Researcher Profile and Settings

researchmap

https://researchmap.jp/norihana2020

Research Interests

• 遺伝情報発現・制御
• 生物学
• gene expression and regulation
• Biochemistry

Research Areas

• Life sciences / Molecular biology
• Life sciences / Functional biochemistry

Research History

• 1987-1990 The mechanisms of cytotoxicity of paraquat
• 1990-1991 Damages of mitochondrial DNA induced by g-irradiation
• 1991-2001 The mechanisms of free radical mediated damages and its protection by antioxidants
• 2001- Regulation of gene expression by free radicals and antioxidants

Research Experience

• The University of Tokyo, Research Center for Advanced Science and Technology, 2002 - 2005
• - 同志社大学工学部 教授, 2005 -
• The University of Tokyo, Research Center for Advanced Science and Technology, 1993 - 2002
• The University of Tokyo, The Faculty of Engineering, 1991 - 1993
• National Institute of Standards and Technology (U.S.A.) 客員研究員, 1990 - 1991
• Teikyo University, School of Medicine, 1987 - 1990

Education

• University of Tsukuba, 医学研究科, - 1987
• University of Tsukuba, Graduate School, Division of Medicine, - 1987
• University of Tsukuba, 医学研究科, - 1983
• University of Tsukuba, Graduate School, Division of Medicine, - 1983
• University of Tsukuba, 第二学群, 生物学類, - 1981
• University of Tsukuba, Second Cluster of College, - 1981

Degree

• Doctor of Medicine, University of Tsukuba
• Master of Medical Science, University of Tsukuba

Association Memberships

• 日本酸化ストレス学会
• 日本生化学会
• 日本油化学会
• 日本ビタミン学会
• 国際フリーラジカル学会
• International Society for Free Radical Research

Committee Memberships

• Associate Editor, 2024/05 - Today, Journal of Free Radical Biology and Medicine
• Associate Editor, 2022/09 - Today, Redox Experimental Medicine, Others
• fellow, 2022/04 - Today, Japan Society of Biochemistry
• （公社）ビタミン・バイオファクター協会 参与, 2021/06 - Today
• education board member, 2019/11 - Today, 教育委員
• 代議員, 2017/04 - Today, 日本ビタミン学会
• fellow, 1998/06 - Today, Society for Free Radical Research Japan
• administration officer, 2000/06 - 2024/06, Society for Free Radical Research Japan
• アジア支部代表, - , 国際フリーラジカル学会, Society, 国際フリーラジカル学会
• representative, - , International Society for Free Radical Research, Society, International Society for Free Radical Research

Awards

• 日本フリーラジカル学会学会賞
  2007
• 日本油化学会進歩賞
  1997, Japan
• Young Investigation Award
  1994, International Society for Free Radical Research
• Outstanding Paper Presentation
  1993, The American Oil Chemists' Society

Published Papers

• Downregulation of the SREBP pathways and disruption of redox status by 25-hydroxycholesterol predispose cells to ferroptosis
  Yasuomi Uranoa, Anan Iwagakia, Arisa Takeishia, Nazuna Uchiyamaa, Noriko Noguchi
  Free Radic Biol Med., Jan. 2025
• Modifications of DJ-1 in which pI shifts to acidic in red blood cells a potential biomarker for Parkinson's disease at early stages.
  Kohei Matsuda; Yuichiro Mita; Kazumasa Saigoh; Yoshiro Saito; Noriko Noguchi
  Free radical research, 1 - 10, 22 Nov. 2024, Scientific journal
  

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• Lysosomal Damage Promotes Autophagy-based Unconventional Secretion of the Parkinson’s Disease Protein PARK7
  Biplab Kumar Dash; Yasuomi Urano; Noriko Noguchi
  Redox Experimental Medicine, Nov. 2024
• Ethanol enhances selenoprotein P expression via ERK-FoxO3a axis in HepG2 cells
  Jian Chen; Yuichiro Mita; Noriko Noguchi
  Journal of Clinical Biochemistry and Nutrition, 75(2) 125 - 132, Sep. 2024
• Vitamin E nomenclature. Is RRR-α-tocopherol the only vitamin E?
  Noguchi Noriko; Niki Etsuo
  Free Radic Biol Med., May 2024
  

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• Enzymatically Formed Oxysterols and Cell Death.
  Yasuomi Urano; Noriko Noguchi
  Advances in experimental medicine and biology, 1440 193 - 211, 2024, Scientific journal
  

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• Cholesterol is more readily oxidized than phospholipid linoleates in cell membranes to produce cholesterol hydroperoxides.
  Saito Y; Noguchi N; Niki E
  Free Radical Biology and Medicine, 211 89 - 95, Dec. 2023
  

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• Association of COVID-19 information media, providers, and content with vaccine uptake among Tokyo residents
  Noriko Noguchi; Ryosuke Yokoi; Taichi Masu; Masataka Watanabe; Sayoko Itoh; Sayumi Yumoto
  Vaccine X, 15 100411 , Nov. 2023
  

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• An efficient selenium transport pathway of selenoprotein P utilizing a high-affinity ApoER2 receptor variant and being independent of selenocysteine lyase
  Ayako Mizuno; Takashi Toyama; Atsuya Ichikawa; Naoko Sakai; Yuya Yoshioka; Yukina Nishito; Renya Toga; Hiroshi Amesaka; Takayuki Kaneko; Kotoko Arisawa; Ryouhei Tsutsumi; Yuichiro Mita; Shun-ichi Tanaka; Noriko Noguchi; Yoshiro Saito
  Journal of Biological Chemistry, Elsevier BV, 299(8) 105009 - 105009, Jul. 2023, Scientific journal
  

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• Actions of Thiols, Persulfides, and Polysulfides as Free Radical Scavenging Antioxidants
  Noriko Noguchi; Yoshiro Saito; Etsuo Niki
  Antioxidant Redox Signaling, 39 728 - 743, Jul. 2023
• Antioxidant action of persulfides and polysulfides against free radical-mediated lipid peroxidation
  Takayuki Kaneko; Yuichiro Mita; Kanako Nozawa-Kumada; Masana Yazaki; Mieko Arisawa; Etsuo Niki; Noriko Noguchi; Yoshiro Saito
  Free Radical Research, Informa UK Limited, 56(9-10) 1 - 14, 11 Jan. 2023, Scientific journal
  

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• Suppression of Amyloid-β Adsorption on Endoplasmic Reticulum Stress-Mimicking Membranes by α-Tocopherol and α-Tocotrienol
  Yusuke Nakatani; Naofumi Shimokawa; Yasuomi Urano; Noriko Noguchi; Masahiro Takagi
  The Journal of Physical Chemistry Letters, American Chemical Society (ACS), 11955 - 11960, 19 Dec. 2022, Scientific journal
  

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• a-Tocopherol suppresses 24(S)-hydroxycholesterol-induced cell death via inhibition of endoplasmic reticulum membrane disruption
  Ren Chiba; Yasuomi Urano; Noriko Noguchi
  Steroid, 189 109136 - 109143, Nov. 2022, Scientific journal
  

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• Integrated stress response is involved in the 24(S)-hydroxycholesterol-induced unconventional cell death mechanism
  Yasuomi Urano; Shoya Osaki; Ren Chiba; Noriko Noguchi
  Cell Death Discovery, 8 406 - 415, Oct. 2022
• Redox-sensitive DJ-1 protein: An insight into physiological roles, secretion, and therapeutic target.
  Biplab K. Dash; Yasuomi Urano; Yoshiro Saito; Noriko Noguchi
  Redox Experimental Medicine, 1(1) 96 - 115, Aug. 2022
• Role of selenoprotein P expression in the function of pancreatic b cells: Prevention of ferroptosis-like cell death and stress-induced nascent granule degradation.
  Nanako Kitabayashi; Shohei Nakao; Yuichiro Mita; Kotoko Arisawa; Takayuki Hoshi; Takashi Toyama; Kiyo-aki Ishii; Toshinari Takamura; Noriko Noguchi; Yoshiro Saito
  Free Radic Biol Med., Elsevier BV, 183 89 - 103, Apr. 2022, Scientific journal
  

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• Therapeutic effect of a novel curcumin derivative GT863 on a mouse model of amyotrophic lateral sclerosis
  Hajime Kato; Hiroyasu Sato; Michiaki Okuda; Jun Wu; Shingo Koyama; Yasuhiko Izumi; Tomonori Waku; Mitsuyoshi Iino; Masashi Aoki; Shigeki Arawaka; Yasuyuki Ohta; Kenichi Ishizawa; Kanan Kawasaki; Yasuomi Urano; Tomohiro Miyasaka; Noriko Noguchi; Toshiaki Kume; Akinori Akaike; Hachiro Sugimoto; Takeo Kato
  Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Informa UK Limited, 23(7-8) 1 - 7, Dec. 2021, Scientific journal
  

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• Different functions of vitamin E homologues in the various types of cell death induced by oxysterols
  Atsuki Suzuki; Yasuomi Urano; Tomohisa Ishida; Noriko Noguchi
  Free Radical Biology and Medicine, 176 356 - 365, Oct. 2021
• NRF3 upregulates gene expression in SREBP2-dependent mevalonate pathway with cholesterol uptake and lipogenesis inhibition
  Tsuyoshi Waku, Toru Hagiwara, Natsuko Tamura, Yuri Atsumi, Yasuomi Urano, Mikiko Suzuki, Takuya Iwami, Katsuya Sato, Masayuki Yamamoto, Noriko Noguchi, Akira Kobayashi
  iScience, Elsevier BV, 24 103180 - 103180, Sep. 2021, Scientific journal
  

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• Identification of a novel endogenous long non-coding RNA that inhibits selenoprotein P translation.
  Yuichiro Mita; Risa Uchida; Sayuri Yasuhara; Kohei Kishi; Takayuki Hoshi; Yoshitaka Matsuo; Tadashi Yokooji; Yoshino Shirakawa; Takashi Toyama; Yasuomi Urano; Toshifumi Inada; Noriko Noguchi; Yoshiro Saito
  Nucleic acids research, 49(12) 6893 - 6907, 09 Jul. 2021, Scientific journal
  

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• Curcumin Derivative GT863 Inhibits Amyloid-Beta Production via Inhibition of Protein N-Glycosylation.
  Yasuomi Urano; Mina Takahachi; Ryo Higashiura; Hitomi Fujiwara; Satoru Funamoto; So Imai; Eugene Futai; Michiaki Okuda; Hachiro Sugimoto; Noriko Noguchi
  Cells, 9(2), 03 Feb. 2020, Scientific journal
  

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• Antioxidant action of vitamin E in vivo as assessed from its reaction products with multiple biological oxidants.
  Etsuo Niki; Noriko Noguchi
  Free Radic Res, 1 - 33, 2020
• Astrocytes release glutamate via cystine/glutamate antiporter upregulated in response to increased oxidative stress related to sporadic amyotrophic lateral sclerosis.
  Miku Kazama; Yoichiro Kato; Akiyoshi Kakita; Noriko Noguchi; Yasuomi Urano; Kenta Masui; Motoko Niida-Kawaguchi; Tomoko Yamamoto; Kazuhiko Watabe; Kazuo Kitagawa; Noriyuki Shibata
  Neuropathology, 40(6) 587 - 598, 2020, Scientific journal
  

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• Soluble iron accumulation induces microglial glutamate release in the spinal cord of sporadic amyotrophic lateral sclerosis.
  Motoko Niida-Kawaguchi; Akiyoshi Kakita; Noriko Noguchi; Miku Kazama; Kenta Masui; Yoichiro Kato; Tomoko Yamamoto; Tatsuo Sawada; Kazuo Kitagawa; Kazuhiko Watabe; Noriyuki Shibata
  Neuropathology : official journal of the Japanese Society of Neuropathology, 28 Dec. 2019
  

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• 角層DJ-1を用いた体内の酸化ストレス評価
  高橋 理子; 鈴木 民恵; 石渡 潮路; 村上 礼一; 秋田 美季; 宮川 泰子; 三上 正治; 八代 壇; 斎藤 芳郎; 野口 範子; 松熊 祥子
  加齢皮膚医学セミナー, 加齢皮膚医学研究会, 14(2) 70 - 70, Dec. 2019
• Brain Targeting of Acyl-CoA:Cholesterol O-Acyltransferase-1 Inhibitor K-604 via the Intranasal Route Using a Hydroxycarboxylic Acid Solution.
  Kimiyuki Shibuya; Shigeru Morikawa; Masayoshi Miyamoto; Shin-Ichiro Ogawa; Yoshihiko Tsunenari; Yasuomi Urano; Noriko Noguchi
  ACS omega, 4(16) 16943 - 16955, 15 Oct. 2019
  

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• 角層DJ-1を用いた体内の酸化ストレス評価
  高橋 理子; 鈴木 民恵; 石渡 潮路; 村上 礼一; 秋田 美季; 宮川 泰子; 三上 正治; 八代 壇; 斎藤 芳郎; 野口 範子; 松熊 祥子
  加齢皮膚医学セミナー, 加齢皮膚医学研究会, 14(1) 49 - 57, Jun. 2019
• 24(S)-Hydroxycholesterol induces ER dysfunction-mediated unconventionall cell death.
  Yasuomi Urano; Diep-Khanh Ho Vo; Hirofumi Araki; Noriko Noguchi
  Cell Death Discov, 5 113 , 2019
• Polymerization of oxidized DJ-1 via noncovalent and covalent binding: Significance of disulfide bond formation.
  Mayuka Kobayashi; Kana Muramatsu; Takamitsu Haruyama; Haruka Uesugi; Ai Kikuchi; Hiroki Konno; Noriko Noguchi; Yoshiro Saito
  ACS Omega, 4 9603 - 9614, 2019
• Comparison of Human Selenoprotein P Determinants in Serum between Our Original Methods and Commercially Available Kits
  Yoshiro Saito; Hirofumi Misu; Hiroaki Takayama; Shin-ichiro Takashima; Soichiro Usui; Masayuki Takamura; Shuichi Kaneko; Toshinari Takamura; Noriko Noguchi
  Biological and Pharmaceutical Bulletin, Pharmaceutical Society of Japan, 41(5) 828 - 832, 01 May 2018, Scientific journal
  

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• Serenoprotein P中和抗体を用いた糖尿病治療の開発
  三田 雄一郎; 中山 華穂; 稲荷 尚吾; 野口 範子; 斎藤 芳郎
  日本内分泌学会雑誌, (一社)日本内分泌学会, 94(1) 360 - 360, Apr. 2018
  

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• Diagnosis of Parkinson's disease and the level of oxidized DJ-1 protein.
  Yuko Yamagishi; Kazumasa Saigoh; Yoshiro Saito; Ikuko Ogawa; Yoshiyuki Mitsui; Yukihiro Hamada; Makoto Samukawa; Hidekazu Suzuki; Motoi Kuwahara; Makito Hirano; Noriko Noguchi; Susumu Kusunoki
  Neuroscience research, 128 58 - 62, Mar. 2018, Scientific journal
  

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• 6-Hydroxydopamine induces secretion of PARK7/DJ-1 via autophagy-based unconventional secretory pathway.
  Yasuomi Urano; Chinatsu Mori; Ayano Fuji; Keito Konno; Takayuki Yamamoto; Shohei Yashirogi; Mayu Ando; Yoshiro Saito; Noriko Noguchi
  Autophagy, 14 1943 - 1958, 2018
• Tocopherol suppresses 24(S)-hydroxycholesterol-induced cell death via inhibition of CaMKII phosphorylation.
  Yuki Kimura; Minori Asa; Yasuomi Urano; Yoshiro Saito; Kiyotaka Nishikawa; Noriko Noguchi
  Biochimie, 153 203 - 209, 2018, Scientific journal
  

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• Distribution of oxidized DJ-1 in Parkinson’s disease-related sites in the brain and in the peripheral tissues: effects of aging and a neurotoxin.
  Yuichiro Mita; Yuto Kataoka; Yoshiro Saito; Takuma Kashi; Kojiro Hayashi; Asa Iwasaki; Takanori Imanishi; Tomohiro Miyasaka; Noriko Noguchi
  Scientific Reports, 8 12056 , 2018
• Hydrogen peroxide-reducing factor released by PC12D cells increases cell tolerance against oxidative stress.
  Asami Muraishi; Emi Haneta; Yoshiro Saito; Yutaka Hitomi; Mamoru Sano; Noriko Noguchi
  Biol.Pharm.Bull., Note,41(5) 777 - 785, 2018, Scientific journal
  

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• Pleckstrin homology domain of p210 BCR-ABL interacts with cardiolipin to regulate its mitochondrial translocation and subsequent mitophagy
  Kentaro Shimasaki; Miho Watanabe-Takahashi; Masato Umeda; Satoru Funamoto; Yoshiro Saito; Noriko Noguchi; Keigo Kumagai; Kentaro Hanada; Fujiko Tsukahara; Yoshiro Maru; Norihito Shibata; Mikihiko Naito; Kiyotaka Nishikawa
  Genes to Cells, Wiley, 23(1) 22 - 34, Jan. 2018, Scientific journal
  

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• 膵β細胞モデルMIN6はセレノプロテインP発現を介して抗酸化システムを維持する
  中尾 昌平; 三田 雄一郎; 斎藤 芳郎; 野口 範子
  生命科学系学会合同年次大会, 生命科学系学会合同年次大会運営事務局, 2017年度 [2P - 0374], Dec. 2017
• 膵β細胞モデルMIN6における過剰Selenoprotein Pによるセレン運搬作用を介したERストレス誘導メカニズムの解析
  長村 尭浩; 稲荷 尚吾; 三田 雄一郎; 野口 範子; 斎藤 芳郎
  生命科学系学会合同年次大会, 生命科学系学会合同年次大会運営事務局, 2017年度 [2P - 1003], Dec. 2017
• non-coding RNAによるSelenoprotein P翻訳抑制メカニズムの解析
  三田 雄一郎; 斎藤 芳郎; 内田 理沙; 安原 小百合; 横大路 将; 野口 範子
  生命科学系学会合同年次大会, 生命科学系学会合同年次大会運営事務局, 2017年度 [3P - 0671], Dec. 2017
• 糖尿病関連タンパク質Selenoprotein Pの翻訳を抑制する内在性long non-coding RNAの発現変化
  内田 理沙; 三田 雄一郎; 横大路 将; 安原 小百合; 斎藤 芳郎; 野口 範子
  生命科学系学会合同年次大会, 生命科学系学会合同年次大会運営事務局, 2017年度 [3P - 0672], Dec. 2017
• ヒト皮膚細胞モデルHaCaTにおけるDJ-1誘導因子の同定および酸化ストレス防御効果の評価
  安藤 万由; 斎藤 芳郎; 石渡 潮路; 松熊 祥子; 野口 範子
  生命科学系学会合同年次大会, 生命科学系学会合同年次大会運営事務局, 2017年度 [4AT18 - 0506)], Dec. 2017
• Selenoprotein P-neutralizing antibodies improve insulin secretion and glucose sensitivity in type 2 diabetes mouse models
  Yuichiro Mita; Kaho Nakayama; Shogo Inari; Yukina Nishito; Yuya Yoshioka; Naoko Sakai; Kanade Sotani; Takahiro Nagamura; Yuki Kuzuhara; Kumi Inagaki; Miki Iwasaki; Hirofumi Misu; Masaya Ikegawa; Toshinari Takamura; Noriko Noguchi; Yoshiro Saito
  NATURE COMMUNICATIONS, NATURE PUBLISHING GROUP, 8 1658 , Nov. 2017, Scientific journal
  

