KITAGISHI Hiroaki
Faculty of Science and Engineering Department of Molecular Chemistry and Biochemistry
Professor
Last Updated :2021/12/04

Researcher Profile and Settings

Profile and Settings

  • Research funding number

    60448090

Research Interests

  • Porphyrin, Cyclodextrin, Heme, CO, Supramolecular Chemistry, Bioinorganic Chemistry

Academic & Professional Experience

  • Department of Molecular Chemistry and Biochemistry, Faculty of Science and Engineering, Doshisha University, 2020/04 - Today
  • Department of Molecular Chemistry and Biochemistry, Faculty of Science and Engineering, Doshisha University, 2014/04 - 2020/03
  • Department of Molecular Chemistry and Biochemistry, Faculty of Science and Engineering, Doshisha University, 2008/04 - 2014/03
  • Postdoctral Fellow, Graduate School of Engineering Division of Applied Chemistry, Osaka University, 2006/04 - 2008/03

Education

  • Doshisha University, 2006
  • Nara Institute of Science and Technology, Graduate School of Materials Science, 2003
  • Doshisha University, 2001

Academic Degrees

  • 博士(工学), 同志社大学
  • 修士(工学), 奈良先端科学技術大学院大学

Published Papers

  • Supramolecular Complexation in Biological Media: NMR Study on Inclusion of an Anionic Tetraarylporphyrin into a Per‐ O ‐Methylated β‐Cyclodextrin Cavity in Serum, Blood, and Urine
    Hiroaki Kitagishi, Mai Saito, Qiyue Mao, Akiko Kiriyama, Shigeru Negi, Koji Kano
    Chemistry – An Asian Journal, Wiley, 14(19)3320 - 3328, Oct. 2019, Research paper (scientific journal)
  • Design and Biological Evaluation of Manganese‐ and Ruthenium‐Based Hybrid CO‐RMs (HYCOs)
    Anthony Ollivier, Roberta Foresti, Zeina El Ali, Thierry Martens, Hiroaki Kitagishi, Roberto Motterlini, Michael Rivard
    ChemMedChem, Wiley, 14(18)1684 - 1691, Sep. 2019, Research paper (scientific journal)
  • Preparation, characterization, and study of the antimicrobial activity of a Hinokitiol-copper(II)/γ-cyclodextrin ternary complex
    Suzuki R, Inoue Y, Murata I, Nomura H, Isshiki Y, Hashimoto M, Kudo Y, Kitagishi H, Kondo S, Kanamoto I
    Journal of Molecular Structure, 119419 - 27, 2019, Research paper (scientific journal)
  • Hydrogen bond directed molecular recognition in water in a strapped-porphyrin-cyclodextrin assembly
    Kitagishi H, Ohara K, Shimoji D, Vonesch M, Weiss J, Wytko J.A
    Journal of Porphyrins and Phthalocyanines, 23(4-5)569 - 574, 2019
  • Arginine residues provide a multivalent effect for cellular uptake of a hemoprotein assembly
    Oohora K, Kajihara R, Jiromaru M, Kitagishi H, Hayashi T
    Chemistry Letters, 48(3)295 - 298, 2019, Research paper (scientific journal)
  • Acceleration of hydrolytic DNA cleavage by dicopper(II) complexes with p-cresol-derived dinucleating ligands at slightly acidic pH and mechanistic insights
    Kodera M, Kadoya Y, Aso K, Fukui K, Nomura A, Hitomi Y, Kitagishi H
    Bulletin of the Chemical Society of Japan, 92(4)739 - 747, 2019, Research paper (scientific journal)
  • Circadian clock disruption by selective removal of endogenous carbon monoxide
    Saika Minegishi, Ikuko Sagami, Shigeru Negi, Koji Kano, Hiroaki Kitagishi
    Scientific Reports, Springer Nature, 8(1), Dec. 2018, Research paper (scientific journal)
  • Optimized synthesis of a per-O-methylated β-cyclodextrin dimer linked at the secondary face by a pyridine ligand
    Qiyue Mao, Hiroaki Kitagishi
    Journal of Inclusion Phenomena and Macrocyclic Chemistry, Springer Science and Business Media {LLC}, 93(1-2)67 - 76, Sep. 2018, Research paper (scientific journal)
