| HITOMI Yutaka |  |
| Faculty of Science and Engineering Department of Molecular Chemistry and Biochemistry | |
| Professor |
Last Updated :2025/05/06
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Researcher
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yhitomi
mail.doshisha.ac.jp
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1994年 京都大学工学部 合成化学科卒業（指導教官：伊藤嘉彦教授）1996年 京都大学大学院工学研究科修士課程 合成・生物化学専攻修了（指導教官：生越久靖教授）
1999年 京都大学大学院工学研究科博士課程 合成・生物化学専攻修了（指導教官：生越久靖教授、北川進教授）
1999年 博士（工学）（京都大学）取得
1996年-1999年 日本学術振興会特別研究員（DC1）
1999年-2000年 日本学術振興会特別研究員（PD）
1999年-2001年 米国ノースウェスタン大学化学科博士研究員（T. V. O'Halloran教授）
2001年～2007年 京都大学大学院工学研究科分子工学専攻助手（船引卓三教授）
2007年～2008年 京都大学大学院工学研究科分子工学専攻講師（田中庸裕教授）
2008年～2014年 同志社大学理工学部機能分子・生命化学科准教授（小寺政人教授）
2014年～現在 同志社大学理工学部機能分子・生命化学科教授
Research funding number
20335186Research Interests
Research Areas
- Nanotechnology/Materials / Chemical biology
- Nanotechnology/Materials / Synthetic organic chemistry
- Nanotechnology/Materials / Biochemistry
Research Experience
- Doshisha University, Faculty of Science and Engineering, 教授, 2014 - Today
- Doshisha University, Faculty of Science and Engineering, 准教授, 2008 - 2014
- Kyoto University, Graduate School of Engineering, Department of Molecular Engineering, 2007 - 2008
- Kyoto University, Graduate School of Engineering, Department of Molecular Engineering, 2001 - 2007
- 米国ノースウェスタン大学化学科博士研究員, 2000 - 2001
- 日本学術振興会特別研究員（ＰＤ）, 1999 - 2000
- 日本学術振興会特別研究員（ＤＣ１）, 1996 - 1999
Education
- Kyoto University, 工学研究科 博士課程, 合成・生物化学専攻, 1996/04 - 1999/03
- Kyoto University, Graduate School, Division of Engineering, 合成・生物化学専攻, 1994/03 - 1996/03
- Kyoto University, Faculty of Engineering, 合成化学科, 1990/04 - 1994/03
Degree
Association Memberships
- Society of Biological Inorganic Chemistry
- CATALYSIS SOCIETY OF JAPAN
- JAPAN SOCIETY OF COORDINATION CHEMISTRY
- アメリカ化学会
- 日本化学会
Committee Memberships
- 評議員, 2017 - Today, 金属の関与する生体関連反応シンポジウム, Society
- 幹事, 2017 - Today, 酸化反応討論会, Society
- 幹事, 2017 - Today, 日本化学会生体機能関連化学部会, Society
- 代議員, 2014 - Today, 日本化学会, Society
- 関西支部幹事, 2003 - 2003, 日本化学会生体機能関連化学部会若手の会, Society
Awards
Published Papers
- Designing Artificial Laccase Catalysts by Introducing Substrate Oxidation Metals into Oxygen‐Reducing Metal‐Organic Frameworks: Cu‐Doped ZIF‐67
Hiroki Nakahara; Yutaka Hitomi
Chemistry – A European Journal, 23 Dec. 2024, Scientific journal - Efficient catalytic direct C–H hydroxylation of benzene by graphite-supported μ-nitrido-bridged iron phthalocyanine dimer
Yasuyuki Yamada; Yoshiki Uno; Chee-Ming Teoh; Hirotaka Ohkita; Yuka Toyoda; Akiko Sakata; Yutaka Hitomi; Kentaro Tanaka
Catalysis Science & Technology, 14(17), 2024, Scientific journal - Blue Light-Promoted Synthesis of Thiochromenopyrroledione Derivatives via Titanium Dioxide-Catalyzed Dual Carbon–Carbon Bond Formation with Thioanisole and Maleimide Derivatives
Kanti Roy, P.; Okunaka, S.; Tokudome, H.; Hitomi, Y.
Advanced Synthesis and Catalysis, 365(24), 19 Dec. 2023, Scientific journal - Superoxide Dismutase-like Activity of Zeolitic Imidazolate Framework Nanoparticles Comprising Biomimetic Imidazolato-bridged CuZn Units
Nakahara, H.; Nomura, A.; Tokuda, S.; Okamura, M.; Fujisawa, K.; Koitaya, T.; Yoshida, Y.; Furukawa, S.; Hitomi, Y.
Chemistry - A European Journal, 29(38), 06 Jul. 2023, Scientific journal - Electrochemical Epoxidation Catalyzed by Manganese Salen Complex and Carbonate with Boron-Doped Diamond Electrode
Pijush Kanti Roy; Keisuke Amanai; Ryosuke Shimizu; Masahito Kodera; Takuya Kurahashi; Kenji Kitayama; Yutaka Hitomi
Molecules, MDPI AG, 28(4) 1797 - 1797, 14 Feb. 2023, Scientific journal - Stacking of a Cofacially Stacked Iron Phthalocyanine Dimer on Graphite Achieved High Catalytic CH4 Oxidation Activity Comparable to That of pMMO
Yasuyuki Yamada; Kentaro Morita; Takuya Sugiura; Yuka Toyoda; Nozomi Mihara; Masanari Nagasaka; Hikaru Takaya; Kiyohisa Tanaka; Takanori Koitaya; Naoki Nakatani; Hiroko Ariga-Miwa; Satoru Takakusagi; Yutaka Hitomi; Toshiji Kudo; Yuta Tsuji; Kazunari Yoshizawa; Kentaro Tanaka
JACS Au, American Chemical Society (ACS), 3(3) 823 - 833, 10 Jan. 2023, Scientific journal - Burst of DNA Double-Strand Breaks by Dicopper(II) Complex with a p-Cresol-2,6-Bis(amide-tether-dpa) Ligand via Reductive O2-Activation
Machi Hata; Yuki Kadoya; Yutaka Hitomi; Masahito Kodera
Bulletin of the Chemical Society of Japan, The Chemical Society of Japan, 95(11), 08 Oct. 2022, Scientific journal - Alkane Oxidation with H2O2 Catalyzed by Dicopper Complex with 6-hpa Ligand: Mechanistic Insights as Key Features for the Methane Oxidation
Hiroto Takahashi; Kazuhiko Wada; Kosei Tanaka; Kyosuke Fujikawa; Yutaka Hitomi; Takatsugu Endo; Masahito Kodera
Bulletin of the Chemical Society of Japan, The Chemical Society of Japan, 95(8) 1148 - 1155, 09 Jun. 2022, Scientific journal - Boosting the visible-light-induced toluene oxidation via synergistic effect between nanoparticulate Pd/BiVO4 photocatalyst and a cyclic nitroxyl redox mediator
Okunaka, S.; Hitomi, Y.; Tokudome, H.
Journal of Catalysis, ACADEMIC PRESS INC ELSEVIER SCIENCE, 414 137 - 142, 2022, Scientific journal - In situ decomposition of bromine-substituted catechol to increase the activity of titanium dioxide catalyst for visible-light-induced aerobic conversion of toluene to benzaldehyde
Kana Aitsuki; Daiki Fukushima; Hiroki Nakahara; Kazumune Yo; Masahito Kodera; Sayuri Okunaka; Hiromasa Tokudome; Takanori Koitaya; Yutaka Hitomi
New Journal of Chemistry, Royal Society of Chemistry (RSC), 46(19) 9010 - 9016, 2022, Scientific journal - Enhancement of cancer-cell-selective cytotoxicity by a dicopper complex with a phenanthrene amide-tether ligand conjugate via mitochondrial apoptosis
Hata, M.; Saito, I.; Kadoya, Y.; Tanaka, Y.; Hitomi, Y.; Kodera, M.
Dalton Transactions, Royal Society of Chemistry (RSC), 51(12) 4720 - 4727, 2022, Scientific journal - Close-Stacking of Iron-Oxo-Based Double-Decker Complex on Graphite Surface Achieved High Catalytic CH4 Oxidation Activity Comparable to that of Methane Monooxygenases
Yasuyuki Yamada; Kentaro Morita; Takuya Sugiura; Yuka Toyoda; Nozomi Mihara; Masanari Nagasaka; Hikaru Takaya; Kiyohisa Tanaka; Takanori Koitaya; Naoki Nakatani; Hiroko Ariga-Miwa; Satoru Takakusagi; Yutaka Hitomi; Toshiji Kudo; Yuta Tsuji; Kazunari Yoshizawa; Kentaro Tanaka
American Chemical Society (ACS), 04 Jun. 2021 - Selective oxidation of toluene to benzaldehyde over Pd/BiVO
4 particles under blue to green light irradiation
Sayuri Okunaka; Hiromasa Tokudome; Yutaka Hitomi
Journal of Catalysis, ACADEMIC PRESS INC ELSEVIER SCIENCE, 391 480 - 484, Nov. 2020, Scientific journal - Enhanced oxidative DNA cleavage activity of iron complex of pentadentate mono-carboxamide ligand having spermine as DNA binding domain
Akiko Nomura; Masahito Kodera; Yutaka Hitomi
Chemistry Letters, The Chemical Society of Japan, 49(11) 1353 - 1355, Nov. 2020, Scientific journal - Dicopper(II) Complexes of p-Cresol-2,6-Bis(dpa) Amide-Tether Ligands: Large Enhancement of Oxidative DNA Cleavage, Cytotoxicity, and Mechanistic Insight by Intracellular Visualization
Yuki Kadoya; MacHi Hata; Yoshiki Tanaka; Atsuhiro Hirohata; Yutaka Hitomi; Masahito Kodera
Inorganic Chemistry, AMER CHEMICAL SOC, 60(8) 5474 - 5482, 2020, Scientific journal - Oxidative DNA Cleavage, Formation of μ-1,1-Hydroperoxo Species, and Cytotoxicity of Dicopper(II) Complex Supported by a p-Cresol-Derived Amide-Tether Ligand
Yuki Kadoya; Katsuki Fukui; Machi Hata; Risa Miyano; Yutaka Hitomi; Sachiko Yanagisawa; Minoru Kubo; Masahito Kodera
Inorganic Chemistry, American Chemical Society ({ACS}), 58(21) 14294 - 14298, 04 Nov. 2019, Scientific journal - Acceleration of hydrolytic DNA cleavage by dicopper(II) complexes with p-cresol-derived dinucleating ligands at slightly acidic pH and mechanistic insights
Masahito Kodera; Yuki Kadoya; Kenta Aso; Katsuki Fukui; Akiko Nomura; Yutaka Hitomi; Hiroaki Kitagishi
Bulletin of the Chemical Society of Japan, CHEMICAL SOC JAPAN, 92(4) 739 - 747, 2019, Scientific journal - Green fabrication of nanoporous BiVO
4 films on ITO substrates for photoelectrochemical water-oxidation
Sayuri Okunaka; Yutaka Hitomi; Hiromasa Tokudome
RSC Advances, Royal Society of Chemistry ({RSC}), 8(55) 31575 - 31580, 2018, Scientific journal - Hydrogen peroxide-reducing factor released by PC12D cells increases cell tolerance against oxidative stress
Asami Muraishi; Emi Haneta; Yoshiro Saito; Yutaka Hitomi; Mamoru Sano; Noriko Noguchi
Biological and Pharmaceutical Bulletin, PHARMACEUTICAL SOC JAPAN, 41(5) 777 - 785, 2018, Scientific journal - Macrophage-mediated delivery of light activated nitric oxide prodrugs with spatial, temporal and concentration control
Michael A. Evans; Po Ju Huang; Yuji Iwamoto; Kelly N. Ibsen; Emory M. Chan; Yutaka Hitomi; Peter C. Ford; Samir Mitragotri
Chemical Science, Royal Society of Chemistry, 9(15) 3729 - 3741, 2018, Scientific journal - Cellular Application of Cell-membrane Permeable Fluorescent Zinc Probe Having a Cationic Peptide Tail
Nomura A; Kashina A; Kodera M; Hitomi Y
Peptide Science, 2017 154 - 155, 2017, Scientific journal - Structurally simple cell-permeable porphyrins: Efficient cellular uptake and phototoxicity of porphyrins with four peripheral primary-amine-terminated oligo(ethylene oxide) chains
Natsumi Ohashi; Akiko Nomura; Masahito Kodera; Yutaka Hitomi
Chemistry Letters, CHEMICAL SOC JAPAN, 46(12) 1754 - 1756, 2017, Scientific journal - DNA Cleavage through reductive dioxygen activation by iron-bleomycin mimics with carboxamido ligation: Correlation between DNA cleavage efficacy and redox potential
Akiko Nomura; Yuji Iwamoto; Kengo Arakawa; Akihiro Kashida; Masahito Kodera; Yutaka Hitomi
Chemistry Letters, CHEMICAL SOC JAPAN, 46(8) 1109 - 1111, 2017, Scientific journal - Specific Enhancement of Catalytic Activity by a Dicopper Core: Selective Hydroxylation of Benzene to Phenol with Hydrogen Peroxide
Tomokazu Tsuji; Antonius Andre Zaoputra; Yutaka Hitomi; Kaoru Mieda; Takashi Ogura; Yoshihito Shiota; Kazunari Yoshizawa; Hiroyasu Sato; Masahito Kodera
Angewandte Chemie - International Edition, WILEY-V C H VERLAG GMBH, 56(27) 7779 - 7782, 2017, Scientific journal - Formation and High Reactivity of the anti-Dioxo Form of High-Spin μ-Oxodioxodiiron(IV) as the Active Species That Cleaves Strong C-H Bonds