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• Effect of vitamin E on 24(S)-hydroxycholesterol-induced necroptosis-like cell death and apoptosis
  Takaya Nakazawa; Yuta Miyanoki; Yasuomi Urano; Madoka Uehara; Yoshiro Saito; Noriko Noguchi
  JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, PERGAMON-ELSEVIER SCIENCE LTD, 169 69 - 76, May 2017, Scientific journal
  

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• Deficiency of the hepatokine selenoprotein P increases responsiveness to exercise in mice through upregulation of reactive oxygen species and AMP-activated protein kinase in muscle
  Hirofumi Misu; Hiroaki Takayama; Yoshiro Saito; Yuichiro Mita; Akihiro Kikuchi; Kiyo-aki Ishii; Keita Chikamoto; Takehiro Kanamori; Natsumi Tajima; Fei Lan; Yumie Takeshita; Masao Honda; Mutsumi Tanaka; Seiji Kato; Naoto Matsuyama; Yuya Yoshioka; Kaito Iwayama; Kumpei Tokuyama; Nobuhiko Akazawa; Seiji Maeda; Kazuhiro Takekoshi; Seiichi Matsugo; Noriko Noguchi; Shuichi Kaneko; Toshinari Takamura
  NATURE MEDICINE, NATURE PUBLISHING GROUP, 23(4) 508 - +, Apr. 2017, Scientific journal
  

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• Interleukin-27 Enhances the Potential of Reactive Oxygen Species Generation from Monocyte-derived Macrophages and Dendritic cells by Induction of p47(phox)
  Bharatwaj Sowrirajan; Yoshiro Saito; Deepak Poudyal; Qian Chen; Hongyan Sui; Suk See DeRavin; Hiromi Imamichi; Toyotaka Sato; Douglas B. Kuhns; Noriko Noguchi; Harry L. Malech; H. Clifford Lane; Tomozumi Imamichi
  SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, 7 43441 , Feb. 2017, Scientific journal
  

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• Decrease of Amyloid-beta Levels by Curcumin Derivative via Modulation of Amyloid-beta Protein Precursor Trafficking
  Rina Kotani; Yasuomi Urano; Hachiro Sugimoto; Noriko Noguchi
  JOURNAL OF ALZHEIMERS DISEASE, IOS PRESS, 56(2) 529 - 542, 2017, Scientific journal
  

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• Esterification of 24S-OHC induces formation of atypical lipid droplet-like structures, leading to neuronal cell death
  Wakako Takabe; Yasuomi Urano; Diep-Khanh Ho Vo; Kimiyuki Shibuya; Masaki Tanno; Hiroaki Kitagishi; Toyoshi Fujimoto; Noriko Noguchi
  JOURNAL OF LIPID RESEARCH, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 57(11) 2005 - 2014, Nov. 2016, Scientific journal
  

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• Oxidized Lipoprotein as a Major Vessel Cell Proliferator in Oxidized Human Serum
  Yoshiro Saito; Noriko Noguchi
  PLOS ONE, PUBLIC LIBRARY SCIENCE, 11(8), Aug. 2016, Scientific journal
  

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• Oxidation and interaction of DJ-1 with 20S proteasome in the erythrocytes of early stage Parkinson's disease patients
  Yoshiro Saito; Yoko Akazawa-Ogawa; Akihiro Matsumura; Kazumasa Saigoh; Sayoko Itoh; Kenta Sutou; Mayuka Kobayashi; Yuichiro Mita; Mototada Shichiri; Shin Hisahara; Yasuo Hara; Harutoshi Fujimura; Hiroyuki Takamatsu; Yoshihisa Hagihara; Yasukazu Yoshida; Takao Hamakubo; Susumu Kusunoki; Shun Shimohama; Noriko Noguchi
  SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, 6 30793 , Jul. 2016, Scientific journal
  

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• Synthesis of 24(S)-hydroxycholesterol esters responsible for the induction of neuronal cell death
  Kimiyuki Shibuya; Toshiaki Watanabe; Yasuomi Urano; Wakako Takabe; Noriko Noguchi; Hiroaki Kitagishi
  BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON-ELSEVIER SCIENCE LTD, 24(11) 2559 - 2566, Jun. 2016, Scientific journal
  

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• The protective role of DJ-1 in ultraviolet-induced damage of human skin: DJ-1 levels in the stratum corneum as an indicator of antioxidative defense
  Shioji Ishiwatari; Minako Takahashi; Chie Yasuda; Maho Nakagawa; Yoshiro Saito; Noriko Noguchi; Shoko Matsukuma
  ARCHIVES OF DERMATOLOGICAL RESEARCH, SPRINGER, 307(10) 925 - 935, Dec. 2015, Scientific journal
  

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• Enhancement of lipid peroxidation and its amelioration by vitamin E in a subject with mutations in the SBP2 gene
  Yoshiro Saito; Mototada Shichiri; Takashi Hamajima; Noriko Ishida; Yuichiro Mita; Shohei Nakao; Yoshihisa Hagihara; Yasukazu Yoshida; Kazuhiko Takahashi; Etsuo Niki; Noriko Noguchi
  JOURNAL OF LIPID RESEARCH, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 56(11) 2172 - 2182, Nov. 2015, Scientific journal
  

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• New aspects of 24(S)-hydroxycholesterol in modulating neuronal cell death
  Noriko Noguchi; Yasuomi Urano; Wakako Takabe; Yoshiro Saito
  FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, 87 366 - 372, Oct. 2015
  

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• Lysophosphatidylcholine promotes SREBP-2 activation via rapid cholesterol efflux and SREBP-2-independent cytokine release in human endothelial cells
  Mayuko Morita; Azusa Sekine; Yasuomi Urano; Taki Nishimura; Wakako Takabe; Hiroyuki Arai; Takao Hamakubo; Tatsuhiko Kodama; Noriko Noguchi
  JOURNAL OF BIOCHEMISTRY, OXFORD UNIV PRESS, 158(4) 331 - 338, Oct. 2015, Scientific journal
  

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• 24(S)-Hydroxycholesterol induces RIPK1-dependent but MLKL-independent cell death in the absence of caspase-8
  Diep-Khanh Ho Vo; Yasuomi Urano; Wakako Takabe; Yoshiro Saito; Noriko Noguchi
  STEROIDS, ELSEVIER SCIENCE INC, 99 230 - 237, Jul. 2015, Scientific journal
  

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• Functional interaction between cyclooxygenase-2 and p53 in response to an endogenous electrophile
  Takeshi Kumagai; Hiroko Usami; Nao Matsukawa; Fumie Nakashima; Miho Chikazawa; Takahiro Shibata; Noriko Noguchi; Koji Uchida
  REDOX BIOLOGY, ELSEVIER SCIENCE BV, 4 74 - 86, Apr. 2015, Scientific journal
  

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• Aβ induces oxidative stress in senescence-accelerated (SAMP8) mice.
  Takagane K; Nojima J; Mitsuhashi H; Suo S; Yanagihara D; Takaiwa F; Urano Y; Noguchi N; Ishiura S
  Bioscience, biotechnology, and biochemistry, 79(6) 912 - 918, 2015
  

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• A? induces oxidative stress in senescence-accelerated (SAMP8) mice.
  Kurara Takagane; Jun Nojima; Hiroaki Mitsuhashi; Satoshi Suo; Dai Yanagihara; Fumio Takaiwa; Yasuomi Urano; Noriko Noguchi; Shoichi Ishiura
  Biosci. Biotech. Biochem., 23 1 - 7, 2015
• Immunostaining of Oxidized DJ-1 in Human and Mouse Brains
  Yoshiro Saito; Tomohiro Miyasaka; Hiroyuki Hatsuta; Kazuko Takahashi-Niki; Kojiro Hayashi; Yuichiro Mita; Osamu Kusano-Arai; Hiroko Iwanari; Hiroyoshi Ariga; Takao Hamakubo; Yasukazu Yoshida; Etsuo Niki; Shigeo Murayama; Yasuo Ihara; Noriko Noguchi
  JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, LIPPINCOTT WILLIAMS & WILKINS, 73(7) 714 - 728, Jul. 2014, Scientific journal
  

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• 7-Hydroxycholestrol as a possible biomarker of cellular lipid peroxidation: Difference between cellular and plasma lipid peroxidation
  Yoshiro Saito; Noriko Noguchi
  Biochemical and Biophysical Research Communications, 446 741 - 744, 11 Apr. 2014
  

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• Diverse functions of 24(S)-hydroxycholesterol in the brain
  Noriko Noguchi; Yoshiro Saito; Yasuomi Urano
  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, 446(3) 692 - 696, Apr. 2014
  

  DOI URL
• パーキンソン病における酸化DJ-1測定のバイオマーカーとしての意義の検討
  小川郁子; 斎藤芳郎; 西郷和真; 細井幸恵; 三井良之; 野口範子; 楠 進
  Brain and Nerve, 66 471 - 477, 2014, Scientific journal
• The significance of oxidized DJ-1 protein (oxDJ-1) as a biomarker for parkinson's disease
  Ikuko Ogawa; Yoshiro Saito; Kazumasa Saigoh; Yoshie Hosoi; Yoshiyuki Mitsui; Noriko Noguchi; Susumu Kusunoki
  Brain and Nerve, Igaku-Shoin Ltd, 66(4) 471 - 477, 2014, Scientific journal
• Induction of apoptosis and necroptosis by 24(S)-hydroxycholesterol is dependent on activity of acyl-CoA: cholesterol acyltransferase 1
  K. Yamanaka; Y. Urano; W. Takabe; Y. Saito; N. Noguchi
  CELL DEATH & DISEASE, NATURE PUBLISHING GROUP, 5 e990 , Jan. 2014, Scientific journal
  

  DOI URL
• Adaptive responses induced by 24S-hydroxycholesterol through liver X receptor pathway reduce 7-ketocholesterol-caused neuronal cell death
  Akishi Okabe; Yasuomi Urano; Sayoko Itoh; Naoto Suda; Rina Kotani; Yuki Nishimura; Yoshiro Saito; Noriko Noguchi
  REDOX BIOLOGY, ELSEVIER SCIENCE BV, 2 28 - 35, 2014, Scientific journal
  

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• Suppression of amyloid-β production by 24S-hydroxycholesterol via inhibition of intracellular amyloid precursor protein trafficking
  Yasuomi Urano; Sachika Ochiai; Noriko Noguchi
  FASEB Journal, FASEB, 27(10) 4305 - 4315, 01 Oct. 2013, Scientific journal
  

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• Deficiency of p62/Sequestosome 1 Causes Hyperphagia Due to Leptin Resistance in the Brain
  Harumi Harada; Eiji Warabi; Taizo Matsuki; Toru Yanagawa; Kosuke Okada; Junya Uwayama; Akira Ikeda; Kazuhiro Nakaso; Kyoko Kirii; Noriko Noguchi; Hiroki Bukawa; Richard C. M. Siow; Giovanni E. Mann; Junichi Shoda; Tetsuro Ishii; Takeshi Sakurai
  JOURNAL OF NEUROSCIENCE, SOC NEUROSCIENCE, 33(37) 14767 - 14777, Sep. 2013, Scientific journal
  

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• Oxidized DJ-1 Inhibits p53 by Sequestering p53 from Promoters in a DNA-Binding Affinity-Dependent Manner
  Izumi Kato; Hiroshi Maita; Kazuko Takahashi-Niki; Yoshiro Saito; Noriko Noguchi; Sanae M. M. Iguchi-Ariga; Hiroyoshi Ariga
  MOLECULAR AND CELLULAR BIOLOGY, AMER SOC MICROBIOLOGY, 33(2) 340 - 359, Jan. 2013, Scientific journal
  

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• Nrf2 in bone marrow-derived cells positively contributes to the advanced stage of atherosclerotic plaque formation
  Nobuhiko Harada; Koichi Ito; Tomonori Hosoya; Junsei Mimura; Atsushi Maruyama; Noriko Noguchi; Ken-ichi Yagami; Naoki Morito; Satoru Takahashi; Jon M. Maher; Masayuki Yamamoto; Ken Itoh
  FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, 53(12) 2256 - 2262, Dec. 2012, Scientific journal
  

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• Enhanced CD36 expression changes the role of Nrf2 activation from anti-atherogenic to pro-atherogenic in apoE-deficient mice
  Hirotaka Sawada; Yoshiro Saito; Noriko Noguchi
  ATHEROSCLEROSIS, ELSEVIER IRELAND LTD, 225(1) 83 - 90, Nov. 2012, Scientific journal
  

  DOI URL
• Cytoprotective effects of geraniin against peroxynitrite- and peroxyl radical-induced cell death via free radical scavenging activity
  Lai Teng Ling; Yoshiro Saito; Uma D. Palanisamy; Hwee Ming Cheng; Noriko Noguchi
  FOOD CHEMISTRY, ELSEVIER SCI LTD, 132(4) 1899 - 1907, Jun. 2012, Scientific journal
  

  DOI URL
• A novel fluorescent probe with high sensitivity and selective detection of lipid hydroperoxides in cells
  Kazunori Yamanaka; Yoshiro Saito; Junji Sakiyama; Yuya Ohuchi; Fumio Oseto; Noriko Noguchi
  RSC ADVANCES, ROYAL SOC CHEMISTRY, 2(20) 7894 - 7900, 2012, Scientific journal
  

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• 赤血球画分を用いた酸化DJ-1定量の検討
  松村 晃寛; 久原 真; 齊藤 正樹; 川又 純; 今井 富裕; 下濱 俊; 斎藤 芳郎; 野口 範子; 二木 鋭雄
  臨床神経学, (一社)日本神経学会, 51(12) 1266 - 1266, Dec. 2011
• Oxidation of DJ-1 Induced by 6-Hydroxydopamine Decreasing Intracellular Glutathione
  Akiko Miyama; Yoshiro Saito; Kazunori Yamanaka; Kojiro Hayashi; Takao Hamakubo; Noriko Noguchi
  PLOS ONE, PUBLIC LIBRARY SCIENCE, 6(11) e27883 , Nov. 2011, Scientific journal
  

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• Analyses of marine-derived tocopherol in processed foods containing fish
  Naohiro Gotoh; Daisuke Mashimo; Tomiko Oka; Kaori Sekiguchi; Mikiko Tange; Hiroyuki Watanabe; Noriko Noguchi; Shun Wada
  FOOD CHEMISTRY, ELSEVIER SCI LTD, 129(2) 279 - 283, Nov. 2011, Scientific journal
  

  DOI URL
• Anti-Atherogenic Effect of Laminar Shear Stress via Nrf2 Activation
  Wakako Takabe; Eiji Warabi; Noriko Noguchi
  ANTIOXIDANTS & REDOX SIGNALING, MARY ANN LIEBERT, INC, 15(5) 1415 - 1426, Sep. 2011
  

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• Redox Going with Vascular Shear Stress
  Noriko Noguchi; Hanjoong Jo
  ANTIOXIDANTS & REDOX SIGNALING, MARY ANN LIEBERT INC, 15(5) 1367 - 1368, Sep. 2011
  

  DOI URL
• 24(S)-Hydroxycholesterol Induces Neuronal Cell Death through Necroptosis, a Form of Programmed Necrosis
  Kazunori Yamanaka; Yoshiro Saito; Tohru Yamamori; Yasuomi Urano; Noriko Noguchi
  JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 286(28) 24666 - 24673, Jul. 2011, Scientific journal
  

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• Actual ratios of triacylglycerol positional isomers consisting of saturated and highly unsaturated fatty acids in fishes and marine mammals
  Naohiro Gotoh; Yumiko Matsumoto; Toshiharu Nagai; Hoyo Mizobe; Ikuko Otake; Kenji Ichioka; Ikuma Kuroda; Hiroyuki Watanabe; Noriko Noguchi; Shun Wada
  FOOD CHEMISTRY, ELSEVIER SCI LTD, 127(2) 467 - 472, Jul. 2011, Scientific journal
  

  DOI URL
• alpha-Tocopheryl phosphate: Uptake, hydrolysis, and antioxidant action in cultured cells and mouse
  Keiko Nishio; Noriko Ishida; Yoshiro Saito; Yoko Ogawa-Akazawa; Mototada Shichiri; Yasukazu Yoshida; Yoshihisa Hagihara; Noriko Noguchi; John Chirico; Jeffrey Atkinson; Etsuo Niki
  FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, 50(12) 1794 - 1800, Jun. 2011, Scientific journal
  

  DOI URL
• Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction
  Akira Kobayashi; Takako Tsukide; Tomohiro Miyasaka; Tomoko Morita; Tatsuya Mizoroki; Yoshiro Saito; Yasuo Ihara; Akihiko Takashima; Noriko Noguchi; Akiyoshi Fukamizu; Yosuke Hirotsu; Makiko Ohtsuji; Fumiki Katsuoka; Masayuki Yamamoto
  GENES TO CELLS, WILEY-BLACKWELL, 16(6) 692 - 703, Jun. 2011, Scientific journal
  

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• Phosphorylation of p66shc mediates 6-hydroxydopamine cytotoxicity
  Tohru Yamamori; Ayano Mizobata; Yoshiro Saito; Yasuomi Urano; Osamu Inanami; Kaikobad Irani; Noriko Noguchi
  FREE RADICAL RESEARCH, INFORMA HEALTHCARE, 45(3) 342 - 350, Mar. 2011, Scientific journal
  

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• Cytoprotective effects of vitamin E homologues against glutamate-induced cell death in immature primary cortical neuron cultures: Tocopherols and tocotrienols exert similar effects by antioxidant function
  Yoshiro Saito; Keiko Nishio; Yoko Ogawa Akazawa; Kazunori Yamanaka; Akiko Miyama; Yasukazu Yoshida; Noriko Noguchi; Etsuo Niki
  FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, 49(10) 1542 - 1549, Nov. 2010, Scientific journal
  

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• Elevation of oxidized DJ-1 in the brain and erythrocytes of Parkinson disease model animals
  Yoko Ogawa Akazawa; Yoshiro Saito; Takao Hamakubo; Yoshinori Masuo; Yasukazu Yoshida; Keiko Nishio; Mototada Shichiri; Tomohiro Miyasaka; Hiroko Iwanari; Yasuhiro Mochizuki; Tatsuhiko Kodama; Noriko Noguchi; Etsuo Niki
  NEUROSCIENCE LETTERS, ELSEVIER IRELAND LTD, 483(3) 201 - 205, Oct. 2010, Scientific journal
  

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• Enhanced neointimal hyperplasia and carotid artery remodelling in sequestosome 1 deficient mice
  Rika Sugimoto; Eiji Warabi; Satoru Katayanagi; Satoshi Sakai; Junya Uwayama; Toru Yanagawa; Ayaka Watanabe; Harumi Harada; Kiyoshi Kitamura; Noriko Noguchi; Hiroshi Yoshida; Richard C. M. Siow; Giovanni E. Mann; Tetsuro Ishii
  JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, WILEY-BLACKWELL, 14(6B) 1546 - 1554, Jun. 2010, Scientific journal
  

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• Characterization of Non-endcapped Polymeric ODS Column for the Separation of Triacylglycerol Positional Isomers
  Naohiro Gotoh; Yumiko Matsumoto; Hiromi Yuji; Toshiharu Nagai; Hoyo Mizobe; Kenji Ichioka; Ikuma Kuroda; Noriko Noguchi; Shun Wada
  JOURNAL OF OLEO SCIENCE, JAPAN OIL CHEMISTS SOC, 59(2) 71 - 79, Feb. 2010, Scientific journal
  