  • Intramolecular Oxidative O-Demethylation of an Oxoferryl Porphyrin Complexed with a Per-O-methylated beta-Cyclodextrin Dimer
    Hiroaki Kitagishi, Shun Kurosawa, Koji Kano
    Chemistry-An Asian Journal, WILEY-V C H VERLAG GMBH, 11(22)3213 - 3219, Nov. 2016, English, Research paper (scientific journal)
  • Supramolecular intracellular delivery of an anionic porphyrin by octaarginine-conjugated per-O-methyl-beta-cyclodextrin
    Hiroaki Kitagishi, Fumihiko Chai, Shigeru Negi, Yukio Sugiura, Koji Kano
    CHEMICAL COMMUNICATIONS, ROYAL SOC CHEMISTRY, 51(12)2421 - 2424, 2015, English, Research paper (scientific journal)
  • Intracellular Delivery of Anionic meso-Tetraarylporphyrin-Per-O-methylated beta-Cyclodextrin Supramolecular Complexes by an Oligoarginine Carrier Peptide
    Hiroaki Kitagishi, Keiko Minami, Koji Kano
    CHEMISTRY LETTERS, CHEMICAL SOC JAPAN, 43(7)1095 - 1097, Jul. 2014, English, Research paper (scientific journal)
  • Intramolecular Oxidative O-Demethylation in a Per-O-methylated beta-Cyclodextrin-Iron Porphyrin Inclusion Complex in Aqueous Solution
    Takunori Ueda, Saki Kumeda, Hiroaki Kitagishi, Koji Kano
    CHEMISTRY LETTERS, CHEMICAL SOC JAPAN, 42(11)1366 - 1368, Nov. 2013, English, Research paper (scientific journal)
  • Cellular uptake of octaarginine-conjugated tetraarylporphyrin included by per-O-methylated beta-cyclodextrin
    Hiroaki Kitagishi, Satoshi Hatada, Toshiaki Itakura, Yuki Maki, Yasuaki Maeda, Koji Kano
    ORGANIC & BIOMOLECULAR CHEMISTRY, ROYAL SOC CHEMISTRY, 11(19)3203 - 3211, 2013, English, Research paper (scientific journal)
  • Functionalization of a Protein Surface with Per-O-Methylated beta-Cyclodextrin
    Hiroaki Kitagishi, Kazuya Kashiwa, Koji Kano
    BIOPOLYMERS, WILEY-BLACKWELL, 97(1)11 - 20, Jan. 2012, English, Research paper (scientific journal)
  • Colorful Virus-like Particles: Fluorescent Protein Packaging by the Q beta Capsid
    Jin-Kyu Rhee, Marisa Hovlid, Jason D. Fiedler, Steven D. Brown, Florian Manzenrieder, Hiroaki Kitagishi, Corwin Nycholat, James C. Paulson, M. G. Finn
    BIOMACROMOLECULES, AMER CHEMICAL SOC, 12(11)3977 - 3981, Nov. 2011, English, Research paper (scientific journal)
  • Preparation and reactivity of a tetranuclear Fe(II) core in the metallothionein alpha-domain
    Yohei Sano, Akira Onoda, Rie Sakurai, Hiroaki Kitagishi, Takashi Hayashi
    JOURNAL OF INORGANIC BIOCHEMISTRY, ELSEVIER SCIENCE INC, 105(5)702 - 708, May 2011, English, Research paper (scientific journal)
  • Anion binding to a ferric porphyrin complexed with per-O-methylated beta-cyclodextrin in aqueous solution
    K Kano, H Kitagishi, S Tamura, A Yamada
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMER CHEMICAL SOC, 126(46)15202 - 15210, Nov. 2004, English, Research paper (scientific journal)
  • Heptakis(2,3-di-O-carboxymethyl)-beta-cyclodextrin as a pH-sensitive host
    K Kano, Y Horiki, T Mabuchi, H Kitagishi
    CHEMISTRY LETTERS, CHEMICAL SOC JAPAN, 33(9)1086 - 1087, Sep. 2004, English, Research paper (scientific journal)
  • Sensitive quantification of carbon monoxide in vivo reveals a protective role of circulating hemoglobin in CO intoxication
    Qiyue Mao, Akira T. Kawaguchi, Shun Mizobata, Roberto Motterlini, Roberta Foresti, Hiroaki Kitagishi
    Communications Biology, 4(1), Dec. 2021, Research paper (scientific journal)
