouse models
    Yuichiro Mita, Kaho Nakayama, Shogo Inari, Yukina Nishito, Yuya Yoshioka, Naoko Sakai, Kanade Sotani, Takahiro Nagamura, Yuki Kuzuhara, Kumi Inagaki, Miki Iwasaki, Hirofumi Misu, Masaya Ikegawa, Toshinari Takamura, Noriko Noguchi, Yoshiro Saito
    NATURE COMMUNICATIONS, NATURE PUBLISHING GROUP, 81658 , Nov. 2017, English, Research paper (scientific journal)
  • Effect of vitamin E on 24(S)-hydroxycholesterol-induced necroptosis-like cell death and apoptosis
    Takaya Nakazawa, Yuta Miyanoki, Yasuomi Urano, Madoka Uehara, Yoshiro Saito, Noriko Noguchi
    JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, PERGAMON-ELSEVIER SCIENCE LTD, 16969 - 76, May 2017, English, Research paper (scientific journal)
  • Deficiency of the hepatokine selenoprotein P increases responsiveness to exercise in mice through upregulation of reactive oxygen species and AMP-activated protein kinase in muscle
    Hirofumi Misu, Hiroaki Takayama, Yoshiro Saito, Yuichiro Mita, Akihiro Kikuchi, Kiyo-aki Ishii, Keita Chikamoto, Takehiro Kanamori, Natsumi Tajima, Fei Lan, Yumie Takeshita, Masao Honda, Mutsumi Tanaka, Seiji Kato, Naoto Matsuyama, Yuya Yoshioka, Kaito Iwayama, Kumpei Tokuyama, Nobuhiko Akazawa, Seiji Maeda, Kazuhiro Takekoshi, Seiichi Matsugo, Noriko Noguchi, Shuichi Kaneko, Toshinari Takamura
    NATURE MEDICINE, NATURE PUBLISHING GROUP, 23(4)508 - +, Apr. 2017, English, Research paper (scientific journal)
  • Interleukin-27 Enhances the Potential of Reactive Oxygen Species Generation from Monocyte-derived Macrophages and Dendritic cells by Induction of p47(phox)
    Bharatwaj Sowrirajan, Yoshiro Saito, Deepak Poudyal, Qian Chen, Hongyan Sui, Suk See DeRavin, Hiromi Imamichi, Toyotaka Sato, Douglas B. Kuhns, Noriko Noguchi, Harry L. Malech, H. Clifford Lane, Tomozumi Imamichi
    SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, 743441 , Feb. 2017, English, Research paper (scientific journal)
  • Decrease of Amyloid-beta Levels by Curcumin Derivative via Modulation of Amyloid-beta Protein Precursor Trafficking
    Rina Kotani, Yasuomi Urano, Hachiro Sugimoto, Noriko Noguchi
    JOURNAL OF ALZHEIMERS DISEASE, IOS PRESS, 56(2)529 - 542, 2017, English, Research paper (scientific journal)
  • Esterification of 24S-OHC induces formation of atypical lipid droplet-like structures, leading to neuronal cell death
    Wakako Takabe, Yasuomi Urano, Diep-Khanh Ho Vo, Kimiyuki Shibuya, Masaki Tanno, Hiroaki Kitagishi, Toyoshi Fujimoto, Noriko Noguchi
    JOURNAL OF LIPID RESEARCH, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 57(11)2005 - 2014, Nov. 2016, English, Research paper (scientific journal)
  • Oxidized Lipoprotein as a Major Vessel Cell Proliferator in Oxidized Human Serum
    Yoshiro Saito, Noriko Noguchi
    PLOS ONE, PUBLIC LIBRARY SCIENCE, 11(8), Aug. 2016, English, Research paper (scientific journal)
  • Synthesis of 24(S)-hydroxycholesterol esters responsible for the induction of neuronal cell death
    Kimiyuki Shibuya, Toshiaki Watanabe, Yasuomi Urano, Wakako Takabe, Noriko Noguchi, Hiroaki Kitagishi
    BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON-ELSEVIER SCIENCE LTD, 24(11)2559 - 2566, Jun. 2016, English, Research paper (scientific journal)
  • The protective role of DJ-1 in ultraviolet-induced damage of human skin: DJ-1 levels in the stratum corneum as an indicator of antioxidative defense
    Shioji Ishiwatari, Minako Takahashi, Chie Yasuda, Maho Nakagawa, Yoshiro Saito, Noriko Noguchi, Shoko Matsukuma
    ARCHIVES OF DERMATOLOGICAL RESEARCH, SPRINGER, 307(10)925 - 935, Dec. 2015, English, Research paper (scientific journal)
  • Enhancement of lipid peroxidation and its amelioration by vitamin E in a subject with mutations in the SBP2 gene
    Yoshiro Saito, Mototada Shichiri, Takashi Hamajima, Noriko Ishida, Yuichiro Mita, Shohei Nakao, Yoshihisa Hagihara, Yasukazu Yoshida, Kazuhiko Takahashi, Etsuo Niki, Noriko Noguchi
    JOURNAL OF LIPID RESEARCH, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 56(11)2172 - 2182, Nov. 2015, English, Research paper (scientific journal)
  • New aspects of 24(S)-hydroxycholesterol in modulating neuronal cell death
    Noriko Noguchi, Yasuomi Urano, Wakako Takabe, Yoshiro Saito
    FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, 87366 - 372, Oct. 2015, English
  • Lysophosphatidylcholine promotes SREBP-2 activation via rapid cholesterol efflux and SREBP-2-independent cytokine release in human endothelial cells
    Mayuko Morita, Azusa Sekine, Yasuomi Urano, Taki Nishimura, Wakako Takabe, Hiroyuki Arai, Takao Hamakubo, Tatsuhiko Kodama, Noriko Noguchi
    JOURNAL OF BIOCHEMISTRY, OXFORD UNIV PRESS, 158(4)331 - 338, Oct. 2015, English, Research paper (scientific journal)
  • 24(S)-Hydroxycholesterol induces RIPK1-dependent but MLKL-independent cell death in the absence of caspase-8
    Diep-Khanh Ho Vo, Yasuomi Urano, Wakako Takabe, Yoshiro Saito, Noriko Noguchi
    STEROIDS, ELSEVIER SCIENCE INC, 99230 - 237, Jul. 2015, English, Research paper (scientific journal)
  • Functional interaction between cyclooxygenase-2 and p53 in response to an endogenous electrophile
    Takeshi Kumagai, Hiroko Usami, Nao Matsukawa, Fumie Nakashima, Miho Chikazawa, Takahiro Shibata, Noriko Noguchi, Koji Uchida
    REDOX BIOLOGY, ELSEVIER SCIENCE BV, 474 - 86, Apr. 2015, English, Research paper (scientific journal)
  • Immunostaining of Oxidized DJ-1 in Human and Mouse Brains
    Yoshiro Saito, Tomohiro Miyasaka, Hiroyuki Hatsuta, Kazuko Takahashi-Niki, Kojiro Hayashi, Yuichiro Mita, Osamu Kusano-Arai, Hiroko Iwanari, Hiroyoshi Ariga, Takao Hamakubo, Yasukazu Yoshida, Etsuo Niki, Shigeo Murayama, Yasuo Ihara, Noriko Noguchi
    JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, LIPPINCOTT WILLIAMS & WILKINS, 73(7)714 - 728, Jul. 2014, English, Research paper (scientific journal)
  • Diverse functions of 24(S)-hydroxycholesterol in the brain
    Noriko Noguchi, Yoshiro Saito, Yasuomi Urano
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, 446(3)692 - 696, Apr. 2014, English
  • The significance of oxidized DJ-1 protein (oxDJ-1) as a biomarker for parkinson's disease
    Ikuko Ogawa, Yoshiro Saito, Kazumasa Saigoh, Yoshie Hosoi, Yoshiyuki Mitsui, Noriko Noguchi, Susumu Kusunoki
    Brain and Nerve, Igaku-Shoin Ltd, 66(4)471 - 477, 2014, Japanese, Research paper (scientific journal)
  • Induction of apoptosis and necroptosis by 24(S)-hydroxycholesterol is dependent on activity of acyl-CoA: cholesterol acyltransferase 1
    K. Yamanaka, Y. Urano, W. Takabe, Y. Saito, N. Noguchi
    CELL DEATH & DISEASE, NATURE PUBLISHING GROUP, 5e990 , Jan. 2014, English, Research paper (scientific journal)