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• An Orally Applicable Shiga Toxin Neutralizer Functions in the Intestine To Inhibit the Intracellular Transport of the Toxin
  Miho Watanabe-Takahashi; Toshio Sato; Taeko Dohi; Noriko Noguchi; Fumi Kano; Masayuki Murata; Takashi Hamabata; Yasuhiro Natori; Kiyotaka Nishikawa
  INFECTION AND IMMUNITY, AMER SOC MICROBIOLOGY, 78(1) 177 - 183, Jan. 2010, Scientific journal
  

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• Preparation and application of monoclonal antibodies against oxidized DJ-1. Significant elevation of oxidized DJ-1 in erythrocytes of early-stage Parkinson disease patients
  Yoshiro Saito; Takao Hamakubo; Yasukazu Yoshida; Yoko Ogawa; Yasuo Hara; Harutoshi Fujimura; Yasuharu Imai; Hiroko Iwanari; Yasuhiro Mochizuki; Mototada Shichiri; Keiko Nishio; Tomoya Kinumi; Noriko Noguchi; Tatsuhiko Kodama; Etsuo Niki
  NEUROSCIENCE LETTERS, ELSEVIER IRELAND LTD, 465(1) 1 - 5, Nov. 2009, Scientific journal
  

  DOI URL
• Dietary Marine-Derived Tocopherol has a Higher Biological Availability in Mice Relative to Alpha-Tocopherol
  Naohiro Gotoh; Hiroyuki Watanabe; Tomiko Oka; Daisuke Mashimo; Noriko Noguchi; Kazuhiko Hata; Shun Wada
  LIPIDS, SPRINGER HEIDELBERG, 44(2) 133 - 143, Feb. 2009, Scientific journal
  

  DOI URL
• Regulation of GCL activity and cellular glutathione through inhibition of ERK phosphorylation
  Zhi-Hua Chen; Yoshiro Saito; Yasukazu Yoshida; Noriko Noguchi; Etsuo Niki
  BIOFACTORS, IOS PRESS, 33(1) 1 - 11, 2008, Scientific journal
  

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• Chronic oxidative stress causes amplification and overexpression of ptprz1 protein tyrosine phosphatase to activate beta-catenin pathway
  Yu-Ting Liu; Donghao Shang; Shinya Akatsuka; Hiroki Ohara; Khokon Kumar Dutta; Katsura Mizushima; Yuji Naito; Toshikazu Yoshikawa; Masashi Izumiya; Kouichiro Abe; Hitoshi Nakagama; Noriko Noguchi; Shinya Toyokuni
  AMERICAN JOURNAL OF PATHOLOGY, AMER SOC INVESTIGATIVE PATHOLOGY, INC, 171(6) 1978 - 1988, Dec. 2007, Scientific journal
  

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• Protective effects of 15-deoxy-Delta(12,14)-prostaglandin J(2) against glutamate-induced cell death in primary cortical neuron cultures: induction of adaptive response and enhancement of cell tolerance primarily through up-regulation of cellular glutathione
  Yoshiro Saito; Keiko Nishio; Yumiko Numakawa; Yoko Ogawa; Yasukazu Yoshida; Noriko Noguchi; Etsuo Niki
  JOURNAL OF NEUROCHEMISTRY, BLACKWELL PUBLISHING, 102(5) 1625 - 1634, Sep. 2007, Scientific journal
  

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• Nrf2-dependent and -independent induction of ABC transporters ABCC1, ABCC2, and ABCG2 in HepG2 cells under oxidative stress
  Tatsuhiko Adachi; Hiroshi Nakagawa; Ivy Chung; Yuichiro Hagiya; Kazuyuki Hoshijima; Noriko Noguchi; Macus Tien Kuo; Toshihisa Ishikawa
  Journal of Experimental Therapeutics and Oncology, 6(4) 335 - 348, 2007, Scientific journal
• Shear stress stabilizes NF-E2-related factor 2 and induces antioxidant genes in endothelial cells: Role of reactive oxygen/nitrogen species
  Eiji Warabi; Wakako Takabe; Takashi Minami; Kenji Inoue; Ken Itoh; Masayuki Yamamoto; Tetsuro Ishii; Tatsuhiko Kodama; Noriko Noguchi
  FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, 42(2) 260 - 269, Jan. 2007, Scientific journal
  

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• alpha-Tocopherol induces calnexin in renal tubular cells: Another protective mechanism against free radical-induced cellular damage
  Wen-Hua Lee; Shinya Akatsuka; Tomoyuki Shirase; Khokon Kumar Dutta; Li Jiang; Yu-Ting Liu; Janice Onuki; Yoshihiro Yamada; Katsuya Okawa; Youichiro Wada; Akira Watanabe; Takahide Kohro; Noriko Noguchi; Shinya Toyokuni
  ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, ELSEVIER SCIENCE INC, 453(2) 168 - 178, Sep. 2006, Scientific journal
  

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• Turning point in apoptosis/necrosis induced by hydrogen peroxide
  Yoshiro Saito; Keiko Nishio; Yoko Ogawa; Junko Kimata; Tomoya Kinumi; Yasukazu Yoshida; Noriko Noguchi; Etsuo Niki
  FREE RADICAL RESEARCH, TAYLOR & FRANCIS LTD, 40(6) 619 - 630, Jun. 2006, Scientific journal
  

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• Activation of mitogen-activated protein kinases by lysophosphatidylcholine-induced mitochondrial reactive oxygen species generation in endothelial cells
  N Watanabe; JW Zmijewski; W Takabe; M Umezu-Goto; C Le Goffe; A Sekine; A Landar; A Watanabe; J Aoki; H Arai; T Kodama; MP Murphy; R Kalyanaraman; VM Darley-Usmar; N Noguchi
  AMERICAN JOURNAL OF PATHOLOGY, AMER SOC INVESTIGATIVE PATHOLOGY, INC, 168(5) 1737 - 1748, May 2006, Scientific journal
  

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• Induction of Adaptive Response and Enhancement of PC12 Cell Tolerance by 7-Hydroxycholesterol and 15-Deoxy-Delta(12,14)-Prostaglandin J(2) through Up-regulation of Cellular Glutathione via Different Mechanisms
  Zhi-Hua Chen; Yasukazu Yoshida; Yoshiro Saito; Azusa Sekine; Noriko Noguchi; Etsuo Niki
  JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 281(20) 14440 - 14445, May 2006, Scientific journal
  

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• Interface of Antioxidant Function and Gene Expression Function
  Noguchi Noriko
  VITAMINS, THE VITAMIN SOCIETY OF JAPAN, 80(10) 499 - 506, 2006
  

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• Quantification Method for Triglyceride Molecular Species in Fish Oil with High Performance Liquid Chromatography - Ultraviolet Detector - Evaporative Light Scattering Detector
  GOTOH Naohiro; AOKI Tomoko; NAKAYASU Kyoko; TOKAIRIN Shigeru; NOGUCHI Noriko; WADA Shun
  Journal of Oleo Science, Japan Oil Chemists' Society, 55(9) 457 - 463, 2006
  

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• Adaptive response induced by lipid peroxidation products in cell cultures
  ZH Chen; Y Yoshida; Y Saito; N Noguchi; E Niki
  FEBS LETTERS, ELSEVIER SCIENCE BV, 580(2) 479 - 483, Jan. 2006, Scientific journal
  

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• Chemical structure-dependent gene expression of proteasome subunits via regulation of the antioxidant response element
  W Takabe; N Matsukawa; T Kodama; K Tanaka; N Noguchi
  FREE RADICAL RESEARCH, TAYLOR & FRANCIS LTD, 40(1) 21 - 30, Jan. 2006, Scientific journal
  

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• 4-Hydroxynonenal induces adaptive response and enhances PC12 cell tolerance primarily through induction of thioredoxin reductase 1 via activation of Nrf2
  ZH Chen; Y Saito; Y Yoshida; A Sekine; N Noguchi; E Niki
  JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 280(51) 41921 - 41927, Dec. 2005, Scientific journal
  

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• Lipid peroxidation: Mechanisms, inhibition, and biological effects
  E Niki; Y Yoshida; Y Saito; N Noguchi
  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, 338(1) 668 - 676, Dec. 2005
  

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• Tumor suppressive effects of tocotrienol in vivo and in vitro
  S Wada; Y Satomi; M Murakoshi; N Noguchi; T Yoshikawa; H Nishino
  CANCER LETTERS, ELSEVIER IRELAND LTD, 229(2) 181 - 191, Nov. 2005, Scientific journal
  

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• Inhibition of cholesterol biosynthesis by 25-hydroxycholesterol is independent of OSBP
  T Nishimura; T Inoue; N Shibata; A Sekine; W Takabe; N Noguchi; H Arai
  GENES TO CELLS, BLACKWELL PUBLISHING, 10(8) 793 - 801, Aug. 2005, Scientific journal
  

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• Differential responses of the Nrf2-Keap1 system to laminar and oscillatory shear stresses in endothelial cells
  T Hosoya; A Maruyama; MI Kang; Y Kawatani; T Shibata; K Uchida; K Itoh; M Yamamoto
  JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 280(29) 27244 - 27250, Jul. 2005, Scientific journal
  

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• A novel protein kinase B (PKB)/AKT-binding protein enhances PKB kinase activity and regulates DNA synthesis
  M Anai; N Shojima; H Katagiri; T Ogihara; H Sakoda; Y Onishi; H Ono; M Fujishiro; Y Fukushima; N Horike; A Viana; M Kikuchi; N Noguchi; S Takahashi; K Takata; Y Oka; Y Uchijima; H Kurihara; T Asano
  JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 280(18) 18525 - 18535, May 2005, Scientific journal
  

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• Tocotrienols reduce 25-hydroxycholesterol-induced monocyte-endothelial cell interaction by inhibiting the surface expression of adhesion molecules
  Y Naito; M Shimozawa; M Kuroda; N Nakabe; H Manabe; K Katada; S Kokura; H Ichikawa; N Yoshida; N Noguchi
  ATHEROSCLEROSIS, ELSEVIER IRELAND LTD, 180(1) 19 - 25, May 2005, Scientific journal
  

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• Association of active gamma-secretase complex with lipid rafts
  Y Urano; Hayashi, I; N Isoo; PC Reid; Y Shibasaki; N Noguchi; T Tomita; T Iwatsubo; T Hamakubo; T Kodama
  JOURNAL OF LIPID RESEARCH, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 46(5) 904 - 912, May 2005, Scientific journal
  

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• Expression of the LXR alpha protein in human atherosclerotic lesions
  Y Watanabe; SY Jiang; W Takabe; R Ohashi; T Tanaka; Y Uchiyama; K Katsumi; H Iwanari; N Noguchi; M Naito; T Hamakubo; T Kodama
  ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, LIPPINCOTT WILLIAMS & WILKINS, 25(3) 622 - 627, Mar. 2005, Scientific journal
  

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• Activation of map kinases by lysophosphatidylcholine-induced mitochondrial reactive oxygen species generation in endothelial cells
  N Watanabe; J Zmijewski; C Le Goffe; A Landar; W Takabe; M Murphy; R Kalyanaraman; N Noguchi; Darley-Usmar, V
  FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, 39 S80 - S80, 2005
  

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• 4-hydroxynonenal induces adaptive response and enhances PC12 cell tolerance primarily through induction of thioredoxin reductase 1 via activation of NRF2
  ZH Chen; Y Saito; Y Yoshida; A Sekine; N Noguchi; E Niki
  FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, 39 S69 - S69, 2005
  

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• Vascular endothelial growth factor-and thrombin-induced termination factor, down syndrome critical region-1, attenuates endothelial cell proliferation and angiogenesis
  T Minami; K Horiuchi; M Miura; MR Abid; W Takabe; N Noguchi; T Kohro; XJ Ge; H Aburatani; T Hamakubo; T Kodama; WC Aird
  JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 279(48) 50537 - 50554, Nov. 2004, Scientific journal
  

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• Inhibition of plasma lipid peroxidation by anti-atherogenic antioxidant BO-653, 2,3-dihydro-5-hydroxy-4,6-di-tert-butyl-2,2-dipentylbenzofuran
  N Itoh; Y Yoshida; M Hayakawa; N Noguchi; T Kodama; O Cynshi; E Niki
  BIOCHEMICAL PHARMACOLOGY, PERGAMON-ELSEVIER SCIENCE LTD, 68(5) 813 - 818, Sep. 2004, Scientific journal
  

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• Effect on endothelial cell gene expression of shear stress, oxygen concentration, and low-density lipoprotein as studied by a novel flow cell culture system
  E Warabi; Y Wada; H Kajiwara; M Kobayashi; N Koshiba; T Hisada; M Shibata; J Ando; M Tsuchiya; T Kodama; N Noguchi
  FREE RADICAL BIOLOGY AND MEDICINE, PERGAMON-ELSEVIER SCIENCE LTD, 37(5) 682 - 694, Sep. 2004, Scientific journal
  

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• Lysophosphatidylcholine enhances cytokine production of endothelial cells via induction of L-type amino acid transporter 1 and cell surface antigen 4F2
  W Takabe; Y Kanai; A Chairoungdua; N Shibata; S Toi; M Kobayashi; T Kodama; N Noguchi
  ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, LIPPINCOTT WILLIAMS & WILKINS, 24(9) 1640 - 1645, Sep. 2004, Scientific journal
  

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• Oxidative stress induces insulin resistance by activating the nuclear factor-kappa B pathway and disrupting normal subcellular distribution of phosphatidylinositol 3-kinase
  T Ogihara; T Asano; H Katagiri; H Sakoda; M Anai; N Shojima; H Ono; M Fujishiro; A Kushiyama; Y Fukushima; M Kikuchi; N Noguchi; H Aburatani; Y Gotoh; Komuro, I; T Fujita
  DIABETOLOGIA, SPRINGER-VERLAG, 47(5) 794 - 805, May 2004, Scientific journal
  

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• Ethanol enhances selenoprotein P expression via ERK-FoxO3a axis in HepG2 cells
  Jian Chen; Yuichiro Mita; Noriko Noguchi
  Journal of Clinical Biology and Nutrition, 2004
• Quantification Method for Triglyceride Molecular Species in Fish Oil with High Performance Liquid Chromatography-Ultraviolet Detector
  Tomoko Aoki; Ikuko Otake; Naohiro Gotoh; Noriko Noguchi; Shun Wada
  Journal of Oleo Science, 53(6) 285 - 294, 2004, Scientific journal
  

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• Dynamics of antioxidant action of vitamin E
  E Niki; N Noguchi
  ACCOUNTS OF CHEMICAL RESEARCH, AMER CHEMICAL SOC, 37(1) 45 - 51, Jan. 2004
  

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• A novel method of following oxidation of low-density lipoprotein using a sensitive fluorescent probe, diphenyl-1-pyrenylphosphine
  Y Okimoto; E Warabi; Y Wada; E Niki; T Kodama; N Noguchi
  FREE RADICAL BIOLOGY AND MEDICINE, PERGAMON-ELSEVIER SCIENCE LTD, 35(6) 576 - 585, Sep. 2003, Scientific journal
  

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• Inhibition of THP-1 cell adhesion to endothelial cells by alpha-tocopherol and alpha-tocotrienol is dependent on intracellular concentration of the antioxidants
  N Noguchi; R Hanyu; A Nonaka; Y Okimoto; T Kodama
  FREE RADICAL BIOLOGY AND MEDICINE, PERGAMON-ELSEVIER SCIENCE LTD, 34(12) 1614 - 1620, Jun. 2003, Scientific journal
  

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• Comparative study on the action of tocopherols and tocotrienols as antioxidant: chemical and physical effects
  Y Yoshida; E Niki; N Noguchi
  CHEMISTRY AND PHYSICS OF LIPIDS, ELSEVIER SCI IRELAND LTD, 123(1) 63 - 75, Mar. 2003, Scientific journal
  

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• Angiotensin II-induced insulin resistance is associated with enhanced insulin signaling
  T Ogihara; T Asano; K Ando; Y Chiba; H Sakoda; M Anai; N Shojima; H Ono; Y Onishi; M Fujishiro; H Katagiri; Y Fukushima; M Kikuchi; N Noguchi; H Aburatani; Komuro, I; T Fujita
  HYPERTENSION, LIPPINCOTT WILLIAMS & WILKINS, 40(6) 872 - 879, Dec. 2002, Scientific journal
  

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• Novel insights into the molecular mechanisms of the antiatherosclerotic properties of antioxidants: The alternatives to radical scavenging
  N Noguchi
  FREE RADICAL BIOLOGY AND MEDICINE, PERGAMON-ELSEVIER SCIENCE LTD, 33(11) 1480 - 1489, Dec. 2002
  

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• Antioxidant action of 2,2,4,6-tetra-substituted 2,3-dihydro-5-hydroxybenzofuran against lipid peroxidation: Effects of substituents and side chain
  Y Yoshida; N Noguchi; A Watanabe; Y Iwaki; M Yanagisawa; T Kodama; O Cynshi; E Niki
  FREE RADICAL RESEARCH, TAYLOR & FRANCIS LTD, 36(11) 1171 - 1178, Nov. 2002, Scientific journal
  

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• Lipid accumulation in smooth muscle cells under LDL loading is independent of LDL receptor pathway and enhanced by hypoxic conditions
  Y Wada; A Sugiyama; T Yamamoto; M Naito; N Noguchi; S Yokoyama; M Tsujita; Y Kawabe; M Kobayashi; A Izumi; T Kohro; T Tanaka; H Taniguchi; H Koyama; K Hirano; S Yamashita; Y Matsuzawa; E Niki; T Hamakubo; T Kodama
  ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, LIPPINCOTT WILLIAMS & WILKINS, 22(10) 1712 - 1719, Oct. 2002, Scientific journal
  

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• Effects of antioxidants against atherosclerosis
  E Niki; N Noguchi
  MOLECULAR AND CELLULAR BIOCHEMISTRY, KLUWER ACADEMIC PUBL, 234(1) 19 - 25, May 2002, Scientific journal
• 15-deoxy-Delta(12,14)-prostaglandin J(2): The endogenous electrophile that induces neuronal apoptosis
  M Kondo; T Shibata; T Kumagai; T Osawa; N Shibata; M Kobayashi; S Sasaki; M Iwata; N Noguchi; K Uchida
  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, 99(11) 7367 - 7372, May 2002, Scientific journal
  

  DOI URL
• The specificity of lipoxygenase-catalyzed lipid peroxidation and the effects of radical-scavenging antioxidants
  N Noguchi; H Yamashita; J Hamahara; A Nakamura; H Kuhn; E Niki
  BIOLOGICAL CHEMISTRY, WALTER DE GRUYTER & CO, 383(3-4) 619 - 626, Mar. 2002, Scientific journal
  

  DOI URL
• Oxidized low density lipoprotein-induced LFA-1-dependent adhesion and transendothelial migration of monocytes via the protein kinase C pathway
  S Mine; T Tabata; Y Wada; T Fujisaki; T Iida; N Noguchi; E Niki; T Kodama; Y Tanaka
  ATHEROSCLEROSIS, ELSEVIER SCI IRELAND LTD, 160(2) 281 - 288, Feb. 2002, Scientific journal
  

  DOI URL
• Specificity and inhibition by antioxidant of lipid peroxidation by lipoxygenase: effects of substrate, lipoxygenase and milieu
  N Noguchi; H Yamashita; H Kuhn; E Niki
  OXYGEN AND LIFE: OXYGENASES, OXIDASE AND LIPID MEDIATORS, ELSEVIER SCIENCE BV, 1233 355 - 356, 2002, International conference proceedings
• Ebselen, a glutathione peroxidase mimetic seleno-organic compound, as a multifunctional antioxidant - Implication for inflammation-associated carcinogenesis
  Y Nakamura; Q Feng; T Kumagai; K Torikai; H Ohigashi; T Osawa; N Noguchi; E Niki; K Uchida
  JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 277(4) 2687 - 2694, Jan. 2002, Scientific journal
  