Masahito Kodera; Shin Ishiga; Tomokazu Tsuji; Katsutoshi Sakurai; Yutaka Hitomi; Yoshihito Shiota; P. K. Sajith; Kazunari Yoshizawa; Kaoru Mieda; Takashi Ogura
Chemistry - A European Journal, WILEY-V C H VERLAG GMBH, 22(17) 5924 - 5936, Apr. 2016, Scientific journal - Preparation of fine particles of sheelite-monoclinic phase BiVO
4 via an aqueous chelating method for efficient photocatalytic oxygen evolution under visible-light irradiation
Sayuri Okunaka; Hiromasa Tokudome; Yutaka Hitomi; Ryu Abe
Journal of Materials Chemistry A, ROYAL SOC CHEMISTRY, 4(10) 3926 - 3932, 2016, Scientific journal - Uncaging a catalytic hydrogen peroxide generator through the photo-induced release of nitric oxide from a {MnNO}6 complex
Yuji Iwamoto; Masahito Kodera; Yutaka Hitomi
Chemical Communications, ROYAL SOC CHEMISTRY, 51(46) 9539 - 9542, 11 Jun. 2015, Scientific journal - Mononuclear nonheme iron(iii) complexes that show superoxide dismutase-like activity and antioxidant effects against menadione-mediated oxidative stress
Yutaka Hitomi; Yuji Iwamoto; Akihiro Kashida; Masahito Kodera
Chemical Communications, ROYAL SOC CHEMISTRY, 51(41) 8702 - 8704, 21 May 2015, Scientific journal - Facile preparation of stable aqueous titania sols for fabrication of highly active TiO
2 photocatalyst films
Sayuri Okunaka; Hiromasa Tokudome; Yutaka Hitomi; Ryu Abe
Journal of Materials Chemistry A, ROYAL SOC CHEMISTRY, 3(4) 1688 - 1695, 28 Jan. 2015, Scientific journal - Effect of central metal ions on the cytotoxicity of metalloporphyrins having a cationic peptide tail
Nomura A; Shashi N; Miyachi R; Kodera M; Hitomi Y
Peptide Science, 261 - 265, 2015, Scientific journal - Synthesis, stability and reactivity of the first mononuclear nonheme oxoiron(iv) species with monoamido ligation: A putative reactive species generated from iron-bleomycin
Yutaka Hitomi; Kengo Arakawa; Masahito Kodera
Chemical Communications, ROYAL SOC CHEMISTRY, 50(56) 7485 - 7487, 17 Jun. 2014, Scientific journal - Roles of carboxylate donors in O-O bond scission of peroxodi-iron(iii) to high-spin oxodi-iron(iv) with a new carboxylate-containing dinucleating ligand
Masahito Kodera; Tomokazu Tsuji; Tomohiro Yasunaga; Yuka Kawahara; Tomoya Hirano; Yutaka Hitomi; Takashi Nomura; Takashi Ogura; Yoshio Kobayashi; P. K. Sajith; Yoshihito Shiota; Kazunari Yoshizawa
Chemical Science, ROYAL SOC CHEMISTRY, 5(6) 2282 - 2292, Jun. 2014, Scientific journal - Nucleophilic ring opening of meso -substituted 5-oxaporphyrin by oxygen, nitrogen, sulfur, and carbon nucleophiles
Kazuhisa Kakeya; Masakatsu Aozasa; Tadashi Mizutani; Yutaka Hitomi; Masahito Kodera
Journal of Organic Chemistry, AMER CHEMICAL SOC, 79(6) 2591 - 2600, 21 Mar. 2014, Scientific journal - Electronic tuning of nitric oxide release from manganese nitrosyl complexes by visible light irradiation: Enhancement of nitric oxide release efficiency by the nitro-substituted quinoline ligand
Yutaka Hitomi; Yuji Iwamoto; Masahito Kodera
Dalton Transactions, ROYAL SOC CHEMISTRY, 43(5) 2161 - 2167, 07 Feb. 2014, Scientific journal - Water proton relaxivity, superoxide dismutase-like activity, and cytotoxicity of a manganese(iii) porphyrin having four poly(ethylene glycol) tails
Yutaka Hitomi; Tomoyuki Ekawa; Masahito Kodera
Chemistry Letters, CHEMICAL SOC JAPAN, 43(5) 732 - 734, 2014, Scientific journal - Gold nanoparticles coated with manganeseporphyrin that effectively shorten the longitudinal relaxation time of water molecules depending on the particle size
Yutaka Hitomi; Kazuki Aoki; Ryosuke Miyachi; Junya Ohyama; Masahito Kodera; Tsunehiro Tanaka; Fuminori Sugihara
Chemistry Letters, CHEMICAL SOC JAPAN, 43(12) 1901 - 1903, 2014, Scientific journal - Development of green-emitting iron complex-based fluorescent probes for intracellular hydrogen peroxide imaging
Yutaka Hitomi; Toshiyuki Takeyasu; Masahito Kodera
Bulletin of the Chemical Society of Japan, CHEMICAL SOC JAPAN, 87(7) 819 - 824, 2014, Scientific journal - Electronic tuning of iron-oxo-mediated C-H activation: Effect of electron-donating ligand on selectivity
Yutaka Hitomi; Kengo Arakawa; Masahito Kodera
Chemistry - A European Journal, 19(43) 14697 - 14701, 18 Oct. 2013, Scientific journal - Iron complex-based fluorescent probes for intracellular hydrogen peroxide detection
Yutaka Hitomi; Toshiyuki Takeyasu; Masahito Kodera
Chemical Communications, ROYAL SOC CHEMISTRY, 49(85) 9929 - 9931, Oct. 2013, Scientific journal - An iron(iii) tetradentate monoamido complex as a nonheme iron-based peroxidase mimetic
Yutaka Hitomi; Kazuaki Hiramatsu; Kengo Arakawa; Toshiyuki Takeyasu; Masashi Hata; Masahito Kodera
Dalton Transactions, Royal Society of Chemistry, 42(36) 12878 - 12882, 28 Sep. 2013, Scientific journal - Peptide conjugates of organoselenium compounds with glutathione peroxidase-like activity
Hitomi, Yutaka; Nomura, Akiko; Miyachi, Ryosuke; Takeyasu, Toshiyuki; Kodera, Masahito
50 199 - 202, Jan. 2013, Scientific journal - A silver complex with an N, S, S-macrocyclic ligand bearing an anthracene pendant arm for optical ethylene monitoring
Yutaka Hitomi; Toshiyuki Nagai; Masahito Kodera
Chemical Communications, ROYAL SOC CHEMISTRY, 48(84) 10392 - 10394, 26 Sep. 2012, Scientific journal - Reversible O-O bond scission of peroxodiiron(III) to high-spin oxodiiron(IV) in dioxygen activation of a diiron center with a bis-tpa dinucleating ligand as a soluble methane monooxygenase model
Masahito Kodera; Yuka Kawahara; Yutaka Hitomi; Takashi Nomura; Takashi Ogura; Yoshio Kobayashi
Journal of the American Chemical Society, AMER CHEMICAL SOC, 134(32) 13236 - 13239, 15 Aug. 2012, Scientific journal - Synthesis, reactivity, and spectroscopic properties of meso-triaryl-5- oxaporphyrins
Kazuhisa Kakeya; Aya Nakagawa; Tadashi Mizutani; Yutaka Hitomi; Masahito Kodera
Journal of Organic Chemistry, AMER CHEMICAL SOC, 77(15) 6510 - 6519, 03 Aug. 2012, Scientific journal - An iron(III)-monoamidate complex catalyst for selective hydroxylation of alkane C-H bonds with hydrogen peroxide
Yutaka Hitomi; Kengo Arakawa; Takuzo Funabiki; Masahito Kodera
Angewandte Chemie - International Edition, WILEY-V C H VERLAG GMBH, 51(14) 3448 - 3452, Apr. 2012, Scientific journal - Formation mechanism of metal nanoparticles studied by XAFS spectroscopy and effective synthesis of small metal nanoparticles
Tsunehiro Tanaka; Junya Ohyama; Kentaro Teramura; Yutaka Hitomi
Catalysis Today, ELSEVIER SCIENCE BV, 183(1) 108 - 118, 20 Mar. 2012, Scientific journal - Oxidative DNA cleavage by synthetic mononuclear nonheme iron complex having cationic short peptide tail for DNA binding
Hitomi, Yutaka; Nomura, Akiko; Matsuda, Shoko; Kashida, Akihiro; Kodera, Masahito
49 279 - 282, 2012, Scientific journal - Synthesis and characterization of ratiometric fluorescent zinc probe having cationic short peptide tail
Hitomi, Yutaka; Takeyasu, Toshiyuki; Matsuda, Shoko; Nomura, Akiko; Kashida, Akihiro; Hayashi, Masanori; Kodera, Masahito
Peptide Science, 49 297 - 300, 2012 - Detection of enzymatically generated hydrogen peroxide by metal-based fluorescent probe
Yutaka Hitomi; Toshiyuki Takeyasu; Takuzo Funabiki; Masahito Kodera
Analytical Chemistry, AMER CHEMICAL SOC, 83(24) 9213 - 9216, 15 Dec. 2011, Scientific journal - Efficient aerobic oxidation of hydrocarbons promoted by high-spin nonheme Fe(II) complexes without any reductant
Shinya Furukawa; Yutaka Hitomi; Tetsuya Shishido; Tsunehiro Tanaka
Inorganica Chimica Acta, ELSEVIER SCIENCE SA, 378(1) 19 - 23, 30 Nov. 2011, Scientific journal - π back-bonding of iron(II) complexes supported by tris(pyrid-2-ylmethyl) amine and its nitro-substituted derivatives
Shinya Furukawa; Yutaka Hitomi; Tetsuya Shishido; Kentaro Teramura; Tsunehiro Tanaka
Journal of Physical Chemistry A, AMER CHEMICAL SOC, 115(46) 13589 - 13595, 24 Nov. 2011, Scientific journal - An in situ quick XAFS spectroscopy study on the formation mechanism of small gold nanoparticles supported by porphyrin-cored tetradentate passivants
Junya Ohyama; Kentaro Teramura; Yasuhiro Higuchi; Tetsuya Shishido; Yutaka Hitomi; Kazuki Aoki; Takuzo Funabiki; Masahito Kodera; Kazuo Kato; Hajime Tanida; Tomoya Uruga; Tsunehiro Tanaka
Physical Chemistry Chemical Physics, ROYAL SOC CHEMISTRY, 13(23) 11128 - 11135, 21 Jun. 2011, International conference proceedings - Multistate CASPT2 study of native iron(III)-dependent catechol dioxygenase and its functional models: Electronic structure and ligand-to-metal charge-transfer excitation
Naoki Nakatani; Yutaka Hitomi; Shigeyoshi Sakaki
Journal of Physical Chemistry B, AMER CHEMICAL SOC, 115(16) 4781 - 4789, Apr. 2011, Scientific journal - In Situ Au L
3 and L2 edge XANES spectral analysis during growth of thiol protected gold nanoparticles for the study on particle size dependent electronic properties
Junya Ohyama; Kentaro Teramura; Tetsuya Shishido; Yutaka Hitomi; Kazuo Kato; Hajime Tanida; Tomoya Uruga; Tsunehiro Tanaka
Chemical Physics Letters, ELSEVIER SCIENCE BV, 507(1-3) 105 - 110, Apr. 2011, Scientific journal - In situ observation of nucleation and growth process of gold nanoparticles by quick XAFS spectroscopy
Junya Ohyama; Kentaro Teramura; Yasuhiro Higuchi; Tetsuya Shishido; Yutaka Hitomi; Kazuo Kato; Hajime Tanida; Tomoya Uruga; Tsunehiro Tanaka
ChemPhysChem, WILEY-V C H VERLAG GMBH, 12(1) 127 - 131, 17 Jan. 2011, Scientific journal - Synthesis and characterization of zinc chelator conjugated with cationic peptide
Hitomi Y; Kashida A; Nomura A; Hayashi M; Kodera M
Peptide Science, 319 - 321, 2011, Scientific journal - Synthesis and catalytic performance of organic-inorganic hybrid mesoporous material having basic nanospace
Tetsuya Shishido; Toru Kawaguchi; Tomohito Iwashige; Kentaro Teramura; Yutaka Hitomi; Tsunehiro Tanaka
Catalysis Letters, SPRINGER, 140(3-4) 121 - 126, Dec. 2010, Scientific journal - Efficient Capping of Growing Gold Nanoparticles by Porphyrin Having Two Disulfide Straps over One Face
Yutaka Hitomi; Junya Ohyama; Yasuhiro Higuchi; Kazuki Aoki; Tetsuya Shishido; Takuzo Funabiki; Masahito Kodera; Tsunehiro Tanaka
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, CHEMICAL SOC JAPAN, 83(11) 1392 - 1396, Nov. 2010, Scientific journal - Coordination Compounds: Tris(2-Picolinyl)Methane and its Copper(I) Complex