  • Adaptive responses induced by 24S-hydroxycholesterol through liver X receptor pathway reduce 7-ketocholesterol-caused neuronal cell death
    Akishi Okabe, Yasuomi Urano, Sayoko Itoh, Naoto Suda, Rina Kotani, Yuki Nishimura, Yoshiro Saito, Noriko Noguchi
    REDOX BIOLOGY, ELSEVIER SCIENCE BV, 228 - 35, 2014, English, Research paper (scientific journal)
  • Suppression of amyloid-β production by 24S-hydroxycholesterol via inhibition of intracellular amyloid precursor protein trafficking
    Yasuomi Urano, Sachika Ochiai, Noriko Noguchi
    FASEB Journal, FASEB, 27(10)4305 - 4315, 01 Oct. 2013, English, Research paper (scientific journal)
  • Suppression of amyloid-beta production by 24S-hydroxycholesterol via inhibition of intracellular amyloid precursor protein trafficking
    Yasuomi Urano, Sachika Ochiai, Noriko Noguchi
    FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, 27(10)4305 - 4315, Oct. 2013, English, Research paper (scientific journal)
  • Deficiency of p62/Sequestosome 1 Causes Hyperphagia Due to Leptin Resistance in the Brain
    Harumi Harada, Eiji Warabi, Taizo Matsuki, Toru Yanagawa, Kosuke Okada, Junya Uwayama, Akira Ikeda, Kazuhiro Nakaso, Kyoko Kirii, Noriko Noguchi, Hiroki Bukawa, Richard C. M. Siow, Giovanni E. Mann, Junichi Shoda, Tetsuro Ishii, Takeshi Sakurai
    JOURNAL OF NEUROSCIENCE, SOC NEUROSCIENCE, 33(37)14767 - 14777, Sep. 2013, English, Research paper (scientific journal)
  • Oxidized DJ-1 Inhibits p53 by Sequestering p53 from Promoters in a DNA-Binding Affinity-Dependent Manner
    Izumi Kato, Hiroshi Maita, Kazuko Takahashi-Niki, Yoshiro Saito, Noriko Noguchi, Sanae M. M. Iguchi-Ariga, Hiroyoshi Ariga
    MOLECULAR AND CELLULAR BIOLOGY, AMER SOC MICROBIOLOGY, 33(2)340 - 359, Jan. 2013, English, Research paper (scientific journal)
  • Nrf2 in bone marrow-derived cells positively contributes to the advanced stage of atherosclerotic plaque formation
    Nobuhiko Harada, Koichi Ito, Tomonori Hosoya, Junsei Mimura, Atsushi Maruyama, Noriko Noguchi, Ken-ichi Yagami, Naoki Morito, Satoru Takahashi, Jon M. Maher, Masayuki Yamamoto, Ken Itoh
    FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, 53(12)2256 - 2262, Dec. 2012, English, Research paper (scientific journal)
  • Enhanced CD36 expression changes the role of Nrf2 activation from anti-atherogenic to pro-atherogenic in apoE-deficient mice
    Hirotaka Sawada, Yoshiro Saito, Noriko Noguchi
    ATHEROSCLEROSIS, ELSEVIER IRELAND LTD, 225(1)83 - 90, Nov. 2012, English, Research paper (scientific journal)
  • Cytoprotective effects of geraniin against peroxynitrite- and peroxyl radical-induced cell death via free radical scavenging activity
    Lai Teng Ling, Yoshiro Saito, Uma D. Palanisamy, Hwee Ming Cheng, Noriko Noguchi
    FOOD CHEMISTRY, ELSEVIER SCI LTD, 132(4)1899 - 1907, Jun. 2012, English, Research paper (scientific journal)
  • A novel fluorescent probe with high sensitivity and selective detection of lipid hydroperoxides in cells
    Kazunori Yamanaka, Yoshiro Saito, Junji Sakiyama, Yuya Ohuchi, Fumio Oseto, Noriko Noguchi
    RSC ADVANCES, ROYAL SOC CHEMISTRY, 2(20)7894 - 7900, 2012, English, Research paper (scientific journal)
  • Oxidation of DJ-1 Induced by 6-Hydroxydopamine Decreasing Intracellular Glutathione
    Akiko Miyama, Yoshiro Saito, Kazunori Yamanaka, Kojiro Hayashi, Takao Hamakubo, Noriko Noguchi
    PLOS ONE, PUBLIC LIBRARY SCIENCE, 6(11)e27883 , Nov. 2011, English, Research paper (scientific journal)
  • Analyses of marine-derived tocopherol in processed foods containing fish
    Naohiro Gotoh, Daisuke Mashimo, Tomiko Oka, Kaori Sekiguchi, Mikiko Tange, Hiroyuki Watanabe, Noriko Noguchi, Shun Wada
    FOOD CHEMISTRY, ELSEVIER SCI LTD, 129(2)279 - 283, Nov. 2011, English, Research paper (scientific journal)
  • Anti-Atherogenic Effect of Laminar Shear Stress via Nrf2 Activation
    Wakako Takabe, Eiji Warabi, Noriko Noguchi
    ANTIOXIDANTS & REDOX SIGNALING, MARY ANN LIEBERT, INC, 15(5)1415 - 1426, Sep. 2011, English
  • Redox Going with Vascular Shear Stress
    Noriko Noguchi, Hanjoong Jo
    ANTIOXIDANTS & REDOX SIGNALING, MARY ANN LIEBERT INC, 15(5)1367 - 1368, Sep. 2011, English
  • 24(S)-Hydroxycholesterol Induces Neuronal Cell Death through Necroptosis, a Form of Programmed Necrosis
    Kazunori Yamanaka, Yoshiro Saito, Tohru Yamamori, Yasuomi Urano, Noriko Noguchi
    JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 286(28)24666 - 24673, Jul. 2011, English, Research paper (scientific journal)
  • Actual ratios of triacylglycerol positional isomers consisting of saturated and highly unsaturated fatty acids in fishes and marine mammals
    Naohiro Gotoh, Yumiko Matsumoto, Toshiharu Nagai, Hoyo Mizobe, Ikuko Otake, Kenji Ichioka, Ikuma Kuroda, Hiroyuki Watanabe, Noriko Noguchi, Shun Wada
    FOOD CHEMISTRY, ELSEVIER SCI LTD, 127(2)467 - 472, Jul. 2011, English, Research paper (scientific journal)
  • alpha-Tocopheryl phosphate: Uptake, hydrolysis, and antioxidant action in cultured cells and mouse
    Keiko Nishio, Noriko Ishida, Yoshiro Saito, Yoko Ogawa-Akazawa, Mototada Shichiri, Yasukazu Yoshida, Yoshihisa Hagihara, Noriko Noguchi, John Chirico, Jeffrey Atkinson, Etsuo Niki
    FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, 50(12)1794 - 1800, Jun. 2011, English, Research paper (scientific journal)
  • Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction
    Akira Kobayashi, Takako Tsukide, Tomohiro Miyasaka, Tomoko Morita, Tatsuya Mizoroki, Yoshiro Saito, Yasuo Ihara, Akihiko Takashima, Noriko Noguchi, Akiyoshi Fukamizu, Yosuke Hirotsu, Makiko Ohtsuji, Fumiki Katsuoka, Masayuki Yamamoto
    GENES TO CELLS, WILEY-BLACKWELL, 16(6)692 - 703, Jun. 2011, English, Research paper (scientific journal)
  • Phosphorylation of p66shc mediates 6-hydroxydopamine cytotoxicity
    Tohru Yamamori, Ayano Mizobata, Yoshiro Saito, Yasuomi Urano, Osamu Inanami, Kaikobad Irani, Noriko Noguchi
    FREE RADICAL RESEARCH, INFORMA HEALTHCARE, 45(3)342 - 350, Mar. 2011, English, Research paper (scientific journal)
  • Cytoprotective effects of vitamin E homologues against glutamate-induced cell death in immature primary cortical neuron cultures: Tocopherols and tocotrienols exert similar effects by antioxidant function
    Yoshiro Saito, Keiko Nishio, Yoko Ogawa Akazawa, Kazunori Yamanaka, Akiko Miyama, Yasukazu Yoshida, Noriko Noguchi, Etsuo Niki
    FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, 49(10)1542 - 1549, Nov. 2010, English, Research paper (scientific journal)
  • Elevation of oxidized DJ-1 in the brain and erythrocytes of Parkinson disease model animals