  • FRET‐Based In‐Cell Detection of Highly Selective Supramolecular Complexes of meso‐Tetraarylporphyrin with Peptide/BODIPY‐modified Per‐O‐methyl‐β‐cyclodextrins
    Atsuki Nakagami, Qiyue Mao, Geraldine Gouhier, Hidetoshi Arima, Hiroaki Kitagishi
    ChemBioChem, Wiley, Sep. 2021, Research paper (scientific journal)
  • Synthetic heme protein models that function in aqueous solution
    Hiroaki Kitagishi, Koji Kano
    Chemical Communications, 57(2)148 - 173, 07 Jan. 2021, Research paper (scientific journal)
  • Functional Myoglobin Model Composed of a Strapped Porphyrin/Cyclodextrin Supramolecular Complex with an Overhanging COOH That Increases O2/CO Binding Selectivity in Aqueous Solution
    Qiyue Mao, Pradip K. Das, Stéphane Le Gac, Bernard Boitrel, Vincent Dorcet, Koji Oohora, Takashi Hayashi, Hiroaki Kitagishi
    Inorganic Chemistry, 2021, Research paper (scientific journal)
  • Intracellular Delivery of Adamantane-Tagged Small Molecule, Proteins, and Liposomes Using an Octaarginine-Conjugated β-Cyclodextrin
    Hiroaki Kitagishi, Misa Jiromaru, Naomi Hasegawa
    ACS Applied Bio Materials, 3(8)4902 - 4911, 17 Aug. 2020, Research paper (scientific journal)
  • Carbon monoxide, a retrograde messenger generated in postsynaptic mushroom body neurons, evokes noncanonical dopamine release
    Kohei Ueno, Johannes Morstein, Kyoko Ofusa, Shintaro Naganos, Ema Suzuki-Sawano, Saika Minegishi, Samir P. Rezgui, Hiroaki Kitagishi, Brian W. Michel, Christopher J. Chang, Junjiro Horiuchi, Minoru Saitoe
    Journal of Neuroscience, 40(18)3533 - 3548, Apr. 2020, Research paper (scientific journal)
  • Boronate sol-gel method for one-step fabrication of polyvinyl alcohol hydrogel coatings by simple cast- And dip-coating techniques
    Ryuhei Nishiyabu, Yuki Takahashi, Taro Yabuki, Shoji Gommori, Yuki Yamamoto, Hiroaki Kitagishi, Yuji Kubo
    RSC Advances, 10(1)86 - 94, 01 Jan. 2020, Research paper (scientific journal)
  • Modelling haemoproteins: porphyrins and cyclodextrins as sources of inspiration
    Maxime Vonesch, Jennifer A. Wytko, Hiroaki Kitagishi, Koji Kano, Jean Weiss
    Chemical Communications, 55(97)14558 - 14565, 2019, Research paper (scientific journal)
  • PEGylated carboxyhemoglobin bovine (SANGUINATE) ameliorates myocardial infarction in a rat model
    Akira T. Kawaguchi, Amankeldi A. Salybekov, Mariko Yamano, Hiroaki Kitagishi, Kaori Sekine, Tetsuro Tamaki
    Artificial Organs, 42(12)1174 - 1184, Dec. 2018, Research paper (scientific journal)
  • Carbon monoxide-induced metabolic switch in adipocytes improves insulin resistance in obese mice
    Laura Braud, Maria Pini, Lucie Muchova, Sylvie Manin, Hiroaki Kitagishi, Daigo Sawaki, Gabor Czibik, Julien Ternacle, Geneviève Derumeaux, Roberta Foresti, Roberto Motterlini
    JCI insight, 3(22), 15 Nov. 2018, Research paper (scientific journal)
  • A water-soluble supramolecular complex that mimics the heme/copper hetero-binuclear site of cytochrome: C oxidase
    Hiroaki Kitagishi, Daiki Shimoji, Takehiro Ohta, Ryo Kamiya, Yasuhiro Kudo, Akira Onoda, Takashi Hayashi, Jean Weiss, Jennifer A. Wytko, Koji Kano
    Chemical Science, Royal Society of Chemistry, 9(7)1989 - 1995, 21 Feb. 2018, English, Research paper (scientific journal)
  • A water-soluble supramolecular complex that mimics the heme/copper hetero-binuclear site of cytochrome: C oxidase
    Hiroaki Kitagishi, Daiki Shimoji, Takehiro Ohta, Ryo Kamiya, Yasuhiro Kudo, Akira Onoda, Takashi Hayashi, Jean Weiss, Jennifer A. Wytko, Koji Kano