Yuuji Kajita; Yoshimitsu Tachi; Yutaka Hitomi; Tomoyuki Nakagawa; Yoshihisa Kishima; Masahito Kodera; Christopher S. Letko; Thomas B. Rauchfuss
Inorganic Syntheses, Inorganic Syntheses, 35 74 - 77, 08 Sep. 2010, In book - Fast guest exchange of a 1:1 zinc porphyrin-amine host-guest complex via a six-coordinated zinc porphyrin
Yutaka Hitomi; Junya Ohyama; Minori Takegoshi; Akira Ando; Takuzo Funabiki; Masahito Kodera; Tsunehiro Tanaka
Bulletin of the Chemical Society of Japan, CHEMICAL SOC JAPAN, 83(8) 950 - 952, 2010, Scientific journal - Size controlled synthesis of gold nanoparticles by porphyrin with four sulfur atoms
Junya Ohyama; Yutaka Hitomi; Yasuhiro Higuchi; Tsunehiro Tanaka
Topics in Catalysis, SPRINGER/PLENUM PUBLISHERS, 52(6-7) 852 - 859, Jun. 2009, International conference proceedings - Synthesis and characterization of a binuclear iron(III) complex bridged by 1-aminocyclopropane-1-carboxylic acid. Ethylene production in the presence of hydrogen peroxide
Wadih Ghattas; Zeinab Serhan; Nadia El Bakkali-Taheri; Marius Réglier; Masahito Kodera; Yutaka Hitomi; A. Jalila Simaan
Inorganic Chemistry, AMER CHEMICAL SOC, 48(9) 3910 - 3912, 04 May 2009, Scientific journal - Mechanism of photooxidation of alcohol over Nb
2 O5
Tetsuya Shishido; Toshiaki Miyatake; Kentaro Teramura; Yutaka Hitomi; Hiromi Yamashita; Tsunehiro Tanaka
Journal of Physical Chemistry C, AMER CHEMICAL SOC, 113(43) 18713 - 18718, 2009, Scientific journal - Promotion effect of tungsten oxide on photo-assisted selective catalytic reduction of NO with NH
3 over TiO2
Seiji Yamazoe; Yasuyuki Masutani; Kentaro Teramura; Yutaka Hitomi; Tetsuya Shishido; Tsunehiro Tanaka
Applied Catalysis B: Environmental, ELSEVIER SCIENCE BV, 83(1-2) 123 - 130, 01 Sep. 2008, Scientific journal - Kinetic study of photo-oxidation of NH
3 over TiO2
Seiji Yamazoe; Yutaka Hitomi; Tetsuya Shishido; Tsunehiro Tanaka
Applied Catalysis B: Environmental, ELSEVIER SCIENCE BV, 82(1-2) 67 - 76, 16 Jul. 2008, Scientific journal - Alkane hydroxylation catalyzed by a series of mononuclear nonheme iron complexes containing 4-nitropyridine ligands
Yutaka Hitomi; Shinya Furukawa; Masakazu Higuchi; Tetsuya Shishido; Tsunehiro Tanaka
Journal of Molecular Catalysis A: Chemical, ELSEVIER SCIENCE BV, 288(1-2) 83 - 86, 03 Jun. 2008, Scientific journal - Identification of a copper(I) intermediate in the conversion of 1-aminocyclopropane carboxylic acid (ACC) into ethylene by Cu(II) - ACC complexes and hydrogen peroxide
Wadih Ghattas; Michel Giorgi; Yasmina Mekmouche; Tsunehiro Tanaka; Antal Rockenbauer; Marius Réglier; Yutaka Hitomi; A. Jalila Simaan
Inorganic Chemistry, AMER CHEMICAL SOC, 47(11) 4627 - 4638, 02 Jun. 2008, Scientific journal - XAFS study of tungsten L
1 - And L3 -edges: structural analysis of WO3 species loaded on TiO2 as a catalyst for photo-oxidation of NH3
Seiji Yamazoe; Yutaka Hitomi; Tetsuya Shishido; Tsunehiro Tanaka
Journal of Physical Chemistry C, AMER CHEMICAL SOC, 112(17) 6869 - 6879, 01 May 2008, Scientific journal - One-phase synthesis of small gold nanoparticles coated by a horizontal porphyrin monolayer
Junya Ohyama; Yutaka Hitomi; Yasuhiro Higuchi; Masashi Shinagawa; Hidefumi Mukai; Masahito Kodera; Kentaro Teramura; Tetsuya Shishido; Tsunehiro Tanaka
Chemical Communications, ROYAL SOC CHEMISTRY, (47) 6300 - 6302, 2008, Scientific journal - Dioxygen activation by a diiron complex of 6-hpa ligand: synthesis, characterization, and functions of diiron(IV)-oxo complex
Masahito Kodera; Shuhei Yamada; Keiichi Kondo; Yutaka Hitomi; Takuzo Funabiki
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, PHARMACEUTICAL SOC JAPAN, 128 37 - 37, 2008 - Visible light absorbed NH
2 species derived from NH3 adsorbed on TiO2 for photoassisted selective catalytic reduction
Seiji Yamazoe; Kentaro Teramura; Yutaka Hitomi; Tetsuya Shishido; Tsunehiro Tanaka
Journal of Physical Chemistry C, AMER CHEMICAL SOC, 111(38) 14189 - 14197, 27 Sep. 2007, Scientific journal - Mechanism of photo-oxidation of NH
3 over TiO2 : Fourier transform infrared study of the intermediate species
Seiji Yamazoe; Taro Okumura; Yutaka Hitomi; Tetsuya Shishido; Tsunehiro Tanaka
Journal of Physical Chemistry C, AMER CHEMICAL SOC, 111(29) 11077 - 11085, 26 Jul. 2007, Scientific journal - Adsorption of manganese porphyrin on metal oxides and its enhanced catalytic activity on epoxidation reaction
Yutaka Hitomi; Hidefumi Mukai; Junya Ohyama; Masashi Shinagawa; Tetsuya Shishido; Tsunehiro Tanaka
Chemistry Letters, CHEMICAL SOC JAPAN, 36(5) 660 - 661, 05 May 2007, Scientific journal - Liquid phase photooxidation of alcohol over niobium oxide without solvents
Tai Ohuchi; Toshiaki Miyatake; Yutaka Hitomi; Tsunehiro Tanaka
Catalysis Today, ELSEVIER SCIENCE BV, 120(2) 233 - 239, 15 Feb. 2007, Scientific journal - Mechanistic study on regioselective oxygenation reaction of 1,2-quinones with peroxybenzoic acids: Relevant to mechanisms of catecholdioxygenases
Yutaka Hitomi; Hiroshi Yoshida; Tsunehiro Tanaka; Takuzo Funabiki
Journal of Molecular Catalysis A: Chemical, ELSEVIER SCIENCE BV, 251(1-2) 239 - 245, 17 May 2006, Scientific journal - Non-covalent modification of the heme-pocket of apomyoglobin by a 1,10-phenanthroline derivative
Yutaka Hitomi; Hidefumi Mukai; Hideaki Yoshimura; Tsunehiro Tanaka; Takuzo Funabiki
Bioorganic and Medicinal Chemistry Letters, PERGAMON-ELSEVIER SCIENCE LTD, 16(2) 248 - 251, 15 Jan. 2006, Scientific journal - Correlation of spin states and spin delocalization with the dioxygen reactivity of catecholatoiron(III) complexes
Masakazu Higuchi; Yutaka Hitomi; Hisataka Minami; Tsunehiro Tanaka; Takuzo Funabiki
Inorganic Chemistry, AMER CHEMICAL SOC, 44(24) 8810 - 8821, 28 Nov. 2005, Scientific journal - Catalytic oxygenative degradation of 4-chlorocatechol by a nonheme iron(III) complex - Mechanism and prevention of catechol ester formation
Yutaka Hitomi; Masakazu Higuchi; Tsunehiro Tanaka; Takuzo Funabiki
Journal of Molecular Catalysis A: Chemical, ELSEVIER SCIENCE BV, 240(1-2) 207 - 213, 03 Oct. 2005, Scientific journal - Electron spray ionization mass study on dioxygenation process in the reaction of catecholatoiron(III) complexes with molecular oxygen
Yutaka Hitomi; Masakazu Higuchi; Tsunehiro Tanaka; Takuzo Funabiki
Inorganica Chimica Acta, ELSEVIER SCIENCE SA, 358(12) 3465 - 3470, 01 Aug. 2005, Scientific journal - Aerobic catechol oxidation catalyzed by a bis(μ-oxo)dimanganese(III,III) complex via a manganese(II)-semiquinonate complex
Yutaka Hitomi; Akira Ando; Hajime Matsui; Tomoyuki Ito; Tsunehiro Tanaka; Seiji Ogo; Takuzo Funabiki
Inorganic Chemistry, AMER CHEMICAL SOC, 44(10) 3473 - 3478, 16 May 2005, Scientific journal - Tuning of spin crossover equilibrium in catecholatoiron(III) complexes by supporting ligands
Yutaka Hitomi; Masakazu Higuchi; Hisataka Minami; Tsunehiro Tanaka; Takuzo Funabiki
Chemical Communications, ROYAL SOC CHEMISTRY, (13) 1758 - 1760, Apr. 2005, Scientific journal - A linear correlation between energy of LMCT band and oxygenation reaction rate of a series of catecholatoiron(III) complexes: Initial oxygen binding during intradiol catechol oxygenation
Yutaka Hitomi; Masato Yoshida; Masakazu Higuchi; Hisataka Minami; Tsunehiro Tanaka; Takuzo Funabiki
Journal of Inorganic Biochemistry, ELSEVIER SCIENCE INC, 99(3) 755 - 763, Mar. 2005, Scientific journal - Chemical properties of sperm whale myoglobins reconstituted with monopropionate hemins
Takashi Hayashi; Tomoyuki Nakagawa; Katsuyoshi Harada; Takashi Matsuo; Yutaka Hitomi; Yoshio Hisaeda
Chemistry Letters, CHEMICAL SOC JAPAN, 33(11) 1512 - 1513, 05 Nov. 2004, Scientific journal - A reaction intermediate involved in oxygenation of catecholatoiron(III) complexes with molecular oxygen - Relevance to catechol dioxygenases
Yutaka Hitomi; Yuichiro Tase; Masakazu Higuchi; Tsunehiro Tanaka; Takuzo Funabiki
Chemistry Letters, CHEMICAL SOC JAPAN, 33(3) 316 - 317, Mar. 2004, Scientific journal - Enhancement of enzymatic activity for myoglobins by modification of heme-propionate side chains
Takashi Hayashi; Hideaki Sato; Takashi Matsuo; Takaaki Matsuda; Yutaka Hitomi; Yoshio Hisaeda
Journal of Porphyrins and Phthalocyanines, SOC PORPHYRINS & PHTHALOCYANINES, 8(1-3) 255 - 264, 2004 - Structures and electronic properties of the catecholatoiron complexes in relation to catechol dioxygenases: Chlorocatecholatoiron complexes are compared to the 3,5-di-tert-butylcatecholatoiron complex in the solid state and in solution
Takuzo Funabiki; Atsushi Fukui; Yutaka Hitomi; Masakazu Higuchi; Takashi Yamamoto; Tsunehiro Tanaka; Fumito Tani; Yoshinori Naruta
Journal of Inorganic Biochemistry, ELSEVIER SCIENCE INC, 91(1) 151 - 158, 25 Jul. 2002, International conference proceedings - Contribution of heme-propionate side chains to structure and function of myoglobin: chemical approach by artificially created prosthetic groups
Takashi Hayashi; Takashi Matsuo; Yutaka Hitomi; Kazufumi Okawa; Akihiro Suzuki; Yoshitsugu Shiro; Tetsutaro Iizuka; Yoshio Hisaeda; Hisanobu Ogoshi
Journal of Inorganic Biochemistry, ELSEVIER SCIENCE INC, 91(1) 94 - 100, 25 Jul. 2002, International conference proceedings - Oxygenative cleavage of catechols including protocatechuic acid with molecular oxygen in water catalysed by water-soluble non-heme iron(III) complexes in relevance to catechol dioxygenases
Takuzo Funabiki; Daisuke Sugio; Matsutaka Maeda; Yutaka Hitomi
Chemical Communications, ROYAL SOC CHEMISTRY, 2(5) 412 - 413, 2002, Scientific journal - Extreme zinc-binding thermodynamics of the metal sensor/regulator protein, ZntR [11]
Y. Hitomi; C. E. Outten; T. V. O'Halloran
Journal of the American Chemical Society, AMER CHEMICAL SOC, 123(35) 8614 - 8615, 05 Sep. 2001 - Interprotein Electron Transfer Reaction Regulated by an Artificial Interface We thank Prof. Dr. I. Morishima and his group for the arrangement of laser flash photolysis equipment. This work was supported by Nagase Science and Technology Foundation, and a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture, Japan. Y. H. was supported by Research Fellowships of the Japanese Society for the Promotion of Science for Young Scientists.