    Yoko Ogawa Akazawa, Yoshiro Saito, Takao Hamakubo, Yoshinori Masuo, Yasukazu Yoshida, Keiko Nishio, Mototada Shichiri, Tomohiro Miyasaka, Hiroko Iwanari, Yasuhiro Mochizuki, Tatsuhiko Kodama, Noriko Noguchi, Etsuo Niki
    NEUROSCIENCE LETTERS, ELSEVIER IRELAND LTD, 483(3)201 - 205, Oct. 2010, English, Research paper (scientific journal)
  • Enhanced neointimal hyperplasia and carotid artery remodelling in sequestosome 1 deficient mice
    Rika Sugimoto, Eiji Warabi, Satoru Katayanagi, Satoshi Sakai, Junya Uwayama, Toru Yanagawa, Ayaka Watanabe, Harumi Harada, Kiyoshi Kitamura, Noriko Noguchi, Hiroshi Yoshida, Richard C. M. Siow, Giovanni E. Mann, Tetsuro Ishii
    JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, WILEY-BLACKWELL, 14(6B)1546 - 1554, Jun. 2010, English, Research paper (scientific journal)
  • Characterization of Non-endcapped Polymeric ODS Column for the Separation of Triacylglycerol Positional Isomers
    Naohiro Gotoh, Yumiko Matsumoto, Hiromi Yuji, Toshiharu Nagai, Hoyo Mizobe, Kenji Ichioka, Ikuma Kuroda, Noriko Noguchi, Shun Wada
    JOURNAL OF OLEO SCIENCE, JAPAN OIL CHEMISTS SOC, 59(2)71 - 79, Feb. 2010, English, Research paper (scientific journal)
  • An Orally Applicable Shiga Toxin Neutralizer Functions in the Intestine To Inhibit the Intracellular Transport of the Toxin
    Miho Watanabe-Takahashi, Toshio Sato, Taeko Dohi, Noriko Noguchi, Fumi Kano, Masayuki Murata, Takashi Hamabata, Yasuhiro Natori, Kiyotaka Nishikawa
    INFECTION AND IMMUNITY, AMER SOC MICROBIOLOGY, 78(1)177 - 183, Jan. 2010, English, Research paper (scientific journal)
  • Preparation and application of monoclonal antibodies against oxidized DJ-1. Significant elevation of oxidized DJ-1 in erythrocytes of early-stage Parkinson disease patients
    Yoshiro Saito, Takao Hamakubo, Yasukazu Yoshida, Yoko Ogawa, Yasuo Hara, Harutoshi Fujimura, Yasuharu Imai, Hiroko Iwanari, Yasuhiro Mochizuki, Mototada Shichiri, Keiko Nishio, Tomoya Kinumi, Noriko Noguchi, Tatsuhiko Kodama, Etsuo Niki
    NEUROSCIENCE LETTERS, ELSEVIER IRELAND LTD, 465(1)1 - 5, Nov. 2009, English, Research paper (scientific journal)
  • Dietary Marine-Derived Tocopherol has a Higher Biological Availability in Mice Relative to Alpha-Tocopherol
    Naohiro Gotoh, Hiroyuki Watanabe, Tomiko Oka, Daisuke Mashimo, Noriko Noguchi, Kazuhiko Hata, Shun Wada
    LIPIDS, SPRINGER HEIDELBERG, 44(2)133 - 143, Feb. 2009, English, Research paper (scientific journal)
  • Regulation of GCL activity and cellular glutathione through inhibition of ERK phosphorylation
    Zhi-Hua Chen, Yoshiro Saito, Yasukazu Yoshida, Noriko Noguchi, Etsuo Niki
    BIOFACTORS, IOS PRESS, 33(1)1 - 11, 2008, English, Research paper (scientific journal)
  • Protective effects of 15-deoxy-Delta(12,14)-prostaglandin J(2) against glutamate-induced cell death in primary cortical neuron cultures: induction of adaptive response and enhancement of cell tolerance primarily through up-regulation of cellular glutathione
    Yoshiro Saito, Keiko Nishio, Yumiko Numakawa, Yoko Ogawa, Yasukazu Yoshida, Noriko Noguchi, Etsuo Niki
    JOURNAL OF NEUROCHEMISTRY, BLACKWELL PUBLISHING, 102(5)1625 - 1634, Sep. 2007, English, Research paper (scientific journal)
  • Nrf2-dependent and -independent induction of ABC transporters ABCC1, ABCC2, and ABCG2 in HepG2 cells under oxidative stress
    Tatsuhiko Adachi, Hiroshi Nakagawa, Ivy Chung, Yuichiro Hagiya, Kazuyuki Hoshijima, Noriko Noguchi, Macus Tien Kuo, Toshihisa Ishikawa
    Journal of Experimental Therapeutics and Oncology, 6(4)335 - 348, 2007, English, Research paper (scientific journal)
  • Shear stress stabilizes NF-E2-related factor 2 and induces antioxidant genes in endothelial cells: Role of reactive oxygen/nitrogen species
    Eiji Warabi, Wakako Takabe, Takashi Minami, Kenji Inoue, Ken Itoh, Masayuki Yamamoto, Tetsuro Ishii, Tatsuhiko Kodama, Noriko Noguchi
    FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, 42(2)260 - 269, Jan. 2007, English, Research paper (scientific journal)
  • alpha-Tocopherol induces calnexin in renal tubular cells: Another protective mechanism against free radical-induced cellular damage
    Wen-Hua Lee, Shinya Akatsuka, Tomoyuki Shirase, Khokon Kumar Dutta, Li Jiang, Yu-Ting Liu, Janice Onuki, Yoshihiro Yamada, Katsuya Okawa, Youichiro Wada, Akira Watanabe, Takahide Kohro, Noriko Noguchi, Shinya Toyokuni
    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, ELSEVIER SCIENCE INC, 453(2)168 - 178, Sep. 2006, English, Research paper (scientific journal)
  • Turning point in apoptosis/necrosis induced by hydrogen peroxide
    Yoshiro Saito, Keiko Nishio, Yoko Ogawa, Junko Kimata, Tomoya Kinumi, Yasukazu Yoshida, Noriko Noguchi, Etsuo Niki
    FREE RADICAL RESEARCH, TAYLOR & FRANCIS LTD, 40(6)619 - 630, Jun. 2006, English, Research paper (scientific journal)
  • Activation of mitogen-activated protein kinases by lysophosphatidylcholine-induced mitochondrial reactive oxygen species generation in endothelial cells
    N Watanabe, JW Zmijewski, W Takabe, M Umezu-Goto, C Le Goffe, A Sekine, A Landar, A Watanabe, J Aoki, H Arai, T Kodama, MP Murphy, R Kalyanaraman, VM Darley-Usmar, N Noguchi
    AMERICAN JOURNAL OF PATHOLOGY, AMER SOC INVESTIGATIVE PATHOLOGY, INC, 168(5)1737 - 1748, May 2006, English, Research paper (scientific journal)
  • Induction of Adaptive Response and Enhancement of PC12 Cell Tolerance by 7-Hydroxycholesterol and 15-Deoxy-Delta(12,14)-Prostaglandin J(2) through Up-regulation of Cellular Glutathione via Different Mechanisms
    Zhi-Hua Chen, Yasukazu Yoshida, Yoshiro Saito, Azusa Sekine, Noriko Noguchi, Etsuo Niki
    JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 281(20)14440 - 14445, May 2006, English, Research paper (scientific journal)
  • Adaptive response induced by lipid peroxidation products in cell cultures
    ZH Chen, Y Yoshida, Y Saito, N Noguchi, E Niki
    FEBS LETTERS, ELSEVIER SCIENCE BV, 580(2)479 - 483, Jan. 2006, English, Research paper (scientific journal)
  • Chemical structure-dependent gene expression of proteasome subunits via regulation of the antioxidant response element
    W Takabe, N Matsukawa, T Kodama, K Tanaka, N Noguchi
    FREE RADICAL RESEARCH, TAYLOR & FRANCIS LTD, 40(1)21 - 30, Jan. 2006, English, Research paper (scientific journal)
  • 4-Hydroxynonenal induces adaptive response and enhances PC12 cell tolerance primarily through induction of thioredoxin reductase 1 via activation of Nrf2
    ZH Chen, Y Saito, Y Yoshida, A Sekine, N Noguchi, E Niki
    JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 280(51)41921 - 41927, Dec. 2005, English, Research paper (scientific journal)
  • Lipid peroxidation: Mechanisms, inhibition, and biological effects