    Chemical Science, Royal Society of Chemistry, 9(7)1989 - 1995, 21 Feb. 2018, English, Research paper (scientific journal)
  • Iron(II)porphyrin Cyclodextrin Supramolecular Complex as a Carbon Monoxide-Depleting Agent in Living Organisms
    Hiroaki Kitagishi, Saika Minegishi
    CHEMICAL & PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOC JAPAN, 65(4)336 - 340, Apr. 2017, English
  • Detection and Removal of Endogenous Carbon Monoxide by Selective and Cell-Permeable Hemoprotein Model Complexes
    Saika Minegishi, Aki Yumura, Hirotsuna Miyoshi, Shigeru Negi, Shigeru Taketani, Roberto Motterlini, Roberta Foresti, Koji Kano, Hiroaki Kitagishi
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMER CHEMICAL SOC, 139(16)5984 - 5991, Apr. 2017, English, Research paper (scientific journal)
  • Participation of Hydroxyl Radical in the Formation of Verdoheme-type Compound in the Reaction of a Ferric Porphyrin with Hydrogen Peroxide
    Hiroaki Kitagishi, Yosuke Sugaya, Kozue Komazawa, Mariko Tamaki, Koji Kano
    CHEMISTRY LETTERS, CHEMICAL SOC JAPAN, 46(4)509 - 512, Apr. 2017, English, Research paper (scientific journal)
  • HemoCD as a Totally Synthetic Artificial Oxygen Carrier: Improvements in the Synthesis and O-2/CO Discrimination
    Hiroaki Kitagishi, Qiyue Mao, Naoya Kitamura, Takahiro Kita
    ARTIFICIAL ORGANS, WILEY, 41(4)372 - 380, Apr. 2017, English, Research paper (scientific journal)
  • Surface modification of a polyvinyl alcohol sponge with functionalized boronic acids to develop porous materials for multicolor emission, chemical sensing and 3D cell culture
    Ryuhei Nishiyabu, Shunsuke Iizuka, Saika Minegishi, Hiroaki Kitagishi, Yuji Kubo
    CHEMICAL COMMUNICATIONS, ROYAL SOC CHEMISTRY, 53(25)3563 - 3566, Mar. 2017, English, Research paper (scientific journal)
  • Esterification of 24S-OHC induces formation of atypical lipid droplet-like structures, leading to neuronal cell death
    Wakako Takabe, Yasuomi Urano, Diep-Khanh Ho Vo, Kimiyuki Shibuya, Masaki Tanno, Hiroaki Kitagishi, Toyoshi Fujimoto, Noriko Noguchi
    JOURNAL OF LIPID RESEARCH, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 57(11)2005 - 2014, Nov. 2016, English, Research paper (scientific journal)
  • Synthesis of 24(S)-hydroxycholesterol esters responsible for the induction of neuronal cell death
    Kimiyuki Shibuya, Toshiaki Watanabe, Yasuomi Urano, Wakako Takabe, Noriko Noguchi, Hiroaki Kitagishi
    BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON-ELSEVIER SCIENCE LTD, 24(11)2559 - 2566, Jun. 2016, English, Research paper (scientific journal)
  • Feedback Response to Selective Depletion of Endogenous Carbon Monoxide in the Blood
    Hiroaki Kitagishi, Saika Minegishi, Aki Yumura, Shigeru Negi, Shigeru Taketani, Yoko Amagase, Yumiko Mizukawa, Tetsuro Urushidani, Yukio Sugiura, Koji Kano
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMER CHEMICAL SOC, 138(16)5417 - 5425, Apr. 2016, English, Research paper (scientific journal)
  • Photoinduced Homolysis of Alkyl-Cobalt(III) Bonds in a Cyclodextrin Cage
    Kohei Imabeppu, Hiroyuki Kuwano, Eriko Yutani, Hiroaki Kitagishi, Koji Kano
    EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, WILEY-V C H VERLAG GMBH, 2016(12)1784 - 1789, Apr. 2016, English, Research paper (scientific journal)
  • Bioconjugation of Serum Albumin to a Maleimide-appended Porphyrin/Cyclodextrin Supramolecular Complex as an Artificial Oxygen Carrier in the Bloodstream