Yutaka Hitomi; Takashi Hayashi; Kenji Wada; Tadashi Mizutani; Yoshio Hisaeda; Hisanobu Ogoshi
Angewandte Chemie (International ed. in English), 40(6) 1098 - 1101, 16 Mar. 2001, Scientific journal - Interprotein electron transfer reaction regulated by an artificial interface
Yutaka Hitomi; Takashi Hayashi; Kenji Wada; Tadashi Mizutani; Yoshio Hisaeda; Hisanobu Ogoshi
Angewandte Chemie - International Edition, WILEY-V C H VERLAG GMBH, 40(6) 1098 - 1101, 14 Mar. 2001, Scientific journal - Peroxidase activity of myoglobin is enhanced by chemical mutation of heme-propionates
Takashi Hayashi; Yutaka Hitomi; Tsutomu Ando; Tadashi Mizutani; Yoshio Hisaeda; Susumu Kitagawa; Hisanobu Ogoshi
Journal of the American Chemical Society, AMER CHEMICAL SOC, 121(34) 7747 - 7750, 01 Sep. 1999, Scientific journal - New approach to the construction of an artificial hemoprotein complex
T. Hayashi; Y. Hitomi; T. Takimura; A. Tomokuni; T. Mizutani; Y. Hisaeda; H. Ogoshi
Coordination Chemistry Reviews, ELSEVIER SCIENCE SA, 190-192 961 - 974, 1999, International conference proceedings - Structure and reactivity of reconstituted myoglobins: Interaction between protein and polar side chain of chemically modified hemin
Takashi Hayashi; Tetsuo Takimura; Yasunori Aoyama; Yutaka Hitomi; Akihiro Suzuki; Hisanobu Ogoshi
Inorganica Chimica Acta, ELSEVIER SCIENCE SA, 275-276(1-2) 159 - 167, 01 Jul. 1998, Scientific journal - Artificial protein-protein complexation between a reconstituted myoglobulin and cytochrome c
Takashi Hayashi; Yutaka Hitomi; Hisanobu Ogoshi
Journal of the American Chemical Society, AMER CHEMICAL SOC, 120(20) 4910 - 4915, 27 May 1998, Scientific journal - MOLECULAR RECOGNITION OF HORSE HEART APOMYOGLOBIN TO MONOPROPIONATE HEMIN - THERMODYNAMIC DETERMINATION OF 2 ORIENTATIONAL ISOMERS BY H-1-NMR SPECTRA
T HAYASHI; Y HITOMI; A SUZUKI; T TAKIMURA; H OGOSHI
CHEMISTRY LETTERS, CHEMICAL SOC JAPAN, (10) 911 - 912, Oct. 1995, Scientific journal - Relationship between electron transfer and the structure of a quinone-linked zinc porphyrin with a flexible peptide spacer
Takashi Hayashi; Tetsuo Takimura; Yutaka Hitomi; Takafumi Ohara; Hisanobu Ogoshi
Journal of the Chemical Society, Chemical Communications, ROYAL SOC CHEMISTRY, (5) 545 - 546, 1995, Scientific journal - Photoinduced electron transfer from zinc porphyrin to a linked quinone in myoglobin
Takashi Hayashi; Tetsuo Takimura; Takafumi Ohara; Yutaka Hitomi; Hisanobu Ogoshi
Journal of the Chemical Society, Chemical Communications, ROYAL SOC CHEMISTRY, (24) 2503 - 2504, 1995, Scientific journal
MISC
- Multicopper Complexes Having a Hydrophobic Pocket to Enhance Methane Oxidation
原田恵一朗; 市川菜摘; 藤川恭祐; 人見穣; 人見穣; 小寺政人; 小寺政人; 小寺政人
日本化学会春季年会講演予稿集(Web), 103rd, 2023 - Methane oxidation catalyzed by dicopper complex with hexadentate binucleating ligand
四宮聖菜; 藤川恭祐; 人見穣; 人見穣; 小寺政人; 小寺政人; 小寺政人
日本化学会春季年会講演予稿集(Web), 103rd, 2023 - Synthesis, structure, and methane oxidation by dicopper complex with hydrophobic pocket
藤川恭祐; 人見穣; 小寺政人; 小寺政人
日本化学会春季年会講演予稿集(Web), 103rd, 2023 - Synthesis, structure, and catalytic activity in the alkane oxidation of new amidate dicopper complexes
下村一輝; 市川菜摘; 藤川恭祐; 人見穣; 人見穣; 小寺政人; 小寺政人; 小寺政人
日本化学会春季年会講演予稿集(Web), 103rd, 2023 - Large acceleration of DNA double strand break by Tetracopper Complexes
松瀬和希; 徳永拓人; 畑真知; 人見穣; 人見穣; 小寺政人; 小寺政人
日本化学会春季年会講演予稿集(Web), 103rd, 2023 - Cytotoxicity of Dicopper (II) Complexes with Amidate Ligands
中嶋彩乃; 上野ジン; 畑真知; 人見穣; 人見穣; 小寺政人; 小寺政人
日本化学会春季年会講演予稿集(Web), 103rd, 2023 - Dissolution, Hydrolysis and Dehydration of Crystalline Cellulose
藤本季来々; 小寺政人; 人見穣
日本化学会春季年会講演予稿集(Web), 103rd, 2023 - Additive Effects of Titanium Dioxide and Lithium Chloride on Visible Light Photoreactions
福島大輝; 小寺政人; 人見穣
基礎有機化学討論会要旨集, 33rd (CD-ROM), 2023 - Study on Azo Coupling Reaction Targeting Lignin Existing in Wood
升田智之; 小寺政人; 人見穣
日本化学会春季年会講演予稿集(Web), 103rd, 2023 - Artificial enzymes expressing antioxidant enzyme functions: from small metal complexes to nanozymes
人見穣
日本分子生物学会年会プログラム・要旨集(Web), 46th, 2023 - Antioxidant Activity of Copper-Substituted Zinc Imidazole Metal-Organic Framework
中原寛樹; 岡村麻美; 野村章子; 小寺政人; 藤澤清史; 吉田安宏; 人見穣
ホスト-ゲスト・超分子化学シンポジウム講演要旨集, 19th, 2022 - DNA Double-Strand Break via Reductive O2-Activation and Cytotoxicity by Dicopper(II) Complexes with p-Cresol-2,6-Bis(dpa4-X) Amide-Tether Ligands
上野ジン; 畑真知; 人見穣; 小寺政人
錯体化学会討論会講演要旨集, 72nd (CD-ROM), 2022 - Development of Methane Oxidation Catalysts: Stabilization of Dicopper(III) Complex with Amide-containing dinucleating Ligands and Alkane Oxidation
市川菜摘; 人見穣; 小寺政人
錯体化学会討論会講演要旨集, 72nd (CD-ROM), 2022 - Rapid Alkane Oxidation with H2O2 Catalyzed by Copper Complex with R-dpa Tridentate Ligand.
藤川恭祐; 人見穣; 小寺政人
錯体化学会討論会講演要旨集, 72nd (CD-ROM), 2022 - Visible-light Driven C-C Bond Formation by Titanium Oxide Catalyst
福島大輝; 小寺政人; 人見穣
酸化反応討論会講演要旨集, 55th, 2022 - Development of Dicopper Complexes with Cancer-cell-selective Cytotoxicity: Role and Optimization of DNA Targets
畑真知; 人見穣; 小寺政人
酸化反応討論会講演要旨集, 55th, 2022 - Copper-substituted zeolite imidazole structures exhibiting copper-dependent enzymatic activity
中原寛樹; 岡村麻美; 野村章子; 小寺政人; 藤沢清史; 吉田安宏; 人見穣
酸化反応討論会講演要旨集, 55th, 2022 - Alkane oxidation by H2O2 catalyzed by amide-containing copper complexes: Effects of binuclear structure and amidate donors
市川菜摘; 人見穣; 小寺政人; 小寺政人
酸化反応討論会講演要旨集, 55th, 2022 - Scavenging, Generation and Detection of Reactive Oxygen Species
人見穣
酸化反応討論会講演要旨集, 55th, 2022 - Effect of Multi Copper Complexes on the Alkane Oxidation with H2O2
藤川恭祐; 田中皐晴; 人見穣; 小寺政人; 吉澤一成; 塩田淑仁; 亀谷陽平
酸化反応討論会講演要旨集, 55th, 2022 - 環状アミン修飾アミド型二核化配位子の合成とその二核銅錯体によるDNA切断・抗がん活性
前川雄哉; 角谷優樹; 人見穣; 小寺政人
錯体化学会討論会講演要旨集, 68th 226 , 10 Jul. 2018 - 二核銅錯体が触媒するH2O2を用いたベンゼンの直接酸化による選択的フェノール生成:6‐hpa配位子の電子効果による酸化触媒活性制御
高橋宏仁; 辻朋和; 人見穣; 小寺政人
錯体化学会討論会講演要旨集, 68th 32 , 10 Jul. 2018 - 酸素発生触媒を目的とする二核コバルト錯体の開発
岩永修; ZAOPUTRA Antonius Andre; 辻朋和; 人見穣; 小寺政人
日本化学会春季年会講演予稿集(CD-ROM), 98th ROMBUNNO.4B1‐15 , 06 Mar. 2018 - 環状アミン修飾アミド型二核化配位子の合成とその二核銅錯体によるDNA切断・抗がん活性
前川雄哉; 角谷優樹; 人見穣; 小寺政人
日本化学会春季年会講演予稿集(CD-ROM), 98th ROMBUNNO.4B1‐21 , 06 Mar. 2018 - 二核銅錯体が触媒するH2O2によるベンゼンの直接酸化に及ぼす配位子の電子効果:活性制御と反応機構解明
高橋宏仁; 辻朋和; 人見穣; 小寺政人
日本化学会春季年会講演予稿集(CD-ROM), 98th ROMBUNNO.4A7‐13 , 06 Mar. 2018 - DNA二重鎖を切断する人工ブレオマイシンの合成
野村章子; 坂井僚介; 岩本勇次; 小寺政人; 人見穣
日本薬学会年会要旨集(CD-ROM), 138th ROMBUNNO.27PA‐am310 , 2018 - 二核銅錯体が触媒するH2O2によるベンゼンの直接酸化による選択的フェノール生成:6‐hpa配位子の電子効果による酸化触媒活性制御
高橋宏仁; 辻朋和; 人見穣; 小寺政人
酸化反応討論会講演要旨集, 50th 139‐141 , 11 Nov. 2017 - 酸素発生触媒を目的とする二核コバルト錯体の開発
岩永修; ZAOPUTRA Antonius Andre; 辻朋和; 人見穣; 小寺政人
酸化反応討論会講演要旨集, 50th 157‐159 , 11 Nov. 2017 - 二核銅(II)錯体が触媒するベンゼンの直接酸化による選択的フェノール生成:水分子の効果に基づく高活性触媒の開発
辻朋和; 人見穣; 塩田淑仁; 吉澤一成; 小寺政人; 小寺政人
酸化反応討論会講演要旨集, 50th 55‐57 , 11 Nov. 2017 - 鉄オキソ種により選択的に不活性C–H結合を酸化する触媒の設計:酵素の戦略をもとに今どこまで設計できるのか?