    E Niki, Y Yoshida, Y Saito, N Noguchi
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, 338(1)668 - 676, Dec. 2005, English
  • Tumor suppressive effects of tocotrienol in vivo and in vitro
    S Wada, Y Satomi, M Murakoshi, N Noguchi, T Yoshikawa, H Nishino
    CANCER LETTERS, ELSEVIER IRELAND LTD, 229(2)181 - 191, Nov. 2005, English, Research paper (scientific journal)
  • Inhibition of cholesterol biosynthesis by 25-hydroxycholesterol is independent of OSBP
    T Nishimura, T Inoue, N Shibata, A Sekine, W Takabe, N Noguchi, H Arai
    GENES TO CELLS, BLACKWELL PUBLISHING, 10(8)793 - 801, Aug. 2005, English, Research paper (scientific journal)
  • Differential responses of the Nrf2-Keap1 system to laminar and oscillatory shear stresses in endothelial cells
    T Hosoya, A Maruyama, MI Kang, Y Kawatani, T Shibata, K Uchida, K Itoh, M Yamamoto
    JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 280(29)27244 - 27250, Jul. 2005, English, Research paper (scientific journal)
  • A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis
    M Anai, N Shojima, H Katagiri, T Ogihara, H Sakoda, Y Onishi, H Ono, M Fujishiro, Y Fukushima, N Horike, A Viana, M Kikuchi, N Noguchi, S Takahashi, K Takata, Y Oka, Y Uchijima, H Kurihara, T Asano
    JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 280(18)18525 - 18535, May 2005, English, Research paper (scientific journal)
  • Tocotrienols reduce 25-hydroxycholesterol-induced monocyte-endothelial cell interaction by inhibiting the surface expression of adhesion molecules
    Y Naito, M Shimozawa, M Kuroda, N Nakabe, H Manabe, K Katada, S Kokura, H Ichikawa, N Yoshida, N Noguchi
    ATHEROSCLEROSIS, ELSEVIER IRELAND LTD, 180(1)19 - 25, May 2005, English, Research paper (scientific journal)
  • Association of active gamma-secretase complex with lipid rafts
    Y Urano, Hayashi, I, N Isoo, PC Reid, Y Shibasaki, N Noguchi, T Tomita, T Iwatsubo, T Hamakubo, T Kodama
    JOURNAL OF LIPID RESEARCH, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 46(5)904 - 912, May 2005, English, Research paper (scientific journal)
  • Expression of the LXR alpha protein in human atherosclerotic lesions
    Y Watanabe, SY Jiang, W Takabe, R Ohashi, T Tanaka, Y Uchiyama, K Katsumi, H Iwanari, N Noguchi, M Naito, T Hamakubo, T Kodama
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, LIPPINCOTT WILLIAMS & WILKINS, 25(3)622 - 627, Mar. 2005, English, Research paper (scientific journal)
  • Activation of map kinases by lysophosphatidylcholine-induced mitochondrial reactive oxygen species generation in endothelial cells
    N Watanabe, J Zmijewski, C Le Goffe, A Landar, W Takabe, M Murphy, R Kalyanaraman, N Noguchi, Darley-Usmar, V
    FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, 39S80 - S80, 2005, English
  • 4-hydroxynonenal induces adaptive response and enhances PC12 cell tolerance primarily through induction of thioredoxin reductase 1 via activation of NRF2
    ZH Chen, Y Saito, Y Yoshida, A Sekine, N Noguchi, E Niki
    FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, 39S69 - S69, 2005, English
  • Vascular endothelial growth factor-and thrombin-induced termination factor, down syndrome critical region-1, attenuates endothelial cell proliferation and angiogenesis
    T Minami, K Horiuchi, M Miura, MR Abid, W Takabe, N Noguchi, T Kohro, XJ Ge, H Aburatani, T Hamakubo, T Kodama, WC Aird
    JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 279(48)50537 - 50554, Nov. 2004, English, Research paper (scientific journal)
  • Inhibition of plasma lipid peroxidation by anti-atherogenic antioxidant BO-653, 2,3-dihydro-5-hydroxy-4,6-di-tert-butyl-2,2-dipentylbenzofuran
    N Itoh, Y Yoshida, M Hayakawa, N Noguchi, T Kodama, O Cynshi, E Niki
    BIOCHEMICAL PHARMACOLOGY, PERGAMON-ELSEVIER SCIENCE LTD, 68(5)813 - 818, Sep. 2004, English, Research paper (scientific journal)
  • Effect on endothelial cell gene expression of shear stress, oxygen concentration, and low-density lipoprotein as studied by a novel flow cell culture system
    E Warabi, Y Wada, H Kajiwara, M Kobayashi, N Koshiba, T Hisada, M Shibata, J Ando, M Tsuchiya, T Kodama, N Noguchi
    FREE RADICAL BIOLOGY AND MEDICINE, PERGAMON-ELSEVIER SCIENCE LTD, 37(5)682 - 694, Sep. 2004, English, Research paper (scientific journal)
  • Lysophosphatidylcholine enhances cytokine production of endothelial cells via induction of L-type amino acid transporter 1 and cell surface antigen 4F2
    W Takabe, Y Kanai, A Chairoungdua, N Shibata, S Toi, M Kobayashi, T Kodama, N Noguchi
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, LIPPINCOTT WILLIAMS & WILKINS, 24(9)1640 - 1645, Sep. 2004, English, Research paper (scientific journal)
  • Oxidative stress induces insulin resistance by activating the nuclear factor-kappa B pathway and disrupting normal subcellular distribution of phosphatidylinositol 3-kinase
    T Ogihara, T Asano, H Katagiri, H Sakoda, M Anai, N Shojima, H Ono, M Fujishiro, A Kushiyama, Y Fukushima, M Kikuchi, N Noguchi, H Aburatani, Y Gotoh, Komuro, I, T Fujita
    DIABETOLOGIA, SPRINGER-VERLAG, 47(5)794 - 805, May 2004, English, Research paper (scientific journal)
  • Quantification Method for Triglyceride Molecular Species in Fish Oil with High Performance Liquid Chromatography-Ultraviolet Detector
    Tomoko Aoki, Ikuko Otake, Naohiro Gotoh, Noriko Noguchi, Shun Wada
    Journal of Oleo Science, 53(6)285 - 294, 2004, English, Research paper (scientific journal)
  • Dynamics of antioxidant action of vitamin E
    E Niki, N Noguchi
    ACCOUNTS OF CHEMICAL RESEARCH, AMER CHEMICAL SOC, 37(1)45 - 51, Jan. 2004, English
  • A novel method of following oxidation of low-density lipoprotein using a sensitive fluorescent probe, diphenyl-1-pyrenylphosphine
    Y Okimoto, E Warabi, Y Wada, E Niki, T Kodama, N Noguchi
    FREE RADICAL BIOLOGY AND MEDICINE, PERGAMON-ELSEVIER SCIENCE LTD, 35(6)576 - 585, Sep. 2003, English, Research paper (scientific journal)
  • Inhibition of THP-1 cell adhesion to endothelial cells by alpha-tocopherol and alpha-tocotrienol is dependent on intracellular concentration of the antioxidants
    N Noguchi, R Hanyu, A Nonaka, Y Okimoto, T Kodama
    FREE RADICAL BIOLOGY AND MEDICINE, PERGAMON-ELSEVIER SCIENCE LTD, 34(12)1614 - 1620, Jun. 2003, English, Research paper (scientific journal)
  • Comparative study on the action of tocopherols and tocotrienols as antioxidant: chemical and physical effects
    Y Yoshida, E Niki, N Noguchi
    CHEMISTRY AND PHYSICS OF LIPIDS, ELSEVIER SCI IRELAND LTD, 123(1)63 - 75, Mar. 2003, English, Research paper (scientific journal)
  • Angiotensin II-induced insulin resistance is associated with enhanced insulin signaling