    Hiroaki Kitagishi, Hiroki Kawasaki, Koji Kano
    CHEMISTRY-AN ASIAN JOURNAL, WILEY-V C H VERLAG GMBH, 10(8)1768 - 1775, Aug. 2015, English, Research paper (scientific journal)
  • Reaction between a haemoglobin model compound and hydrosulphide in aqueous solution
    Kenji Watanabe, Toshikane Suzuki, Hiroaki Kitagishi, Koji Kano
    CHEMICAL COMMUNICATIONS, ROYAL SOC CHEMISTRY, 51(19)4059 - 4061, 2015, English, Research paper (scientific journal)
  • Supramolecular ferric porphyrins and a cyclodextrin dimer as antidotes for cyanide poisoning
    T. Yamagiwa, A. T. Kawaguchi, T. Saito, S. Inoue, S. Morita, K. Watanabe, H. Kitagishi, K. Koji, S. Inokuchi
    HUMAN & EXPERIMENTAL TOXICOLOGY, SAGE PUBLICATIONS LTD, 33(4)360 - 368, Apr. 2014, English, Research paper (scientific journal)
  • Hydroxylation of an axial pyridine ligand in a supramolecule composed of a porphinatoiron(III) and a per-O-methyl-beta-cyclodextrin dimer with mCPBA
    T. Ueda, S. Kumeda, H. Kitagishi, K. Kano
    JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, SPRINGER, 19S546 - S546, Mar. 2014, English
  • Intramolecular Direct Oxygen Transfer from Oxoferryl Porphyrin to a Sulfide Bond
    Takunori Ueda, Hiroaki Kitagishi, Koji Kano
    INORGANIC CHEMISTRY, AMER CHEMICAL SOC, 53(1)543 - 551, Jan. 2014, English, Research paper (scientific journal)
  • Elongation of Circulation Time of a Diatomic Molecule Receptor in Bloodstream by Attachment to Small Gold Nanoparticles
    Keiichi Karasugi, Hiroaki Kitagishi, Koji Kano
    CHEMISTRY LETTERS, CHEMICAL SOC JAPAN, 42(2)115 - 117, Feb. 2013, English, Research paper (scientific journal)
  • Supramolecular Iron Porphyrin/Cyclodextrin Dimer Complex that Mimics the Functions of Hemoglobin and Methemoglobin
    Kenji Watanabe, Hiroaki Kitagishi, Koji Kano
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, WILEY-V C H VERLAG GMBH, 52(27)6894 - 6897, 2013, English, Research paper (scientific journal)
  • Supramolecular Linear Assemblies of Cytochrome b(562) Immobilized on a Gold Electrode
    Yasuaki Kakikura, Akira Onoda, Emi Kubo, Hiroaki Kitagishi, Taro Uematsu, Susumu Kuwabata, Takashi Hayashi
    JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS, SPRINGER, 23(1)172 - 179, Jan. 2013, English, Research paper (scientific journal)
  • Modification of a Dioxygen Carrier, HemoCD, with PEGylated Dendrons for Extension of Circulation Time in the Bloodstream
    Keiichi Karasugi, Hiroaki Kitagishi, Koji Kano
    BIOCONJUGATE CHEMISTRY, AMER CHEMICAL SOC, 23(12)2365 - 2376, Dec. 2012, English, Research paper (scientific journal)
  • Glycan-Targeted Virus-like Nanoparticles for Photodynamic Therapy
    Jin-Kyu Rhee, Michael Baksh, Corwin Nycholat, James C. Paulson, Hiroaki Kitagishi, M. G. Finn
    BIOMACROMOLECULES, AMER CHEMICAL SOC, 13(8)2333 - 2338, Aug. 2012, English, Research paper (scientific journal)
  • Supramolecular dioxygen receptors composed of an anionic water-soluble porphinatoiron(II) and cyclodextrin dimers
    Koji Kano, Syoichi Chimoto, Mariko Tamaki, Yoshiki Itoh, Hiroaki Kitagishi
    DALTON TRANSACTIONS, ROYAL SOC CHEMISTRY, 41(2)453 - 461, 2012, English, Research paper (scientific journal)
  • PEGylation of an artificial O-2 and CO receptor: synthesis, characterisation and pharmacokinetic study
    Takunori Ueda, Hiroaki Kitagishi, Koji Kano
    ORGANIC & BIOMOLECULAR CHEMISTRY, ROYAL SOC CHEMISTRY, 10(22)4337 - 4347, 2012, English, Research paper (scientific journal)
