TAKAHASHI Miho
Faculty of Life and Medical Sciences Department of Medical Life Systems
Assistant Professor
Last Updated :2021/10/23

Researcher Profile and Settings

Research Areas

  • Life sciences/Clinical pharmacy

Education

  • Hoshi University, 2003/04 - 2006/03
  • Hoshi University, Graduate School, Division of Pharmaceutical Sciences, 2006
  • Hoshi University, 2001/04 - 2003/03
  • Hoshi University, Graduate School, Division of Pharmaceutical Sciences, 2003
  • Hoshi University, Hoshi University, 2001
  • Hoshi University, Faculty of Pharmaceutical Science, 2001

Academic Degrees

  • 博士(薬学), 星薬科大学
  • 修士(薬学), 星薬科大学

Published Papers

  • The Inducible Amphisome Isolates Viral Hemagglutinin and Defends Against Influenza A Virus Infection.
    Omi J, Watanabe-Takahashi M, Igai K, Shimizu E, Ching-Yi Tseng, Miyasaka, T, Waku T, Hama S, Nakanishi R, Goto Y, Nishino Y, Miyazawa A, Natori Y, Yamashita M, Kiyotaka Nishikawa K
    Nat. Commun., 11(1)162doi; 10.1038/s41467-019-13974- , Jan. 2020, English, Research paper (scientific journal)
  • Acuired Resistance to Shiga toxin-induced apoptosis by loss of CD77 expression in Human myelogenous leukemia cell line, THP-1.
    Takahashi M, Hattori T, Watanabe-Takahashi M, Nishikawa K, Nito M
    Biological and Pharmaceutical Bulletin, 41;91475 - 1479, 2018
  • Synthetic construction of sugar-amino acid hybrid polymers involving globotriaose or lactose and evaluation of their biological activities against Shiga toxins produced by Escherichia coli O157:H7.
    Matsuoka K, Nishikawa K, Goshu Y, Koyama T, Hatano K, Matsushita T, Watanabe-Takahashi M, Natori Y, Terunuma D
    Bioorganic and Medicinal Chemistry., 265792 - 5803, 2018, English, Research paper (scientific journal)
  • The pleckstrin homology domain of p210 BCR-ABL interacts with cardiolipin to regulate its mitochondrial translocation and subsequent mitophagy.
    Shimasaki K, Watanabe-Takahashi M, Umeda M, Funamoto S, Saito Y, Noguchi N, Kumagai K, hanada K, Tsukahara F, Maru Y, Shibata N, Naito M, Nishikawa K
    Genes to Cells, 2017
  • Substrate ectodomain is critical for substrate preference and inhibition of γ-secretase
    Satoru Funamoto, Toru Sasaki, Seiko Ishihara, Mika Nobuhara, Masaki Nakano, Miho Watanabe-Takahashi, Takashi Saito, Nobuto Kakuda, Tomohiro Miyasaka, Kiyotaka Nishikawa, Takaomi C. Saido, Yasuo Ihara
    Nature Communications, 4, 2013, English, Research paper (scientific journal)
  • Identification of a peptide motif that potently inhibits two functionally distinct subunits of Shiga toxin
    Miho Watanabe-Takahashi, Masakazu Tamada, Miki Senda, Masahiro Hibino, Eiko Shimizu, Akiko Okuta, Atsuo Miyazawa, Toshiya Senda, Kiyotaka Nishikawa
    Communications Biology, Springer Science and Business Media LLC, 4(1), Dec. 2021, Research paper (scientific journal)
  • A nontoxigenic form of Shiga toxin 2 suppresses the production of amyloid β by altering the intracellular transport of amyloid precursor protein through its receptor-binding B-subunit
    Waka Sato, Miho Watanabe-Takahashi, Takashi Hamabata, Koichi Furukawa, Satoru Funamoto, Kiyotaka Nishikawa
    Biochemical and Biophysical Research Communications, Elsevier BV, 557247 - 253, Jun. 2021, Research paper (scientific journal)
  • Exosome-associated Shiga toxin 2 is released from cells and causes severe toxicity in mice.
    Miho Watanabe-Takahashi, Shinji Yamasaki, Masayuki Murata, Fumi Kano, Jun Motoyama, Jyoji Yamate, Jumpei Omi, Waka Sato, Hirofumi Ukai, Kentaro Shimasaki, Masaya Ikegawa, Miwa Tamura-Nakano, Ryohei Yanoshita, Yuri Nishino, Atsuo Miyazawa, Yasuhiro Natori, Noriko Toyama-Sorimachi, Kiyotaka Nishikawa
    Scientific reports, 8(1)10776 - 10776, 17 Jul. 2018, English, Research paper (scientific journal)
  • Affinity-Based Screening of Tetravalent Peptides Identifies SubtypeS-elective Neutralizers of Shiga Toxin 2d, a Highly Virulent Subtype, by Targeting a Unique Amino Acid Involved in Its Receptor Recognition
    Takaaki Mitsui, Miho Watanabe-Takahashi, Eiko Shimizu, Baihao Zhang, Satoru Funamoto, Shinji Yamasaki, Kiyotaka Nishikawa
    INFECTION AND IMMUNITY, AMER SOC MICROBIOLOGY, 84(9)2653 - 2661, Sep. 2016, English, Research paper (scientific journal)
  • M-COPA, a novel Golgi system disruptor, suppresses apoptosis induced by Shiga toxin