    T Ogihara, T Asano, K Ando, Y Chiba, H Sakoda, M Anai, N Shojima, H Ono, Y Onishi, M Fujishiro, H Katagiri, Y Fukushima, M Kikuchi, N Noguchi, H Aburatani, Komuro, I, T Fujita
    HYPERTENSION, LIPPINCOTT WILLIAMS & WILKINS, 40(6)872 - 879, Dec. 2002, English, Research paper (scientific journal)
  • Novel insights into the molecular mechanisms of the antiatherosclerotic properties of antioxidants: The alternatives to radical scavenging
    N Noguchi
    FREE RADICAL BIOLOGY AND MEDICINE, PERGAMON-ELSEVIER SCIENCE LTD, 33(11)1480 - 1489, Dec. 2002, English
  • Antioxidant action of 2,2,4,6-tetra-substituted 2,3-dihydro-5-hydroxybenzofuran against lipid peroxidation: Effects of substituents and side chain
    Y Yoshida, N Noguchi, A Watanabe, Y Iwaki, M Yanagisawa, T Kodama, O Cynshi, E Niki
    FREE RADICAL RESEARCH, TAYLOR & FRANCIS LTD, 36(11)1171 - 1178, Nov. 2002, English, Research paper (scientific journal)
  • Lipid accumulation in smooth muscle cells under LDL loading is independent of LDL receptor pathway and enhanced by hypoxic conditions
    Y Wada, A Sugiyama, T Yamamoto, M Naito, N Noguchi, S Yokoyama, M Tsujita, Y Kawabe, M Kobayashi, A Izumi, T Kohro, T Tanaka, H Taniguchi, H Koyama, K Hirano, S Yamashita, Y Matsuzawa, E Niki, T Hamakubo, T Kodama
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, LIPPINCOTT WILLIAMS & WILKINS, 22(10)1712 - 1719, Oct. 2002, English, Research paper (scientific journal)
  • Effects of antioxidants against atherosclerosis
    E Niki, N Noguchi
    MOLECULAR AND CELLULAR BIOCHEMISTRY, KLUWER ACADEMIC PUBL, 234(1)19 - 25, May 2002, English, Research paper (scientific journal)
  • The specificity of lipoxygenase-catalyzed lipid peroxidation and the effects of radical-scavenging antioxidants
    N Noguchi, H Yamashita, J Hamahara, A Nakamura, H Kuhn, E Niki
    BIOLOGICAL CHEMISTRY, WALTER DE GRUYTER & CO, 383(3-4)619 - 626, Mar. 2002, English, Research paper (scientific journal)
  • Oxidized low density lipoprotein-induced LFA-1-dependent adhesion and transendothelial migration of monocytes via the protein kinase C pathway
    S Mine, T Tabata, Y Wada, T Fujisaki, T Iida, N Noguchi, E Niki, T Kodama, Y Tanaka
    ATHEROSCLEROSIS, ELSEVIER SCI IRELAND LTD, 160(2)281 - 288, Feb. 2002, English, Research paper (scientific journal)
  • Specificity and inhibition by antioxidant of lipid peroxidation by lipoxygenase: effects of substrate, lipoxygenase and milieu
    N Noguchi, H Yamashita, H Kuhn, E Niki
    OXYGEN AND LIFE: OXYGENASES, OXIDASE AND LIPID MEDIATORS, ELSEVIER SCIENCE BV, 1233355 - 356, 2002, English, Research paper (international conference proceedings)
  • Ebselen, a glutathione peroxidase mimetic seleno-organic compound, as a multifunctional antioxidant - Implication for inflammation-associated carcinogenesis
    Y Nakamura, Q Feng, T Kumagai, K Torikai, H Ohigashi, T Osawa, N Noguchi, E Niki, K Uchida
    JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 277(4)2687 - 2694, Jan. 2002, English, Research paper (scientific journal)
  • Formation of active oxygen species and lipid peroxidation induced by hypochlorite
    N Noguchi, A Nakada, Y Itoh, A Watanabe, E Niki
    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, ACADEMIC PRESS INC ELSEVIER SCIENCE, 397(2)440 - 447, Jan. 2002, English, Research paper (scientific journal)
  • In vivo complex formation of oxidized alpha(1)-antitrypsin and LDL
    S Mashiba, Y Wada, M Takeya, A Sugiyama, T Hamakubo, A Nakamura, N Noguchi, E Niki, A Izumi, M Kobayashi, K Uchida, T Kodama
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, LIPPINCOTT WILLIAMS & WILKINS, 21(11)1801 - 1808, Nov. 2001, English, Research paper (scientific journal)
  • Anti-atherogenic antioxidants regulate the expression and function of proteasome alpha-type subunits in human endothelial cells
    W Takabe, T Kodama, T Hamakubo, K Tanaka, T Suzuki, H Aburatani, N Matsukawa, N Noguchi
    JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 276(44)40497 - 40501, Nov. 2001, English, Research paper (scientific journal)
  • Oxidative stress promotes the development of transformation: involvement of a potent mutagenic lipid peroxidation product, acrolein
    W Takabe, E Niki, K Uchida, S Yamada, K Satoh, N Noguchi
    CARCINOGENESIS, OXFORD UNIV PRESS, 22(6)935 - 941, Jun. 2001, English, Research paper (scientific journal)
  • New Functions of 20-Hydroxyecdysone in Lipid Peroxidation
    Alexander I. Kuzmenko, Etsuo Niki, Noriko Noguchi
    Journal of Oleo Science, 50(6)497 - 506, 2001, English, Research paper (scientific journal)
  • Role of myeloperoxidase in the neutrophil-induced oxidation of low density lipoprotein as studied by myeloperoxidase-knockout mouse
    N Noguchi, K Nakano, Y Aratani, H Koyama, T Kodama, E Niki
    JOURNAL OF BIOCHEMISTRY, JAPANESE BIOCHEMICAL SOC, 127(6)971 - 976, Jun. 2000, English, Research paper (scientific journal)
  • A novel fluorescent probe diphenyl-1-pyrenylphosphine to follow lipid peroxidation in cell membranes
    Y Okimoto, A Watanabe, E Niki, T Yamashita, N Noguchi
    FEBS LETTERS, ELSEVIER SCIENCE BV, 474(2-3)137 - 140, Jun. 2000, English, Research paper (scientific journal)
  • Stability and reactivity of aryloxyl radicals derived from a novel antioxidant BO-653 and related compounds. Effects of substituent and side chain in solution and membranes
    A Watanabe, N Noguchi, A Fujisawa, T Kodama, K Tamura, O Cynshi, E Niki
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMER CHEMICAL SOC, 122(23)5438 - 5442, Jun. 2000, English, Research paper (scientific journal)
  • Phenolic antioxidants: A rationale for design and evaluation of novel antioxidant drug for atherosclerosis
    Noriko Noguchi, Etsuo Niki
    Free Radical Biology and Medicine, 28(10)1538 - 1546, 15 May 2000, English, Research paper (international conference proceedings)
  • Antioxidant action, of the antihypertensive drug, carvedilol, against lipid peroxidation
    N Noguchi, K Nishino, E Niki
    BIOCHEMICAL PHARMACOLOGY, PERGAMON-ELSEVIER SCIENCE LTD, 59(9)1069 - 1076, May 2000, English, Research paper (scientific journal)
  • Inhibition of c-jun expression induces antioxidant enzymes under serum deprivation
    YH Kim, M Takahashi, N Noguchi, E Suzuki, K Suzuki, N Taniguchi, E Niki
    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, ACADEMIC PRESS INC, 374(2)339 - 346, Feb. 2000, English, Research paper (scientific journal)
  • Diverse functions of antioxidants
    N. Noguchi, A. Watanabe, H. Shi
    Free Radical Research, 33(6)809 - 817, 2000, English
  • 1-Methyl-4-phenyl-2,3-dihydropyridinium is transformed by ubiquinone to the selective nigrostriatal toxin 1-methyl-4-phenylpyridinium