  • Supramolecular Ferric Porphyrins as Cyanide Receptors in Aqueous Solution
    Kenji Watanabe, Hiroaki Kitagishi, Koji Kano
    ACS MEDICINAL CHEMISTRY LETTERS, AMER CHEMICAL SOC, 2(12)943 - 947, Dec. 2011, English, Research paper (scientific journal)
  • Preparation and Function of Poly(acrylic acid)s Modified by Supramolecular Complex Composed of Porphinatoiron and a Cyclodextrin Dimer That Bind Diatomic Molecules (O-2 and CO) in Aqueous Solution
    Koji Kano, Toshiro Ochi, Sayuri Okunaka, Yusuke Ota, Keiichi Karasugi, Takunori Ueda, Hiroaki Kitagishi
    CHEMISTRY-AN ASIAN JOURNAL, WILEY-BLACKWELL, 6(11)2946 - 2955, Nov. 2011, English, Research paper (scientific journal)
  • Calorimetric Study on Coordination of Tridentate Imidazolyl Calix[6]arene Ligands to Zinc Ion in Organic Solvents
    Koji Kano, Masataka Kondo, Haruka Inoue, Hiroaki Kitagishi, Benoit Colasson, Olivia Reinaud
    INORGANIC CHEMISTRY, AMER CHEMICAL SOC, 50(13)6353 - 6360, Jul. 2011, English, Research paper (scientific journal)
  • Gold Nanoparticles Carrying Diatomic Molecules (O-2 and CO) in Aqueous Solution
    Keiichi Karasugi, Hiroaki Kitagishi, Koji Kano
    CHEMISTRY-AN ASIAN JOURNAL, WILEY-BLACKWELL, 6(3)825 - 833, Mar. 2011, English, Research paper (scientific journal)
  • A chemically-controlled supramolecular protein polymer formed by a myoglobin-based self-assembly system
    Koji Oohora, Akira Onoda, Hiroaki Kitagishi, Hiroyasu Yamaguchi, Akira Harada, Takashi Hayashi
    CHEMICAL SCIENCE, ROYAL SOC CHEMISTRY, 2(6)1033 - 1038, 2011, English, Research paper (scientific journal)
  • Oxoferryl Porphyrin/Hydrogen Peroxide System Whose Behavior is Equivalent to Hydroperoxoferric Porphyrin
    Hiroaki Kitagishi, Mariko Tamaki, Takunori Ueda, Shun Hirota, Takehiro Ohta, Yoshinori Naruta, Koji Kano
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMER CHEMICAL SOC, 132(47)16730 - 16732, Dec. 2010, English, Research paper (scientific journal)
  • Structural Basis of the Lactate-dependent Allosteric Regulation of Oxygen Binding in Arthropod Hemocyanin
    Shun Hirota, Naoki Tanaka, Ivan Micetic, Paolo Di Muro, Satoshi Nagao, Hiroaki Kitagishi, Koji Kano, Richard S. Magliozzo, Jack Peisach, Mariano Beltramini, Luigi Bubacco
    JOURNAL OF BIOLOGICAL CHEMISTRY, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 285(25)19338 - 19345, Jun. 2010, English, Research paper (scientific journal)
  • A Diatomic Molecule Receptor That Removes CO in a Living Organism
    Hiroaki Kitagishi, Shigeru Negi, Akiko Kiriyama, Akino Honbo, Yukio Sugiura, Akira T. Kawaguchi, Koji Kano
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, WILEY-V C H VERLAG GMBH, 49(7)1312 - 1315, 2010, English, Research paper (scientific journal)
  • Thermodynamically Controlled Supramolecular Polymerization of Cytochrome b(562)
    Hiroaki Kitagishi, Koji Oohora, Takashi Hayashi
    BIOPOLYMERS, WILEY-BLACKWELL, 91(3)194 - 200, Mar. 2009, English, Research paper (scientific journal)
  • HemoCD as an Artificial Oxygen Carrier: Oxygen Binding and Autoxidation
    Koji Kano, Hiroaki Kitagishi
    ARTIFICIAL ORGANS, WILEY-BLACKWELL PUBLISHING, INC, 33(2)177 - 182, Feb. 2009, English, Research paper (scientific journal)
  • Self-Assembly of One- and Two-Dimensional Hemoprotein Systems by Polymerization through Heme-Heme Pocket Interactions
    Hiroaki Kitagishi, Yasuaki Kakikura, Hiroyasu Yamaguchi, Koji Oohora, Akira Harada, Takashi Hayashi