    Takayuki Hattori, Miho Watanabe-Takahashi, Isamu Shiina, Yoshimi Ohashi, Shingo Dan, Kiyotaka Nishikawa, Takao Yamori, Mikihiko Naito
    GENES TO CELLS, WILEY, 21(8)901 - 906, Aug. 2016, English, Research paper (scientific journal)
  • Development of a Novel Tetravalent Synthetic Peptide That Binds to Phosphatidic Acid
    Rina Ogawa, Kohjiro Nagao, Kentaro Taniuchi, Masaki Tsuchiya, Utako Kato, Yuji Hara, Takehiko Inaba, Toshihide Kobayashi, Yoshihiro Sasaki, Kazunari Akiyoshi, Miho Watanabe-Takahashi, Kiyotaka Nishikawa, Masato Umeda
    PLOS ONE, PUBLIC LIBRARY SCIENCE, 10(7), Jul. 2015, English, Research paper (scientific journal)
  • Identification of a Wide Range of Motifs Inhibitory to Shiga Toxin by Affinity-Driven Screening of Customized Divalent Peptides Synthesized on a Membrane
    Mihoko Kato, Miho Watanabe-Takahashi, Eiko Shimizu, Kiyotaka Nishikawa
    APPLIED AND ENVIRONMENTAL MICROBIOLOGY, AMER SOC MICROBIOLOGY, 81(3)1092 - 1100, Feb. 2015, English, Research paper (scientific journal)
  • Proteasome inhibitors prevent cell death and prolong survival of mice challenged by Shiga toxin
    Takayuki Hattori, Miho Watanabe-Takahashi, Nobumichi Ohoka, Takashi Hamabata, Koichi Furukawa, Kiyotaka Nishikawa, Mikihiko Naito
    FEBS OPEN BIO, ELSEVIER SCIENCE LONDON, 5605 - 614, 2015, English, Research paper (scientific journal)
  • Identification of a Peptide-Based Neutralizer That Potently Inhibits Both Shiga Toxins 1 and 2 by Targeting Specific Receptor-Binding Regions
    Kazue Tsutsuki, Miho Watanabe-Takahashi, Yasuaki Takenaka, Eiji Kita, Kiyotaka Nishikawa
    INFECTION AND IMMUNITY, AMER SOC MICROBIOLOGY, 81(6)2133 - 2138, Jun. 2013, English, Research paper (scientific journal)
  • An Orally Applicable Shiga Toxin Neutralizer Functions in the Intestine To Inhibit the Intracellular Transport of the Toxin
    Miho Watanabe-Takahashi, Toshio Sato, Taeko Dohi, Noriko Noguchi, Fumi Kano, Masayuki Murata, Takashi Hamabata, Yasuhiro Natori, Kiyotaka Nishikawa
    INFECTION AND IMMUNITY, AMER SOC MICROBIOLOGY, 78(1)177 - 183, Jan. 2010, English, Research paper (scientific journal)
  • Yip1A regulates the COPI-independent retrograde transport from the Golgi complex to the ER
    Fumi Kano, Shinobu Yamauchi, Yumi Yoshida, Miho Watanabe-Takahashi, Kiyotaka Nishikawa, Nobuhiro Nakamura, Masayuki Murata
    JOURNAL OF CELL SCIENCE, COMPANY OF BIOLOGISTS LTD, 122(13)2218 - 2227, Jul. 2009, English, Research paper (scientific journal)
  • A multivalent peptide library approach identifies a novel Shiga toxin inhibitor that induces aberrant cellular transport of the toxin
    Kiyotaka Nishikawa, Miho Watanabe, Eiji Kita, Katsura Igai, Kazumi Omata, Michael B. Yaffe, Yasuhiro Natori
    FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, 20(14)2597 - +, Dec. 2006, English, Research paper (scientific journal)
  • Development of dialyzer with immobilized glycoconjugate polymers for removal of Shiga-toxin
    A Miyagawa, M Watanabe, K Igai, MCZ Kasuya, Y Natori, K Nishikawa, K Hatanaka
    BIOMATERIALS, ELSEVIER SCI LTD, 27(17)3304 - 3311, Jun. 2006, English, Research paper (scientific journal)
  • Structural analysis of the interaction between Shiga toxin B subunits and linear polymers bearing clustered globotriose residues
    M Watanabe, K Igai, K Matsuoka, A Miyagawa, T Watanabe, R Yanoshita, Y Samejima, D Terunuma, Y Natori, K Nishikawa
    INFECTION AND IMMUNITY, AMER SOC MICROBIOLOGY, 74(3)1984 - 1988, Mar. 2006, English, Research paper (scientific journal)
  • Identification of the optimal structure required for a Shiga toxin neutralizer with oriented carbohydrates to function in the circulation
    K Nishikawa, K Matsuoka, M Watanabe, K Igai, K Hino, K Hatano, A Yamada, N Abe, D Terunuma, H Kuzuhara, Y Natori
    JOURNAL OF INFECTIOUS DISEASES, UNIV CHICAGO PRESS, 191(12)2097 - 2105, Jun. 2005, English, Research paper (scientific journal)
  • Oral therapeutic agents with highly clustered globotriose for treatment of Shiga toxigenic Escherichia coli infections
    M Watanabe, K Matsuoka, E Kita, K Igai, N Higashi, A Miyagawa, T Watanabe, R Yanoshita, Y Samejima, D Terunuma, Y Natori, K Nishikawa
    JOURNAL OF INFECTIOUS DISEASES, UNIV CHICAGO PRESS, 189(3)360 - 368, Feb. 2004, English, Research paper (scientific journal)