人見 穣
ファルマシア, 公益社団法人 日本薬学会, 53(9) 870 - 874, 2017 - Size-controlled Synthesis and Functionalization of Gold Nanoparticles with Multidentate Passivants
人見 穣
同志社大学理工学研究報告, 同志社大学理工学研究所, 55(4) 18 - 23, Jan. 2015 - Development and Biological Application of Metal Complex Catalysts that Function in Aqueous Media
人見 穣
同志社大学理工学研究報告, 同志社大学理工学研究所, 55(4) 87 - 90, Jan. 2015 - Development of molecular probes for intracellular hydrogen peroxide imaging
Takeyasu Toshiyuki; Hitomi Yutaka; Kodera Masahito
The science and engineering review of Doshisha University, Doshisha University, 55(1) 1 - 9, Apr. 2014 - A synthetic high spin oxodiiron(IV) complex that cleaves strong C-H bond
Y. Kawahara; Y. Hitomi; M. Kodera
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, SPRINGER, 19 S538 - S538, Mar. 2014, Summary international conference - Effect of a carboxylate-donor on conversion of peroxodiiron(III) to high spin oxodiiron(IV) via O-O bond scission
M. Kodera; Y. Kawahara; Y. Hitomi; T. Nomura; T. Ogura; Y. Kobayashi
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, SPRINGER, 19 S539 - S539, Mar. 2014, Summary international conference - 6-hpa配位子のanti-dioxo high-spin diiron(IV)酸化活性種の生成と反応性:過酸化水素を酸化剤とする高効率高選択的アルカン水酸化
石賀慎; 河原由佳; 辻朋和; 人見穣; 小寺政人
錯体化学会討論会講演要旨集, 64th, 2014 - Nature-inspired Selective Oxidation Catalysts
人見 穣; 小寺 政人
Bio industry, シーエムシー出版, 30(3) 36 - 46, Mar. 2013 - high spin(S=2)オキソ二核鉄(IV)錯体によるC-H活性化
河原由佳; 人見穣; 小寺政人
日本化学会講演予稿集, 93rd(2), 2013 - 高スピン二核鉄(IV)酸化活性種のsyn-anti構造変化による活性化
河原由佳; 人見穣; 小寺政人
錯体化学会討論会講演要旨集, 63rd, 2013 - 二核鉄錯体の酸素活性化に及ぼす電子効果: 6-hpaR(R=4-OMe-3,5-Me2or4-NO2)二核化配位子を用いた二核鉄錯体の合成,結晶構造,及び酸素活性化
日野彰大; 河原由佳; 人見穣; 小寺政人
日本化学会講演予稿集, 93rd(2), 2013 - 二核化配位子6-hpaの二核鉄錯体と過酸化水素の反応:パーオキソ二核鉄(III)からオキソ二核鉄(IV)酸化活性種への変換の分光学的追跡
河原由佳; 野村高志; 小倉尚志; 小林義男; 人見穣; 小寺政人
日本化学会講演予稿集, 92nd(2), 2012 - 4つの電子供与性ペンダントピリジル基をもつbis-tpa型新規二核化配位子を用いた二核鉄錯体の合成
葛尾昌晃; 入江寛彰; 河原由佳; 人見穣; 小寺政人
日本化学会講演予稿集, 92nd(2), 2012 - オキソ二核鉄(IV)high spin(S=2)錯体の反応性
河原由佳; 野村高志; 小倉尚志; 小林義男; 人見穣; 小寺政人
錯体化学会討論会講演要旨集, 62nd, 2012 - オキソ二核鉄(IV)high spin(S=2)錯体の酸化反応活性
河原由佳; 野村高志; 人見穣; 小林義男; 小倉尚志; 小寺政人
酸化反応討論会講演要旨集, 45th, 2012 - 非ヘム二核鉄酸化酵素のcarboxylate-rich配位環境を模倣したカルボン酸含有二核化配位子(BPG2E)を用いた二核鉄錯体による酸素活性化:パーオキソ二核鉄(III)およびオキソ二核鉄(IV)の生成と反応
平野智也; 安永具弘; 河原由佳; 野村高志; 人見穣; 小林義男; 小倉尚志; 小寺政人
酸化反応討論会講演要旨集, 45th, 2012 - Development of metal-complex catalysts inspired by the action mechanism of metalloenzymes
Hitomi Yutaka; Arakawa Kengo; Yano Junya; Hata Masashi; Saito Sachi; Kodera Masahito
The science and engineering review of Doshisha University, Doshisha University, 52(3) 171 - 176, Oct. 2011 - 二核化配位子6-hpaの二核鉄錯体と過酸化水素の反応:パーオキソ二核鉄(III)から高原子価二核鉄(IV)酸化活性種への変換の検出
河原由佳; 小林義男; 人見穣; 小寺政人
酸化反応討論会講演要旨集, 44th, 2011 - Hydrogen peroxide and metal complex: studies toward precise control of the reaction with hydrogen peroxide and sensitive detection of hydrogen peroxide
人見 穣
The Science and engineering review of Doshisha University, 同志社大学理工学研究所, 50(4) 57 - 60, Jan. 2010 - Synthesis of gold nanoparticles protected with porphyrin derivatives through four Au-S bonds
OHYAMA Junya; HIGUCHI Yasuhiro; HITOMI Yutaka; TERAMURA Kentaro; SHISHIDO Tetsuya; TANAKA Tsunehiro
触媒 = Catalyst, 触媒学会, 51(2) 147 - 149, 10 Mar. 2009 - Mechanism of photooxidation of alcohol over Nb_2O_5 catalyst
SHISHIDO Tetsuya; MIYATAKE Toshiaki; TERAMURA Kentaro; HITOMI Yutaka; TANAKA Tsunehiro
觸媒 = Catalyst, 触媒学会, 50(6) 505 - 507, 10 Sep. 2008 - Kinetic and mechanistic analysis on ammonia photo-oxidation
YAMAZOE Seiji; HITOMI Yutaka; SHISHIDO Tetsuya; TANAKA Tsunehiro
触媒 = Catalysts & Catalysis, 触媒学会, 49(2) 159 - 161, 10 Mar. 2007 - Chemical Approach to Catecholdioxygenases Based on Homogeneous Catalysis and Bioinorganic Chemistry
人見 穣; 船引 卓三
Bulletin of Japan Society of Coordination Chemistry, 錯体化学会, (48) 17 - 32, Nov. 2006 - 金ナノ粒子を一つずつ並べる
人見 穣
化学と工業 = Chemistry and chemical industry, 58(11) 1349 - 1349, 01 Nov. 2005 - Hydrolytic Reaction Catalyzed by a Zinc Complex Incorporated into a Protein Hydrophobic Pocket
人見穣; 向井英史; 吉村英哲; 田中庸裕; 船引卓三
日本化学会講演予稿集, 84th(2) 1323 , 11 Mar. 2004 - On the mechanisms of oxygenations of catechols by oxygenases and their model complexes
T Funabiki; M Yoshida; H Yoshida; Y Tase; A Ando; Y Hitomi
JOURNAL OF INORGANIC BIOCHEMISTRY, ELSEVIER SCIENCE INC, 96(1) 135 - 135, Jul. 2003, Summary international conference - Development of a Metal Complex-Protein Hybrid Catalyst
吉村英哲; 人見穣; 船引卓三
日本化学会講演予稿集, 83rd(1) 590 , 03 Mar. 2003 - Development of Oxygenation Catalysts Based on Model Studies of Non-Heme Iron Enzymes
HITOMI YUTAKA; FUNABIKI TAKUZO
触媒 = Catalysts & Catalysis, 触媒学会, 45(1) 44 - 49, 15 Jan. 2003 - Zinc-binding thermodynamics of the metal sensor/regulator protein, ZntR
Y Hitomi; CE Outten; TV O'Halloran
JOURNAL OF INORGANIC BIOCHEMISTRY, ELSEVIER SCIENCE INC, 86(1) 265 - 265, Aug. 2001, Summary international conference - Enhancement of peroxidase activity by use of reconstituted myoglobin
T Hayashi; Y Hitomi; Y Hisaeda; S Kitagawa
JOURNAL OF INORGANIC BIOCHEMISTRY, ELSEVIER SCIENCE INC, 74(1-4) 156 - 156, Apr. 1999, Summary international conference - Molecular Recognition of Horse Heart Apomyoglobin for Monopropionate Hemin : modynamic ermination of Two Orientational Isomers by 1H NMR Spectra
Takashi Hayashi; Yutaka Hitomi; Akihiko Suzuki; Tetsuo Takimura; Hisanobu Ogoshi
Chem, Lett., (10) 911 - 912, 1995
Presentations
- 金属オキソ種を活性種とする選択酸化触媒の作り方
人見 穣
触媒学会 第 47 回オルガノメタリックセミナー, 01 Oct. 2019 - C–H酸化酵素の働きを理解した触媒設計
人見 穣
けいはんな学研都市先端シーズフォーラム, 22 Aug. 2019 - Selective Oxidation Catalyzed by Bioinspired Metal Complex
Yutaka HITOMI
19th International Symposium on Applied Bioinorganic Chemistry (Japan, Nara), 02 Jun. 2019 - Detection and Generation of Hydrogen Peroxide by Functional Model Complexes
HITOMI Yutaka
Chemistry & Biological Chemistry Seminar, NTU, 14 Dec. 2018, Invited oral presentation - DEVELOPMENT OF USEFUL FUNCTIONAL MOLECULES BASED ON BIOINSPIRED COMPLEXES
HITOMI Yutaka
9th Asian Biological Inorganic Chemistry Conference, 13 Dec. 2018, Invited oral presentation - Selective Oxidation Catalysts Inspired by Iron-dependent Oxygenases
HITOMI Yutaka
3rd International Symposium on Precisely Designed Catalysts with Customized Scaffolding, 29 Aug. 2018, Invited oral presentation - Selective Alkane Oxidation Catalyzed by Mononuclear Nonheme Iron
HITOMI Yutaka
43rd International Conference on Coordination Chemistry, 30 Jul. 2018, Invited oral presentation - Development of Useful Molecules Based on Bioinspired Metal Complexes
HITOMI Yutaka
International Congress on Pure & Applied Chemistry 2018, Mar. 2018, Invited oral presentation - Generation of Hydrogen Peroxide by Functional Model Complexes for Superoxide Dismutase
HITOMI Yutaka
EWHA Bioinorganic Chemistry Symposium 2017, Nov. 2017, Invited oral presentation - Site-Selective C-H Bond Oxidation Catalyzed by Mononuclear Nonheme Iron Complexes: Additive Effects of Carboxylic Acids
HITOMI Yutaka
2017 DGIST Global Innovation Festival, Nov. 2017, Invited oral presentation - カルボキサミド配位単核非ヘム鉄錯体を用いた選択酸化触媒の開発
HITOMI Yutaka
第120回触媒討論会, Sep. 2017, Invited oral presentation - 鉄オキソ種により選択的に不活性C-H結合を酸化する触媒の設計
HITOMI Yutaka
錯体化学若手の会夏の学校2017, Jul. 2017, Invited oral presentation - 金属オキソ種を活性種とする選択的アルカン酸化の開発から過酸化水素蛍光プローブまで
HITOMI Yutaka
第500回東北大学大学院薬学研究科セミナー, Mar. 2017, Invited oral presentation - BIOLOGICALLY USEFUL FUNCTIONAL MODELS OF METALLOENZYMES
HITOMI Yutaka
8th Asian Biolgical Inorganic Chemistry Conference, Dec. 2016, Invited oral presentation - Novel Iron-based Superoxide Dismutase Mimics
HITOMI Yutaka
Japan-Korea-Taiwan Bioinorganic Chemistry Symposium, Sep. 2016, Invited oral presentation - Bioinspired Iron Catalysts for Selective Alkane Hydroxylation
HITOMI Yutaka
1st Japan-Australia Joint Symposium on Coordination Chemistry, Sep. 2016, Invited oral presentation - Bioinspired mononuclear nonheme iron complexes for detection of hydrogen peroxide inside living cells
HITOMI Yutaka
42th International Conference on Coordination Chemistry, Jul. 2016, Invited oral presentation - 生体酵素のストラテジーから学ぶ選択酸化触媒のデザイン
HITOMI Yutaka
先端化学･材料技術部会高選択性反応分科会講演会, Apr. 2016, Invited oral presentation - "Iron catalysts with carboxylamido ligands for regio-selective hydroxylation
HITOMI Yutaka
Pacifichem2015, Dec. 2015, Invited oral presentation - Selective Alkane Hydroxylation by Basic OxoIron Species Supported by Carboxylamido Ligands
HITOMI Yutaka
Pacifichem2015, Dec. 2015, Invited oral presentation - 活性酸素種を操るための生物無機化学
HITOMI Yutaka
IUPAC-2015, Aug. 2015, Invited oral presentation - Selective Oxidation by Mononuclear Oxoiron Complexes with Monoamido Ligation