    HL Shi, N Noguchi, YX Xu, E Niki
    FEBS LETTERS, ELSEVIER SCIENCE BV, 461(3)196 - 200, Nov. 1999, English, Research paper (scientific journal)
  • An in vitro coculture model of transmigrant monocytes and foam cell formation
    M Takaku, Y Wada, K Jinnouchi, M Takeya, K Takahashi, H Usuda, M Naito, H Kurihara, Y Yazaki, Y Kumazawa, Y Okimoto, M Umetani, N Noguchi, E Niki, T Hamakubo, T Kodama
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, LIPPINCOTT WILLIAMS & WILKINS, 19(10)2330 - 2339, Oct. 1999, English, Research paper (scientific journal)
  • Comparative study on dynamics of antioxidative action of alpha-tocopheryl hydroquinone, ubiquinol, and alpha-tocopherol, against lipid peroxidation
    HL Shi, N Noguchi, E Niki
    FREE RADICAL BIOLOGY AND MEDICINE, PERGAMON-ELSEVIER SCIENCE LTD, 27(3-4)334 - 346, Aug. 1999, English, Research paper (scientific journal)
  • Rate constants for hydrogen atom abstraction by alpha-tocopheroxyl radical from lipid, hydroperoxide and ascorbic acid
    A Watanabe, N Noguchi, M Takahashi, E Niki
    CHEMISTRY LETTERS, CHEMICAL SOC JAPAN, (7)613 - 614, Jul. 1999, English, Research paper (scientific journal)
  • Vitamin E protects against polymorphonuclear leukocyte-dependent adhesion to endothelial cells
    N Yoshida, T Yoshikawa, H Manabe, Y Terasawa, M Kondo, N Noguchi, E Niki
    JOURNAL OF LEUKOCYTE BIOLOGY, FEDERATION AMER SOC EXP BIOL, 65(6)757 - 763, Jun. 1999, English, Research paper (scientific journal)
  • Action of quinolinic and indolinonic aminoxyls as radical-scavenging antioxidants
    N Noguchi, E Damiani, L Greci, E Niki
    CHEMISTRY AND PHYSICS OF LIPIDS, ELSEVIER IRELAND LTD, 99(1)11 - 19, May 1999, English, Research paper (scientific journal)
  • Formation of phospholipid hydroperoxides and its inhibition by alpha-tocopherol in rat brain synaptosomes induced by peroxynitrite
    HL Shi, N Noguchi, YX Xu, E Niki
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, 257(3)651 - 656, Apr. 1999, English, Research paper (scientific journal)
  • Oxidation of low density lipoprotein and plasma by 15-lipoxygenase and free radicals
    H Yamashita, A Nakamura, N Noguchi, E Niki, H Kuhn
    FEBS LETTERS, ELSEVIER SCIENCE BV, 445(2-3)287 - 290, Feb. 1999, English, Research paper (scientific journal)
  • Action of Pyrroloquinolinequinol As an Antioxidant Against Lipid Peroxidation in Solution
    Kazuhiro Miyauchi, Teiji Urakami, Hiroyuki Abeta, Honglian Shi, Noriko Noguchi, Etsuo Niki
    Antioxidants and Redox Signaling, Mary Ann Liebert Inc., 1(4)547 - 554, 1999, English, Research paper (scientific journal)
  • Dynamics of action of bisphenol as radical-scavenging antioxidant against lipid peroxidation in solution and liposomal membranes
    K Nishino, N Noguchi, E Niki
    FREE RADICAL RESEARCH, HARWOOD ACAD PUBL GMBH, 31(6)535 - 548, 1999, English, Research paper (scientific journal)
  • Dynamics of antioxidant action of ubiquinol: a reappraisal
    HL Shi, N Noguchi, E Niki
    BIOFACTORS, IOS PRESS, 9(2-4)141 - 148, 1999, English, Research paper (scientific journal)
  • Antiatherogenic effects of the antioxidant BO-653 in three different animal models
    O Cynshi, Y Kawabe, T Suzuki, Y Takashima, H Kaise, M Nakamura, Y Ohba, Y Kato, K Tamura, A Hayasaka, A Higashida, H Sakaguchi, M Takeya, K Takahashi, K Inoue, N Noguchi, E Niki, T Kodama
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, 95(17)10123 - 10128, Aug. 1998, English, Research paper (scientific journal)
  • Acrolein is a product of lipid peroxidation reaction - Formation of free acrolein and its conjugate with lysine residues in oxidized low density lipoproteins
    K Uchida, M Kanematsu, Y Morimitsu, T Osawa, N Noguchi, E Niki
    JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 273(26)16058 - 16066, Jun. 1998, English, Research paper (scientific journal)
  • Protein-bound acrolein: Potential markers for oxidative stress
    K Uchida, M Kanematsu, K Sakai, T Matsuda, N Hattori, Y Mizuno, D Suzuki, T Miyata, N Noguchi, E Niki, T Osawa
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, 95(9)4882 - 4887, Apr. 1998, English, Research paper (scientific journal)
  • Action of 21-aminosteroid U74006F as an antioxidant against lipid peroxidation
    N Noguchi, M Takahashi, J Tsuchiya, H Yamashita, E Komuro, E Niki
    BIOCHEMICAL PHARMACOLOGY, PERGAMON-ELSEVIER SCIENCE LTD, 55(6)785 - 791, Mar. 1998, English, Research paper (scientific journal)
  • Inhibition of oxidative modifications of low density lipoprotein by antioxidants
    N Noguchi, E Niki
    PATHOPHYSIOLOGY OF LIPID PEROXIDES AND RELATED FREE RADICALS, KARGER, 91 - 101, 1998, English, Research paper (international conference proceedings)
  • Action of vitamin E as antioxidant against oxidative modification of low density lipoprotein
    Noriko Noguchi, Naohiro Gotoh, Etsuo Niki
    BIOFACTORS, WILEY, 7(1-2)41 - 50, 1998, English, Research paper (scientific journal)
  • Inhibition of oxidative modification of low density lipoprotein by novel antioxidant BO-653 prepared by theoretical design
    N Noguchi, Y Okimoto, O Cynshi, T Kodama, E Niki
    BIOLOGICAL OXIDANTS AND ANTIOXIDANTS: MOLECULAR MECHANISMS AND HEALTH EFFECTS, AMER OIL CHEMISTS SOC, 139 - 152, 1998, English, Research paper (international conference proceedings)
  • Oxidation of lipids in low density lipoprotein particles
    N Noguchi, R Numano, H Kaneda, E Niki
    FREE RADICAL RESEARCH, HARWOOD ACAD PUBL GMBH, 29(1)43 - 52, 1998, English, Research paper (scientific journal)
  • Dynamics of vitamin E action against LDL oxidation
    N Noguchi, E Niki
    FREE RADICAL RESEARCH, HARWOOD ACAD PUBL GMBH, 28(6)561 - 572, 1998, English, Research paper (scientific journal)
  • Inhibition of oxidation of low-density lipoprotein by a novel antioxidant, BO-653, prepared by theoretical design
    N Noguchi, Y Okimoto, J Tsuchiya, O Cynshi, T Kodama, E Niki
    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, ELSEVIER SCIENCE INC, 347(1)141 - 147, Nov. 1997, English, Research paper (scientific journal)
  • 2,3-dihydro-5-hydroxy-2,2-dipentyl-4,6-di-tert-butylbenzofuran: Design and evaluation as a novel radical-scavenging antioxidant against lipid peroxidation
    N Noguchi, Y Iwaki, M Takahashi, E Komuro, Y Kato, K Tamura, O Cynshi, T Kodama, E Niki
    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS, 342(2)236 - 243, Jun. 1997, English, Research paper (scientific journal)
  • Dynamics of oxidation of LDL and its inhibition by antioxidants
    E Niki, N Noguchi
    BIOFACTORS, WILEY, 6(2)201 - 208, 1997, English, Research paper (scientific journal)