Conference Activities & Talks

  • Exosome-associated Shiga toxin 2 is released from cells and causes severe toxicity in mice.
    VTEC2018, 2018
  • Structural analysis of the interaction between Shiga toxin B subunits and linear polymers bearing clustered globotriose residues
    VTEC2006, 2006, Poster presentation
  • Carbohydorate-containing linear polymers that neutralize Shiga toxin
    VTEC 2003, 2003, Poster presentation

Patents

  • Stx2阻害4価ペプチドおよびこのStx2阻害4価ペプチドを含む治療薬
    特願2013-13746, 特願2013-13746
  • CT阻害4価ペプチドおよびコレラ治療薬
    特願2013-51032, 特願2014-050828

Research Seeds

  • Development of a novel therapeutic agent for CML that targets a PH domain of p210-BCR-ABL
    Research Fields: Medical and Pharmaceutical Sciences
    Summary: The tyrosine kinase inhibitors (TKIs) for CML treatment causes drug-resistance, and shows only a poor effect against CML stem cells. In CML cells and CML stem cells, it has been shown that a high level of ROS production is sustained to promote the proliferation of these cells. Thus, the compound targeting the PH domain to regulate its function can be a novel type of therapeutic agent against CML.
  • A new technology identifying a specific peptide-based inhibitor for a protein kinase.
    Research Fields: Medical and Pharmaceutical Sciences, Life Sciences
    Affiliation/Name: Kiyotaka Nishikawa:Miho Takahashi

    Patent Information: 特願2014-128632, 特願2010-019731, 特願2010-019728