HITOMI Yutaka
生体機能関連化学部会若手の会 第27回サマースクール (2015), Jun. 2015, Invited oral presentation - Metal Complex-Based Fluorescent Probes for Imaging Hydrogen Peroxide
HITOMI Yutaka
41st International Conference on Coordination Chemistry, Jul. 2014, Invited oral presentation - Alkane hydroxylation by oxoiron species supported by pentadentate N5 ligands with monoamidocoordination
HITOMI Yutaka
International conference on hydrogen atom transfer, Jun. 2014, Invited oral presentation - Development of Metal Complexes Working in Cells: Fluorescent Probes for Intracellular Hydrogen Peroxide
HITOMI Yutaka
錯体化学会第63回討論会(2013), Nov. 2013, Invited oral presentation - 使える分子活性化触媒の開発:生体金属酵素モデル研究からのｱﾌﾟﾛｰﾁ
HITOMI Yutaka
日本化学会第93春季年会(2013), Mar. 2013, Invited oral presentation
Industrial Property Rights
- Patent right
抗癌剤
人見 穣, 岩本 勇次
特願2013-151507, 特開2015-020986, 特許第6154231号, 学校法人同志社 - Patent right
ポルフィリン誘導体、及びこれを含む光増感剤等
人見 穣, 大橋 なつみ
特願2015-033566, 特開2016-155768, 学校法人同志社 - Patent right
金属錯体、蛍光プローブ
人見 穣, 小寺 政人, 武安 俊幸
特願2012-529581, 特許第5800816号, 学校法人同志社 - Patent right
抗癌剤、金属錯体及び複素環化合物
人見 穣, 岩本 勇次
特願2013-151507, 特開2015-020986, 学校法人同志社 - Patent right
複素環化合物、酸化触媒及びその使用
人見 穣, 荒川 健吾
特願2012-112606, 特開2013-237650, 特許第5659191号, 学校法人同志社 - Patent right
酸化触媒及び酸化反応生成物の製造方法
人見 穣, 斉藤 沙知, 荒川 健吾
特願2013-028790, 特開2014-156439, 学校法人同志社 - Patent right
酸化触媒及び酸化反応生成物の製造方法
人見 穣, 斉藤 沙知, 荒川 健吾
特願2012-188353, 特開2014-047136, 特許第5552510号, 学校法人同志社 - Patent right
酸化触媒及び酸化反応生成物の製造方法
人見 穣, 斉藤 沙知, 荒川 健吾
特願2013-028790, 特許第5552550号, 学校法人同志社 - Patent right
複素環化合物、金属錯体及び蛍光プローブ
人見 穣, 武安 俊幸
特願2012-186647, 特開2014-043417, 特許第5512764号, 学校法人同志社 - Patent right
sp3C−H結合の酸化方法
人見 穣, 斉藤 沙知, 荒川 健吾
特願2012-188353, 特開2014-047136, 学校法人同志社 - Patent right
複素環化合物、金属錯体及び蛍光プローブ
人見 穣, 武安 俊幸
特願2012-186647, 特開2014-043417, 学校法人同志社 - Patent right
複素環化合物、金属錯体触媒及びその使用
人見 穣, 荒川 健吾
特願2012-112606, 特開2013-237650, 学校法人同志社 - Patent right
アルケン類検出用化合物及びアルケン類の検出方法
人見 穣, 永井 俊行
特願2012-037834, 特開2013-173680, 学校法人同志社 - Patent right
金属ナノ粒子及びそれを含む造影剤
人見 穣, 青木 一樹
特願2011-053879, 特開2012-188708, 学校法人同志社 - Patent right
金属錯体、蛍光プローブ
人見 穣, 小寺 政人, 武安 俊幸
JP2011068360, WO2012-023487, 学校法人同志社
Research Projects
- 過酸化水素の精密イメージングのための分子プローブ開発
人見 穣
日本学術振興会, 科学研究費助成事業, 2022/04 -2025/03, 基盤研究(C), 同志社大学 - Precise Formation of Catalysts Having Specified Fields through Fixation of Metal Complexes in Biological Molecules
人見 穣
水中においても安定なカルボキサミドの鉄イオンへの配位に着目し、過酸化水素を酸化剤として選択的にアルカンを酸化する単核非ヘム鉄錯体Fe(dpaq)を開発してきた。Fe(dpaq)は金属酵素の機能の一部を再現するが、反応速度、基質特異性の面で天然酵素に及ばない。そのため、この錯体触媒をもとに高性能な人工酵素の創製を目指した。Fe(dpaq)錯体はヒト血清アルブミンの薬物結合サイトに強く結合する。種々の条件において酸化触媒能を検討した結果、Fe(dpaq)アルブミン複合体は過酸化水素を酸化剤としてプラスミドDNAを効率よく切断することを発見した。この結果は、Fe(dpaq)は蛋白質内部においても酸化触媒活性を発現できることを実証するものである。この結果をもとに、アルブミンの疎水ポケットに結合した鉄アミド錯体による不斉スルホキシド化を検討した。触媒回転数は、アセトフェノンを内部基準としGC分析により行い、不斉選択性はキラルカラムによるHPLC分析により行った。用いた鉄アミド錯体は、有機溶媒中で過酸化水素を用いた優れた選択アルカン酸化触媒となることが判明しているFe(dpaq)、水中で過酸化水素による一電子酸化反応活性（ペルオキシダーゼ活性）を示すことが判明している窒素４座カルボキシルアミド鉄錯体Fe(mpaq)、さらに、L-プロリンを出発原料とする窒素４座カルボキシルアミド鉄錯体Fe(Propaq)である。Fe(dpaq)は不斉を持たず、Fe(mpaq)はラセミ体として存在するが、Fe(Propaq)は不斉錯体である。不斉鉄錯体を用いた先行研究の反応条件に従い、触媒反応を評価した結果、錯体のみでは触媒回転数も低く、不斉選択性が観測されないが、アルブミン存在下では、触媒回転数が向上すること（Fe(dpaq)では10倍以上）、不斉選択性も僅かであるが観測されることが判明した。, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), 2018/04 -2020/03, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Doshisha University - 金属錯体の生体分子への精密固定化を基軸とする精密制御生体分子反応場の創出
人見 穣
科学研究費補助金, 新学術領域研究(研究領域提案型), 2018/04 -2020/03, Principal investigator, Competitive research funding - Development of Small-molecule Fluorescent Probes Based on the Reactivity of Metal Complexes
Hitomi Yutaka
We have developed a fluorescent probe that can rapidly visualize hydrogen peroxide released from cells as a signal. Fluorescent probes comprise complexes, profluorophores, and linkers linking them. In this study, the complex structure, profluorophore, and linker were improved. Hydrogen peroxide could be detected even in HeLa cells which do not overexpress the EGF receptor, when the most sensitive hydrogen peroxide fluorescent probe was used. In addition, it was shown that the emission of nitrogen monoxide could be achieved in the hypoxia region of cell spheroids by using MnNO complex. The mechanism by which the complex cleaves DNA by reductive oxygen activation was also elucidated., Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), 2016/04 -2019/03, Grant-in-Aid for Scientific Research (B), Doshisha University - 金属錯体の反応性を駆使する小分子蛍光プローブの開発と生物応用
人見 穣
科学研究費補助金, 基盤研究(B), 2016/04 -2019/03, Principal investigator, Competitive research funding - Development of Selective Oxidation Catalysts that Precisely Recognize Substrates in a Size-tunable Space
人見 穣
鉄錯体を触媒とするアルカンのC－H結合選択的な水酸化反応が報告されており、その有機合成化学への利用が期待されている。これらの触媒を用いれば、過酸化水素によって、基質の中の最も酸化されやすいC－H結合を高い選択性をもって触媒的に酸化することができるが、有機合成の現場で酸化したいC－H結合と最も酸化されやすいC－H結合とが一致するケースは多くない。本研究では、基質の酸化されやすさに依存しないC－H結合の酸化のための精密制御反応場を鉄錯体の近傍に構築し、従来では不可能であった位置にあるC－H結合の選択的酸化反応を可能にすることを目指した。また、鉄錯体を蛋白質とハイブリッド化し、水中で酵素型触媒反応を実現することも目指した。ポルフィリン分子、さらに、ベンゼン環を５つ有するイプチセン誘導体を極めて嵩高い立体障害基として有する窒素配位子を合成することに成功した。また、A03班の大阪大学林高史教授、小野田晃准教授との共同研究によって、ヒト血清アルブミンの疎水ポケットに我々が保有する鉄錯体の一つFe(dpaq)が特異的に結合することが判明した。水中において鉄錯体－蛋白質ハイブリッドが酸化活性を示すか、酸化活性を調べた結果、過酸化水素によるプラスミドDNA酸化的切断に高い活性を示すことを見出した。Fe(dpaq)と比較した場合、その酸化活性は約2倍となった。この結果は、蛋白質とDNAとの相互作用によって、DNA酸化活性が向上したと考えられた。Fe(dpaq)に生体ポリアミンとして知られるスペルミンを結合させた場合にも、プラスミドDNAの酸化的切断が向上することを見出した。さらに、配位子に一連の置換基を導入し、鉄錯体の酸化還元電位とDNA酸化切断活性の相関を調べた結果、DNA酸化反応の初速の対数値と酸化還元電位に直線相関関係があり、鉄中心が還元されやすくなるほど活性が高くなることが分かった。, Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), 2016/04 -2018/03, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Doshisha University - Development of fluorination catalysts generating metal oxo species as active species
Hitomi Yutaka
Inspired by the reaction mechanism of mononuclear nonheme iron enzyme, SyrB2, which catalyzes direct halogenation of alkane C-H bonds under mild conditions, novel fluorination catalysts have been designed. SyrB2 generates nonheme oxoiron(IV) species as an active oxidant, which has a halogen ligand coordinated cis to the oxygen ligand. In order to reproduce the biological oxidant, new iron complexes that contain two cis-labile coordination sites have been synthesized. Some fluorinated products have been obtained using the catalysts under mild conditions., Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, 2015/04 -2018/03, Grant-in-Aid for Challenging Exploratory Research, Doshisha University - 自在制御可能な反応空間によって基質の形状を見分ける酵素型選択酸化触媒の開発
人見 穣
科学研究費補助金, 新学術領域研究(研究領域提案型), 2016/04 -2018/03, Principal investigator, Competitive research funding - 金属酵素の感応性化学種を鍵とする新型鉄錯体酸化触媒の設計開発
人見 穣
鉄オキソ種を活性種とする触媒によるLate-stage Oxidationのための選択酸化反応が脚光を浴びている。しかし、これらの触媒が真に有機合成の現場で使用されるには、触媒回転数が低い、選択性が基質の酸化されやすさに依存している等の克服すべき課題がある。金属酵素の酸化活性種となる金属オキソ種は、対応するパーオキソ種のO－O結合の開裂により生成する。本研究では、金属酵素が行っているパーオキソ種のO－O結合の開裂により生成する金属オキソ種への変換を触媒設計に取り入れる。具体的には、鉄パーオキソ種から鉄オキソ種を行い、かつ基質結合によって鉄オキソ種を生成する鉄錯体を合成し、高い触媒回転数と位置特異的酸化を達成する。これまでに、過酸化水素によるアルカンの水酸化反応に対して例外的に高い選択性と耐久性を示す鉄錯体触媒を開発してきた。また、触媒活性の向上だけでなく、触媒活性種である鉄オキソ種の単離と反応解析も行ってきた。本研究では、カルボン酸の添加によって、過酸化水素の酸素―酸素結合の開裂が誘起され、鉄オキソ種の生成が促進されることを基質酸化および吸収スペクトル変化より確認することに成功した。さらに、カルボン酸を有する炭化水素を基質として用いた場合には、カルボン酸部位が配向基として働くために、位置特異的な酸化反応が進行することも見いだした。種々のカルボン酸を用いてアルカン酸化の選択性を評価した結果、立体障害の大きなカルボン酸を用いた場合、選択性を低下させずに触媒回転数が向上することを見いだした。, 日本学術振興会, 科学研究費助成事業 新学術領域研究(研究領域提案型), 2015/04 -2017/03, 新学術領域研究(研究領域提案型), 同志社大学 - 金属オキソ種を活性種とするフッ素化触媒の開発
人見 穣
科学研究費補助金, 挑戦的萌芽研究, 2015/04 -2017/03, Principal investigator, Competitive research funding - 金属酵素の感応性化学種を鍵とする新型鉄錯体酸化触媒の設計開発
人見 穣
科学研究費補助金, 新学術領域研究(研究領域提案型), 2015/04 -2017/03, Principal investigator, Competitive research funding - Development of Rapid and Sensitive Fluorescent Probes for Hydrogen Peroxide Bio-imaging
HITOMI Yutaka
A series of fluorescent probes for hydrogen peroxide have been developed that have a mononuclear nonheme iron complex as a reaction site toward hydrogen peroxide. They are all non-fluorescent, but once reacting with low concentrations of hydrogen peroxide inside cells, they release green- or red-emitting fluorescent dyes such as resorufin and fluorescein. We have succeeded in real-time imaging of hydrogen peroxide that was produced as a messenger inside A431 cells upon stimulation of epidermal growth factors., Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), 2012/04 -2015/03, Grant-in-Aid for Scientific Research (C), Doshisha University - 過酸化水素バイオイメージングのための高速・高感度過酸化水素蛍光プローブの開発
人見 穣
科学研究費補助金, 基盤研究(C), 2012/04 -2015/03, Principal investigator, Competitive research funding - 分子生命化学を指向した水中で機能する金属錯体の合成