  • Inhibition of oxidation of low density lipoprotein by troglitazone
    N Noguchi, H Sakai, Y Kato, J Tsuchiya, Y Yamamoto, E Niki, H Horikoshi, T Kodama
    ATHEROSCLEROSIS, ELSEVIER SCI IRELAND LTD, 123(1-2)227 - 234, Jun. 1996, English, Research paper (scientific journal)
  • Inhibition of oxidation of low density lipoprotein by vitamin E and related compounds
    N Gotoh, N Noguchi, J Tsuchiya, K Morita, H Sakai, H Shimasaki, E Niki
    FREE RADICAL RESEARCH, TAYLOR & FRANCIS LTD, 24(2)123 - 134, 1996, English, Research paper (scientific journal)
  • ACTION OF NITRIC-OXIDE AS AN ANTIOXIDANT AGAINST OXIDATION OF SOYBEAN PHOSPHATIDYLCHOLINE LIPOSOMAL MEMBRANES
    K HAYASHI, N NOGUCHI, E NIKI
    FEBS LETTERS, ELSEVIER SCIENCE BV, 370(1-2)37 - 40, Aug. 1995, English, Research paper (scientific journal)
  • HEPATIC DAMAGE-INDUCED BY PERFUSION OF RADICAL GENERATING AZO COMPOUND AND ITS INHIBITION BY VITAMIN-E
    H YASUDA, N NOGUCHI, M MIKI, W MORINOBU, K HIRANO, T OGIHARA, T TANABE, M MINO, K TERAO, E NIKI
    CHEMICO-BIOLOGICAL INTERACTIONS, ELSEVIER SCI PUBL IRELAND LTD, 97(1)11 - 23, Jun. 1995, English, Research paper (scientific journal)
  • DYNAMICS OF FREE-RADICAL FORMATION FROM THE REACTION OF PEROXIDES WITH HAEMPROTEINS AS STUDIED BY STOPPED-FLOW CHEMILUMINESCENCE
    N NOGUCHI, E NIKI
    FREE RADICAL RESEARCH, HARWOOD ACAD PUBL GMBH, 23(4)329 - 338, 1995, English, Research paper (scientific journal)
  • EFFECTS OF EBSELEN AND PROBUCOL ON OXIDATIVE MODIFICATIONS OF LIPID AND PROTEIN OF LOW-DENSITY-LIPOPROTEIN INDUCED BY FREE-RADICALS
    N NOGUCHI, N GOTOH, E NIKI
    BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM, ELSEVIER SCIENCE BV, 1213(2)176 - 182, Jul. 1994, English, Research paper (scientific journal)
  • 2,2'-AZOBIS(4-METHOXY-2,4-DIMETHYLVALERONITRILE), A NEW LIPID-SOLUBLE AZO RADICAL INITIATOR
    N GOTOH, T YOSHINO, N NOGUCHI, E NIKI
    FRONTIERS OF REACTIVE OXYGEN SPECIES IN BIOLOGY AND MEDICINE, ELSEVIER SCIENCE PUBL B V, 105859 - 62, 1994, English, Research paper (international conference proceedings)
  • ANTIOXIDANT EFFECTS OF PROBUCOL AND EBSELEN AGAINST OXIDATIVE MODIFICATION OF LDL INDUCED BY FREE-RADICALS GENERATED AT DIFFERENT SITES
    N NOGUCHI, N GOTOH, T YOSHINO, E NIKI
    FRONTIERS OF REACTIVE OXYGEN SPECIES IN BIOLOGY AND MEDICINE, ELSEVIER SCIENCE PUBL B V, 1058191 - 194, 1994, English, Research paper (international conference proceedings)
  • DYNAMICS OF THE OXIDATION OF LOW-DENSITY-LIPOPROTEIN INDUCED BY FREE-RADICALS
    N NOGUCHI, N GOTOH, E NIKI
    BIOCHIMICA ET BIOPHYSICA ACTA, ELSEVIER SCIENCE BV, 1168(3)348 - 357, Jul. 1993, English, Research paper (scientific journal)
  • DYNAMICS OF LIPID-PEROXIDATION AND ITS INHIBITION BY ANTIOXIDANTS
    E NIKI, N NOGUCHI, N GOTOH
    BIOCHEMICAL SOCIETY TRANSACTIONS, PORTLAND PRESS LTD, 21(2)313 - 317, May 1993, English, Research paper (scientific journal)
  • EFFECTS OF PARAQUAT ON MG2+-ATPASE ACTIVITY IN RAT-LIVER
    N NOGUCHI, HA YAMAMOTO, S MISAWA
    ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, SPRINGER VERLAG, 24(4)483 - 486, May 1993, English, Research paper (scientific journal)
  • INHIBITION OF OXIDATIVE MODIFICATION OF LOW-DENSITY-LIPOPROTEIN BY ANTIOXIDANTS
    E NIKI, N NOGUCHI, N GOTOH
    JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY, CENTER ACADEMIC PUBL JAPAN, 39S1 - S8, 1993, English, Research paper (scientific journal)
  • ANTIOXIDANT ACTIVITIES OF PROBUCOL AGAINST LIPID PEROXIDATIONS
    N GOTOH, K SHIMIZU, E KOMURO, J TSUCHIYA, N NOGUCHI, E NIKI
    BIOCHIMICA ET BIOPHYSICA ACTA, ELSEVIER SCIENCE BV, 1128(2-3)147 - 154, Oct. 1992, English, Research paper (scientific journal)
  • ACTION OF EBSELEN AS AN ANTIOXIDANT AGAINST LIPID-PEROXIDATION
    N NOGUCHI, Y YOSHIDA, H KANEDA, Y YAMAMOTO, E NIKI
    BIOCHEMICAL PHARMACOLOGY, PERGAMON-ELSEVIER SCIENCE LTD, 44(1)39 - 44, Jul. 1992, English, Research paper (scientific journal)
  • THE OXIDATIVE MODIFICATION OF LOW-DENSITY-LIPOPROTEIN INDUCED BY COPPER OR WATER-SOLUBLE RADICAL INITIATOR
    N NOGUCHI, N GOTOH, E KOMURO, Y YAMAMOTO, E NIKI, H SHIMASAKI
    OXYGEN RADICALS, ELSEVIER SCIENCE PUBL B V, 998377 - 380, 1992, English, Research paper (international conference proceedings)
  • Initial accumulation of paraquat in the heart leading to acute death
    N. Noguchi, E. Tanaka, H. Yamamoto, S. Misawa
    Japanese Journal of Legal Medicine, 44(1)6 - 11, 1990, English, Research paper (scientific journal)
  • LARGE MYELINATED CLUB ENDINGS ON THE MAUTHNER CELL IN THE GOLDFISH - A STUDY WITH THIN SECTIONING AND FREEZE-FRACTURING
    K KOHNO, N NOGUCHI
    ANATOMY AND EMBRYOLOGY, SPRINGER VERLAG, 173(3)361 - 370, 1986, English, Research paper (scientific journal)
  • CARDIORESPIRATORY EFFECTS OF PARAQUAT WITH AND WITHOUT EMETICS ON WISTER RATS
    N NOGUCHI, S MISAWA, S TSUCHIYA, H YAMAMOTO, H NAITO
    VETERINARY AND HUMAN TOXICOLOGY, COMPARATIVE TOXICOLOGY LAB, 27(6)508 - 510, 1985, English, Research paper (scientific journal)

Misc

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    三田 雄一郎, 中山 華穂, 稲荷 尚吾, 西藤 有希奈, 吉岡 佑弥, 曽谷 奏, 高部 稚子, 御簾 博文, 篁 俊成, 高橋 和彦, 野口 範子, 斎藤 芳郎
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  • 膵臓β細胞モデルMIN6は過剰なSelenoprotein Pにより障害を受ける
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    野口 範子, 斎藤 芳郎
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  • Study on Involvement of Reactive Oxygen Species in Neuronal Cell Death Induced by Oxidation Product of Cholesterol
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  • パーキンソン病における酸化型DJ-1測定とMIBG心筋シンチグラフィーの関連について
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  • 早期パーキンソン病患者の赤血球におけるDJ‐1の酸化
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  • リポ多糖(LPS)により誘導される適応反応・酸化ストレス耐性メカニズムの解析
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  • Accumulation of Nrf2 due to its modification by oxidative stress and laminar share stress in endothelial cell
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  • Induction of Lung Kruppel-Like Factor by lysophosphatidylcholine in human endothelial cell
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  • Cholesterol biosynthesis inhibition by 25-hydroxycholesterol is independent of OSBP
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  • Identification of genes that are up-regulated or down-regulated during foam cell formation in mouse peritoneal macrophage
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  • Scavenger receptors and pathogenesis of atherosclerosis
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  • The hyperlipidemia drug. The target for limited treatment. Treatment by the antioxidant and the significance.