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, WILEY-V C H VERLAG GMBH, 48(7)1271 - 1274, 2009, English, Research paper (scientific journal)
  • A supramolecular receptor of diatomic molecules (O-2, CO, NO) in aqueous solution
    Koji Kano, Yoshiki Itoh, Hiroaki Kitagishi, Takashi Hayashi, Shun Hirota
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMER CHEMICAL SOC, 130(25)8006 - 8015, Jun. 2008, English, Research paper (scientific journal)
  • Supramolecular hemoprotein linear assembly by successive interprotein heme-heme pocket interactions
    Hiroaki Kitagishi, Koji Oohora, Hiroyasu Yamaguchi, Hideaki Sato, Takashi Matsuo, Akira Harada, Takashi Hayashi
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, AMER CHEMICAL SOC, 129(34)10326 - +, Aug. 2007, English, Research paper (scientific journal)
  • Characterization of an inclusion complex of 5,10,15,20-tetrakis(4- sulfonatophenyl)-porphinato iron and an O-methylated β-cyclodextrin dimer having a pyridine linker and its related complexes in aqueous solution
    Koji Kano, Hiroaki Kitagishi, Shigeki Tanaka
    Journal of Inclusion Phenomena and Macrocyclic Chemistry, 56(1-2)69 - 74, Oct. 2006, English, Research paper (international conference proceedings)
  • Redox behavior of a manganese porphyrin complexed with per-O-methylated beta-cyclodextrin in aqueous solution
    Koji Kano, Hiroaki Kitagishi, Yumiko Sone, Nami Nakazawa, Masahito Kodera
    EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, WILEY-V C H VERLAG GMBH, 2006(20)4043 - 4053, Oct. 2006, English, Research paper (scientific journal)
  • Characterization of an inclusion complex of 5,10,15,20-tetrakis(4-sulfonatophenyl)-porphinato iron and an O-methylated beta-cyclodextrin dimer having a pyridine linker and its related complexes in aqueous solution
    Koji Kano, Hiroaki Kitagishi, Shigeki Tanaka
    JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, SPRINGER, 56(1-2)69 - 74, Oct. 2006, English, Research paper (scientific journal)
  • A myoglobin functional model composed of a ferrous porphyrin and a cyclodextrin dimer with an imidazole linker
    Koji Kano, Hiroaki Kitagishi, Takahiro Mahuchi, Masahito Kodera, Shun Hirota
    CHEMISTRY-AN ASIAN JOURNAL, WILEY-V C H VERLAG GMBH, 1(3)358 - 366, Sep. 2006, English, Research paper (scientific journal)
  • Iron porphyrin-cyclodextrin supramolecular complex as a functional model of myoglobin in aqueous solution
    K Kano, H Kitagishi, C Dagallier, M Kodera, T Matsuo, T Hayashi, Y Hisaeda, S Hirota
    INORGANIC CHEMISTRY, AMER CHEMICAL SOC, 45(11)4448 - 4460, May 2006, English, Research paper (scientific journal)
  • Dioxygen binding to a simple myoglobin model in aqueous solution
    K Kano, H Kitagishi, M Kodera, S Hirota
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, WILEY-V C H VERLAG GMBH, 44(3)435 - 438, 2005, English, Research paper (scientific journal)
  • Dynamic structural change of a twisted hexaporphyrin complex by highly specific molecular recognition
    H Kitagishi, A Satake, Y Kobuke
    INORGANIC CHEMISTRY, AMER CHEMICAL SOC, 43(11)3394 - 3405, May 2004, English, Research paper (scientific journal)
  • Simple Myoglobin Model Composed of Permethylated β-Cyclodextrin Dimmer and Water-Soluble Fe(II)porphyrin
    Kano, K, Kitagishi, H, Kodera, M, Hirota, S
    International Conference on Supramolecular Science and Technology, 98s71 , 01 Apr. 2004, English