  DOI URL
• Formation of active oxygen species and lipid peroxidation induced by hypochlorite
  N Noguchi; A Nakada; Y Itoh; A Watanabe; E Niki
  ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, ACADEMIC PRESS INC ELSEVIER SCIENCE, 397(2) 440 - 447, Jan. 2002, Scientific journal
  

  DOI URL
• In vivo complex formation of oxidized alpha(1)-antitrypsin and LDL
  S Mashiba; Y Wada; M Takeya; A Sugiyama; T Hamakubo; A Nakamura; N Noguchi; E Niki; A Izumi; M Kobayashi; K Uchida; T Kodama
  ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, LIPPINCOTT WILLIAMS & WILKINS, 21(11) 1801 - 1808, Nov. 2001, Scientific journal
• Anti-atherogenic antioxidants regulate the expression and function of proteasome alpha-type subunits in human endothelial cells
  W Takabe; T Kodama; T Hamakubo; K Tanaka; T Suzuki; H Aburatani; N Matsukawa; N Noguchi
  JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 276(44) 40497 - 40501, Nov. 2001, Scientific journal
  

  DOI URL
• Oxidative stress promotes the development of transformation: involvement of a potent mutagenic lipid peroxidation product, acrolein
  W Takabe; E Niki; K Uchida; S Yamada; K Satoh; N Noguchi
  CARCINOGENESIS, OXFORD UNIV PRESS, 22(6) 935 - 941, Jun. 2001, Scientific journal
  

  DOI URL
• New Functions of 20-Hydroxyecdysone in Lipid Peroxidation
  Alexander I. Kuzmenko; Etsuo Niki; Noriko Noguchi
  Journal of Oleo Science, 50(6) 497 - 506, 2001, Scientific journal
  

  DOI URL
• Role of myeloperoxidase in the neutrophil-induced oxidation of low density lipoprotein as studied by myeloperoxidase-knockout mouse
  N Noguchi; K Nakano; Y Aratani; H Koyama; T Kodama; E Niki
  JOURNAL OF BIOCHEMISTRY, JAPANESE BIOCHEMICAL SOC, 127(6) 971 - 976, Jun. 2000, Scientific journal
• A novel fluorescent probe diphenyl-1-pyrenylphosphine to follow lipid peroxidation in cell membranes
  Y Okimoto; A Watanabe; E Niki; T Yamashita; N Noguchi
  FEBS LETTERS, ELSEVIER SCIENCE BV, 474(2-3) 137 - 140, Jun. 2000, Scientific journal
  

  DOI URL
• Stability and reactivity of aryloxyl radicals derived from a novel antioxidant BO-653 and related compounds. Effects of substituent and side chain in solution and membranes
  A Watanabe; N Noguchi; A Fujisawa; T Kodama; K Tamura; O Cynshi; E Niki
  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMER CHEMICAL SOC, 122(23) 5438 - 5442, Jun. 2000, Scientific journal
  

  DOI URL
• Phenolic antioxidants: A rationale for design and evaluation of novel antioxidant drug for atherosclerosis
  Noriko Noguchi; Etsuo Niki
  Free Radical Biology and Medicine, 28(10) 1538 - 1546, 15 May 2000, International conference proceedings
  

  DOI URL
• Antioxidant action, of the antihypertensive drug, carvedilol, against lipid peroxidation
  N Noguchi; K Nishino; E Niki
  BIOCHEMICAL PHARMACOLOGY, PERGAMON-ELSEVIER SCIENCE LTD, 59(9) 1069 - 1076, May 2000, Scientific journal
  

  DOI URL
• Inhibition of c-jun expression induces antioxidant enzymes under serum deprivation
  YH Kim; M Takahashi; N Noguchi; E Suzuki; K Suzuki; N Taniguchi; E Niki
  ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, ACADEMIC PRESS INC, 374(2) 339 - 346, Feb. 2000, Scientific journal
  

  DOI URL
• Diverse functions of antioxidants
  N. Noguchi; A. Watanabe; H. Shi
  Free Radical Research, 33(6) 809 - 817, 2000
  

  DOI URL
• Gene expression induced by BO-653, probucol and BHQ in human endothelial cells.
  W. Takabe; C. Mataki; Y. Wada; M. Ishii; A Izumi; H. Aburatani; T. Hamakubo; E. Niki; T. Kodama; N. Noguchi
  J. Atheroscler. Thromb., 7 223 - 230, 2000
  

  DOI URL
• 1-Methyl-4-phenyl-2,3-dihydropyridinium is transformed by ubiquinone to the selective nigrostriatal toxin 1-methyl-4-phenylpyridinium
  HL Shi; N Noguchi; YX Xu; E Niki
  FEBS LETTERS, ELSEVIER SCIENCE BV, 461(3) 196 - 200, Nov. 1999, Scientific journal
  

  DOI URL
• An in vitro coculture model of transmigrant monocytes and foam cell formation
  M Takaku; Y Wada; K Jinnouchi; M Takeya; K Takahashi; H Usuda; M Naito; H Kurihara; Y Yazaki; Y Kumazawa; Y Okimoto; M Umetani; N Noguchi; E Niki; T Hamakubo; T Kodama
  ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, LIPPINCOTT WILLIAMS & WILKINS, 19(10) 2330 - 2339, Oct. 1999, Scientific journal
• Comparative study on dynamics of antioxidative action of alpha-tocopheryl hydroquinone, ubiquinol, and alpha-tocopherol, against lipid peroxidation
  HL Shi; N Noguchi; E Niki
  FREE RADICAL BIOLOGY AND MEDICINE, PERGAMON-ELSEVIER SCIENCE LTD, 27(3-4) 334 - 346, Aug. 1999, Scientific journal
  

  DOI URL
• Rate constants for hydrogen atom abstraction by alpha-tocopheroxyl radical from lipid, hydroperoxide and ascorbic acid
  A Watanabe; N Noguchi; M Takahashi; E Niki
  CHEMISTRY LETTERS, CHEMICAL SOC JAPAN, (7) 613 - 614, Jul. 1999, Scientific journal
  

  DOI URL
• Vitamin E protects against polymorphonuclear leukocyte-dependent adhesion to endothelial cells
  N Yoshida; T Yoshikawa; H Manabe; Y Terasawa; M Kondo; N Noguchi; E Niki
  JOURNAL OF LEUKOCYTE BIOLOGY, FEDERATION AMER SOC EXP BIOL, 65(6) 757 - 763, Jun. 1999, Scientific journal
• Action of quinolinic and indolinonic aminoxyls as radical-scavenging antioxidants
  N Noguchi; E Damiani; L Greci; E Niki
  CHEMISTRY AND PHYSICS OF LIPIDS, ELSEVIER IRELAND LTD, 99(1) 11 - 19, May 1999, Scientific journal
  

  DOI URL
• Formation of phospholipid hydroperoxides and its inhibition by alpha-tocopherol in rat brain synaptosomes induced by peroxynitrite
  HL Shi; N Noguchi; YX Xu; E Niki
  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ACADEMIC PRESS INC ELSEVIER SCIENCE, 257(3) 651 - 656, Apr. 1999, Scientific journal
  

  DOI URL
• Oxidation of low density lipoprotein and plasma by 15-lipoxygenase and free radicals
  H Yamashita; A Nakamura; N Noguchi; E Niki; H Kuhn
  FEBS LETTERS, ELSEVIER SCIENCE BV, 445(2-3) 287 - 290, Feb. 1999, Scientific journal
  

  DOI URL
• Action of Pyrroloquinolinequinol As an Antioxidant Against Lipid Peroxidation in Solution
  Kazuhiro Miyauchi; Teiji Urakami; Hiroyuki Abeta; Honglian Shi; Noriko Noguchi; Etsuo Niki
  Antioxidants and Redox Signaling, Mary Ann Liebert Inc., 1(4) 547 - 554, 1999, Scientific journal
  

  DOI URL
• Dynamics of action of bisphenol as radical-scavenging antioxidant against lipid peroxidation in solution and liposomal membranes
  K Nishino; N Noguchi; E Niki
  FREE RADICAL RESEARCH, HARWOOD ACAD PUBL GMBH, 31(6) 535 - 548, 1999, Scientific journal
  

  DOI URL
• Dynamics of antioxidant action of ubiquinol: a reappraisal
  HL Shi; N Noguchi; E Niki
  BIOFACTORS, IOS PRESS, 9(2-4) 141 - 148, 1999, Scientific journal
• Antiatherogenic effects of the antioxidant BO-653 in three different animal models
  O Cynshi; Y Kawabe; T Suzuki; Y Takashima; H Kaise; M Nakamura; Y Ohba; Y Kato; K Tamura; A Hayasaka; A Higashida; H Sakaguchi; M Takeya; K Takahashi; K Inoue; N Noguchi; E Niki; T Kodama
  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, 95(17) 10123 - 10128, Aug. 1998, Scientific journal
  

  DOI URL
• Acrolein is a product of lipid peroxidation reaction - Formation of free acrolein and its conjugate with lysine residues in oxidized low density lipoproteins
  K Uchida; M Kanematsu; Y Morimitsu; T Osawa; N Noguchi; E Niki
  JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 273(26) 16058 - 16066, Jun. 1998, Scientific journal
  

  DOI URL
• Protein-bound acrolein: Potential markers for oxidative stress
  K Uchida; M Kanematsu; K Sakai; T Matsuda; N Hattori; Y Mizuno; D Suzuki; T Miyata; N Noguchi; E Niki; T Osawa
  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, NATL ACAD SCIENCES, 95(9) 4882 - 4887, Apr. 1998, Scientific journal
  

  DOI URL
• Action of 21-aminosteroid U74006F as an antioxidant against lipid peroxidation
  N Noguchi; M Takahashi; J Tsuchiya; H Yamashita; E Komuro; E Niki
  BIOCHEMICAL PHARMACOLOGY, PERGAMON-ELSEVIER SCIENCE LTD, 55(6) 785 - 791, Mar. 1998, Scientific journal
  

  DOI URL
• Inhibition of oxidative modifications of low density lipoprotein by antioxidants
  N Noguchi; E Niki
  PATHOPHYSIOLOGY OF LIPID PEROXIDES AND RELATED FREE RADICALS, KARGER, 91 - 101, 1998, International conference proceedings
• Action of vitamin E as antioxidant against oxidative modification of low density lipoprotein
  Noriko Noguchi; Naohiro Gotoh; Etsuo Niki
  BIOFACTORS, WILEY, 7(1-2) 41 - 50, 1998, Scientific journal
  

  DOI URL
• Inhibition of oxidative modification of low density lipoprotein by novel antioxidant BO-653 prepared by theoretical design
  N Noguchi; Y Okimoto; O Cynshi; T Kodama; E Niki
  BIOLOGICAL OXIDANTS AND ANTIOXIDANTS: MOLECULAR MECHANISMS AND HEALTH EFFECTS, AMER OIL CHEMISTS SOC, 139 - 152, 1998, International conference proceedings
• Oxidation of lipids in low density lipoprotein particles
  N Noguchi; R Numano; H Kaneda; E Niki
  FREE RADICAL RESEARCH, HARWOOD ACAD PUBL GMBH, 29(1) 43 - 52, 1998, Scientific journal
  

  DOI URL
• Dynamics of vitamin E action against LDL oxidation
  N Noguchi; E Niki
  FREE RADICAL RESEARCH, HARWOOD ACAD PUBL GMBH, 28(6) 561 - 572, 1998, Scientific journal
  

  DOI URL
• 2,2'-azobis (4-methoxy-2,4-dimethylvaleronitrile), a new lipid-soluble azo initiator: Application to oxidations of lipids and low-density lipoprotein in solution and in aqueous dispersions
  N Noguchi; H Yamashita; N Gotoh; Y Yamamoto; R Numano; E Niki
  FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, 24(2) 259 - 268, Jan. 1998, Scientific journal
  

  DOI URL
• Inhibition of oxidation of low-density lipoprotein by a novel antioxidant, BO-653, prepared by theoretical design
  N Noguchi; Y Okimoto; J Tsuchiya; O Cynshi; T Kodama; E Niki
  ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, ELSEVIER SCIENCE INC, 347(1) 141 - 147, Nov. 1997, Scientific journal
  

  DOI URL
• Design, Synthesis and Evaluation of Novel Radical-Scavenging Antioxidant against Lipid Peroxidation
  NOGUCHI Noriko
  Journal of Oleo Science, Japan Oil Chemists' Society, 46(10) 1167 - 1175, 20 Oct. 1997
  

  DOI URL
• 2,3-dihydro-5-hydroxy-2,2-dipentyl-4,6-di-tert-butylbenzofuran: Design and evaluation as a novel radical-scavenging antioxidant against lipid peroxidation
  N Noguchi; Y Iwaki; M Takahashi; E Komuro; Y Kato; K Tamura; O Cynshi; T Kodama; E Niki
  ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS, 342(2) 236 - 243, Jun. 1997, Scientific journal
  

  DOI URL
• Dynamics of oxidation of LDL and its inhibition by antioxidants
  E Niki; N Noguchi
  BIOFACTORS, WILEY, 6(2) 201 - 208, 1997, Scientific journal
• イチョウ葉エキスの抗酸化作用.
  野口範子; 西野公大; 鷲尾英一; 石 紅朕; 陳 京生; 二木鋭雄
  J. Jpn. Oil Chem. Soc., 12 1481 - 1488, 1997
• Inhibition of oxidation of low density lipoprotein by troglitazone
  N Noguchi; H Sakai; Y Kato; J Tsuchiya; Y Yamamoto; E Niki; H Horikoshi; T Kodama
  ATHEROSCLEROSIS, ELSEVIER SCI IRELAND LTD, 123(1-2) 227 - 234, Jun. 1996, Scientific journal
  

  DOI URL
• Inhibition of oxidation of low density lipoprotein by vitamin E and related compounds
  N Gotoh; N Noguchi; J Tsuchiya; K Morita; H Sakai; H Shimasaki; E Niki
  FREE RADICAL RESEARCH, TAYLOR & FRANCIS LTD, 24(2) 123 - 134, 1996, Scientific journal
  

  DOI URL
• INTERACTION AMONG VITAMIN-C, VITAMIN-E, AND BETA-CAROTENE
  E NIKI; N NOGUCHI; H TSUCHIHASHI; N GOTOH
  AMERICAN JOURNAL OF CLINICAL NUTRITION, AMER SOC NUTRITION-ASN, 62(6) 1322 - 1326, Dec. 1995, Scientific journal
• ACTION OF NITRIC-OXIDE AS AN ANTIOXIDANT AGAINST OXIDATION OF SOYBEAN PHOSPHATIDYLCHOLINE LIPOSOMAL MEMBRANES
  K HAYASHI; N NOGUCHI; E NIKI
  FEBS LETTERS, ELSEVIER SCIENCE BV, 370(1-2) 37 - 40, Aug. 1995, Scientific journal
  

  DOI URL
• HEPATIC DAMAGE-INDUCED BY PERFUSION OF RADICAL GENERATING AZO COMPOUND AND ITS INHIBITION BY VITAMIN-E
  H YASUDA; N NOGUCHI; M MIKI; W MORINOBU; K HIRANO; T OGIHARA; T TANABE; M MINO; K TERAO; E NIKI
  CHEMICO-BIOLOGICAL INTERACTIONS, ELSEVIER SCI PUBL IRELAND LTD, 97(1) 11 - 23, Jun. 1995, Scientific journal
  

  DOI URL
• DYNAMICS OF FREE-RADICAL FORMATION FROM THE REACTION OF PEROXIDES WITH HAEMPROTEINS AS STUDIED BY STOPPED-FLOW CHEMILUMINESCENCE
  N NOGUCHI; E NIKI
  FREE RADICAL RESEARCH, HARWOOD ACAD PUBL GMBH, 23(4) 329 - 338, 1995, Scientific journal
  

  DOI URL
• EFFECTS OF EBSELEN AND PROBUCOL ON OXIDATIVE MODIFICATIONS OF LIPID AND PROTEIN OF LOW-DENSITY-LIPOPROTEIN INDUCED BY FREE-RADICALS
  N NOGUCHI; N GOTOH; E NIKI
  BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM, ELSEVIER SCIENCE BV, 1213(2) 176 - 182, Jul. 1994, Scientific journal
• 2,2'-AZOBIS(4-METHOXY-2,4-DIMETHYLVALERONITRILE), A NEW LIPID-SOLUBLE AZO RADICAL INITIATOR
  N GOTOH; T YOSHINO; N NOGUCHI; E NIKI
  FRONTIERS OF REACTIVE OXYGEN SPECIES IN BIOLOGY AND MEDICINE, ELSEVIER SCIENCE PUBL B V, 1058 59 - 62, 1994, International conference proceedings
• ANTIOXIDANT EFFECTS OF PROBUCOL AND EBSELEN AGAINST OXIDATIVE MODIFICATION OF LDL INDUCED BY FREE-RADICALS GENERATED AT DIFFERENT SITES
  N NOGUCHI; N GOTOH; T YOSHINO; E NIKI
  FRONTIERS OF REACTIVE OXYGEN SPECIES IN BIOLOGY AND MEDICINE, ELSEVIER SCIENCE PUBL B V, 1058 191 - 194, 1994, International conference proceedings
• Action of curcumin as an antioxidant against lipid peroxidation.
  N. Noguchi; E. Komuro; E. Niki; R. L. Willson
  J. Jpn. Oil Chem. Soc., Japan Oil Chemists' Society, 43(12) 1045 - 1051, 1994
  

  DOI URL
• Dynamics of the oxidation of low density lipoprotein induced by free radicals
  Noguchi Noriko; Gotoh Naohiro; Niki Etsuo
  Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism, 1168(3) 348 - 357, 01 Jul. 1993, Scientific journal
  

  DOI URL
• DYNAMICS OF THE OXIDATION OF LOW-DENSITY-LIPOPROTEIN INDUCED BY FREE-RADICALS
  N NOGUCHI; N GOTOH; E NIKI
  BIOCHIMICA ET BIOPHYSICA ACTA, ELSEVIER SCIENCE BV, 1168(3) 348 - 357, Jul. 1993, Scientific journal
• DYNAMICS OF LIPID-PEROXIDATION AND ITS INHIBITION BY ANTIOXIDANTS
  E NIKI; N NOGUCHI; N GOTOH
  BIOCHEMICAL SOCIETY TRANSACTIONS, PORTLAND PRESS LTD, 21(2) 313 - 317, May 1993, Scientific journal
• EFFECTS OF PARAQUAT ON MG2+-ATPASE ACTIVITY IN RAT-LIVER
  N NOGUCHI; HA YAMAMOTO; S MISAWA
  ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, SPRINGER VERLAG, 24(4) 483 - 486, May 1993, Scientific journal
  

  DOI URL
• INHIBITION OF OXIDATIVE MODIFICATION OF LOW-DENSITY-LIPOPROTEIN BY ANTIOXIDANTS
  E NIKI; N NOGUCHI; N GOTOH
  JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY, CENTER ACADEMIC PUBL JAPAN, 39 S1 - S8, 1993, Scientific journal
• ANTIOXIDANT ACTIVITIES OF PROBUCOL AGAINST LIPID PEROXIDATIONS
  N GOTOH; K SHIMIZU; E KOMURO; J TSUCHIYA; N NOGUCHI; E NIKI
  BIOCHIMICA ET BIOPHYSICA ACTA, ELSEVIER SCIENCE BV, 1128(2-3) 147 - 154, Oct. 1992, Scientific journal
  