小寺政人
科学研究費補助金, 基盤研究(C), 2009/04 -2012/03, Competitive research funding - 細胞内イメージングを指向した発光性金属ナノクラスターの選択合成
人見 穣
科学研究費補助金, 若手研究（B), 2008/03 -2011/03, Principal investigator, Competitive research funding - Synthesis of Metal Complexes that can function in an Aqueous Solution Aiming at Application to Chemical Biology
KODERA Masahito; HITOMI Yutaka; FUNABIKI Takuzo
For the purpose of developing bio-inspired metal complexes applicable to chemical biology, we synthesized metal complexes with newly designed various ligands that specifically stabilize the structures of the metal complexes in solution. With the metal complexes, we successfully attained following biologically relevant functions, (1) mimicking P-to-Q conversion in the O_2-activation of soluble methane monooxygenase(sMMO), (2) roles of the carboxylate-rich coordination environment in O_2-activating diiron enzymes, and (3) enhancement of catalytic activity of ruthenium complexes for O_2-evolution by water oxidation as a model of oxygen evolution complex(OEC). In these systems, we found that stabilization of the optimal structures for the functions in solution leads to enhancement of the functionality, essential for developing effective bio-inspired metal complexes., Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), 2009 -2011, Grant-in-Aid for Scientific Research (B), Doshisha University - Selective synthesis of luminescent metal nanoclusters for intracellular imaging
HITOMI Yutaka
A new porphyrin-based passivant was synthesized which has two disulfide bonds in the same direction. Small gold nanoclusters were easily obtained when gold(III) ion was reduced in the presence of the passivants. Resulting gold nanoclusters exhibited an intense fluorescence due to the porphyrin molecules. Gold nanoparticles prepared with manganese-inserted porphyrin passivants accelerated the relaxation of water protons, indicating that the nanoparticles could be used as a MRI contrast agent., Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), 2008 -2010, Grant-in-Aid for Young Scientists (B), Doshisha University - 生体内酸化反応の機能原理に基づくバイオインスパイヤード酸化触媒
人見 穣
科学研究費補助金, 特定領域研究, 2007/04 -2009/03, Principal investigator, Competitive research funding - 生体内酸化反応の機能原理に基づくバイオインスパイヤード酸化触媒
人見 穣
アミドアニオン配位を有する単核鉄錯体を開発し,過酸化水素およびアルキルペルオキシドとの反応を解析した.その結果,ヒドロペルキソ付加種の生成には,塩基の共存が必須であるが,この塩基の塩基性の程度がヒドロペルキソ種の安定性に影響を与えることをみいだした.この結果は,過酸化水素からプロトンを受け取った塩基が,ヒドロペルキソ種に対して共役酸として働き,ヒドロペルキソ種の酸素-酸素結合のヘテロリシスを誘起した結果であることを強く示唆している.そこで,pKaの様々に異なる一連の塩基を用いて,ヒドロペルキソ種の安定性を評価し,添加した塩基の酸塩基触媒としての機能を評価し,共役酸の酸性度とヒドロペルオキソ種との安定性の間に良い相関関係が存在することを明らかにした.また,共役酸はペルオキシド中間体の安定性を低下させるだけでなく,酸素-素結合のイオン的開裂を促進することも明らかにすることができた.これらは,金属酵素の反応中心で金属イオンに配位しないアミノ酸側鎖が第2配位圏で行う協奏機能を人工系において発現可能であることを実証した点で重要である.本研究では,本金属錯体が水中でも安定に存在することに着眼し,水中での過酸化水素の活性化および外部基質の酸化へと展開した.その結果,上記の5座配位金属錯体ではなく,4座モノアミドアニオン配位単核鉄錯体が高いペルオキシダーゼ活性を発現することを見いだした.反応解析の結果,新しく開発した鉄錯体には空配位座がシスの関係に存在しているために,過酸化水素の活性化においても,基質酸化においても,その反応速度定数が向上していることが判明した., 日本学術振興会, 科学研究費助成事業 特定領域研究, 2008 -2009, 特定領域研究, 同志社大学 - Development of highly efficient reaction process for aerobic selective oxidation on the basis of photocatalytic conversion
TANAKA Tsunehiro; SHISHIDO Tetsuya; SATO Tohru; TERAMURA Kentarou
In the vapor phase selective photocatalytic oxidation of alkanes, alkali-ion-modified silica-supported vanadium oxide was found to be appropriate catalyst system while in the liquid phase selective photocatalytic oxidation, alumina-supported vanadium oxide was found to be suitable. The general mechanism of photocatalytic oxidation of alkanes was proposed. In the liquid phase selective photocatalytic oxidation of alcohols, niobium oxide itself was found to be the best and its reaction mechanism was proposed. Although low-loaded vanadium oxide supported on silica was known to be effective for photo-epoxidation of propene with molecular oxygen, the active species is now under discussion. New photocatalytic system with porphyrin complex was developed for liquid phase photocatalytic oxidation of alkenes. Photoexcited mechanism of surface vanadium oxide species was clarified by both experimental and theoretical investigations., Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), 2007 -2009, Grant-in-Aid for Scientific Research (B), Kyoto University - 光触媒化学変換に基づく高効率エアロビック選択酸化反応プロセスの開発
田中庸裕
科学研究費補助金, 基盤研究(B), 2007/03 -2008/03, Competitive research funding - ポルフィリン金属錯体による分子表面認識とナノサイズ反応場の構築
人見 穣
科学研究費補助金, 若手研究（B), 2005/03 -2008/03, Principal investigator, Competitive research funding - 生体内酸素分子活性化の機能原理の抽出に基づく小分子鉄錯体による酸素酸化触媒の開発
人見 穣
科学研究費補助金, 特定領域研究, 2005/03 -2008/03, Principal investigator, Competitive research funding - 生体内酸素分子活性化の機能原理の抽出に基づく小分子鉄錯体による酸素酸化触媒の開発
人見 穣
生体内において、選択的な酸化反応を行う金属酵素、例えば,ヘム依存性のHorseradish Peroxidase(HRP)は、アミノ酸によるPush-Pull効果によって、ヘテロリシスを誘起することが知られている。この点に着眼し、強いドナー性配位となるアミドアニオン配位を導入した単核鉄錯体を設計、合成した。本錯体は、マイナス40度の低温下、過酸化水素との反応により、単核鉄3価ヒドロペルオキシド種を与えた。安定性を評価した結果、Push効果によって、ヒドロペルオキシド基の酸素-酸素結合のヘテロリシスの誘起されることを見いだした。また、シクロヘキセンを酸化基質とし、触媒酸化反応を検討した結果、ドナー性の高いアミドアニオン配位子を用いるほど、鉄3価ヒドロペルオキシド種の安定性が低下することを見出した。また、中性の配位子を用いた場合のように酸素-酸素結合のホモリシスが優先的に進行するのではなく、テロリシスが誘起されるために、シクロヘキセンのアリル位の水酸化ではなく、エポキシ化生成物が得られることが判明した。この結果は、アミドアニオン配位の導入によるPush効果によって、単核鉄3価ヒドロペルオキシド種の酸素-酸素結合のヘテロリシスが進行し、アリル位の酸化の原因となるヒドロキシルラジカルの生成が抑止されたためと考えられる。, 日本学術振興会, 科学研究費助成事業 特定領域研究, 2007 -2007, 特定領域研究, 京都大学 - ポルフィリン金属錯体による分子表面認識とナノサイズ反応場の構築
人見 穣
十分に設計された配位子を用いれば、生成される金ナノ粒子の粒子径だけでなく、その形状、電子状態、反応性の制御、反応空間の構築も可能であり、その先に豊かな金ナノクラスター科学を展開できるのではないかという着想の基に、『ポルフィリン金属錯体による分子表面認識とナノサイズ反応場の構築』を目指して、金ナノ粒子表面を認識する強固に認識する表面保護配位子Por_ClSを設計、合成した。本表面保護配位子Por_ClSは、ポルフィリン骨格から同一方向に4つのアセチル基によって保護された硫黄原子を提示しており、金表面を認識することが可能である。当初の分子設計通り、表面保護配位子Por_ClSの存在下、HAuCl4を還元することで、Por_ClSによって表面が保護された極めて安定な金ナノクラスターが調製可能であることを見出した。また、ポルフィリン表面保護配位子のHAuCl4に対する仕込み比を増加させることによって、粒子径分布の狭い金ナノクラスターを調製することにも成功した(2.0±0.2nm)。この知見を基に、アセチル基によって保護された硫黄原子ではなく、ジスルフィド結合を有するポルフィリン表面保護配位子を設計、合成した結果、ポルフィリン表面保護配位子のHAuCl4に対する仕込み比に関係なく、粒子径分布の狭い金ナノクラスターが得られることを見いだした。また、得られたポルフィリン保護金ナノクラスターが自己組織化し、超格子を形成することも判明した。, 日本学術振興会, 科学研究費助成事業 若手研究(B), 2005 -2007, 若手研究(B), 京都大学 - Development of low temperature processes of deNOx with ammonia and oxidative removal of ammonia
TANAKA Tsunehiro; TAKAOKA Masaki; HITOMI Yutaka
The aim of the resent research is the development of low temperature selective catalytic reduction of nitrogen oxides with ammonia using photo-energy (photo-SCO) and the goal is the development of low temperature selective catalytic oxidation of ammonia on the basis of photo-SCO. We had found that NO can be reduced selectively by ammonia over photoirradiated titania in the presence of excess oxygen. During the first two years, the catalyst composition was optimized and the catalyst system operated under sunlight and fluorescent light was developed. Through this study, we could clarify the detailed reaction mechanism. Catalytic activity depends on the phase of titania but the response to the visible light does not. This result was deduced by observation of electron transfer from amide anion, an intermediated, to titanium cation 3d orbital with ESR and action spectrum. As an additive component to titania, molybdenum, niobium, and tungsten were found to be effective. The modification of titania with these metal cations brings about the enhancement of the acid strength of titania, resulting in the acceleration of the rate-determining step. During the last two years, we developed the catalytic system for abatement of ammonia at low temperature by applying the photo-SCR. Kinetic analysis of reaction mechanism and the infrared study led us to the finding that TiO-11 is the most effective catalyst. Since the intermediate of this reaction is the same as that in photo-SCR, the same catalyst can be utilized., Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), 2004 -2006, Grant-in-Aid for Scientific Research (B), Kyoto University - 人工非ヘム鉄酵素:合目的配位子デザインによる高原子価活性種の生成と基質酸化の制御
人見 穣
科学研究費補助金, 若手研究（B), 2002/04 -2005/03, Principal investigator, Competitive research funding - 人工非ヘム鉄酵素:合目的配位子デザインによる高原子価活性種の生成と基質酸化の制御
人見 穣
本研究では合目的配位子デザインにより人工非ヘム鉄酵素の構築を目指した。研究の前半では、鉄3価イオンを活性中心に有し、分子状酸素を用いてカテコールを開裂する非ヘム鉄酵素であるカテコールジオキシゲナーゼに着目した。(1)新規水溶性非ヘム鉄錯体を用いて水溶液中におけるカテコールの酸素添加開裂反応を可能にし、pH依存性等の反応機構に関わる因子を明らかにした。(2)種々の置換基を有するカテコール配位子から一連の非ヘム鉄錯体を調製し、電子状態に対するカテコール配位子上の置換基効果を詳細に検討した。これらの錯体と酸素分子との反応速度の対数が、カテコールから鉄(III)イオンへの電荷移動エネルギーと良好な直線関係を示すことを初めて明らかにした。この結果を基に、鉄2価セミキノン励起状態が関与し、鉄3価イオン上で酸素分子が活性化される新しいカテコールジオキシゲナーゼの反応機構を提唱した。(3)一方、電子吸引性基を有する窒素4座配位子を有する錯体では低スピン状態が誘起されることが判明した。これらの低スピン錯体種は高スピン錯体種に比べ著しく反応性が低いことが明らかとなった。(4)鉄3価イオン上で酸素分子が活性化を促進するため、空配位座を有する鉄3価カテコール錯体をデザインしたところ、酸素分子と迅速に反応するだけでなく、比較的安定な酸素錯体を形成することが明らかとなった。更に、酸素錯体の形成が可逆過程であることを明らかにした。(5)一方、マンガン2価セミキノン錯体は分子状酸素と反応し、定量的にキノンとマンガン2核(III,III)ビス-mu-オキソ錯体を形成した。また、この2核マンガン錯体の溶液にカテコールを加えたところ、マンガン2価セミキノン錯体が再生した。これらを基に、高効率のカテコール酸化触媒システムを構築することに成功した。反応機構を詳細に検討した結果、本システムは従来のカテコール酸化反応と異なり、分子状酸素を水に還元することが判明した。, 日本学術振興会, 科学研究費助成事業 若手研究(B), 2002 -2004, 若手研究(B), 京都大学 - 酸素存在下におけるNOxのCOによる選択還元