Misc

  • Application of Supramolecular Hemoprotein Model Compounds Toward Biological Systems
    54(4)71 - 74, Jan. 2014, Japanese
  • Artificial Cyanide Ion and Dioxygen Receptors
    53(4)45 - 49, Jan. 2013, Japanese
  • Cell-targeted photodynamic therapy using virus-like particles
    Jin-Kyu Rhee, Michael M. Baksh, Hiroaki Kitagishi, Corwin Nycholat, James C. Paulson, M. G. Finn
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, AMER CHEMICAL SOC, 243, Mar. 2012, English, Research paper, summary (international conference)
  • IMIDAZOLE CYCLODEXTRIN (IMCD), TOTALLY SYNTHETIC SUPRAMOLECULAR COMPLEX AS AN ANTIDOTE FOR CYANIDE POISONING
    T. Yamagiwa, A. T. Kawaguchi, T. Saito, K. Umezawa, H. Kitagishi, K. Watanabe, K. Kano, S. Inokuchi
    INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, WICHTIG EDITORE, 34(8)621 - 621, Aug. 2011, English, Research paper, summary (international conference)
  • Completely Synthetic Compounds That Bind Diatomic Molecules (O2,CO,NO) in Aqueous Solution
    H. Kitagishi, K. Kano
    17(4)160 - 168, 2009
  • COLL 122-Cyclodextrin dimers as simple myoglobin models in aqueous solution
    Koji Kano, Hiroaki Kitagishi
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, AMER CHEMICAL SOC, 236, Aug. 2008, English, Research paper, summary (international conference)

Research Grants & Projects

  • Mechanistic study on circadian clock system regulated by heme/CO crosstalk
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), 2020/04 -2023/03, Grant-in-Aid for Scientific Research (B)
  • Development of innovative drugs having multistep action for treatment of central cerebral amyloidosis
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), 2020/04 -2023/03, Grant-in-Aid for Scientific Research (B)
  • Development of non-viral vector to realize treatment of hereditary disease using genome editing RNA technology
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Research (Exploratory), 2019/06 -2022/03, Grant-in-Aid for Challenging Research (Exploratory)
  • High-Performance Catalyst and Device Prepared by Metalloporphyrin
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Fund for the Promotion of Joint International Research (Fostering Joint International Research (B)), 2018/10 -2021/03, Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
  • Study on the role of endogenous CO in the circadian clock system
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), 2017/04 -2020/03, Hiroaki Kitagishi, Grant-in-Aid for Scientific Research (B)
  • Experimental approach to respiratory and circulatory failure using artificial oxygen carriers and their derivatives
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A), 2015/04 -2020/03, KAWAGUCHI Akira, Grant-in-Aid for Scientific Research (A)
  • A stusy on biological function of endogenous CO as a byproduct of heme metabolism
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, 2016/04 -2018/03, Hiroaki Kitagishi, Grant-in-Aid for Challenging Exploratory Research
  • Investigation of the role of intracellular CO using a supramolecular heme protein model complex showing high CO affinity
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), 2014/04 -2016/03, Kitagishi Hiroaki, Grant-in-Aid for Young Scientists (B)
  • Creation of a Supramolecular CO Receptor for Investigation of Biological Roles of Endogenously-Produced Internal CO
    Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), 2012 -2013, KITAGISHI Hiroaki, Grant-in-Aid for Young Scientists (B)

Research Seeds

  • The chemical tools for removal and delivery of carbon monoxide that is a toxic but essential gas in the living organisms
    Research Fields: Life Sciences, Chemicals, Nanotechnology and Materials, Medical and Pharmaceutical Sciences
    Summary: Whereas carbon monoxide (CO) is well known as a toxic gas, CO is continuously produced in our body. CO works as a signal messenger in the living systems, mainly working for cell-protection. In our laboratory, we have been developing a selective CO removal and delivery agents, which are useful for life science research to elucidate the biological function of CO. Similar but different from nitric oxide (NO), CO exerts an unique biological properties and therefore we can use CO as a medicinal tool.
    Patent Information: 特開2010-194475
    特願2019-040610