  DOI URL
• ACTION OF EBSELEN AS AN ANTIOXIDANT AGAINST LIPID-PEROXIDATION
  N NOGUCHI; Y YOSHIDA; H KANEDA; Y YAMAMOTO; E NIKI
  BIOCHEMICAL PHARMACOLOGY, PERGAMON-ELSEVIER SCIENCE LTD, 44(1) 39 - 44, Jul. 1992, Scientific journal
  

  DOI URL
• THE OXIDATIVE MODIFICATION OF LOW-DENSITY-LIPOPROTEIN INDUCED BY COPPER OR WATER-SOLUBLE RADICAL INITIATOR
  N NOGUCHI; N GOTOH; E KOMURO; Y YAMAMOTO; E NIKI; H SHIMASAKI
  OXYGEN RADICALS, ELSEVIER SCIENCE PUBL B V, 998 377 - 380, 1992, International conference proceedings
• Initial accumulation of paraquat in the heart leading to acute death
  N. Noguchi; E. Tanaka; H. Yamamoto; S. Misawa
  Japanese Journal of Legal Medicine, 44(1) 6 - 11, 1990, Scientific journal
• LARGE MYELINATED CLUB ENDINGS ON THE MAUTHNER CELL IN THE GOLDFISH - A STUDY WITH THIN SECTIONING AND FREEZE-FRACTURING
  K KOHNO; N NOGUCHI
  ANATOMY AND EMBRYOLOGY, SPRINGER VERLAG, 173(3) 361 - 370, 1986, Scientific journal
• CARDIORESPIRATORY EFFECTS OF PARAQUAT WITH AND WITHOUT EMETICS ON WISTER RATS
  N NOGUCHI; S MISAWA; S TSUCHIYA; H YAMAMOTO; H NAITO
  VETERINARY AND HUMAN TOXICOLOGY, COMPARATIVE TOXICOLOGY LAB, 27(6) 508 - 510, 1985, Scientific journal

MISC

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  日本酸化ストレス学会学術集会プログラム・抄録集, 77th, 2024
• パーキンソン病で増加するDJ-1の翻訳後修飾に53番目のシステインが関与する
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  日本酸化ストレス学会学術集会プログラム・抄録集, 77th, 2024
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  日本内分泌学会雑誌, 96 1 - 4, Jul. 2020
• コレステロールメタボライト研究の新展開: 構造的・機能的多様性に迫る オキシステロール誘導性の新規細胞死機構
  浦野 泰臣; 野口 範子
  日本生化学会大会プログラム・講演要旨集, (公社)日本生化学会, 92回 [1S11a - 04], Sep. 2019
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  中谷 祐将; 下川 直史; 浦野 泰臣; 野口 範子; 高木 昌宏
  日本生物工学会大会講演要旨集, (公社)日本生物工学会, 2019年 224 - 224, Aug. 2019
• ステロールおよび脂質の代謝・代謝物と疾病に関する研究の最先端 コレステロール酸化物による神経細胞死とビタミンEの役割
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  日本栄養・食糧学会大会講演要旨集, (公社)日本栄養・食糧学会, 73回 176 - 176, Apr. 2019
• 【レドックス疾患学 酸素・窒素・硫黄活性種はどう作用するのか、どこまで健康・疾患と関わるのか?】 (第2章)レドックスと疾患 セレノプロテインPによるレドックス制御と2型糖尿病
  斎藤 芳郎; 野口 範子; 御簾 博文; 篁 俊成
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  Permalink
• Decrease of Insulin Secretion is Induced by Excess Selenoprotein P-Improving Effects of Neutralizing Antibody
  Yoshiro Saito; Yuichiro Mita; Kaho Nakayama; Shogo Inari; Takahiro Nagamura; Noriko Noguchi
  FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, 112 156 - 156, Nov. 2017, Summary international conference
  

  DOI URL
• Interleukin-27 Induces p47(phox) in Monocyte-derived Macrophages and Dendritic cells and Enhances the Potential of Reactive Oxygen Species Generation
  Yoshiro Saito; Bharatwaj Sowrirajan; Deepak Poudyal; Noriko Noguchi; Harry L. Malech; H. Clifford Lane; Tomozumi Imamichi
  FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, 112 210 - 210, Nov. 2017, Summary international conference
  

  DOI URL
• P210型BCR‐ABL PHドメインのリガンド特性およびその病理的意義の解明
  島崎健太朗; 高橋美帆; 梅田真郷; 舟本聡; 斎藤芳郎; 野口範子; 熊谷圭吾; 花田賢太郎; 塚原富士子; 丸義朗; 柴田識人; 内藤幹彦; 内藤幹彦; 西川喜代孝
  日本生化学会大会(Web), 生命科学系学会合同年次大会運営事務局, 90th ROMBUNNO.1PT26‐07(2P‐0039) (WEB ONLY) - 0039)], 2017
  

  URL
• セレノプロテインPの阻害抗体による糖尿病治療効果の解析 インスリン抵抗性および分泌能を改善する抗体医薬の開発
  三田 雄一郎; 中山 華穂; 稲荷 尚吾; 西藤 有希奈; 吉岡 佑弥; 曽谷 奏; 高部 稚子; 御簾 博文; 篁 俊成; 高橋 和彦; 野口 範子; 斎藤 芳郎
  糖尿病, (一社)日本糖尿病学会, 59(Suppl.1) S - 444, Apr. 2016
• 4.神経細胞死メカニズムの違いとビタミンEの作用特異性について(研究発表,第348回会議研究発表要旨,脂溶性ビタミン総合研究委員会)
  野口 範子; 新井 洋由
  ビタミン, 日本ビタミン学会, 90(2) 85 - 86, 25 Feb. 2016
• Selenoprotein Pの中和抗体による耐糖能異常及びインスリン分泌能の改善
  三田雄一郎; 三田雄一郎; 中山華穂; 稲荷尚吾; 吉岡佑弥; 高部稚子; 御簾博文; 篁俊成; 野口範子; 斎藤芳郎
  日本酸化ストレス学会学術集会プログラム・抄録集, 69th, 2016
• セレノプロテインPの阻害抗体による糖尿病治療効果の解析-インスリン抵抗性および分泌能を改善する抗体医薬の開発
  三田雄一郎; 中山華穂; 稲荷尚吾; 西藤有希奈; 吉岡佑弥; 曽谷奏; 高部稚子; 御簾博文; 篁俊成; 高橋和彦; 野口範子; 斎藤芳郎
  糖尿病(Web), 59(Suppl), 2016
• 膵臓β細胞モデルMIN6は過剰なSelenoprotein Pにより障害を受ける
  稲荷 尚吾; 高部 稚子; 三田 雄一郎; 御簾 博文; 篁 俊成; 野口 範子; 斎藤 芳郎
  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, (公社)日本生化学会, 88回・38回 [4T特L - 10(3P1201)], Dec. 2015
• SBP2変異によるセレン含有タンパク質欠乏患者におけるコレステロールの酸化-細胞膜と血漿リポタンパク質の酸化反応の違い
  齋藤 芳郎; 七里 元督; 濱島 崇; 萩原 義久; 吉田 康一; 野口 範子
  脂質生化学研究, 日本脂質生化学会, 57 146 - 149, May 2015
• Novel Method for Suppression of Neuronal Cell Death by 24S-Hydroxycholesterol
  野口 範子; 斎藤 芳郎; 浦野 泰臣
  同志社大学理工学研究報告, 同志社大学理工学研究所, 55(4) 59 - 62, Jan. 2015
• 1-I-11 血漿セレン含有タンパク質セレノプロテインPを標的とした2型糖尿病の抗体医薬の開発(一般演題要旨,ビタミン・バイオファクター研究のさらなる魅力～大和まほろぱからの発信～,第67回大会講演要旨)
  斎藤 芳郎; 中山 華穂; 三田 雄一郎; 野口 範子
  ビタミン, 公益社団法人 日本ビタミン学会, 89(4) 214 - 214, 2015
• Identification of neuron-derived protecting factors against oxidative stress
  野口 範子; 斎藤 芳郎
  コスメトロジー研究報告, コスメトロジー研究振興財団, 23 61 - 64, 2015
• Enhancement of Oxidative Stress and Its Amelioration by Vitamin E in a Subject with Mutations in the Selenocysteine Insertion Sequence-Binding Protein 2 (SBP2) Gene
  Yoshiro Saito; Mototada Shichiri; Takashi Hamajima; Noriko Noguchi
  FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, 76 S90 - S90, Nov. 2014, Summary international conference
  

  DOI URL
• 血中oxDJ-1の異常高値を示し、幻覚を認めたPDの4例
  西郷 和真; 斎藤 芳郎; 小川 郁子; 細井 幸恵; 三井 良之; 花田 一志; 上田 昌美; 石井 一成; 野口 範子; 楠 進
  Dementia Japan, (一社)日本認知症学会, 28(4) 504 - 504, Oct. 2014
• 血中酸化型DJ‐1異常高値の臨床的意義
  西郷和真; 斎藤芳郎; 小川郁子; 細井幸恵; 三井良之; 花田一志; 上田昌美; 石井一成; 野口範子; 楠進
  日本酸化ストレス学会学術集会プログラム・抄録集, 67th 52 , 29 Aug. 2014
• セレンタンパク質研究の最前線 血漿セレノプロテインPによるセレン代謝制御と2型糖尿病
  斎藤 芳郎; 吉岡 佑弥; 三田 雄一郎; 御簾 博文; 田中 睦; 篁 俊成; 野口 範子
  Biomedical Research on Trace Elements, 日本微量元素学会, 25(2) 50 - 50, Jun. 2014
• 脳特異的オキシステロール24S-hydroxycholesterolによる細胞死メカニズムの解析
  浦野泰臣; 山中一哲; 高部稚子; 斎藤芳郎; 野口範子
  日本Cell Death学会学術集会プログラム抄録集, 23rd, 2014
• アストロサイトに対する24S-hydroxycholesterolの細胞死誘導機序の解明
  西村祐貴; 浦野泰臣; 高部稚子; 野口範子
  日本酸化ストレス学会学術集会プログラム・抄録集, 67th, 2014
• 酸化コレステロール24S-OHCにより誘導されるNecroptosisのメカニズム
  高部稚子; 山中一哲; 浦野泰臣; 斎藤芳郎; 野口範子
  日本酸化ストレス学会学術集会プログラム・抄録集, 67th, 2014
• Study on Involvement of Reactive Oxygen Species in Neuronal Cell Death Induced by Oxidation Product of Cholesterol
  野口 範子; 斎藤 芳郎; 浦野 泰臣
  同志社大学理工学研究報告, 同志社大学理工学研究所, 54(4) 21 - 25, Jan. 2014
• 脳特異的24(S)-ヒドロキシコレステロールにより誘導されるプログラムネクローシスおよび細胞保護作用の分子メカニズム
  斎藤 芳郎; 山中 一哲; 浦野 泰臣; 野口 範子
  脂質生化学研究, 55 9 - 9, 28 May 2013
• Novel insights of brain-specific produced oxysterol in neurodegenerative diseases
  NOGUCHI Noriko; YAMANAKA Kazunori; TAKABE Wakako; URANO Yasuomi; SAITO Yoshiro
  日本生化学会大会(Web), 86th, 2013
• 2-IV-13 セレン欠乏に伴う酸化ストレス障害に対するビタミンEの効果 : SBP2遺伝子異常に対する治療への応用(一般演題要旨,第65回大会講演要旨)
  斎藤 芳郎; 七里 元督; 濱島 崇; 萩原 義久; 吉田 康一; 野口 範子
  ビタミン, 公益社団法人 日本ビタミン学会, 87(4), 2013
• パーキンソン病における酸化型DJ-1測定とMIBG心筋シンチグラフィーの関連について
  西郷 和真; 斎藤 芳郎; 池上 郁子; 細井 幸子; 高田 和男; 宮本 勝一; 三井 良之; 楠 進; 野口 範子
  臨床神経学, (一社)日本神経学会, 52(12) 1428 - 1428, Dec. 2012
• G020021 Reduction of Vitamin E radical in Electron-beam-irradiated dl-α-Tocopherol-blended Ultra High Molecular Weight Polyethylene
  Iwade H; Kawasaki T; Tajima K; Sakurai Y; Noguchi N; Saito Y; Uetsuki K; Tomita N
  Mechanical Engineering Congress, Japan, The Japan Society of Mechanical Engineers, 2012 "G020021 - 1"-"G020021-4", 09 Sep. 2012
• アミロイド前駆体タンパク質細胞内輸送へのオキシステロールの関与機構の解明
  浦野 泰臣; 野口 範子
  脂質生化学研究, 54 118 - 120, 28 May 2012
• 早期パーキンソン病患者の赤血球におけるDJ‐1の酸化
  斎藤芳郎; 浜窪隆雄; 下濱俊; 二木鋭雄; 野口範子
  日本酸化ストレス学会学術集会プログラム・抄録集, 64th 60 , 27 Jun. 2011
• パーキンソン病における新たなバイオマーカーとしての酸化型DJ‐1測定の可能性
  西郷和真; 斎藤芳郎; 三井良之; 楠進; 野口範子
  パーキンソン病・運動障害疾患コングレスプログラム・抄録集, 5th 92 , 2011
• 脂質酸化物により誘導される適応反応のメカニズム
  斎藤 芳郎; 野口 範子
  放射線生物研究, 放射線生物研究会, 45(2) 160 - 169, Jun. 2010
• 24(S)-Hydroxycholesterol Induces SH-SY5Y Cell Death via Necroptosis, Programmed Necrosis
  Kazunori Yamanaka; Yoshiro Saito; Tohru Yamamori; Yasuomi Urano; Noriko Noguchi
  FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, 49 S137 - S137, 2010, Summary international conference
  

  DOI URL
• Cytoprotective Effect of Vitamin E Homologues Against Glutamate-induced Cell Death in Immature Primary Cortical Neuron Cultures: Tocopherols and Tocotrienols Exert Similar Effects by Antioxidant Function
  Yoshiro Saito; Yasukazu Yoshida; Noriko Noguchi; Etsuo Niki
  FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, 49 S196 - S196, 2010, Summary international conference
  

  DOI URL
• Elevation of Oxidized DJ-1 in the Erythrocytes of Parkinson Disease Patients and Animal Models
  Yoshiro Saito; Yoko O. Akazawa; Takao Hamakuho; Yasukazu Yoshida; Noriko Noguchi; Etsuo Niki
  FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, 49 S171 - S171, 2010, Summary international conference
  

  DOI URL
• 3.24(S)-HyDroxycholesterolによる神経細胞死の誘導メカニズム(第327回会議研究発表要旨,脂溶性ビタミン総合研究委員会)
  野口 範子; 山中 哲一; 斉藤 芳郎; 浦野 泰臣
  ビタミン, 公益社団法人 日本ビタミン学会, 84(9) 448 - 448, 2010
  

  DOI URL
• グルタミン酸誘導性の神経細胞死に対するビタミンE類の抑制効果
  斎藤芳郎; 西尾敬子; 赤澤(小川)陽子; 吉田康一; 野口範子; 二木鋭雄
  ビタミンE研究の進歩, 14 27 - 32, 2010
• 24S-hydroxycholesterol による神経細胞傷害メカニズムの解析
  山中 一哲; 斎藤 芳郎; 山盛 徹; 浦野 泰臣; 野口 範子
  脂質生化学研究, 51 69 - 72, 10 Jul. 2009
• 酸化DJ-1とパーキンソン病(1):抗体作成とELISA開発
  斎藤芳郎; 斎藤芳郎; 浜窪隆雄; 吉田康一; 小川陽子; 岩成宏子; 望月康弘; 七里元督; 西尾敬子; 絹見朋也; 野口範子; 児玉龍彦; 二木鋭雄
  日本酸化ストレス学会学術集会プログラム・抄録集, 62nd, 2009
• 酸化DJ-1とパーキンソン病(2):臨床検体の測定
  小川陽子; 斎藤芳郎; 浜窪隆雄; 児玉龍彦; 原保夫; 藤村晴俊; 今井康陽; 岩成宏子; 七里元督; 西尾敬子; 野口範子; 吉田康一; 二木鋭雄
  日本酸化ストレス学会学術集会プログラム・抄録集, 62nd, 2009
• Significant Elevation of Oxidized DJ-1 in Erythrocytes of Early-Stage Parkinson Disease Patients: Potential Application of Oxidized DJ-1 Levels for Diagnosis of PD at Early Stage
  Yoshiro Saito; Takao Hamakuba; Yasukazu Yoshida; Yoko Ogawa Akazawa; Mototado Shichiri; Noriko Noguchi; Etsuo Niki
  FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, 47 S80 - S80, 2009, Summary international conference
• 酸化ストレスと老化・寿命を結びつけるタンパク質--p66shc
  山盛 徹; 野口 範子
  放射線生物研究, 放射線生物研究会, 43(3) 261 - 271, Sep. 2008
• Induction of Adaptive Response and Enhancement of PC12 Cell Tolerance by Lipopolysaccharide Primarily Through the Upregulation of Glutathione S-Transferase A3 Via Nrf2 Activation
  Yoshiro Saito; Yo Omata; Yasukazu Yoshida; Noriko Noguchi; Etsuo Niki
  FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, 45 S37 - S37, 2008, Summary international conference
• リポ多糖(LPS)により誘導される適応反応・酸化ストレス耐性メカニズムの解析
  斎藤芳郎; 小俣葉; 藤田克英; 吉田康一; 野口範子; 二木鋭雄
  生化学, 4P-0442 , 2008
  