田中庸裕
科学研究費補助金, 基盤研究(C), 2001/04 -2003/03, Competitive research funding - セルフアセンブルな光触媒を用いた低温アンモニア脱硝システムの開発
田中庸裕
科学研究費補助金, 基盤研究(B), 2001/04 -2003/03, Competitive research funding - 光触媒を用いた低温アンモニア脱硝プロセスおよび低温アンモニア酸化プロセスの開発
田中庸裕
科学研究費補助金, 基盤研究(B), 2001/04 -2003/03, Competitive research funding - 単核非ヘム鉄酸素化酵素の機能発現を基盤とする選択酸素化触媒開発
船引卓三
科学研究費補助金, 基盤研究(B), 2000/04 -2003/03, Competitive research funding - Development of ammonia SCR system with self-assembled photocatalyst
TANAKA Tsunehiro; TAKAOKA Masaki; HITOMI Yutaka; FUNABIKI Takuzo; NAGAI Yasutaka
We have synthesized supported metal oxide catalysts by self-assembling of the active composites and evaluate the photocatalytic activity of thus prepared catalysts. To evaluate the capability of the catalysts for partial oxidations, we carried out photooxidation of light alkanes and liquid phase photooxidation of cyclohexane. We found that Rb2O-V2O5/SiO2 exhibited high activity for the former reaction and response to visible light while for the latter V2O5/Al2O3 catalyst was found to be effective. Titanium dioxide showed comparable high activity but catalyze non selective oxidation. We carried out the evaluation of these catalyst candidates for low temperature ammonia SCR reaction (NO photo-SCR with ammonia). The reaction was carried out in a continuous flow reactor with a fixed catalyst bed which models a practical condition. The practical condition means the feed, GHSV = 4000 h-1, NO and ammonia -1000 ppm, O2 2%. Opposite to the results of partial oxidation, V2O5/Al2O3 was almost inactive and Rb2O-V2O5/SiO2 exhibited 40 % conversion of NO while TiO2 exhibited the highest activity 80% conversion rate was maintained for 100 h. We speculated that ammonia SCR is fundamentally equal to the total oxidation. By varying the reaction conditions and spectral consideration with FT-IR, UV/VIS, and ESR, we proposed the reaction mechanism of a series of elemental steps (1) adsorption of ammonia onto titanium oxide, (2) photoactivation of adsorbed ammonia, (3) reduction of NO as well as the reduction of Ti cations and (4) re-oxidation of reduced Ti cations. In the absence of oxygen. NO acts as an oxidant of the reduced Ti cations. A point of the present catalytic system is that an intermediate is a adsorbed amide radical which arisen from adosorbed ammonia and the restriction of the spin state prevent O2 from reaction with amide radical, resulting in the preferential reduction of NO., Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), 2001 -2002, Grant-in-Aid for Scientific Research (B), KYOTO UNIVERSITY - Selecteve catalytic reduction of NO with CO in the presence of oxygen
TANAKA Tsunehiro; HITOMI Yutaka; FUNABIKI Takuzo
Since an outbreak of Nox gas in high temperature burning is inevitable, the reduction and/or removal of Nox is strongly requested from the viewpoint of environmental preservation. Although there have been a series of studies aiming at reduction and/or removal of Nox exhausted from diesel engine and lean-burn engine by reduction with hydrocarbons as an reductant, yet any catalysis system has not been used in practice because of the dependence of activity upon the kind of hydrocarbon and because of the catalyst life. In the present study, we attempted to develop the Nox removal SCR system with CO as a reductant, Cu/Al203 exhibits as high catalytic activity in the presence of oxygen as Rh/A1203, a model three-way catalyst, and higher activity in the region of lean-burn than Rh/A1203. In the term of project, we have found out the correlation between catalyst state and activity in the lean-burn condition and carried out the optimization of the catalyst. Catalytic activity varied with the loading of Cu and 1 wt% loaded catalyst exhibited the highest activity. But 0.25 wt% loaded catalyst exhibited highest TOF (turn-over-frequency) . ESR and XAFS showed that Cu species which is sintered by high temperature treatment exhibits high activity for CO oxidation resulting in the prevention from NO reduction. The Cu species effective for NO reduction was found to be highly dispersed mononuclear Cu species which is dominant species in 0.25 wt% loaded catalyst TPR spectral features of this catalyst showed that this Cu species is hardly reduced and the H2 reduction at higher than 1000 K does not bring about the formation of metallic Cu but monovalent Cu. The auto-reduction of this Cu species was observed by ESR and photoluminescence and reduced Cu is easily re-oxidized by NO but hardly re-oxidized by O2., Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), 2001 -2002, Grant-in-Aid for Scientific Research (C), KYOTO UNIVERSITY - Studies on development of the selective oxygenation catalysts based on mimicking function of nonheme monoiron oxygenases
FUNABIKI Takuzo; HITOMI Yutaka; TANAKA Tsunehiro
Following studies were performed on the development of oxygenase-like catalytic functions by nonheme monoiron complexes and manganese complexes and on the clarification of mechanisms of electron transfer that is essential for activation of substrates. 1)Intradiol and extradiol oxygenative cleavage of catechols by monoiron complexes Catalytic activity of oxygenations by monoiron complexes ligated by tripodal ligands and tridentate ligands were studied. Effect of electronic and steric effects of substituents on the selective intradiol cleavage gave important information of the oxygen activation and oxygen insertion process into the C-C bonds. In the extraiol cleavage by iron complexes with tridentate ligands also clarified the mechanism of oxygenation via the direct oxygen binding to the iron center. Not only ligands with only the N binding sites but also ligands with N and O binding sites were used for clarification of the O2 insertion into catechols. 2)Intra and extradiol oxygenative cleavage of catechols by manganese complexes By mimicking manganese-containing extradiol cleaving oxygenases, Mn(II)-semiquinone complexes were first synthesized. The complexes were found to be oxygenated to give the intradiol cleavage productws. Interestingly, the reversible uptake of oxygen was observed, indicating that the molecular oxygen binds first to the metal center (iron and manganese) prior to binding to the catechol carbon. 3)Oxygenations in water by iron complexes with water-soluble ligands Although enzymatic oxygenations proceeds in aqueous media, models oxygenations have been performed in organic solvents. This is partly due to the ligands soluble only in organic solvents, and partly on exclusion of oxygen saurce other than molecular oxygen. We have first developed a model system that works in water to give the selective intradiol cleavage of mono-alkyl catechols, e.g. 4-butyl catechols, catechols with the electron-withdrawing substituents, such as chloro and carboxylate, by using the TPA ligands with sulfonate subsitutients. It is important to find that the protocatechuic acid was found to be oxygenatively cleaved by monoiron complexes, because the model oxygenation has not be developed in spite of the most popular enzyme, protocatechuic oxygenases. It was also found that the pH control of the media is essential for the aqueous system. We also found that the TPA complexes without the solfonate substituents are also effective for the reaction in aqueous media., Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), 2000 -2002, Grant-in-Aid for Scientific Research (B), Kyoto University - ミオグロビンにおける非天然ヘムとタンパク質との相互作用及び機能発現の解析
人見 穣
日本学術振興会, 科学研究費助成事業 特別研究員奨励費, 1998 -1998, 特別研究員奨励費, 京都大学
Research Seeds
- Fast Responsible and Highly Sensitive Fluorescent Probes for Hydrogen PeroxideResearch Fields: Life Sciences, Chemicals, Nanotechnology and MaterialsPatent Information:
特許5800816
特許5512764 - Iron-based Catalysts for Selective C-H Hydroxylation of Inert Alkanes with Hydrogen PeroxideResearch Fields: Chemicals, Nanotechnology and Materials, Life Sciences, Medical and Pharmaceutical SciencesAffiliation/Name: Yutaka Hitomi
Patent Information: 特願 2012-112606, 特願 2012-188353, 特願 2013-028790