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  • コレステロールメタボライト研究の新展開: 構造的・機能的多様性に迫る オキシステロール誘導性の新規細胞死機構
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  • Decrease of Insulin Secretion is Induced by Excess Selenoprotein P-Improving Effects of Neutralizing Antibody
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  • Interleukin-27 Induces p47(phox) in Monocyte-derived Macrophages and Dendritic cells and Enhances the Potential of Reactive Oxygen Species Generation
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  • Cytoprotective Effect of Vitamin E Homologues Against Glutamate-induced Cell Death in Immature Primary Cortical Neuron Cultures: Tocopherols and Tocotrienols Exert Similar Effects by Antioxidant Function
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  • Elevation of Oxidized DJ-1 in the Erythrocytes of Parkinson Disease Patients and Animal Models
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  • Significant Elevation of Oxidized DJ-1 in Erythrocytes of Early-Stage Parkinson Disease Patients: Potential Application of Oxidized DJ-1 Levels for Diagnosis of PD at Early Stage
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  • Induction of Adaptive Response and Enhancement of PC12 Cell Tolerance by Lipopolysaccharide Primarily Through the Upregulation of Glutathione S-Transferase A3 Via Nrf2 Activation
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  • Differential responses of the Nrf2-Keap1 system to laminar and oscillatory shear stresses in endothelial cells. (vol 280, pg 27244, 2005)
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  • Evaluation of antioxidant capacity. What capacity is being measured by which method?
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  • Reactivity and stability of antioxidant-derived phenoxyl radical
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  • Antioxidant action of antihypertensive drug, carvedilol
    N Noguchi, K Nishino, E Niki
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  • Inhibition of oxidation of low density lipoprotein by a novel antioxidant BO-653 prepared by theoretical design
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    ATHEROSCLEROSIS, ELSEVIER SCI IRELAND LTD, 134(1-2)206 - 206, Oct. 1997, English, Research paper, summary (international conference)
  • Inhibition of plasma cholesterol ester hydroperoxide and phosphatidylcholine hydroperoxide formation as measures of antioxidant status
    N Noguchi, E Niki
    VITAMINS AND COENZYMES, PT L, ELSEVIER ACADEMIC PRESS INC, 282271 - 278, 1997, English, Book review, literature introduction, etc.
  • APOLIPOPROTEIN-B PROTEIN OXIDATION IN LOW-DENSITY LIPOPROTEINS
    N NOGUCHI, E NIKI
    OXYGEN RADICALS IN BIOLOGICAL SYSTEMS, PT C, ACADEMIC PRESS INC, 233490 - 494, 1994, English, Book review, literature introduction, etc.

Books etc

  • (Vitamin E: Chemistry and Nutritional Benefits.) Action of Vitamin E Against Lipid Peroxidation and Cell Death
    Noriko Noguchi
    Royal Society of Chemistry, 2018, Contributor, pp. 165-172
  • 脳のコレステロール代謝と神経変性疾患, 生物の科学遺伝
    エヌティーエス, 2016
  • 酸化ストレスと疾患
    ストレスシグナルと疾患 医学のあゆみ 医歯薬出版, 2015
  • パーキンソン病と酸化ストレス
    医歯薬出版, 2014
  • Necroptosis 医学のあゆみ
    医歯薬出版, 2011
  • HDAC
    朝日書店, 2011
  • Nrf 血管生物学事典
    朝日書店, 2011
  • 抗酸化ビタミンの相互作用 「ビタミン・ミネラルの科学(五十嵐修、 江指隆年編集)
    朝倉書店, 2011
  • Uptake, Distribution, and Antioxidant Actions of Tocotrienol in Cultured Cells. Tocotrienols:Vitamin E Beyond Tocopherols
    CRC Press, 2008
  • 動脈硬化症と酸化ストレス「酸化ストレスの医学(吉川敏一編集)」
    診断と治療社, 2008
  • 酸化ストレス 「ストレスの科学と健康(二木鋭雄編著)」
    共立出版, 2008
  • 抗酸化ビタミンの大規模臨床試験 「酸化ストレスと心血管病
    日本医学出版, 2007
  • 抗酸化ビタミン 「酸化ストレスと心血管病(横山光宏、藤田敏郎編 集)」
    日本医学出版, 2007
  • DNAマイクロアレイを用いた遺伝子発現解析 レドックス/ストレス防御の医学(谷口直之監)医学のあゆ
    医歯薬出版, 2005
  • Specificity and inhibition by antioxidant of lipid peroxidation by lipoxygenase: effects of substrate, lipoxygenase and milieu
    International Congress Series, 2002
  • Natural antioxidants
    Antioxidants in food, 2001
  • Galvinoxyl method for standardizing electron and proton donation activity
    Methods in Enzymology, 2001
  • Action of ginkgo biloba extract as an antioxidant.
    Antioxidants & Disease, CAB International, Oxford, 1999
  • Chemistry of oxygen species and antioxidant.
    Antioxidant Status, Diet, Nutrition and Health, CRC press, FL, 1998
  • Inhibition of oxidation of low density lipoprotein by antioxidants.
    Pathophysiology of lipid peroxides and related free radicals, 1998
  • Inhibition of oxidative modification of low density lipoprotein by novel antioxidant BO-653 prepared by theoretical design.
    Nutrition, Lipids, Health, and Disease, 1998
  • Protection of human low-density lipoprotein from oxidative modification by vitamin C.
    Vitamin C in health and disease, 1997
  • Antioxidand properties of ebselen
    Hand book of synthetic antioxidants, 1997
  • Antioxidant properties of probucol
    Hand book of synthetic antioxidants, 1997

Works

  • Antioxidant activity of α-, β-, γ-, δ-tocopherol
    2000 -2001
  • Study of antioxidant activity and gene expression of α, γ-tocopherol and tocotrienol
    2001
  • Antioxidant activity of extract of garlic
    1999 -2000

Patents

  • 細胞死抑制剤
    第6143435号
  • 過酸化脂質の測定方法
    2011-260819
  • 含硫アミノ残基を含むポリペプチドに対する抗体
    2012-028138

Research Grants & Projects

  • regulation of gene expression by antioxidants
  • Mechanisms of damage induced by free radicals in vivo and its prevention

Social Contribution

  • World Student Environment Summit, Consultant;Planner, 2018/08/26-2018/08/30, Other

Research cooperation among industry, academia and government

  • Joint Research Theme:Regulation of gene expression by vitamin E
    Remarks:Cooperative research with other research organization of universities, etc.
  • Joint Research Theme:Effects of anti-atherogenic drag on different animal species
    Remarks:Cooperative research with other research organization including private (industrial) sectors