  URL
• Activity of shogaol derivatives as antioxidant and gene expression regulator
  野口 範子
  Cosmetology, コスメトロジー研究振興財団, 15 23 - 28, 2007
• マクロファージの泡沫化に伴う遺伝子発現変化の網羅的解析
  島田 芽衣; 山田 知広; 高根沢 康一; 野口 範子; 新井 洋由
  脂質生化学研究, 日本脂質生化学会, 48 73 - 75, May 2006
• Accumulation of Nrf2 due to its modification by oxidative stress and laminar share stress in endothelial cell
  TAKABE Wakako; WARABI Eiji; SEKINE Azusa; KODAMA Tatsuhiko; NOGUCHI Noriko; NOGUCHI Noriko
  生化学, 2006
• 腹腔マクロファージの泡沫化に伴う遺伝子変動の解析
  山田知広; 高根沢康一; 関根あずさ; 高部稚子; 野口範子; 新井洋由
  衛生薬学・環境トキシコロジー講演要旨集, 2006, 2006
• 25ハイドロキシコレステロールによるコレステロール生合成抑制作用はオキシステロール結合蛋白質(OSBP)非依存的である
  西村多喜; 西村多喜; 井上貴雄; 柴田識人; 関根あずさ; 高部稚子; 野口範子; 新井洋由
  脂質生化学研究, 48, 2006
• 25ハイドロキシコレステロールによるコレステロール生合成抑制はオキシステロール結合タンパク質(OSBP)非依存的である
  西村多喜; 井上貴雄; 柴田識人; 関根あずさ; 高部稚子; TRIPUVANUNTAKUL Pearlta; 野口範子; 新井洋由
  日本薬学会年会要旨集, 126th(3), 2006
• 流れストレスによる遺伝子の発現メカニズムにおける活性酸素の寄与
  高部稚子; 蕨栄治; 野口範子; 野口範子
  万有生命科学振興国際交流財団若手研究者のための生命科学セミナー, 9th, 2006
• Induction of Lung Kruppel-Like Factor by lysophosphatidylcholine in human endothelial cell
  SHIRAHATA Satoshi; TAKABE Wakako; KOHRO Takahide; MINAMI Takashi; KODAMA Tatsuhiko; NOGUCHI Noriko
  生化学, 2006
• Nitric oxide-independent expression of Nrf2-regulated genes by laminar shear stress in human endothelial cells
  Wakako Takabe; Eiji Warabi; Noriko Noguchi
  FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, 41 S43 - S43, 2006, Summary international conference
• Differential responses of the Nrf2-Keap1 system to laminar and oscillatory shear stresses in endothelial cells. (vol 280, pg 27244, 2005)
  T Hosoya; A Maruyama; MI Kang; Y Kawatani; T Shibata; K Uchida; E Warabi; N Noguchi; K Itoh; M Yamamoto
  JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 280(33) 29988 - 29988, Aug. 2005, Others
• Regulation of cell functions by redox signaling
  NOGUCHI Noriko
  生化学, 日本生化学会, 77(7) 659 - 663, 25 Jul. 2005
• 酸化ストレスによる遺伝子発現変化のビタミンEによる修飾について
  李 文華; 野口 範子; 赤塚 慎也; 白瀬 智之; 鶴山 竜昭; 山田 義博; 豊國 伸哉
  日本病理学会会誌, (一社)日本病理学会, 94(1) 305 - 305, Mar. 2005
• Cholesterol biosynthesis inhibition by 25-hydroxycholesterol is independent of OSBP
  NISHIMURA Taki; INOUE Takao; SHIBATA Norihito; SEKINE Azusa; TAKABE Wakako; TRIPUVANUNTAKUL Pearlta; NOGUCHI Noriko; ARAI Hiroyuki
  生化学, 77(8), 2005
• Identification of genes that are up-regulated or down-regulated during foam cell formation in mouse peritoneal macrophage
  YAMADA Tomohiro; TAKANEZAWA Yasukazu; SEKINE Azusa; TAKABE Wakako; NOGUCHI Noriko; ARAI Hiroyuki
  生化学, 77(8), 2005
• Lysophosphatidylcholine activates the promoter of solute carrier family 7 member 5 via induction Egr-1 in vascular endothelial cell
  W Takabe; T Minami; M Miura; T Kodama; N Noguchi
  FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, 39 S79 - S79, 2005, Summary international conference
• Lysophosphatidylcholine increases cholesterol levels via SREBP pathway in endothelial cell
  N Noguchi; A Sekine; W Takabe; H Arai; T Kodama
  FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, 39 S76 - S76, 2005, Summary international conference
• A turning point to apoptotic and necrotic cell death induced by hydrogen peroxide
  Y Saito; K Nishio; Y Ogawa; T Kinumi; Y Yoshida; N Noguchi; E Niki
  FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, 39 S147 - S147, 2005, Summary international conference
• Gene expression profiles in human and mice endothelial cells exposed to laminar shear stress
  K Inoue; E Warabi; T Minami; N Noguchi; T Kodama
  CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, 110(17) 284 - 284, Oct. 2004, Summary international conference
• NRF-2 regulated genes expression in endothelial cell exposed to shear stress regardless of oxygen concentration and low-density lipoprotein
  N Noguchi; E Warabi; Y Wada; H Kajiwara; M Kobayashi; M Tsuchiya; T Kodama
  FREE RADICAL BIOLOGY AND MEDICINE, PERGAMON-ELSEVIER SCIENCE LTD, 37 S68 - S68, 2004, Summary international conference
• Vitamin E and BO-653: Natural vs. synthetic antioxidant
  E Niki; Y Yoshida; Y Saito; N Itoh; O Cynshi; N Noguchi; T Kodama
  FREE RADICAL BIOLOGY AND MEDICINE, PERGAMON-ELSEVIER SCIENCE LTD, 36 S7 - S7, 2004, Summary international conference
• Oxidative stress induces insulin resistance by changing the subcellular IRS-1 distribution and NF-Kappa B activation
  T Ogihara; H Sakoda; N Shojima; M Anai; N Noguchi; M Kikuchi; T Fujita; T Asano
  DIABETES, AMER DIABETES ASSOC, 52 A292 - A292, Jun. 2003, Summary international conference
• ビタミンE欠乏及び過剰状態における遺伝子発現の比較
  斎藤 尚子; 野口 範子; 藤原 葉子; 近藤 和雄; 新井 洋由
  ビタミン, (公社)日本ビタミン学会, 77(4) 229 - 229, Apr. 2003
• トコトリエノールの生理作用
  二木 鋭雄; 野口 範子
  ビタミン, 日本ビタミン学会, 77(3) 172 - 175, 25 Mar. 2003
• Exercise-related oxidative stress and antioxidant effects
  NOGUCHI Noriko
  Journal of exercise and sports physiology, 日本運動生理学会事務局, 10(1) 1 - 8, 2003
• トコトリエノールによるコレステロール合成経路の新たな制御機構
  野口範子; 高部稚子; 新井洋由
  ビタミン, 77(4), 2003
• LysoPCによるアミノ酸トランスポーター遺伝子発現と炎症における寄与
  高部稚子; 野口範子; 金井好克; 児玉龍彦
  脂質生化学研究, 45, 2003
• Lysophosphatidylcholineによるアミノ酸トランスポーター遺伝子発現と炎症における寄与
  高部稚子; 金井好克; CHAIROUNGDUA A; 児玉龍彦; 野口範子
  日本分子生物学会年会プログラム・講演要旨集, 26th, 2003
• Increase of cytokine production by lysophosphatidylcholine through induction of amino acid transporter in endothelial cell
  N Noguchi; W Takabe; T Kodama
  FREE RADICAL BIOLOGY AND MEDICINE, PERGAMON-ELSEVIER SCIENCE LTD, 35 S71 - S71, 2003, Summary international conference
• Antioxidant action of vitamin E isoforms
  E Niki; Y Yoshida; Y Saito; R Piga; N Noguchi
  FREE RADICAL RESEARCH, TAYLOR & FRANCIS LTD, 37 40 - 40, 2003, Summary international conference
• Gene regulation by oxidation products of LDL in endothelial cell
  N Noguchi; W Takabe; T Kodama
  FREE RADICAL RESEARCH, TAYLOR & FRANCIS LTD, 37 21 - 21, 2003, Summary international conference
• 平成14年度日本油化学会エディター賞受賞によせて : 実を結んだ"日-ウクライナ国際共同研究"
  KUZMENKO A. I.; 二木 鋭雄; 野口 範子
  オレオサイエンス = / Japan oil chemists' society, 2(8) 447 - 447, 01 Aug. 2002
• ビタミンE同族体の構造特異的な遺伝子発現制御
  野口範子; 沖本優子; 高部稚子; 児玉龍彦
  ビタミン, 76(3), 2002
• トランスクリプトーム解析から見た抗酸化薬剤開発の展望
  高部稚子; 野口範子
  日本動脈硬化学会総会プログラム・抄録集, 34th, 2002
• Chemical structure-specific gene expression by phenolic compounds
  N Noguchi; W Takabe; T Kodama
  FREE RADICAL BIOLOGY AND MEDICINE, PERGAMON-ELSEVIER SCIENCE LTD, 33 S207 - S207, 2002, Summary international conference
• Accumulation of lipids in smooth muscle cell with LDL loading under hypoxia
  N Noguchi; Y Wada; S Shimakawa; Y Yoshida; E Niki; T Kodama
  FREE RADICAL BIOLOGY AND MEDICINE, PERGAMON-ELSEVIER SCIENCE LTD, 33 S399 - S400, 2002, Summary international conference
• Life Science of Human Stress
  NIKI Etsuo; NOGUCHI Noriko
  Oleoscience : Journal of Japan Oil Chemists' Society, 日本油化学会, 1(5) 509 - 513, 01 May 2001
• 2-I-15 ビタミンE同族体の抗酸化活性と遺伝子発現調節を介する細胞機能制御に関する研究
  野口 範子; 野中 綾; 沖本 優子; 二木 鋭雄
  ビタミン, 日本ビタミン学会, 75(4) 225 - 225, 25 Apr. 2001
• Scavenger receptors and pathogenesis of atherosclerosis
  KODAMA Tatsuhiko; HAMAKUBO Takao; WADA Yoichiro; NOGUCHI Noriko; NIKI Etsuo
  生化學, 日本生化学会, 73(3) 179 - 183, 25 Mar. 2001
• CHAOS [Cambridge Heart Antioxidant Study
  E. Niki; N. Noguchi
  Nippon rinsho. Japanese journal of clinical medicine, 59 448 - 451, 2001, Book review
• Galvinoxyl method for standardizing electron and proton donation activity
  HL Shi; N Noguchi; E Niki
  FLAVONOIDS AND OTHER POLYPHENOLS, ELSEVIER ACADEMIC PRESS INC, 335 157 - 166, 2001, Book review
• A novel method to follow lipid peroxidation in low-density lipoprotein using diphenyl-1-pyrenylphosphine
  Y Okimoto; Y Wada; E Niki; T Kodama; N Noguchi
  FREE RADICAL BIOLOGY AND MEDICINE, PERGAMON-ELSEVIER SCIENCE LTD, 31 S88 - S88, 2001, Summary international conference
• Novel insights into the molecular mechanisms of the anti-atherogenic effects of antioxidants through genomic analysis; regulation of proteasome function
  W Takabe; T Kodama; K Tanaka; T Suzuki; H Aburatani; N Noguchi
  FREE RADICAL BIOLOGY AND MEDICINE, PERGAMON-ELSEVIER SCIENCE LTD, 31 S62 - S62, 2001, Summary international conference
• Evaluation of antioxidant capacity. What capacity is being measured by which method?
  E Niki; N Noguchi
  IUBMB LIFE, TAYLOR & FRANCIS INC, 50(4-5) 323 - 329, Oct. 2000, Book review
• 2-I-21 α-トコフェロール及び新規抗酸化物BO-653由来のラジカルの反応性について
  渡辺 亮; 野口 範子; 高橋 希之; 二木 鋭雄
  ビタミン, 日本ビタミン学会, 73(4) 274 - 274, 25 Apr. 1999
• 2. α-トコフェリルヒドロキノンの抗酸化作用
  二木 鋭雄; 野口 範子; 石 紅聯
  ビタミン, 日本ビタミン学会, 73(1) 63 - 63, 23 Jan. 1999
• The hyperlipidemia drug. The target for limited treatment. Treatment by the antioxidant and the significance.
  高部稚子; 野口範子; 児玉龍彦
  治療学, 33(10), 1999
• Reactivity and stability of antioxidant-derived phenoxyl radical
  A Watanabe; N Noguchi; M Takahashi; HL Shi; E Niki
  FREE RADICAL BIOLOGY AND MEDICINE, PERGAMON-ELSEVIER SCIENCE LTD, 27 S45 - S45, 1999, Summary international conference
• Antioxidant action of antihypertensive drug, carvedilol
  N Noguchi; K Nishino; E Niki
  FREE RADICAL BIOLOGY AND MEDICINE, PERGAMON-ELSEVIER SCIENCE LTD, 25 S35 - S35, 1998, Summary international conference
• Inhibition of oxidation of low density lipoprotein by a novel antioxidant BO-653 prepared by theoretical design
  N Noguchi; Y Okimoto; O Cynshi; T Kodama; E Niki
  ATHEROSCLEROSIS, ELSEVIER SCI IRELAND LTD, 134(1-2) 206 - 206, Oct. 1997, Summary international conference
• 生体の酸化傷害と防御機構 (特集 生体の酸化と抗酸化成分の開発と応用)
  野口 範子; 二木 鋭雄
  フレグランスジャーナル, フレグランスジャーナル社, 25(4) 9 - 16, Apr. 1997
• Inhibition of plasma cholesterol ester hydroperoxide and phosphatidylcholine hydroperoxide formation as measures of antioxidant status
  N Noguchi; E Niki
  VITAMINS AND COENZYMES, PT L, ELSEVIER ACADEMIC PRESS INC, 282 271 - 278, 1997, Book review
• 脂質の酸化と抗酸化における一酸化窒素(NO)の二面作用
  野口 範子; 林 克亘; 近藤 洋; 二木 鋭雄
  日本分子生物学会年会プログラム・講演要旨集, 19 502 - 502, 01 Aug. 1996
• 3-III-14 ピロロキノリンキノール(PQQH_2)の抗酸化作用 : 第48回大会研究発表要旨 : 一般研究発表要旨
  宮内 一浩; 阿部田 浩之; 野口 範子; 二木 鋭雄; 浦上 貞治
  ビタミン, 日本ビタミン学会, 70(4) 214 - 215, 25 Apr. 1996
• 2-II-41 LDLの酸化変性におけるビタミンCによるビタミンEとプロブコールの再生効率 : 第47回大会研究発表要旨
  野口 範子; 二木 鋭雄
  ビタミン, 日本ビタミン学会, 69(4) 291 - 292, 25 Apr. 1995
• 1-II-23 脂質酸化に対するビタミンEと合成抗酸化剤の協同抑制作用 : ビタミンの発癌予防効果 : 第46回大会研究発表要旨
  野口 範子; 吉野 哲也; 後藤 直宏; 二木 鋭雄
  ビタミン, 日本ビタミン学会, 68(4) 222 - 222, 25 Apr. 1994
• APOLIPOPROTEIN-B PROTEIN OXIDATION IN LOW-DENSITY LIPOPROTEINS
  N NOGUCHI; E NIKI
  OXYGEN RADICALS IN BIOLOGICAL SYSTEMS, PT C, ACADEMIC PRESS INC, 233 490 - 494, 1994, Book review
• 2.LDLの酸化変性に対するビタミンEの防御作用の考察 : 脂溶性ビタミン総合研究委員会 第257回会議研究発表要旨
  二木 鋭雄; 野口 範子; 後藤 直宏; 吉田 康一
  ビタミン, 日本ビタミン学会, 67(12) 690 - 691, 25 Dec. 1993

Books etc

• Implication of Oxysterols and Phytosterols in Aging and Human Diseases. Advances in Experimental Medicine and Biology
  Yasuomi Urano; Noriko Noguchi
  Springer Nature Switzerland, Dec. 2023, Contributor, Enzymatically formed oxysterols and cell death
• サイエンスとインテリジェンスーサイエンスコミュニケーター養成副専攻受講生論文集－
  佐藤 優; 野口 範子
  Ｋ＆Ｋプレス, Sep. 2020, Editor
• (Vitamin E: Chemistry and Nutritional Benefits.) Action of Vitamin E Against Lipid Peroxidation and Cell Death
  Noriko Noguchi
  Royal Society of Chemistry, 2018, Contributor, pp. 165-172
• 脳のコレステロール代謝と神経変性疾患, 生物の科学遺伝
  エヌティーエス, 2016
• 酸化ストレスと疾患
  ストレスシグナルと疾患 医学のあゆみ 医歯薬出版, 2015
• パーキンソン病と酸化ストレス
  医歯薬出版, 2014
• Necroptosis 医学のあゆみ
  医歯薬出版, 2011
• HDAC
  朝日書店, 2011
• Nrf 血管生物学事典
  朝日書店, 2011
• 抗酸化ビタミンの相互作用 「ビタミン・ミネラルの科学（五十嵐修、 江指隆年編集）
  朝倉書店, 2011
• Uptake, Distribution, and Antioxidant Actions of Tocotrienol in Cultured Cells. Tocotrienols:Vitamin E Beyond Tocopherols
  CRC Press, 2008
• 動脈硬化症と酸化ストレス「酸化ストレスの医学（吉川敏一編集）」
  診断と治療社, 2008
• 酸化ストレス 「ストレスの科学と健康（二木鋭雄編著）」
  共立出版, 2008
• 抗酸化ビタミンの大規模臨床試験 「酸化ストレスと心血管病
  日本医学出版, 2007
• 抗酸化ビタミン 「酸化ストレスと心血管病（横山光宏、藤田敏郎編 集）」
  日本医学出版, 2007
• DNAマイクロアレイを用いた遺伝子発現解析 レドックス/ストレス防御の医学（谷口直之監）医学のあゆ
  医歯薬出版, 2005
• Specificity and inhibition by antioxidant of lipid peroxidation by lipoxygenase: effects of substrate, lipoxygenase and milieu
  International Congress Series, 2002
• Natural antioxidants
  Antioxidants in food, 2001
• Galvinoxyl method for standardizing electron and proton donation activity
  Methods in Enzymology, 2001
• Action of ginkgo biloba extract as an antioxidant.
  Antioxidants & Disease, CAB International, Oxford, 1999
• Chemistry of oxygen species and antioxidant.
  Antioxidant Status, Diet, Nutrition and Health, CRC press, FL, 1998
• Inhibition of oxidation of low density lipoprotein by antioxidants.
  Pathophysiology of lipid peroxides and related free radicals, 1998
• Inhibition of oxidative modification of low density lipoprotein by novel antioxidant BO-653 prepared by theoretical design.
  Nutrition, Lipids, Health, and Disease, 1998
• Protection of human low-density lipoprotein from oxidative modification by vitamin C.
  Vitamin C in health and disease, 1997
• Antioxidand properties of ebselen
  Hand book of synthetic antioxidants, 1997
• Antioxidant properties of probucol
  Hand book of synthetic antioxidants, 1997
• Noguchi N., Action of vitamin E against lipid peroxidation and cell death, Niki E. ed. Vitamin E, chemistry and nutritional benefits, pp. 165-174, 2019, Royal Society of Chemistry, UK
• 山中一哲，斉藤芳郎，山盛 徹, 浦野泰臣, 野口範子， 24S-OHC誘導性細胞死に対するビタミンE類の添加効果，ビタミンE研究の進歩XV (ビタミンE研究会編), pp. 20-25, 2012, 共立出版株式会社 （ビタミンE研究会, Jan. 2011, 京都）
• 斎藤芳郎, 西尾敬子, 小川陽子, 吉田康一, 野口範子, 二木鋭雄, グルタミン酸誘導性神経細胞死に対するビタミンE類の抑制効果，ビタミンE研究の進歩XIV (ビタミンE研究会編), pp. 27-32, 2010, 共立出版株式会社 （ビタミンE研究会, Jan. 2009, 奈良）
• 野口範子， 脂質酸化生成物に対する内皮細胞の遺伝子発現応答，放射線の固体影響?機構研究からのアプローチ, pp. 135-140, 2005, 独立行政法人放射線医学総合研究所（放医研シンポジウム, Dec., 2004, 千葉）
• 野口範子， 抗酸化機能と遺伝子制御機能の接点，ビタミン誌 79, 225-226, 2005
• 野口範子, 伊藤靖浩, 二木鋭雄, 新井洋由, 柴田亮行， α-TTPノックアウトマウスにみられる酸化傷害，ビタミンE研究の進歩X (ビタミンE研究会編), pp. 45-49, 2001, 共立出版株式会社 （ビタミンE研究会, Jan. 2001, 東京）
• 野口範子, 二木鋭雄， α-トコフェロールの化学構造を基に設計合成した新規抗酸化物質の抗酸化作用，ビタミンE研究の進歩VIII (ビタミンE研究会編), pp. 59-65, 1998, 共立出版株式会社 （ビタミンE研究会, Feb.1997, 京都）
• N. Noguchi, N. Gotoh, E. Niki, Action of vitamin E as antioxidant against oxidative modification of low density lipoprotein. Biofactors, 7, 41-50, 1998. (International Conference on Vitamin E, Feb., 1997, Kyoto)
• N. Noguchi, E. Niki, Inhibition of oxidation of low density lipoprotein by antioxidants. Pathophysiology of lipid peroxides and related free radicals (K. Yagi, ed), pp. 91-101, 1998, Jpn. Sci. Soc. Press, Tokyo (International Conference on Lipid Peroxide
• N. Noguchi, E. Niki, Cooperative antioxidant action of probucol, ?-tocopherol and ascorbic acid against the oxidation of LDL of human and rabbit. BioFactors, 6, 259-260, 1997 (Lipid and Thrombosis, Aug., 1996, Marstricht)
• E. Niki, N. Noguchi, Dynamics of oxidation of LDL and its inhibition by antioxidants. BioFactors, 6, 201-208, 1997 (Workshop Oxidative Stress, July, 1996, Graz)
• 野口範子，山本裕子，二木鋭雄， 低比重リポ蛋白質の酸化におけるアポリポ蛋白Ｂの変性に対するビタミンEの抑制作用，ビタミンE研究の進歩VII (ビタミンE研究会編), pp. 84-88, 1997, 共立出版株式会社 （ビタミンE研究会, Mar. 1996, 浜松）
• N. Gotoh, T. Yoshino, N. Noguchi, E. Niki, 2,2'-Azobis(4-methoxy- 2,4-dimethylvaleronitrile), a new lipid-soluble azo radical initiator. (K. Asada, T. Yoshikawa eds.) pp. 59-62, 1994, Elsevier Science Publisher, Amsterdam (SOD meeting, Oct., 1993, Kyoto)
• N. Noguchi, N. Gotoh, T. Yoshino, E. Niki, Antioxidant effects of probucol and ebselen against oxidative modification of LDL induced by free radicals generated at different sites. (K. Asada, T. Yoshikawa eds.), pp.191-194, 1994, Elsevier Science Publisher
• 野口範子，保田 浩，二木鋭雄，三木正之，美濃 真， 脳脂質の酸化に対するビタミンＥの抗酸化作用，ビタミンE研究の進歩IV (ビタミンE研究会編), pp. 80-84, 1994, 共立出版株式会社（ビタミンE研究会, Feb. 1993, 京都）
• 後藤直宏，野口範子，土屋順一，二木鋭雄，島崎弘幸， LDLの酸化に対するビタミンEの抗酸化作用，ビタミンE研究の進歩III (ビタミンE研究会編), pp. 57-62, 1993, 共立出版株式会社（ビタミンE研究会, Feb. 1992, 東京）
• N. Noguchi, N. Gotoh, E. Komuro, Y. Yamamoto, E. Niki, H. Shimasaki, The oxidative modification of low density lipoprotein induced by copper or water-soluble radical initiator. Oxygen Radicals ( K. Yagi, M. Kondo, E. Niki, T. Yoshikawa, eds.), pp. 377-380
• 野口範子, 酸化ストレスと疾患 医学のあゆみ別冊, ストレスシグナルと疾患?細胞恒常性維持機構の破綻と病態, pp. 347-352, 2015, 医歯薬出版, 東京
• 斎藤芳郎，野口範子， 神経変性とレドックスーパーキンソン病関連分子DJ-1のレドックス制御機能 レドックスUPDATE, 第4章, 224-228, 2015
• 斎藤芳郎，野口範子， Parkinson病と酸化ストレス 酸化ストレスの医学, pp. 264-271, 2014, 診断と治療社，東京
• 西尾敬子, 石田規子, 斉藤芳郎, 赤澤陽子, 七里基督, 吉田康一, 萩原義久,野口範子, John Chirico, Jefferey Atkinson, 二木鋭雄, ビタミン ?-トコフェロールリン酸の細胞および生体への取り込みと抗酸化作用, ビタミンEの進歩, pp. 15-19, 2012, ビタミンE研究会
• 山中一哲, 斉藤芳郎, 山盛徹, 浦野泰臣, 野口範子, 24S-0HC誘導性細胞死に対するビタミンE類の添加効果, ビタミンEの進歩, pp. 20-25, 2012, ビタミンE研究会
• 野口範子， Necroptosis医学のあゆみ別冊, pp. 142-144, 2011, 医歯薬出版, 東京
• 野口範子， HDAC，血管生物医学事典，pp. 386-387, 2011, 朝日書店，東京
• 野口範子， Nrf，血管生物医学事典，pp. 397-398, 2011, 朝日書店，東京
• 二木鋭雄，野口範子， 抗酸化ビタミンの相互作用 「ビタミン・ミネラルの科学（五十嵐修，江指隆年編集）」pp.157-165, 2011, 朝倉書店、東京
• Noguchi N, Saito, Y. Niki E, Uptake, Distribution, and Antioxidant Actions of Tocotrienol in Cultured Cells. Tocotrienols: Vitamin E Beyond Tocopherols, pp 159-167, CRC Press, UK, 2008
• 野口範子， 動脈硬化症と酸化ストレス「酸化ストレスの医学（吉川敏一編集）」pp.240-247, 2008，診断と治療社，東京
• 野口範子， 酸化ストレス 「ストレスの科学と健康（二木鋭雄編著）」，pp.38-43,2008 共立出版，東京
• 太田好次、阿部皓一、野口範子， 抗酸化ビタミンの大規模臨床試験 「酸化ストレスと心血管病（横山光宏、藤田敏郎編集）」,pp.275-279, 2007，日本医学出版，東京
• 野口範子， 抗酸化ビタミン 「酸化ストレスと心血管病（横山光宏、藤田敏郎編 集）」,pp.255-258, 2007，日本医学出版，東京
• 野口範子， DNAマイクロアレイを用いた遺伝子発現解析，レドックス/ストレス防御の医学（谷口直之監）医学のあゆみ別冊,151-156,2005, 医師薬出版
• 二木鋭雄，野口範子，内田浩ニ編集， 酸化ストレスマーカー、2005. 5, 学会出版センター，東京
• 野口範子， 抗酸化物質の新規機能の追究，酸化ストレス/フリーラジカル医学生物学の最前線 (吉川敏一監) 医学のあゆみ別冊, pp. 142-144, 2001, 医歯薬出版, 東京
• H. Shi, N. Noguchi, E. Niki, Natural antioxidants,Antioxidants in food. (F. Dodds ed.), Chapter 3, 2001, Woodhead Publishing Limited
• 野口範子， 老化の制御方法，老化に対する防御機構 (吉川敏一監) pp. 61-68, 2001, シーエムシー, 東京
• H. Shi, N. Noguchi, E. Niki, Galvinoxyl method for standardizing electron and proton donation activity. Methods in Enzymology, 335, 157-166, 2001, Academic Press, New York
• 野口範子， 血管の老化とフリーラジカル，老化予防食品の開発 (吉川敏一監) pp. 79-85,1999, シーエムシー, 東京
• N. Noguchi, K. Nishino, E. Washio, H. Shi, E. Niki, Action of ginkgo biloba extract as an antioxidant. Antioxidants & Disease (N. J. Temple ed.), pp. 131-140, 1999, CAB International, Oxford
• 野口範子， 動脈硬化，抗酸化物質のすべて(吉川敏一編), pp. 241-247, 1998, 先端医学社, 東京
• 野口範子， プロブコール，抗酸化物質のすべて(吉川敏一編), pp. 200-205, 1998, 先端医学社, 東京
• N. Noguchi, E. Niki, Chemistry of oxygen species and antioxidant. Antioxidant Status, Diet, Nutrition and Health (A.M. Papas ed.), pp. 3-20, 1998, CRC press, FL
• N. Noguchi, Y. Okimoto, O. Cynshi, T. Kodama, E. Niki, Inhibition of oxidative modification of low density lipoprotein by novel antioxidant BO-653 prepared by theoretical design. Nutirition, Lipids, Health, and Disease (L. Packer, ed.), pp. 139-152, 1998,
• E. Niki, N. Noguchi, Protection of human low-density lipoprotein from oxidative modification by vitamin C. Vitamin C in health and disease, (L. Packer, E. Cadenas, eds), pp. 183-192, 1997, Marcel Dekker, New York
• N. Noguchi, E. Niki, Inhibition of plasma cholesterol ester hydroperoxide and phosphatidylcholine hydroperoxide formation as measures of antioxidant status. Methods in Enzymology (D.B. MacCormick, J.W. Suttie, C. Wagner eds.), 282, 271-278, 1997, Academic
• N. Noguchi, E. Niki, Antioxidant properties of ebselen. Handbook of Synthetic Antioxidants (L. Packer, E. Cadenas, eds), pp. 285-303, 1997, Marcel Dekker, New York
• E. Niki, N. Noguchi, Antioxidant properties of probucol,Handbook of Synthetic Antioxidants (L. Packer, E. Cadenas, eds), pp.225-239, 1997, Marcel Dekker, New York
• 二木鋭雄，野口範子， フリーラジカルによる各種疾病の発症と抗酸化物による予防新食品機能材料の開発 (太田明一監) ，pp. 28-36,1996, シーエムシー, 東京
• E. Niki, N. Noguchi, M. Iwatsuki, Antioxidant Activities of Phenolic Compounds in Solutions, Membranes, and Lipoproteins. Nutrition, Lipids, Health, and Disease (A. S. H. Ong., E. Niki, L. Packer,eds.) pp. 1-7, 1995, AOCS Press, Champaign, IL
• 野口範子， 細胞分画法，過酸化脂質 フリーラジカル実験法 生物化学実験法34（島崎弘幸，五十嵐脩編）pp.192-198,1995, 学会出版センター, 東京
• E. Niki, N. Noguchi, N. Gotoh, H. Sakai,
• N. Noguchi, E. Niki, Apo B protein oxidation in LDL. Oxygen radicals in biological systems, part C, Methods in Enzymology (L. Packer ed.) 233, 490-494, 1994, Academic Press, Calif.
• 野口範子，後藤直宏，二木鋭雄， ＬＤＬの酸化とその抑制，フリーラジカルの臨床 7（近藤元治監，大柳善彦，吉川敏一編）pp. 49-54, 1993, 日本医学館, 東京
• 二木鋭雄，野口範子， 生体内に生じるフリーラジカル，体内動態と生体傷害機序（近藤元治編）最新医学からのアプローチ4 ｢フリーラジカル｣分担執筆，pp. 7-26, 1992, メジカルビュー社, 東京
• 河野邦雄，大野良樹，野口範子， 神経細胞の構造的研究法，
• Noriko Noguchi, Ebselen, a useful tool for understanding cellular redox biology and a promissing drug candidate for use in human diseases. Arc. Biochem. Biophys. 595, 109-112, 2016
• 野口範子， 脳のコレステロール代謝と神経変性疾患，生物の科学,70, 225-229, 2016
• 山中一哲，野口範子， 新しい細胞死ネクロトーシス?プログラムされたネクローシス?,DOJINDO NEWS, 145, 1-6, 2012
• 斎藤，野口， 脂質酸化物により誘導される適応反応のメカニズム，放射線生物研究 45, 160-169, 2010
• 山盛、野口， 酸化ストレスと老化／寿命を結びつけるタンパク質―p66shc 放射線生物研究 43, 261-271, 2008
• Noriko Noguchi, Role of oxidative stress in adaptive responses in special reference to atherogenesis, J. Clin. Nutr. Biol. 43, 131-138 , 2008
• 野口範子， 生体の酸化傷害とその防御機構，フレグランスジャーナル, 2, 12-17, 2008, フレグランスジャーナル社
• 野口範子， 遺伝子で応える細胞のストレス応答，日本薬理学雑誌、129, 85-88, 2007, 日本薬理学会
• 野口範子， 過酸化物調整機構としての肝，The Lipid, 17: 28-32, 2006, メディカルレビュー社
• 野口範子， 酸化ストレスと遺伝子発現，アンチ・エイジング医学, 2: 97-101, 2006, メディカルレビュー社
• 野口範子， 酸化脂質はどのように動脈硬化を進行させるか？，Vascular Medicine, 2: 33-39, 2006, 先端医学社
• J.W. Zmijewski, A. Landar, N Watanabe, D.A. Dickinson, N. Noguchi, V.M. Darley-Usmar,Cell signalling by oxidized lipids and the role of reactive oxygen species in the endothelium. Review Biochem. Soc. Trans., 33, 1385-1389, 2005.
• 野口範子， 酸化?還元による細胞機能の制御，生化学ミニレビュー,日本生化学会, 77: 659-663, 2005
• 野口範子， 酸化ストレスによる血管内皮細胞の遺伝子応答プロファイリング，血管医学, 6: 41-45, 2005, メジカルビュー社
• 野口範子， オキシステロールの生物活性と血管，血管医学, 5: 13-18, 2004, メジカルビュー社
• 野口範子， 酸化脂質の生成メカニズムと生物学的作用，The Lipid, 15: 33-38, 2004,メディカルレビュー社
• E. Niki, N. Noguchi, Dynamics of antioxidant action of vitamin E. Accounts of Chemical Research, 37: 45-51, 2004
• 野口範子， 運動に関連する酸化ストレスと抗酸化作用，日本運動生理学雑誌, 10: 1-8, 2003
• 二木鋭雄, 野口範子， トコトリエノールの生理作用，ビタミン, 77: 172-175, 2003
• E. Niki, N. Noguchi, Effects of antioxidants against atherosclerosis. Mol. Cell. Biochem., 234: 19-25, 2002
• 野口範子， 抗酸化物質による血管障害の防御，血管医学, 3:41-47, 2002 , メジカルビュー社
• 野口範子， 酸化ストレスと動脈硬化，
• 二木鋭雄, 野口範子， ストレスの生命科学，オレオサイエンス、1(5), 509-514, 2001
• N. Noguchi, E. Niki, Evaluation of antioxidant capacity. What capacity is being measured by which method? IUBMB Life, 50, 323-329, 2001
• 二木鋭雄, 野口範子， CHAOS [Cambridge Heart Antioxidant Study]，日本臨床, 高脂血症（下巻）, 59,3, 448-451, 2001
• 野口範子， ラジカル消去を作用機序とする疾患治療薬，日本病院薬剤師会雑誌, 37,29(205)-31(207), 2001
• 野口範子， Gombergのフリーラジカル発見から100年，ISOTOPE NEWS, No. 559, 24-28, 2000
• N. Noguchi, A. Watanabe, H. Shi, Diverse functions of antioxidants. Free Rad. Res., 33, 809-817, 2000
• N. Noguchi, E. Niki, Phenolic antioxidants: A rationale for design and evaluation of novel antioxidant drug for atherosclerosis. Free Rad. Biol. Med., 28, 1538-1546, 2000
• 野口範子， 生体にとってフリーラジカルとは何か，ヒューマンサイエンス, 10, 16-18, 1999, ヒューマンサイエンス振興財団
• N. Noguchi, E. Niki, Dynamics of vitamin E action against LDL oxidation.Free Rad. Res., 28, 561-572, 1998
• 野口範子, 二木鋭雄， 酸化変性のメカニズム, 治療学, 32, 9-15, 1998, ライフサエンス出版
• 野口範子， 新規抗酸化物質の設計・合成とその活性評価, 日本油化学会誌, 46, 1167-1174, 1997
• 野口範子，二木鋭雄， 生体の酸化傷害と防御機構, FRAGNANCE JOURNAL , April, 9-16, 1997
• 野口範子， 酸化LDL，臨床栄養, 85, NO.7, 802-808, 1994, 医歯薬出版
• 野口範子， 動脈硬化と過酸化脂質，Geriatric Medicine, 32, No.9, 1047-1053, 1994, ライフサイエンス出版
• 野口範子， 血管とフリーラジカル, フリーラジカルの臨床, Mebio 11, No.4, 36-42, 1993, メジカルビュー社
• E. Niki, N. Noguchi, N. Goto, Inhibition of oxidative modification of low dinsity lipoprotein by antioxidants. J. Nutr. Sci. Vitaminol., 39, S1-S8, 1993
• 野口範子， 動脈硬化, Up date フリーラジカルー基礎と臨床 現代医療 25, 89-95, 1993, 現代医療社
• E. Niki, N. Noguchi, N. Gotoh, Dynamics of lipid peroxidation and its inhibition by antioxidants. Mechanisms of free radical damage in the vascular and central nervous systems and control by antioxidant intervention, Biochem. Soc. Transact., 21, 313-317,
• 野口範子，二木鋭雄, ＬＤＬの酸化とその抑制,実験医学 10, 42-47, 1992, 羊土社

Works

• トコフェロールの抗酸化作用
  2000 -2001
• Antioxidant activity of α-, β-, γ-, δ-tocopherol
  2000 -2001
• α, γ-トコフェロールとトコトリエノールの抗酸化作用と遺伝子発現制御に関する研究
  2001
• Study of antioxidant activity and gene expression of α, γ-tocopherol and tocotrienol
  2001
• にんにく抽出物の抗酸化作用
  1999 -2000
• Antioxidant activity of extract of garlic
  1999 -2000

Industrial Property Rights

• Patent right
  Aβ産生抑制剤
  浦野 泰臣, 野口 範子, 髙八 美菜
  特願2019-205225
• Patent right
  経鼻投与用医薬組成物
  2016-222605
• Patent right
  細胞死抑制剤
  第6143435号
• Patent right
  「ヒドロキシコレステロール脂肪酸エステルの検出方法」
  2015-186371
• Patent right
  ２型糖尿病の治療及び/又は予防薬
  2013-175612
• Patent right
  細胞死抑制剤
  2012-242950
• Patent right
  生体の抗酸化能測定方法
  2011-181963
• Patent right
  過酸化脂質の測定方法
  2011-260819
• Patent right
  含硫アミノ残基を含むポリペプチドに対する抗体
  2012-028138
• Patent right
  内皮細胞防御剤および抗アテローム性動脈硬化剤
  特許2004-11月出願
• Patent right
  低比重リポタンパクの酸化変性防止剤および抗アテローム性動脈硬化剤
  特許2004-089925
• Patent right
  低比重リポタンパクの酸化変性防止剤および抗アテローム性動脈硬化剤
  特許2004-150811
• Patent right
  抗酸化力増強剤
  特許2002-83138
• Patent right
  細胞の過酸化の分析方法
  特許2000-311821
• Patent right
  細胞死抑制剤
  第6143435号
• Patent right
  過酸化脂質の測定方法
  2011-260819
• Patent right
  含硫アミノ残基を含むポリペプチドに対する抗体
  2012-028138

Research Projects

• The regulation mechanism of oxidation and hypersulfidation in increase of effects of exercise for diabetes prevention
  野口範子; 浦野泰臣; 三田雄一郎; 斎藤芳郎
  JST, KAKENHI, 2024/04 -2027/03, B, Doshisha University
• 新興感染症に対する非特異的対策のための行動変容と科学コミュニケーションに 関する合理化および最適化研究
  西浦博; 野口範子; 桝太一; 渡辺政隆; 碓井真史
  JST, RISTEX, 2022/10 -2026/03, 京都大学 同志社大学 新潟青陵大学
• 京都発世界に通じるオンリーワン技術の継承
  NORIKO NOGUCHI
  文部科学省, 実社会の課題に対応するコミュニケーションの推進事業, 2019/09 -2024/03, 学校法人同志社
• 皮膚細胞を保護するタンパク質の分泌機構の解明と分泌促進因子の探索
  野口 範子
  公益財団法人コスメトロジー研究振興財団, コスメトロジー研究振興財団研究助成, 2017/12 -2019/03, Principal investigator, Competitive research funding
• コレステロール酸化物が誘導する神経細胞死に対するビタミンEの抑制機構
  野口 範子
  独立法人日本学術振興会, 科学研究費基盤C, 2016 -2019, Principal investigator, Competitive research funding
• Professional Confidence and Career Development for Women in Science, Technology, Engineering and Mathematics
  Fujimoto Tetsushi
  Professional confidence for women in academic and corporate science increases their motivation to persist in professional careers. Women’s perceived balance between work and personal life promotes their confidence as a professional, but perceived imbalance undermines the likelihood of their persisting in science careers. Confidence as a professional scientist/engineer is likely to affect women’s various decision-making in work and life, it is important to provide support for women in forming confidence in their early career stages, so that they are more likely to remain in their professional occupations., Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2013/04 -2018/03, Grant-in-Aid for Scientific Research (B), Doshisha University
• Selenium-transport mechanism of selenoprotein P
  Saito Yoshiro; NOGUCHI Noriko; TAKAHASHI Kazuhiko
  Selenoprotein P (SeP) is plasma selenoprotein containing essential trace element selenium. SeP functions as a transporter of selenium, delivering selenium to the cells. However, details of selenium-transport mechanisms of SeP remain unknown. In the present study, we identified SeP receptors in several tissues such as skeletal muscle, pancreas, and lymphocytes. Further, we identified SeP receptors with different affinity for SeP, and found a different molecular pathway to transport selenium of SeP to the cells. Collectively, we revealed selenium-transport mechanisms of SeP., Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2013/04 -2017/03, Grant-in-Aid for Scientific Research (B), Doshisha University
• Development of diagnosis and treatment of Parkinson disease at early stage using novel biomarker oxidized DJ-1
  Yoshiro Saito; NOGUCHI Noriko; SAIGOH Kazumasa
  DJ-1, the product of the causative gene of a familial form of Parkinson’s disease (PD), undergoes preferential oxidation at the cysteine residue at position 106 (Cys-106) under oxidative stress. In the present study using specific antibodies against Cys-106-oxidized DJ-1 (oxDJ-1), we evaluated oxDJ-1 levels in brain and blood of PD patients. It was found that DJ-1 oxidation in erythrocytes and in the brain occurs in PD patients, particularly during the early phases. DJ-1 oxidation was effectively inhibited by endogenous antioxidant glutathione. We could develop the molecular base for the diagnosis and treatment of PD at early phases based on the levels of oxDJ-1., Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2013/04 -2016/03, Grant-in-Aid for Challenging Exploratory Research, Doshisha University
• Activation of Arterial Wall Cells during Atherogenesis : A study using a in vitor co-culture model system
  KODAMA Tatsuhiko; NAITO Makoto; DOI Takefumi; NOGUCHI Noriko; MINAMI Takashi
  A new in vitro system for the co-culture of vascular endothelial cell(EC), smooth muscle cell(SMC) and monocyte/macrophage has been developed for the anaylysis of pathogenesis of atherosclerosis. We have established a vascular cell under flow. Using this system we examined the molecular pathogenesis of atherosclerosis and endothelial activation. Results (1)Oxidative modification of lipoproteins : We established a method for tracing oxidative modification. Transcriptome analysis indicated lyso-PC affects many genes in EC. (2)Using co-culture system, we found the involvement of NRF2 in shear stress sensing. (3)Changes in transcriptome were analyzed during inflammation, growth and coagulation in EC. Adding to Ets, GATA and Hex, the role of NFATc in these signal transduction was found. We also found that DSCRl can inhibit NFATc signaling. (4)We found a novel inhibitor for upregulation of adhesion molecule using co-culture system. This drug is also effective for the treatment of psoriasis., Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 2003 -2004, Grant-in-Aid for Scientific Research (A), The University of Tokyo
• Evaluation of antioxidant activity against atherosclerosis using co-culture system
  NOGUCHI Noriko
  To analyze in vitro the migration of monocytes to the subendothelial space, their differentiation into macrophages, and the subsequent formation of form cells in vitro, we developed a 2-coculture system with rabbit aortic endothelial cells, aortic smooth muscle cells, and a mixture of matrix proteins on polyethylene folters in chemotaxis chambers. When oxidized low density lipoprotein (LDL) was added to the matrixlayer of coculture, on day 4 transmigrant cells exhibited lipid deposit droplets, and by day 7, they had the appearance of typical foam cells. To follow lipid oxidation of low density lipoprotein andwithin cells we developed a novel method using diphenyl-1-pyrenylphosphine (DPPP) as a fluorescent probe. DPPP reacted with organic hydroperoxides and hydrogen peroxide stoichiometrically to give DPPP oxide (DPPP=O). DPPP incorporated into phosphatidylcholine liposomal membranes and polymorphonuclear leukocytes (PMNs) reacted with methyl linoleate hydroperoxide rapidly but not with hydrogen peroxide nor with tert-butyl hydroperoxide. This novel method revealed that lipid peroxidation proceeded within membranes of PMN stimulated by phorbol-12-myristate-13-acetate, which is known to produce several kinds of free radicals. It was found that DPPP is a suitable fluorescent probe to monitor lipid peroxidation within the cell membranes specifically. DPPP incorporated into LDL gave a strong fluo-rescence within macrophage after macrophage took up DPPP-containing LDL. We examined antioxidant activity of 4 isomers of vitamin E, (α- and γ-) tocopherol and tocotrienol, and inhibitory effect on expression of adhesion molecule of human endothelial cell. There were not significant deffereces in antioxidant activity and inhibitory effect on adhesion molecule expression. However, the concentrations of tocotrienols within cell were more than 10 times higher than that of tocopherol due to double bond in side chain of tocotrienol. By taking the defference in the concentrations of these antioxidants into considerations , tocopherols were more efficient in inhibition of the expression of adhesion molecules than tocotrienols. It is interesting to investigate these effects in coculture system we developed., Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 1999 -2000, Grant-in-Aid for Scientific Research (C), Research Center for Advanced Science and Technology, University of Tokyo
• Development and Application of Quantitative Evaluation System for Oxidative Damage of Lipids
  NIKI Etsuo; NOGUCHI Noriko; TAKAHASHI Mareyuki
  Lipids in oil products and foods are continuously damaged by aerobic oxygen and light. This results in quality deterioration and causes safety problems. Consequently, to inhibit such oxidation and to evaluate oxidative damage are of prime importance. The objective of this research is to develop a method by which the extent of oxidation of oils and lipids can be measured with high specificity, sensitivity, speed, and simplicity. It has been also aimed at developing and evaluating novel antioxidants which can effectively inhibit such oxidation. Lipid peroxidation products from fatty acids, phosphatidylcholines and cholesteryl esters were quantified regio-, stereo- and optical-specifically with a high performance liquid chromatography (HPLC) equipped with UV and chemiluminescence detector. The quantitative analyses have been successfully applied to oils, micelles, liposomes, lipoproteins, plasma and cells. This enabled us to distinguish and identify the active oxidants and mechanisms involved in lipid peroxidations. Furthermore, cholesterol esters were analyzed for different classes of fatty acids. Diphenylpyrenylphosphine (DPPP) was used to develop a ultra-sensitive analytical method. DPPP oxide formed stoichiometrically by the reaction of DPPP and lipid peroxides was analyzed and applied to the quantification of lipid peroxides. It was confirmed by this method that the location of lipid peroxides in the cells could be visualized with a conforcal fluorescence microscope. This method could be quite promising for further application and development. The antioxidant capacities of various compounds were evaluated from the lipid peroxides measured by the above methods and a potential novel antioxidant is now being developed., Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 1996 -1998, Grant-in-Aid for Scientific Research (A), The University of Tokyo
• Measuring Lipid peroxidation in the matrix using ESR spin labeling
  TAKAHASHI Mareyuki; NOGUCHI Noriko
  The novel method for measuring lopid peroxidation in the heterogeneous micro environments such as lopid bilayrs has been studied. This method might be useful for studying the degradation of newly synthesized materials such as functional polymers and biomembranes and also be useful for evaluating the activity of antioxidans which are designed to reside within the matrix. Followings are the results obtained. First, we evaluated the degree of lipid peroxidation taking place in the artificial lipid bilayrs (liposome) prepared with phosphatidylcholine, using ESR spin label technique with 5,10 and 16NS as spin probes. When azo compound AAPH was used as a free radical generator, ESR signal intensity of spin probes were decreased with time-and dose-dependently. By comparing with the formation of lipid hydroperoxides this method was proved to be useful to evaluate lipid peroxidation of the artificial membranes quantiatively. We next tried to apply this method to biological materials. Human leukemia cell line THP-1 or U937 was labeled with spin probes 5NS and 16NS by incubating cells with thin film formed on the inner surface of a round-bottom flask. The various kinds of reactive oxygen species were applied. In the case of AAPH,an extracellular peroxyl radical generator, the signal intensity of 5NS was diminished faster than that of 16NS,suggesting that the amount of free radicals near the surface was greater than deep inside the membranes. On the other hand, hydrogen peroxide, one of the most common reactive oxygen species, did not reduce the signal intensities of these two spin probes significantly, suggesting that hydrogen peroxide itself has little interaction with the plasma membrane of the cell. Thus this method was shown to be useful to evaluate lipid peroxidation in the microenvironment., Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 1996 -1997, Grant-in-Aid for Scientific Research (B), The University of Tokyo
• Design and Evaluation of Novel Selenium-Containing Antioxidant
  NIKI Etsuo; NOGUCHI Noriko; YAMAMOTO Yorihiro
  There is now increasing evidence which shows that the free-radical mediated oxidations proceed in vivo as in plastics rubber and lipids and that they play a causative role in the progression of various diseases, cancer and aging. As a consequence, the inhibition of such oxidations and development of novel potent antioxidants have received much attention. The present research has been carried out aiming at developing a novel selenium-containing antioxidant and evaluating its antioxidant potency. Ebselen, 2-phenyl-1,2-benzisoselenazol-3 (2H) -one, was chosen as a candidate and its antioxidant action and activity were studied. It was confirmed that ebselen did not act as a radical scavenger nor did it reduce vitamin E radical to regenerate vitamin E.Ebselen reduced hydroperoxides rapidly to corresponding alcohol and thereby inhibited the metal-catalyzed oxidations of lipids and low density lipoproteins. Furthermore, it was found that ebselen completely inhibited the lipid oxidation induce by lipoxygenase. Ebselen also exerted potent antioxidant activity against lipid peroxidation induced by peroxynitrite. It was concluded that ebselen is a potent antioxidant against oxidations induced by metal ions and peroxynitrite., Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 1995 -1996, Grant-in-Aid for Scientific Research (B), University of Tokyo
• リポ蛋白質の超分子構造と機能
  二木 鋭雄; 野口 範子
  LDLは,コレステロールエステル(CE)とトリグリセリド(TG)から成る核を,主としてホスファチジルコリン(PC)とコレステロールから成る一枚膜が外からとり囲んでおり,さらに分子量55万のアポタンパクB-100が全体をとりまくという,特徴ある超分子複合体である.ラジカルの攻撃を受け,酸化されるのは主としてPCとCEに含まれる高度不飽和脂肪酸部位である.興味深いことに,PCとCEの相対的酸化反応性が環境に大きく依存することを見出した.すなわちLDL中ではCEがPCよりも酸化されやすいこと、同じものでもt-ブチルアルコール中ではPCとCEが同程度酸化されやすくなり、一方ヘキサン中ではPCだけが圧倒的に酸化されることを認めた. LDLの構造と反応性,その場での抗酸化物の作用機序を明かにするために,ドキシルステアリン酸をスピンプローブとしてLDL内にとりこませ,そのドキシル基の位置を変えることにより,LDL内の流動性,反応性を検討した.また,ドキシルステアリン酸のコレステロールエステルを合成し,コレステロールエステル転移蛋白(CETP)を用いてLDL内にとりこませ,同様の検討を行った.その結果,LDLの表層は流動性が低く,内部に入るほど流動性が高くなること,中心の核の流動性が大きいことが分かった.ドキシル基のニトロキシドはアスコルビン酸(ビタミンC)により速やかに還元されるが,LDLの内部に入るほど,水層のアスコルビン酸による還元速度が遅くなることを明らかにした.これはビタミンCとEによる相乗効果と関連して重要である. LDLの酸化反応が連鎖的に進行し、CEとPCのヒドロペルオキシドを主生成物として与えることを確認した.アポ蛋白B-100の酸化に伴い、開裂による低分子化と橋かけ反応による高分子化が同時に進行するとともに、負負荷が増加していくことを確認した.そして重要なことは、それにつれてマクロファージによるとりこみも増加した., 日本学術振興会, 科学研究費助成事業, 1994 -1994, 重点領域研究, 東京大学
• 食品に含まれる抗酸化物質の機能解析と新規生体防御物質の設計
  二木 鋭雄; 野口 範子; 山本 順寛
  要旨:食品に含まれる種々の抗酸化物質およびそれらの類縁化合物、新規化合物の抗酸化作用について検討し、以下に示すような結果を得ている。 (1)カレー粉に含まれるカーキュミンをはじめコーヒー酸など数種の天然フェノール化合物の抗酸化活性を求めたが、α-トコフェロール(ビタミンE)を超えるものはなかった。 (2)β-カロテンをはじめとするカロテノイド類の抗酸化作用について基礎的検討を行ない、β-カロテンの抗酸化活性が、均一溶液中よりは膜中で、また酸素圧の低いほど抗酸化活性が大きいことを認めた。 (3)チオール化合物の抗酸化作用について研究をはじめた。 (4)トコフェロール、ヒドロキシカルバゾール、および2,6-ジ-tert-ブチル-4-ヒドロキシトルエン(BHT)など合成抗酸化物の膜における抗酸化作用について詳細に検討し、これらの相対的な活性や水相にあるアスコルビン酸との反応が、これらの膜内での存在位置、その場での動きやすさ、ラジカルの生成場に依存することを実験的に明らかにした。 (5)低比重リポタンパク質(LDL)の脂質の酸化、アポリポプロテインB100の変性に対する抗酸化物の抑制作用について検討し、不均一な場であるLDLの酸化に対しては、特に抗酸化物の存在場と動きやすさが重要な因子であることを明らかにした。 (6)これらの知見をもとに、現在新規の抗酸化物の開発、評価を行なっている。, 日本学術振興会, 科学研究費助成事業, 1993 -1993, 重点領域研究, 東京大学
• Development, Design and Evaluation of Novel Natural and Synthetic Antioxidants
  NIKI Etsuo; NOGUCHI Noriko; YAMAMOTO Yorihiro
  This study has been carried out aiming at the development, design and evaluation of novel natural and synthetic antioxidants which effectively inhibit the oxidative deterioration of biological molecules, membranes and tissues as well as foods and oil products. Following results were obtained. 1. The antioxidant activities of vitamin E, phenolic compounds and carbazoles were evaluated quantitatively and it was shown that physical factors such as mobility at the microenvironment as well as chemical reactivities are quite important in determining overall antioxidant potency. 2. Inhibition of oxidation of low density lipoprotein, which is an important initial event of atherosclerosis, by antioxidant was studied in detail. 3. Inhibition of oxidation of lipids by various phenols, aminophenols and carbazoles was studied and the correlation between structure and chemical reactivity was discussed. 4. The kinetics of mechanisms of antioxidation by selenium containing novel compound was studied. 5. Action of metal chelating agents was found to depend on metal, but not on lipids., Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, 1992 -1993, Grant-in-Aid for General Scientific Research (B), University of Tokyo, Research Center for Advanced Science and Technology
• 食品に含まれる抗酸化物質の機能解析と新規生体防御物質の設計
  二木 鋭雄; 野口 範子; 保田 浩; 山本 順寛
  フリーラジカルや活性酸素種により生ずる生体の傷害に対して、食品が有している防御因子を解明するとともに、その知見をもとによりすぐれた防御機能を有する物質を設計、開発することを目指して研究を進め、以下の結果を得た。 1)ビタミンE(トコフェロール)およびその類縁化合物の膜、低比重リポタンパク(LDL)中での抗酸化作用をスピンラベル法などにより検討し、ビタミンEの活性基が膜、LDLの表面に存在していること、動きが制限されていること、そのため内部のラジカルを捕捉しにくいことを明らかにした。 2)特にLDL中において側鎖の長さの影響が大きく、側鎖が短いほど抗酸化活性が大きくなることを見出した。LDL中では、抗酸化物の化学的反応性よりはむしろミクロな場での濃度、動きやすさがより重要な因子となることを明らかにし、そのためにビタミンEより化学的活性が小さいにもかかわらず、プロブコールがより強い抗酸化作用を持つことを示した。 3)放線菌Strep to myces chromotucusより抽出されたカラゾスタチンをはじめ種々のカルバゾール、アミノフェノール、クロマノール類の高度不飽和脂肪酸および脂質の酸化に対する抗酸化作用を定量的に検討した。 4)含セレン化合物であるエブセレンはラジカル捕捉能を有しないが、速やかにヒドロペンオキンドを分解するために、鉄あるいは銅により誘起される脂質の酸化反応を顕著に抑制することを明らかにした。, 日本学術振興会, 科学研究費助成事業, 1992 -1992, 重点領域研究, 東京大学
• フリーラジカルによる細胞の酸化的傷害とその防御機構に関する基礎的研究
  二木 鋭雄; 野口 範子; 保田 浩; 山本 順寛
  フリーラジカルが細胞、特に脳神経細胞に対して如何にして酸化的傷害を与えるのか、またそに対してどうすれば防御できるのかについて反応論的観点から基礎的に研究を行ない、解明することを目的として研究を進め、以下の結果を得た。潅流後、ラットより摘出した脳、肝のホモジネート(10mg protein/ml Tris-HCl緩衝液pH7.4)の酸化とその抑制について比較検討を行なった。ホモジネート中のビタミンE(α-トコフエロール)の濃度は、脳で0.12nmol/mg protein、肝では0.06nmol/mg proteinであった。EDTA存在下で水溶性ラディカル開始剤AAPH(2,2'-azobis(2-amidinopropane)dihydrochloride)10mM添加により、一定速度でペルオキシルラディカルを発生させて酸化を開始すると、肝では反応2時間までにビタミンEは消費され、3時間でTBARSは1.1nmol/mg protein増加した。同じ反応時間における脳のTBARSは0.3nmol/mg proteinでビタミンEの減少は10%以下であった。一方、EDTA非存在下で開始剤を添加しない場合、肝の酸化はほとんど起こらないのに対して、脳は速やに酸化し、0.05nmol/mg proteinのビタミンEが残存しているにもかかわらず、TBARSは1.48nmol/mg proteinに達した。以上の結果から、脳脂質は高濃度存在するビタミンEによってペルオキシルラディカルによる酸化はよく抑えられるが、金属依存性の酸化を受けやすく、またビタミンEはこれをよく抑制することができないことが示唆された。 含セレン化合物であるエブセレンはヒドロペルオキシドを速やかに分解することにより、金属依存性の酸化をきれいに抑制することを認めた。, 日本学術振興会, 科学研究費助成事業, 1992 -1992, 重点領域研究, 東京大学
• 抗酸化物貭による遺伝子発現制御
  Competitive research funding
• 活性酵素フリーラジカルによる生体の傷害とその防御機構
  Competitive research funding
• regulation of gene expression by antioxidants
  Competitive research funding
• Mechanisms of damage induced by free radicals in vivo and its prevention
  Competitive research funding

Social Contribution

• World Student Environment Summit, 同志社大学, サミット, 2018/08/26-2018/08/30, Others

Research cooperation among industry, academia and government

• Joint Research Theme：Regulation of gene expression by vitamin E

  Remarks：Cooperative research with other research organization of universities, etc.
• Joint Research Theme：Effects of anti-atherogenic drag on different animal species

  Remarks：Cooperative research with other research organization including private (industrial) sectors